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Number of items: 48.

Zuanon, Marika, Brancale, Andrea and Young, Mark ORCID: https://orcid.org/0000-0002-9615-9002 2025. Identification of new human P2X7 antagonists using ligand- and structure-based virtual screening. Journal of Chemical Information and Modeling 65 (13) , pp. 7143-7155. 10.1021/acs.jcim.5c00552
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Davies, James G., Platts, James A. ORCID: https://orcid.org/0000-0002-1008-6595, Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 and Menzies, Georgina E. ORCID: https://orcid.org/0000-0002-6600-6507 2025. Increased functional unit flexibility and solvent accessibility favours oxygen capture in molluscan hemocyanin †. RSC Advances 15 (26) , pp. 20373-20384. 10.1039/d5ra03248b
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Coates, Ryan J., Scofield, Simon ORCID: https://orcid.org/0000-0001-5466-314X and Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 2024. Incorporation of regulatory DNA elements within a viral vector improves recombinant protein expression in plants. Scientific Reports 14 (1) , 28865. 10.1038/s41598-024-80444-9
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Smalley, Christopher J. H., Hughes, Colan E., Hildebrand, Mariana, Aizen, Ruth, Bauer, Melanie, Yamano, Akihito, Levy, Davide, Mirsky, Simcha K., Shaked, Natan T., Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002, Kolb, Ute, Gazit, Ehud, Kronik, Leeor and Harris, Kenneth D. M. ORCID: https://orcid.org/0000-0001-7855-8598 2024. Understanding the solid-state structure of riboflavin through a multitechnique approach. Crystal Growth and Design 24 (15) , pp. 6256-6266. 10.1021/acs.cgd.4c00480
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Williamson, Lainey J., Galchenkova, Marina, Best, Hannah L., Bean, Richard J., Munke, Anna, Awel, Salah, Pena, Gisel, Knoska, Juraj, Schubert, Robin, Dörner, Katerina, Park, Hyun-Woo, Bideshi, Dennis K., Henkel, Alessandra, Kremling, Viviane, Klopprogge, Bjarne, Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611, Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002, Valerio, Joana, Kloos, Marco, Sikorski, Marcin, Mills, Grant, Bielecki, Johan, Kirkwood, Henry, Kim, Chan, de Wijn, Raphael, Lorenzen, Kristina, Xavier, Paul Lourdu, Rahmani Mashhour, Aida, Gelisio, Luca, Yefanov, Oleksandr, Mancuso, Adrian P., Federici, Brian A., Chapman, Henry N., Crickmore, Neil, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Berry, Colin ORCID: https://orcid.org/0000-0002-9943-548X and Oberthür, Dominik 2023. Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX. Proceedings of the National Academy of Sciences 120 (49) , e2203241120. 10.1073/pnas.2203241120
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Pasqualetto, Gaia, Mack, Andrew, Lewis, Emily, Cooper, Ryan, Holland, Alistair, Borucu, Ufuk, Mantell, Judith, Davies, Tom, Weckener, Miriam, Clare, Dan, Green, Tom, Kille, Pete ORCID: https://orcid.org/0000-0001-6023-5221, Muhlhozl, Alex and Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 2023. CryoEM structure and Alphafold molecular modelling of a novel molluscan hemocyanin. PLoS ONE 18 (6) , e0287294. 10.1371/journal.pone.0287294
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Pasqualetto, Gaia, Zuanon, Marika, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Young, Mark T ORCID: https://orcid.org/0000-0002-9615-9002 2023. Identification of the molecular determinants of antagonist potency in the allosteric binding pocket of human P2X4. Frontiers in Pharmacology 14 10.3389/fphar.2023.1101023
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Pasqualetto, Gaia, Zuanon, Marika, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 2023. Identification of a novel P2X7 antagonist using structure-based virtual screening. Frontiers in Pharmacology 13 , 1094607. 10.3389/fphar.2022.1094607
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Coates, Ryan J., Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 and Scofield, Simon ORCID: https://orcid.org/0000-0001-5466-314X 2022. Optimising expression and extraction of recombinant proteins in plants. Frontiers in Plant Science 13 , 1074531. 10.3389/fpls.2022.1074531
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Picarazzi, Francesca, Zuanon, Marika, Pasqualetto, Gaia, Cammarone, Silvia, Romeo, Isabella, Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868 and Mori, Mattia 2022. Identification of small molecular chaperones binding p23h mutant opsin through an in silico structure-based approach. Journal of Chemical Information and Modeling 62 (22) , pp. 5794-5805. 10.1021/acs.jcim.2c01040
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Smalley, Christopher, Hoskyns, Harriet E., Hughes, Colan E, Johnstone, Duncan N., Willhammar, Tom, Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002, Pickard, Chris J., Logsdail, Andrew J. ORCID: https://orcid.org/0000-0002-2277-415X, Midgley, Paul and Harris, Kenneth D. M. ORCID: https://orcid.org/0000-0001-7855-8598 2022. A structure determination protocol based on combined analysis of 3D-ED data, powder XRD data, solid-state NMR data and DFT-D calculations reveals the structure of a new polymorph of L-tyrosine. Chemical Science 13 (18) , pp. 5277-5288. 10.1039/D1SC06467C
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Mender, Mender M., Bolton, Fiona, Berry, Colin ORCID: https://orcid.org/0000-0002-9943-548X and Young, Mark ORCID: https://orcid.org/0000-0002-9615-9002 2022. Antivenom: An immunotherapy for the treatment of snakebite envenoming in sub-Saharan Africa. Donev, Rossen, ed. Immunotherapeutics, Vol. 129. Advances in Protein Chemistry and Structural Biology, Elsevier, pp. 435-477. (10.1016/bs.apcsb.2021.11.004)

Smalley, Christopher J. H., Logsdail, Andrew J. ORCID: https://orcid.org/0000-0002-2277-415X, Hughes, Colan E., Iuga, Dinu, Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 and Harris, Kenneth D. M. ORCID: https://orcid.org/0000-0001-7855-8598 2022. Solid-state structural properties of alloxazine determined from powder XRD data in conjunction with DFT-D calculations and solid-state NMR spectroscopy: unraveling the tautomeric identity and pathways for tautomeric interconversion. Crystal Growth and Design 22 (1) , pp. 524-534. 10.1021/acs.cgd.1c01114
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Grimes, Leanne, Griffiths, Julia, Pasqualetto, Gaia, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 and van der Goes van Naters, Wynand ORCID: https://orcid.org/0000-0002-6808-0161 2020. Drosophila taste neurons as an agonist-screening platform for P2X receptors. Scientific Reports 10 , 8292. 10.1038/s41598-020-65169-9
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Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 2020. Journal club. Purinergic Signalling 16 , pp. 257-259. 10.1007/s11302-020-09720-3
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Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 2020. Studying purinoceptor cell-surface expression by protein biotinylation. Pelegrin, P., ed. Purinergic Signaling: Methods and Protocols, Vol. 2041. Methods in Molecular Biology, Springer, pp. 137-146. (10.1007/978-1-4939-9717-6_9)

Giancotti, Gilda, Rigo, Ilaria, Pasqualetto, Gaia, Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002, Neyts, Johan, Rocha-Pereira, Joana, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237 and Bassetto, Marcella 2019. A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase. Scientific Reports 9 (1) , 18413. 10.1038/s41598-019-54903-7
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Pasqualetto, Gaia, Pileggi, Elisa, Schepelmann, Martin ORCID: https://orcid.org/0000-0002-7017-5426, Heard, Charles ORCID: https://orcid.org/0000-0001-9703-9777, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Rozanowska, Malgorzata B. ORCID: https://orcid.org/0000-0003-2913-8954, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Bassetto, Marcella 2019. Novel small-molecule chaperones to overcome opsin misfolding, mistrafficking and aggregation in retinal blinding diseases. Presented at: 2019 ARVO Annual Meeting, Vancouver, Canada, 28 April - 02 May 2019. Investigative ophthalmology & visual science. , vol.60 (9) ARVO,

Pasqualetto, Gaia, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002 2018. The molecular determinants of small-molecule ligand binding at P2X receptors. Frontiers in Pharmacology 9 , 58. 10.3389/fphar.2018.00058
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Palma, L., Scott, D. J., Harris, G., Din, Salah-Ud, Williams, Thomas, Roberts, Oliver, Young, Mark ORCID: https://orcid.org/0000-0002-9615-9002, Caballero, P. and Berry, Colin ORCID: https://orcid.org/0000-0002-9943-548X 2017. The Vip3Ag4 insecticidal protoxin from Bacillus thuringiensis adopts a tetrameric configuration that is maintained on proteolysis. Toxins 9 (5) , p. 165. 10.3390/toxins9050165
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Grimes, Leanne and Young, Mark ORCID: https://orcid.org/0000-0002-9615-9002 2015. Purinergic P2X receptors: Structural and functional features depicted by X-ray and molecular modelling studies. Current Medicinal Chemistry 22 (7) , pp. 783-798. 10.2174/0929867321999141212131457
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Fowler, Benjamin J., Gelfand, Bradley D., Kim, Younghee, Kerur, Nagaraj, Tarallo, Valeria, Hirano, Yoshio, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T. ORCID: https://orcid.org/0000-0002-9615-9002, Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous A., Hinton, David R., Bastos-Carvalho, Ana, Li, Shengjian, Yasuma, Tetsuhiro, Mizutani, Takeshi, Yasuma, Reo, Wright, Charles and Ambati, Jayakrishna 2014. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science 346 (6212) , pp. 1000-1003. 10.1126/science.1261754
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Roberts, J. A., Allsopp, R. C., El Ajouz, S., Vial, C., Schmid, R., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002 and Evans, R. J. 2012. Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel. Proceedings of the National Academy of Sciences 109 (12) , pp. 4663-4667. 10.1073/pnas.1201872109
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Valente, Maria, Watterson, Summer J., Parker, Mark D., Ford, Robert C. and Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002 2011. Expression, purification, electron microscopy, N-glycosylation mutagenesis and molecular modeling of human P2X4 and Dictyostelium discoideum P2XA. Biochimica et Biophysica Acta (BBA) - Biomembranes 1808 (12) , pp. 2859-2866. 10.1016/j.bbamem.2011.08.025
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Fujii, Kotaro, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002 and Harris, Kenneth David Maclean ORCID: https://orcid.org/0000-0001-7855-8598 2011. Exploiting powder X-ray diffraction for direct structure determination in structural biology: the P2X4 receptor trafficking motif YEQGL. Journal of Structural Biology 174 (3) , pp. 461-467. 10.1016/j.jsb.2011.03.001
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Wu, Fiona, Saleem, Moin A., Kampik, Nicola B., Satchwell, Timothy J., Williamson, Rosalind C., Blattner, Simone M., Ni, Lan, Toth, Tibor, White, Graham, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Parker, Mark D., Alper, Seth L., Wagner, Carsten A. and Toye, Ashley M. 2010. Anion exchanger 1 interacts with nephrin in podocytes. Journal of the American Society of Nephrology 21 (9) , pp. 1456-1467. 10.1681/ASN.2009090921

Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002 2010. P2X receptors: dawn of the post-structure era. Trends in Biochemical Sciences 35 (2) , pp. 83-90. 10.1016/j.tibs.2009.09.006
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Cao, Lishuang, Broomhead, Helen, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002 and North, R. Alan 2009. Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification. Journal of Neuroscience 29 (45) , pp. 14257-14264. 10.1523/JNEUROSCI.4403-09.2009
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Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Fisher, J., Fountain, S. J., Ford, R. C., North, R. and Khakh, B. S. 2008. Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy. Journal of Biological Chemistry 283 (38) , pp. 26241-26251. 10.1074/jbc.M804458200
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Fountain, S. J., Cao, L., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002 and North, R. 2008. Permeation properties of a P2X receptor in the green algae Ostreococcus tauri. Journal of Biological Chemistry 283 (22) , pp. 15122-15126. 10.1074/jbc.M801512200
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Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Zhang, Yi-Hong, Cao, Lishuang, Broomhead, Helen and Jiang, Lin-Hua 2008. Role of the domain encompassing Arg304–Ile328 in rat P2X2 receptor conformation revealed by alterations in complex glycosylation at Asn298. Biochemical Journal 416 (1) , pp. 137-143. 10.1042/BJ20081182
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Cao, Lishuang, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Broomhead, Helen E., Fountain, Samuel J. and North, R. Alan 2007. Thr(339)-to-serine substitution in rat P2X(2) receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys(308). Journal of Neuroscience 27 (47) , pp. 12916-12923. 10.1523/JNEUROSCI.4036-07.2007
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Fountain, Samuel J., Parkinson, Katie, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Cao, Lishuang, Thompson, Christopher R. L. and North, R. Alan 2007. An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum. Nature 448 (7150) , pp. 200-203. 10.1038/nature05926

Barth, K., Weinhold, K., Guenther, A., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Schnittler, H. and Kasper, M. 2007. Caveolin-1 influences P2X(7) receptor expression and localization in mouse lung alveolar epithelial cells. Febs Journal 274 (12) , pp. 3021-3033. 10.1111/j.1742-4658.2007.05830.x

Parker, Mark D., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Daly, Christopher M., Meech, Robert W., Boron, Walter F. and Tanner, Michael J. A. 2007. A conductive pathway generated from fragments of the human red cell anion exchanger AE1. The Journal of Physiology 581 (1) , pp. 33-50. 10.1113/jphysiol.2007.128389

Lopez-Castejon, Gloria, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Meseguer, Jose, Surprenant, Annmarie and Mulero, Victoriano 2007. Characterization of ATP-gated P2X(7) receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta. Molecular Immunology 44 (6) , pp. 1286-1299. 10.1016/j.molimm.2006.05.015

Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Pelegrin, Pablo and Surprenant, Annmarie 2007. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Molecular Pharmacology 71 (1) , pp. 92-100. 10.1124/mol.106.030163

Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Pelegrin, P. and Surprenant, A. 2006. Identification of Thr(283) as a key determinant of P2X(7) receptor function. British Journal of Pharmacology 149 (3) , pp. 261-268. 10.1038/sj.bjp.0706880

Sim, Joan A., Chaumont, Severine, Jo, Jihoon, Ulmann, Lauriane, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Cho, Kwangwook, Buell, Gary, North, R. Alan and Rassendren, Francois 2006. Altered hippocampal synaptic potentiation in P2X(4) knock-out mice. Journal of Neuroscience 26 (35) , pp. 9006-9009. 10.1523/JNEUROSCI.2370-06.2006
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Mackenzie, A. B., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Adinolfi, E. and Surprenant, A. 2005. Pseudoapoptosis induced by brief activation of ATP-gated P2X7 receptors. Journal of Biological Chemistry 280 (40) , pp. 33968-33976. 10.1074/jbc.M502705200

Toye, A. M., Ghosh, S., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Jones, G. K., Sessions, R. B., Ramauge, M., Leclerc, P., Basu, J., Delaunay, J and Tanner, M. J. A. 2005. Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia. Blood 105 (10) , pp. 4088-4095. 10.1182/blood-2004-05-1895

Sim, J. A., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Sung, H. Y., North, R. A. and Surprenant, A. 2004. Reanalysis of P2X(7) receptor expression in rodent brain. Journal of Neuroscience 24 (28) , pp. 6307-6314. 10.1523/JNEUROSCI.1469-04.2004
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Adinolfi, E., Kim, M., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Di Virgilio, F. and Surprenant, A. 2003. Tyrosine phosphorylation of HSP90 within the P2X(7) receptor complex negatively regulates P2X(7) receptors. Journal of Biological Chemistry 278 (39) , pp. 37344-37351. 10.1074/jbc.M301508200

Young, Mark ORCID: https://orcid.org/0000-0002-9615-9002 and Tanner, M. J. A. 2003. Distinct regions of human glycophorin A enhance human red cell anion exchanger (Band 3; AE1) transport function and surface trafficking. Journal of Biological Chemistry 278 (35) , pp. 32954-32961. 10.1074/jbc.M302527200

Kanki, T., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Sakaguchi, M., Hamasaki, N. and Tanner, M. J. A. 2003. The N-terminal region of the transmembrane domain of human erythrocyte band 3. Residues critical for membrane insertion and transport activity. Journal of Biological Chemistry 278 (8) , pp. 5564-5573. 10.1074/jbc.M211662200

Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Beckmann, R., Toye, A. M. and Tanner, M. J. A. 2000. Red-cell glycophorin A-band 3 interactions associated with the movement of band 3 to the cell surface. Biochemical Journal 350 , pp. 53-60. 10.1042/0264-6021:3500053

Bruce, L. J., Wrong, O., Toye, A. M., Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Ogle, G., Ismail, Z., Sinha, A. K., McMaster, P., Hwaihwanje, I., Nash, G. B., Hart, S., Lavu, E., Palmer, R., Othman, A., Unwin, R. J. and Tanner, M. J. A. 2000. Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells. Biochemical Journal 350 (1) , pp. 41-51.

Dempsey, C. E., Sessions, R. B., Halsall, A., Takei, J., Gibbs, N and Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002 1998. Helical structure and dynamics in membrane polypeptides. Biochemical Society Transactions 26 (3) , pp. 444-450. 10.1042/bst0260444

This list was generated on Mon Oct 27 11:02:16 2025 GMT.


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