Browse by All Cardiff Authors

Harrison, D. J., Linehan, P., Patel, Y., Bayram-Weston, Z., Rosser, A. E. ORCID: https://orcid.org/0000-0002-4716-4753, Dunnett, S. B. ORCID: https://orcid.org/0000-0003-1826-1578, Brooks, S. P. ORCID: https://orcid.org/0000-0001-9853-6177 and Lelos, M. J. ORCID: https://orcid.org/0000-0001-7102-055X 2025. Complex cognitive and motivational deficits precede motor dysfunction in the zQ175 (190 CAG repeat) Huntington's disease model. Experimental Neurology 392 , 115350. 10.1016/j.expneurol.2025.115350

Bagnoli, Enrico, Lin, Yu-En, Burel, Sophie, Jaimon, Ebsy, Antico, Odetta, Themistokleous, Christos, Nikoloff, Jonas M., Squires, Samuel, Morella, Ilaria ORCID: https://orcid.org/0000-0001-5691-5400, Watzlawik, Jens O., Fiesel, Fabienne C., Springer, Wolfdieter, Tonelli, Francesca, Lis, Pawel, Brooks, Simon P. ORCID: https://orcid.org/0000-0001-9853-6177, Dunnett, Stephen B., Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706, Alessi, Dario R., Pfeffer, Suzanne R. and Muqit, Miratul M. K. 2025. Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain. Proceedings of the National Academy of Sciences 122 (5) , e2412029122. 10.1073/pnas.2412029122

Indrigo, Marzia, Morella, Ilaria ORCID: https://orcid.org/0000-0001-5691-5400, Orellana, Daniel, d'Isa, Raffaele, Papale, Alessandro ORCID: https://orcid.org/0000-0002-8794-0171, Parra, Riccardo, Gurgone, Antonia, Lecca, Daniela, Cavaccini, Anna, Tigaret, Cezar M. ORCID: https://orcid.org/0000-0001-5848-6697, Cagnotto, Alfredo, Jones, Kimberley, Brooks, Simon ORCID: https://orcid.org/0000-0001-9853-6177, Ratto, Gian Michele, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Lelos, Mariah J. ORCID: https://orcid.org/0000-0001-7102-055X, Middei, Silvia, Giustetto, Maurizio, Carta, Anna R., Tonini, Raffaella, Salmona, Mario, Hall, Jeremy ORCID: https://orcid.org/0000-0003-2737-9009, Thomas, Kerrie ORCID: https://orcid.org/0000-0003-3355-9583, Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706 and Fasano, Stefania ORCID: https://orcid.org/0000-0002-3696-7139 2023. Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2. EMBO Molecular Medicine 15 (11) , e15984. 10.15252/emmm.202215984

Muha, Villo, Williamson, Ritchie, Hills, Rachel, McNeilly, Alison D., McWilliams, Thomas G., Alonso, Jana, Schimpl, Marianne, Leney, Aneika C., Heck, Albert J. R., Sutherland, Calum, Read, Kevin D., McCrimmon, Rory J., Brooks, Simon P. ORCID: https://orcid.org/0000-0001-9853-6177 and van Aalten, Daan M. F. 2019. Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. Open Biology 9 (11) , 190192. 10.1098/rsob.190192

Fjodorova, Marija, Louessard, Morgane, Li, Zongze ORCID: https://orcid.org/0000-0002-4803-4643, De La Fuente, Daniel, Dyke, Emma, Brooks, Simon ORCID: https://orcid.org/0000-0001-9853-6177, Perrier, Anselme and Li, Meng ORCID: https://orcid.org/0000-0002-4803-4643 2019. CTIP2-regulated reduction in PKA-dependent DARPP32 phosphorylation in human medium spiny neurons: implications for Huntington’s disease. Stem Cell Reports 13 (3-6) , pp. 448-457. 10.1016/j.stemcr.2019.07.015

McWilliams, Thomas, Barini, Erica, Pohjolan-Pirhonen, Risto, Brooks, Simon ORCID: https://orcid.org/0000-0001-9853-6177, Singh, Francois, Burel, Sophie, Balk, Kristin, Kumar, Atul, Montava-Garriga, Lambert, Prescott, Alan, Hassoun, Sidi, Mouton-Liger, Francois, Ball, Graeme, Hills, Rachel, Knebel, Axel, Ulusoy, Ayse, Di Monte, Donato, Tamjar, Jevgenia, Antico, Odetta, Fears, Kyle, Smith, Laura ORCID: https://orcid.org/0000-0002-2684-8179, Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706, Palin, Eino, Valori, Miko, Eerola-Rautio, Johanna, Tienari, Pentti, Corti, Olga, Dunnett, Stephen ORCID: https://orcid.org/0000-0003-1826-1578, Ganley, Ian, Suomalainen, Anu and Muqit, Miratul 2018. Phosphorylation of Parkin at Serine65 is essential for its activation in vivo. Open Biology 8 , 180108. 10.1098/rsob.180108

Harrison, David, Roberton, Victoria, Vinh, Ngoc-Nga, Brooks, Simon ORCID: https://orcid.org/0000-0001-9853-6177, Dunnett, Stephen ORCID: https://orcid.org/0000-0003-1826-1578 and Rosser, Anne ORCID: https://orcid.org/0000-0002-4716-4753 2018. The effect of tissue preparation and donor age on striatal graft morphology in the mouse. Cell Transplantation 27 (2) , pp. 230-244. 10.1177/0963689717744788

McWilliams, Thomas G., Prescott, Alan R., Montava-Garriga, Lambert, Ball, Graeme, Singh, Francois, Barini, Erica, Muqit, Miratul M. K., Brooks, Simon P. ORCID: https://orcid.org/0000-0001-9853-6177 and Ganley, Ian G. 2018. Basal mitophagy occurs independently of PINK1 in mouse tissues of high metabolic demand. Cell Metabolism 27 (2) , 439-449.e5. 10.1016/j.cmet.2017.12.008

Bragg, Robert M., Coffey, Sydney R., Weston, Rory M., Ament, Seth A., Cantle, Jeffrey P., Minnig, Shawn, Funk, Cory C., Shuttleworth, Dominic D., Woods, Emily L., Sullivan, Bonnie R., Jones, Lindsey, Glickenhaus, Anne, Anderson, John S., Anderson, Michael D., Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Wheeler, Vanessa C., MacDonald, Marcy E., Brooks, Simon P. ORCID: https://orcid.org/0000-0001-9853-6177, Price, Nathan D. and Carroll, Jeffrey B. 2017. Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease. Scientific Reports 7 , 41570. 10.1038/srep41570

Yhnell, Emma ORCID: https://orcid.org/0000-0003-3960-5181, Dunnett, Stephen ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon ORCID: https://orcid.org/0000-0001-9853-6177 2016. A longitudinal operant assessment of cognitive and behavioural changes in the HdhQ111 mouse model of Huntington's Disease. PLoS ONE 11 (10) , e0164072. 10.1371/journal.pone.0164072

Yhnell, Emma ORCID: https://orcid.org/0000-0003-3960-5181, Lelos, Mariah Jillian ORCID: https://orcid.org/0000-0001-7102-055X, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2016. L30 Cognitive training improves disease symptoms in a mouse model of huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry 87 (Supp 1) , A100-A101. 10.1136/jnnp-2016-314597.285

Yhnell, Emma ORCID: https://orcid.org/0000-0003-3960-5181, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2016. A longitudinal motor characterisation of the HdhQ111 mouse model of Huntington's Disease. Journal of Huntington's Disease 5 (2) , pp. 149-161. 10.3233/JHD-160191

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2016. Foreword. Journal of Neuroscience Methods 265 , pp. 1-2. 10.1016/j.jneumeth.2016.01.011

Bayram-Weston, Zubeyde, Olsen, Elliott, Harrison, David, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon ORCID: https://orcid.org/0000-0001-9853-6177 2016. Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease. Journal of Neuroscience Methods 265 , pp. 81-88. 10.1016/j.jneumeth.2015.09.033

Yhnell, Emma ORCID: https://orcid.org/0000-0003-3960-5181, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2016. The utilisation of operant delayed matching and non-matching to position for probing cognitive flexibility and working memory in mouse models of Huntington's disease. Journal of Neuroscience Methods 265 , pp. 72-80. 10.1016/j.jneumeth.2015.08.022

Bayram-Weston, Zubeyde, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2016. Comparison of mHTT antibodies in Huntington's disease mouse models reveal specific binding profiles and steady-state ubiquitin levels with disease development. PloS One 10.1371/journal.pone.0155834

Yhnell, Emma ORCID: https://orcid.org/0000-0003-3960-5181, Lelos, Mariah Jillian ORCID: https://orcid.org/0000-0001-7102-055X, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2016. Cognitive training modifies disease symptoms in a mouse model of Huntington's disease. Experimental Neurology 282 , pp. 19-26. 10.1016/j.expneurol.2016.05.008

Bayram-Weston, Zubeyde, Stone, Timothy C. ORCID: https://orcid.org/0000-0003-4591-9611, Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Elliston, Linda Anne, Janghra, Narinder, Higgs, Gemma, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2015. Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence. BMC Genomics 16 , -. 10.1186/s12864-015-2251-4

Bowles, Kathryn R., Brooks, Simon P. ORCID: https://orcid.org/0000-0001-9853-6177, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2015. Huntingtin subcellular localisation is regulated by Kinase signalling activity in the StHdhQ111 model of HD. PLoS ONE 10 (12) , e0144864. 10.1371/journal.pone.0144864

Steventon, Jessica, Harrison, David John, Trueman, Rebecca C., Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753, Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2015. In Vivo MRI evidence that neuropathology is attenuated by cognitive enrichment in the Yac128 Huntington's Disease mouse model. Journal of Huntington's Disease 4 (2) , pp. 149-160. 10.3233/JHD-150147

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2015. Mouse models of Huntington's disease. Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease, Current Topics in Behavioral Neurosciences, vol. 22. Berlin: Springer, pp. 101-133. (10.1007/7854_2013_256)

Yhnell, Emma ORCID: https://orcid.org/0000-0003-3960-5181, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2014. C04 A longitudinal behavioural characterisation of the HDHQ111 mouse model of Huntington's Disease. Journal of Neurology, Neurosurgery & Psychiatry 85 (Supp 1) , A26. 10.1136/jnnp-2014-309032.77

Hughes, Alis, Mort, Matthew Edwin, Elliston, Linda Anne, Thomas, Rhian M., Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2014. Identification of novel alternative splicing events in the Huntingtin gene and assessment of the functional consequences using structural protein homology modelling. Journal of Molecular Biology 426 (7) , pp. 1428-1438. 10.1016/j.jmb.2013.12.028

Yhnell, Emma ORCID: https://orcid.org/0000-0003-3960-5181, Dunnett, Stephen B. ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon P. ORCID: https://orcid.org/0000-0001-9853-6177 2014. The development of operant delayed matching to position for Huntington's disease mouse models. Presented at: 12th meeting of the International Society for Neural Transplantation and Restoration, NeuroReport. , vol.25 (3) Lippincott, Williams & Wilkins, p. 163. 10.1097/01.wnr.0000443076.61006.22

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2013. Cognitive deficits in animal models of basal ganglia disorders. Brain Research Bulletin 92 , pp. 29-40. 10.1016/j.brainresbull.2012.04.011

Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Tarasova, Tatiana, Springe, Signe, Kukharsky, Michail S., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Kozin, Sergey A., Kotelevtsev, Yury, Bachurin, Sergey O., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2013. Chronic administration of dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice. Journal of Alzheimer's Disease 36 (3) , pp. 589-596. 10.3233/JAD-130071

Harrison, David John, Busse, Monica ORCID: https://orcid.org/0000-0002-5331-5909, Openshaw, Rebecca ORCID: https://orcid.org/0000-0002-0150-4353, Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2013. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental Neurology 248 , pp. 457-469. 10.1016/j.expneurol.2013.07.014

Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Fuller, Anna, Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2012. A novel extended sequence learning task (ESLeT) for rodents: validation and the effects of amphetamine, scopolamine and striatal lesions. Brain Research Bulletin 88 (2-3) , pp. 237-250. 10.1016/j.brainresbull.2010.10.005

Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Heuer, Andreas ORCID: https://orcid.org/0000-0003-0300-7606, Lelos, Mariah Jillian ORCID: https://orcid.org/0000-0001-7102-055X, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 and Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 2012. Bilateral striatal lesions disrupt performance in an operant delayed reinforcement task in rats. Brain Research Bulletin 88 (2-3) , pp. 251-260. 10.1016/j.brainresbull.2011.04.002

Deschepper, Mia Pieter, Hoogendoorn, Bastiaan ORCID: https://orcid.org/0000-0001-9753-169X, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88 (2-3) , pp. 210-222. 10.1016/j.brainresbull.2011.01.012

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Higgs, Gemma, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Longitudinal analysis of the behavioural phenotype in HdhQ92 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 148-155. 10.1016/j.brainresbull.2010.05.003

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Higgs, Gemma, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 182-188. 10.1016/j.brainresbull.2010.05.004

Bayram-Weston, Zubeyde, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the R6/1 Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 104-112. 10.1016/j.brainresbull.2011.07.009

Bayram-Weston, Zubeyde, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2012. Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 137-147. 10.1016/j.brainresbull.2011.05.005

Bayram-Weston, Zubeyde, Torres, Eduardo Miguel, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh((CAG)150) Huntington's disease knock-in mouse. Brain Research Bulletin 88 (2-3) , pp. 189-198. 10.1016/j.brainresbull.2011.03.014

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Higgs, Gemma, Janghra, Nari, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 113-120. 10.1016/j.brainresbull.2010.05.005

Trueman, Rebecca C., Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2012. Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 163-170. 10.1016/j.brainresbull.2011.10.019

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Janghra, Nari, Workman, Victoria Louise, Bayram-Weston, Zubeyde, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 94-103. 10.1016/j.brainresbull.2011.01.010

Bayram-Weston, Zubeyde, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2012. Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 171-181. 10.1016/j.brainresbull.2011.03.013

Trueman, Rebecca C., Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2012. Operant-based instrumental learning for analysis of genetically modified models of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 261-275. 10.1016/j.brainresbull.2011.03.015

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Janghra, Narinder, Higgs, Gemma V., Bayram-Weston, Zubeyde, Heuer, Andreas ORCID: https://orcid.org/0000-0003-0300-7606, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Selective cognitive impairment in the YAC128 Huntington's disease mouse. Brain Research Bulletin 88 (2-3) , pp. 121-129. 10.1016/j.brainresbull.2011.05.010

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Longitudinal analyses of operant performance on the serial implicit learning task (SILT) in the YAC128 Huntington's disease mouse line. Brain Research Bulletin 88 (2-3) , pp. 130-136. 10.1016/j.brainresbull.2011.06.008

Trueman, Rebecca C., Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2012. Early onset deficits on the delayed alternation task in the HdhQ92 knock-in mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 156-162. 10.1016/j.brainresbull.2011.03.012

Bowles, Kathryn R., Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2012. Gene expression and behaviour in mouse models of HD. Brain Research Bulletin 88 (2-3) , pp. 276-284. 10.1016/j.brainresbull.2011.07.021

Fielding, Steven A., Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Klein, Alexander, Bayram-Weston, Zubeyde, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Profiles of motor and cognitive impairment in the transgenic rat model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 223-236. 10.1016/j.brainresbull.2011.09.011

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 81-93. 10.1016/j.brainresbull.2011.10.002

Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Elliston, Linda Anne, Higgs, Gemma, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2012. Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 199-209. 10.1016/j.brainresbull.2011.10.001

Bayram-Weston, Zubeyde, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon P. ORCID: https://orcid.org/0000-0001-9853-6177 2012. B08 Differential sensitivity of aggregate markers in HdhQ150 and YAC128 HD mouse models. Journal of Neurology, Neurosurgery & Psychiatry 83 (Suppl) , A8-A8. 10.1136/jnnp-2012-303524.24

Busse, Monica ORCID: https://orcid.org/0000-0002-5331-5909, Khalil, Hanan, Quinn, Lori ORCID: https://orcid.org/0000-0002-2982-923X, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 and Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 2012. Practice, progress and future directions for physical therapies in Huntington's Disease. Journal of Huntington's Disease 1 (2) , pp. 175-185. 10.3233/JHD-120025

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2010. Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task [Meeting abstract]. Journal of Neurology, Neurosurgery and Psychiatry 81 (1) , A9-A10. 10.1136/jnnp.2010.222570.29

Twohig, Jason Peter, Roberts, Malcolm I., Gavalda, Nuria, Rees-Taylor, Emma Louise, Giralt, Albert, Adams, Deborah, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Bull, Melanie Jane, Calder, Claudia Jane, Cuff, Simone ORCID: https://orcid.org/0000-0002-0546-3579, Yong, Audrey Alice, Alberch, Jordi, Davies, Alun M. ORCID: https://orcid.org/0000-0001-5841-8176, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Tolkovsky, Aviva M. and Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30 (10) , pp. 3782-3792. 10.1523/JNEUROSCI.1928-09.2010

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Fielding, Steven A., Döbrössy, Màtè, von Hörsten, Stephan and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2009. Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance. Brain Research Bulletin 79 (5) , pp. 310-315. 10.1016/j.brainresbull.2009.03.003

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2009. Tests to assess motor phenotype in mice: a user's guide. Nature Reviews Neurosciences 10 (7) , pp. 519-529. 10.1038/nrn2652

Trueman, Rebecca C., Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2009. Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease. Behavioural Brain Research 203 (2) , pp. 215-222. 10.1016/j.bbr.2009.05.006

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2009. Lesions of the premotor and supplementary motor areas fail to prevent implicit learning in the operant serial implicit learning task. Brain Research 1284 , pp. 116-124. 10.1016/j.brainres.2009.05.081

Hodges, Angela Kaye, Hughes, Gareth, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Elliston, Linda Anne, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2008. Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease. Genes, Brain and Behavior 7 (3) , pp. 288-299. 10.1111/j.1601-183X.2007.00350.x

Trueman, Rebecca C., Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2008. Time course of choice reaction time deficits in the Hdh Q92/Q92 knock-in mouse model of Huntington's disease. Behavioural Brain Research 189 (2) , pp. 317-334. 10.1016/j.bbr.2008.01.020

Trueman, Rebecca C., Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2007. The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock-in mouse model of Huntington's disease. European Journal of Neuroscience 25 (2) , pp. 551-558. 10.1111/j.1460-9568.2007.05307.x

Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Trueman, Rebecca C. and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2007. Striatal lesions in the mouse disrupt acquisition and retention, but not implicit learning, in the SILT procedural motor learning task. Brain Research 1185 , pp. 179-188. 10.1016/j.brainres.2007.09.017

Brooks, Simon ORCID: https://orcid.org/0000-0001-9853-6177, Betteridge, H., Trueman, R.C., Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Dunnett, S.B. 2006. Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease. Brain Research Bulletin 69 (4) , pp. 452-7. 10.1016/j.brainresbull.2006.02.011

Hughes, G. P., Brooks, Simon P. ORCID: https://orcid.org/0000-0001-9853-6177, Hodges, A. H., Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Thomas, J. M., Goldstein, D., Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2005. Integrating behaviour and brain gene expression in Huntington's disease transgenic mouse models. Journal of Neurology, Neurosurgery and Psychiatry 76 , A41-A41.

Brooks, Simon P. ORCID: https://orcid.org/0000-0001-9853-6177, Higgs, G., Trueman, R. C., Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Cheng, P., Redfern, A. R. and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2005. Longitudinal behavioural characterisation of the Q92 mouse line. Journal of Neurology, Neurosurgery and Psychiatry 76 , A48-A48.