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Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin.
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Vanden Avond, Mark A., Meng, Hui, Beatka, Margaret J., Helbling, Daniel C., Prom, Mariah J., Sutton, Jessica L., Slick, Rebecca A., Dimmock, David P., Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Pileggi, Elisa, Crutcher, Patrick, Thomas, Stephen and Lawlor, Michael W.
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The nucleotide prodrug CERC‐913 improves mtDNA content in primary hepatocytes from DGUOK‐deficient rats.
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Pasqualetto, Gaia, Schepelmann, Martin ORCID: https://orcid.org/0000-0002-7017-5426, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Pileggi, Elisa, Khogali, Caroline, Morgan, Siân R., Boostrom, Ian, Rozanowska, Malgorzata ORCID: https://orcid.org/0000-0003-2913-8954, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237 and Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868
2020.
Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins.
Molecules
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Pileggi, Elisa, Richards, Jennifer, Wootton, Mandy, Van Leemputte, Thijs, Persoons, Leentje, De Coster, David, Villanueva, Xabier, Daelemans, Dirk, Steenackers, Hans, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910
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Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials.
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Pileggi, Elisa
2019.
Novel synthetic pathways for the preparation of
ProTides as potential therapeutic agents.
PhD Thesis,
Cardiff University.
Item availability restricted. |
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Pasqualetto, Gaia, Pileggi, Elisa, Schepelmann, Martin ORCID: https://orcid.org/0000-0002-7017-5426, Heard, Charles ORCID: https://orcid.org/0000-0001-9703-9777, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Rozanowska, Malgorzata B. ORCID: https://orcid.org/0000-0003-2913-8954, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Bassetto, Marcella
2019.
Novel small-molecule chaperones to overcome opsin misfolding, mistrafficking and aggregation in retinal blinding diseases.
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Vancouver, Canada,
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Pileggi, Elisa, Pasqualetto, Gaia, Rozanowska, Malgorzata ORCID: https://orcid.org/0000-0003-2913-8954, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868
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Development of novel treatments against inherited blinding diseases Retinitis pigmentosa and Leber's congenital amaurosis [Abstract].
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Pileggi, Elisa, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101
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Preparation of pyrimidine alkenyl acyclic nucleoside phosphonoamidates.
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Pileggi, Elisa, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Andrei, Graciela, Schols, Dominique, Snoeck, Robert and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101
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Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
Bioorganic and Medicinal Chemistry
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