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Number of items: 24.

Tribble, James R., Jöe, Melissa, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Otmani, Amin, Canovai, Alessio, Habchi, Baninia, Daskalakis, Evangelia, Chaleckis, Romanas, Loreto, Andrea, Gilley, Jonathan, Wheelock, Craig E., Jóhannesson, Gauti, Wong, Raymond C. B., Coleman, Michael P., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Williams, Pete A. 2024. NMNAT2 is a druggable target to drive neuronal NAD production. Nature Communications 15 (1) , 6256. 10.1038/s41467-024-50354-5
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Lucero, Bobby, Francisco, Karol R., Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Liu, Lawrence J., Yao, Yuemang, Brancale, Andrea, Brunden, Kurt R., Caffrey, Conor R. and Ballatore, Carlo 2024. Design, synthesis, and evaluation of an anti‐trypanosomal [1,2,4]triazolo[1,5‐ a ]pyrimidine probe for photoaffinity labeling studies. ChemMedChem 19 (8) , e202300656. 10.1002/cmdc.202300656
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Monti, Ludovica, Liu, Lawrence J., Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Lucero, Bobby, Alle, Thibault, Yang, Wenqian, Bem‐Shalom, Ido, Gilson, Michael, Brunden, Kurt R., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Caffrey, Conor R. and Ballatore, Carlo 2023. Structure‐activity relationships, tolerability and efficacy of microtubule‐active 1,2,4‐Triazolo[1,5‐ a ]pyrimidines as potential candidates to treat human African trypanosomiasis. ChemMedChem 18 (20) , e202300193. 10.1002/cmdc.202300193
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Lambourne, Olivia A., Bell, Shane, Wilhelm, Léa P., Yarbrough, Erika B., Holly, Gabriel G., Russell, Oliver M., Alghamdi, Arwa M., Fdel, Azeza M., Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Lane, Emma L. ORCID: https://orcid.org/0000-0001-8800-3764, Ganley, Ian G., Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Goldberg, Matthew S. and Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513 2023. PINK1-Dependent mitophagy inhibits elevated ubiquitin phosphorylation caused by mitochondrial damage. Journal of Medicinal Chemistry 66 (11) , pp. 7645-7656. 10.1021/acs.jmedchem.3c00555
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Xiang, Haoyue, Ferla, Salvatore, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Brown, Nicola L., Black, Gary W., Turner, Nicholas J. and Castagnolo, Daniele 2023. Biocatalytic and chemo-enzymatic synthesis of quinolines and 2‑quinolones by monoamine oxidase (MAO-N) and horseradish peroxidase (HRP) biocatalysts. ACS Catalysis 13 (5) , pp. 3370-3378. 10.1021/acscatal.2c05902
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Salerno, Martina, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Bevilacqua, Federica, Jochmans, Dirk, Neyts, Johan, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Ferla, Salvatore and Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868 2023. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. European Journal of Medicinal Chemistry 246 , 114942. 10.1016/j.ejmech.2022.114942
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Alle, Thibault, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Yao, Yuemang, Lucero, Bobby, Nzou, Goodwell, Demuro, Stefania, Muench, Megan, Vuong, Khoa D., Oukoloff, Killian, Cornec, Anne-Sophie, Francisco, Karol R., Caffrey, Conor R., Lee, Virginia M.-Y., Smith, Amos B., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Brunden, Kurt R. and Ballatore, Carlo 2023. Microtubule-stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as candidate therapeutics for neurodegenerative disease: Matched molecular pair analyses and computational studies reveal new structure-activity insights. Journal of Medicinal Chemistry 66 (1) , pp. 435-459. 10.1021/acs.jmedchem.2c01411
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Wong, Anepmete, Fallon, Melissa, Celiksoy, Vildan, Ferla, Salvatore, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Whitaker, David ORCID: https://orcid.org/0000-0002-8271-7552, Quantock, Andrew J. ORCID: https://orcid.org/0000-0002-2484-3120 and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2022. A composite system based upon hydroxypropyl cyclodextrins and soft hydrogel contact lenses for the delivery of therapeutic doses of econazole to the cornea, in vitro. Pharmaceutics 14 (8) , e1631. 10.3390/pharmaceutics14081631
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Narayanan, Anoop, Narwal, Manju, Majowicz, Sydney A., Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Toner, Shay A., Ballatore, Carlo, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Murakami, Katsuhiko S. and Jose, Joyce 2022. Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay. Communications Biology 5 (1) , 169. 10.1038/s42003-022-03090-9
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Alrashidi, Amal, Jafar, Mohammed, Higgins, Niamh, Mulligan, Ciara, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735, Celiksoy, Vildan, Houston, David MJ and Heard, Charles M ORCID: https://orcid.org/0000-0001-9703-9777 2021. A time-kill assay study on the synergistic bactericidal activity of pomegranate rind extract and Zn (II) against Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa. Biomolecules 11 (12) , 1889. 10.3390/biom11121889
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Pasqualetto, Gaia, Pileggi, Elisa, Schepelmann, Martin ORCID: https://orcid.org/0000-0002-7017-5426, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Rozanowska, Malgorzata ORCID: https://orcid.org/0000-0003-2913-8954, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868 2021. Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin. European Journal of Medicinal Chemistry 226 , 113841. 10.1016/j.ejmech.2021.113841
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Francisco, Karol R., Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Paniak, Thomas J., Kozlowski, Marisa C., Brancale, Andrea and Ballatore, Carlo 2021. Corrigendum to "structure property relationships of N-Acylsulfonamides and related bioisosteres" European journal of medicinal chemistry, 218 (2021), 113399. European Journal of Medicinal Chemistry 226 , 113894. 10.1016/j.ejmech.2021.113894

Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Knight, William, Ho, Pui Kei, Saporito, Fabiana, Tropea, Beatrice, Fagan, Giulio, Flude, Ben Matthew, Bevilacqua, Federica, Santos-Ferreira, Nanci, Van Dycke, Jana, Neyts, Johan, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Rocha-Pereira, Joana and Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868 2021. Structure-activity relationship studies on novel antiviral agents for norovirus infections. Microorganisms 9 (9) , 1795. 10.3390/microorganisms9091795
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Francisco, Karol R., Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Paniak, Thomas J., Kozlowski, Marisa C., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Ballatore, Carlo 2021. Structure property relationships of N-acylsulfonamides and related bioisosteres. European Journal of Medicinal Chemistry 218 , 113399. 10.1016/j.ejmech.2021.113399
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Eigel, Dimitri, Schuster, Romy, Männel, Max J., Thiele, Julian, Panasiuk, Martyna J., Andreae, Laura C., Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Welzel, Petra B., Huttner, Wieland B., Werner, Carsten, Newland, Ben ORCID: https://orcid.org/0000-0002-5214-2604 and Long, Katherine R. 2021. Sulfonated cryogel scaffolds for focal delivery in ex-vivo brain tissue cultures. Biomaterials 271 , 120712. 10.1016/j.biomaterials.2021.120712
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Oukoloff, Killian, Nzou, Goodwell, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Lucero, Bobby, Alle, Thibault, Kovalevich, Jane, Monti, Ludovica, Cornec, Anne-Sophie, Yao, Yuemang, James, Michael J., Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Brunden, Kurt R. and Ballatore, Carlo 2021. Evaluation of the structure-activity relationship of microtubule-targeting 1,2,4-Triazolo[1,5-a]pyrimidines identifies new candidates for neurodegenerative tauopathies. Journal of Medicinal Chemistry 64 (2) , pp. 1073-1102. 10.1021/acs.jmedchem.0c01605
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Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Beirne, Kathy, Aeschlimann, Pascale, Heard, Charles ORCID: https://orcid.org/0000-0001-9703-9777, Rozanowska, Malgorzata ORCID: https://orcid.org/0000-0003-2913-8954, Votruba, Marcela ORCID: https://orcid.org/0000-0002-7680-9135 and Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 2020. Discovery of Novel 2-Aniline-1,4-naphthoquinones as potential new drug treatment for Leber’s hereditary optic neuropathy (LHON). Journal of Medicinal Chemistry 63 (22) , 13638 -13655. 10.1021/acs.jmedchem.0c00942
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Pasqualetto, Gaia, Schepelmann, Martin ORCID: https://orcid.org/0000-0002-7017-5426, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Pileggi, Elisa, Khogali, Caroline, Morgan, Siân R., Boostrom, Ian, Rozanowska, Malgorzata ORCID: https://orcid.org/0000-0003-2913-8954, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237 and Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868 2020. Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins. Molecules 25 (21) , 4904. 10.3390/molecules25214904
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Newland, Ben ORCID: https://orcid.org/0000-0002-5214-2604, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Körner, Yvonne, Hoppe, Franziska, Taplan, Christian, Newland, Heike ORCID: https://orcid.org/0000-0002-5214-2604, Eigel, Dimitri, Tornillo, Giusy, Pette, Dagmar, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Welzel, Petra B., Seib, F. Philipp and Werner, Carsten 2020. Focal drug administration via heparin-containing cryogel microcarriers reduces cancer growth and metastasis. Carbohydrate Polymers 245 , 116504. 10.1016/j.carbpol.2020.116504
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Zhao, Fei, Masci, Domiziana, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Colonna, Serena, Black, Gary W., Turner, Nicholas J. and Castagnolo, Daniele 2020. Monoamine oxidase (MAO-N) biocatalyzed synthesis of indoles from indolines prepared via photocatalytic cyclization/arylative dearomatization. ACS Catalysis 10 (11) , pp. 6414-6421. 10.1021/acscatal.0c01351
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Varricchio, C. ORCID: https://orcid.org/0000-0002-1673-4768, Beirne, K., Heard, C. ORCID: https://orcid.org/0000-0001-9703-9777, Newland, B. ORCID: https://orcid.org/0000-0002-5214-2604, Rozanowska, M. ORCID: https://orcid.org/0000-0003-2913-8954, Brancale, A. ORCID: https://orcid.org/0000-0002-9728-3419 and Votruba, M. ORCID: https://orcid.org/0000-0002-7680-9135 2020. The ying and yang of idebenone: Not too little, not too much - cell death in NQO1 deficient cells and the mouse retina. Free Radical Biology and Medicine 152 , pp. 551-560. 10.1016/j.freeradbiomed.2019.11.030
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Bender, Lena, Boostrom, Hannah M. ORCID: https://orcid.org/0000-0002-7367-3631, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Zuanon, Marika, Celiksoy, Vildan, Sloan, Alastair ORCID: https://orcid.org/0000-0002-1791-0903, Cowpe, Jonathan and Heard, Charles M ORCID: https://orcid.org/0000-0001-9703-9777 2020. A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis. European Journal of Pharmaceutics and Biopharmaceutics 149 , pp. 85-94. 10.1016/j.ejpb.2020.01.007
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Hewitt, Melissa G., Morrison, Peter W. J. ORCID: https://orcid.org/0000-0002-3712-7908, Boostrom, Hannah M. ORCID: https://orcid.org/0000-0002-7367-3631, Morgan, Siân R., Fallon, Melissa ORCID: https://orcid.org/0000-0002-0267-3829, Lewis, Philip N. ORCID: https://orcid.org/0000-0002-3353-0708, Whitaker, David ORCID: https://orcid.org/0000-0002-8271-7552, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Quantock, Andrew J. ORCID: https://orcid.org/0000-0002-2484-3120, Burton, Matthew J. and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2020. In Vitro Topical Delivery of Chlorhexidine to the Cornea: Enhancement Using Drug-Loaded Contact Lenses and β-Cyclodextrin Complexation, and the Importance of Simulating Tear Irrigation. Molecular Pharmaceutics 17 (4) , pp. 1428-1441. 10.1021/acs.molpharmaceut.0c00140
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Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768 2019. Novel drug therapy for mitochondrial optic neuropathy. PhD Thesis, Cardiff University.
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