Lewis, Thomas, Corcoran, David B., Thurston, David E., Giles, Peter J. ORCID: https://orcid.org/0000-0003-3143-6854, Ashelford, Kevin ORCID: https://orcid.org/0000-0003-3217-2811, Walsby, Elisabeth J. ORCID: https://orcid.org/0000-0001-8523-5017, Fegan, Christopher D. ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Andrea G.S., Rahman, Khondaker Miraz and Pepper, Chris 2021. Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers. Haematologica 106 (4) , pp. 958-967. 10.3324/haematol.2019.238584 |
Lang, Fabian, Wunderle, Lydia, Badura, Susanne, Schleyer, Eberhard, Brüggemann, Monika, Serve, Hubert, Schnittger, Susanne, Gökbuget, Nicola, Pfeifer, Heike, Wagner, Sebastian, Ashelford, Kevin ORCID: https://orcid.org/0000-0003-3217-2811, Bug, Gesine and Ottmann, Oliver G. ORCID: https://orcid.org/0000-0001-9559-1330 2020. A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia. BMC Pharmacology and Toxicology 21 (1) , 70. 10.1186/s40360-020-00446-x |
Badder, Luned M., Hollins, Andrew J. ORCID: https://orcid.org/0000-0002-0324-9376, Herpers, Bram, Yan, Kuan, Ewan, Kenneth B. ORCID: https://orcid.org/0000-0001-6622-9009, Thomas, Mairian, Shone, Jennifer R., Badder, Delyth A., Naven, Marc ORCID: https://orcid.org/0000-0002-6339-3257, Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Hargest, Rachel ORCID: https://orcid.org/0000-0001-9830-3832, Clarke, Alan R. ORCID: https://orcid.org/0000-0002-4281-426X, Esdar, Christina, Buchstaller, Hans-Peter, Treherne, J. Mark, Boj, Sylvia, Ramezanpour, Bahar, Wienke, Dirk, Price, Leo S., Shaw, Paul H. ORCID: https://orcid.org/0000-0002-7467-0619 and Dale, Trevor C. ORCID: https://orcid.org/0000-0002-4880-9963 2020. 3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors. PLoS ONE 15 (8) , e0235319. 10.1371/journal.pone.0235319 |
Dart, D A, Ashelford, K ORCID: https://orcid.org/0000-0003-3217-2811 and Jiang, W G ORCID: https://orcid.org/0000-0002-3283-1111 2020. AR mRNA Stability is increased with AR-antagonist resistance via 3' UTR variants. Endocrine Connections 9 (1) , pp. 9-19. 10.1530/EC-19-0340 |
Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Ruis, Brian, Kan, Yinan, Cleal, Kez, Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Hendrickson, Eric A. and Baird, Duncan M. ORCID: https://orcid.org/0000-0001-8408-5467 2019. DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase. Nucleic Acids Research 47 (5) , pp. 2402-2424. 10.1093/nar/gky1279 |
Thomas, Laura E. ORCID: https://orcid.org/0000-0002-8621-5285, Hurley, Joanna J., Meuser, Elena, Jose, Sian, Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Mort, Matthew ORCID: https://orcid.org/0000-0002-3986-0935, Idziaszczyk, Shelley, Maynard, Julie, Leon Brito, Helena, Harry, Manon, Walters, Angharad, Raja, Meera, Walton, Sarah-Jane, Dolwani, Sunil ORCID: https://orcid.org/0000-0002-3113-5472, Williams, Geraint T. ORCID: https://orcid.org/0000-0003-3768-9940, Morgan, Meleri, Moorghen, Morgan, Clark, Susan K. and Sampson, Julian R. ORCID: https://orcid.org/0000-0002-2902-2348 2017. Burden and profile of somatic mutation in duodenal adenomas from patients with familial adenomatous- and MUTYH-associated polyposis. Clinical Cancer Research 23 (21) , pp. 6721-6732. 10.1158/1078-0432.CCR-17-1269 |
Sohier, Pierre, Luscan, Armelle, Lloyd, Angharad, Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Laurendeau, Ingrid, Briand-Suleau, Audrey, Vidaud, Dominique, Ortonne, Nicolas, Pasmant, Eric and Upadhyaya, Meena 2017. Confirmation of mutation landscape of NF1-associated malignant peripheral nerve sheath tumors. Genes, Chromosomes and Cancer 56 (5) , pp. 421-426. 10.1002/gcc.22446 |
Penselin, Daniel, Münsterkötter, Martin, Kirsten, Susanne, Felder, Marius, Taudien, Stefan, Platzer, Matthias, Ashelford, Kevin ORCID: https://orcid.org/0000-0003-3217-2811, Paskiewicz, Konrad H., Harrison, Richard J., Hughes, David J., Wolf, Thomas, Shelest, Ekaterina, Graap, Jenny, Hoffmann, Jan, Wenzel, Claudia, Wöltje, Nadine, King, Kevin M., Fitt, Bruce D. L., Güldener, Ulrich, Avrova, Anna and Knogge, Wolfgang 2016. Comparative genomics to explore phylogenetic relationship, cryptic sexual potential and host specificity of Rhynchosporium species on grasses. BMC Genomics 17 (1) , 953. 10.1186/s12864-016-3299-5 |
Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Ruis, Brian, Takasugi, Taylor, Harvey, Adam, Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Hendrickson, Eric A. and Baird, Duncan M. ORCID: https://orcid.org/0000-0001-8408-5467 2016. Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4. Genome Research 26 , pp. 588-600. 10.1101/gr.200840.115 |
Bryant, Dean, Onions, Tiffany, Raybould, Rachel, Flynn, Áine, Tristram, Amanda, Meyrick, Sian, Giles, Peter ORCID: https://orcid.org/0000-0003-3143-6854, Ashelford, Kevin ORCID: https://orcid.org/0000-0003-3217-2811, Hibbitts, Samantha, Fiander, Alison and Powell, Ned 2014. mRNA sequencing of novel cell lines from human papillomavirus type-16 related vulval intraepithelial neoplasia: Consequences of expression of HPV16 E4 and E5. Journal of Medical Virology 86 (9) , pp. 1534-1541. 10.1002/jmv.23994 |
Jones, Rhiannon E., Oh, Sehyun, Grimstead, Julia W., Zimbric, Jacob, Roger, Laureline, Heppel, Nicole H., Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Hendrickson, Eric A. and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2014. Escape from telomere-driven crisis is DNA Ligase III dependent. Cell Reports 8 (4) , pp. 1063-1076. 10.1016/j.celrep.2014.07.007 |
Horn, Matthias, Merga, J. Yvette, Williams, Nicola J., Miller, William G., Leatherbarrow, Andrew J. H., Bennett, Malcolm, Hall, Neil, Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811 and Winstanley, Craig 2013. Exploring the diversity of arcobacter butzleri from cattle in the UK using MLST and whole genome sequencing. PLoS ONE 8 (2) , e55240. 10.1371/journal.pone.0055240 |
Yang, Ruifu, Bronowski, Christina, Fookes, Maria C., Gilderthorp, Ruth, Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Harris, Simon R., Phiri, Amos, Hall, Neil, Gordon, Melita A., Wain, John, Hart, Charles A., Wigley, Paul, Thomson, Nicholas R. and Winstanley, Craig 2013. Genomic characterisation of invasive non-typhoidal salmonella enterica subspecies enterica serovar bovismorbificans isolates from Malawi. PLOS Neglected Tropical Diseases 7 (11) , e2557. 10.1371/journal.pntd.0002557 |
Pascoal, Sonia, Carvalho, Gary, Vasieva, Olga, Hughes, Roger, Cossins, Andrew, Fang, Yongxiang, Ashelford, Kevin ORCID: https://orcid.org/0000-0003-3217-2811, Olohan, Lisa, Barroso, Carlos, Mendo, Sonia and Creer, Simon 2012. Transcriptomics andin vivotests reveal novel mechanisms underlying endocrine disruption in an ecological sentinel, Nucella lapillus. Molecular Ecology 22 (6) , pp. 1589-1608. 10.1111/mec.12137 |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Hepworth, Philip J., Hinds, Jason, Gould, Katherine A., Witney, Adam A., Williams, Nicola J., Leatherbarrow, Howard, French, Nigel P., Birtles, Richard J., Mendonca, Chriselle, Dorrell, Nick, Wren, Brendan W., Wigley, Paul, Hall, Neil and Winstanley, Craig 2011. Genomic variations define divergence of water/wildlife-associated Campylobacter jejuniniche specialists from common clonal complexes. Environmental Microbiology 13 (6) , pp. 1549-1560. 10.1111/j.1462-2920.2011.02461.x |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Eriksson, Maria E., Allen, Christopher M., D'Amore, Rosalinda, Johansson, Mikael, Gould, Peter, Kay, Suzanne, Millar, Andrew J., Hall, Neil and Hall, Anthony 2011. Full genome re-sequencing reveals a novel circadian clock mutation in Arabidopsis. Genome Biology 12 (3) , R28. 10.1186/gb-2011-12-3-r28 |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Stewart, R. M. K., Wiehlmann, L., Preston, S. J., Frimmersdorf, E., Campbell, B. J., Neal, T. J., Hall, N., Tuft, S., Kaye, S. B. and Winstanley, C. 2011. Genetic characterization indicates that a specific subpopulation of Pseudomonas aeruginosa is associated with keratitis infections. Journal of Clinical Microbiology 49 (3) , pp. 993-1003. 10.1128/JCM.02036-10 |
Gilbert, Jack A., Craft, John A., Temperton, Ben, Dempsey, Kate E., Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Tiwari, Bela, Hutchinson, Tom H. and Chipman, J. Kevin 2010. Pyrosequencing of Mytilus galloprovincialis cDNAs: tissue-specific expression patterns. PLoS ONE 5 (1) , e8875. 10.1371/journal.pone.0008875 |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Weynberg, Karen D., Allen, Michael J., Scanlan, David J. and Wilson, William H. 2009. From small hosts come big viruses: the complete genome of a second Ostreococcus taurivirus, OtV-1. Environmental Microbiology 11 (11) , pp. 2821-2839. 10.1111/j.1462-2920.2009.01991.x |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Bontell, Irene, Hall, Neil, Dubey, J. P., Boyle, Jon P., Lindh, Johan and Smith, Judith E. 2009. Whole genome sequencing of a natural recombinant Toxoplasma gondii strain reveals chromosome sorting and local allelic variants. Genome Biology 10 (5) , R53. 10.1186/gb-2009-10-5-r53 |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Chuzhanova, Nadia A., Fry, John C., Jones, Antonia J. and Weightman, Andrew John ORCID: https://orcid.org/0000-0002-6671-2209 2006. New screening software shows that most recent large 16S rRNA gene clone libraries contain chimeras. Applied and Environmental Microbiology 72 (9) , pp. 5734-5741. 10.1128/AEM.00556-06 |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Day, M. J. and Fry, J. C. 2003. Elevated abundance of bacteriophage infecting bacteria in soil. Applied and Environmental Microbiology 69 (1) , pp. 285-289. 10.1128/AEM.69.1.285-289.2003 |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Bailey, Mark J., Fry, John C. and Day, Martin J. 2002. Characterization of Serratia isolates from soil, ecological implications and transfer of Serratia proteamaculans subsp. quinovora Grimont et al. 1983 to Serratia quinivorans corrig., sp. nov. International Journal of Systematic and Evolutionary Microbiology 52 (6) , pp. 2281-2289. 10.1099/00207713-52-6-2281 |
Ashelford, Kevin ORCID: https://orcid.org/0000-0003-3217-2811, Learner, Michael A. and Fry, John C. 2001. Gene transfer and plasmid instability within pilot-scale sewage filter beds and the invertebrates that live in them. FEMS Microbiology Ecology 35 (2) , pp. 197-205. 10.1111/j.1574-6941.2001.tb00804.x |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Norris, S. J., Fry, J. C., Bailey, M. J. and Day, M. J. 2000. Seasonal Population Dynamics and Interactions of Competing Bacteriophages and Their Host in the Rhizosphere. Applied and Environmental Microbiology 66 (10) , pp. 4193-4199. 10.1128/AEM.66.10.4193-4199.2000 |
Ashelford, Kevin E. ORCID: https://orcid.org/0000-0003-3217-2811, Fry, John C., Day, Martin J., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Learner, Michael A., Marchesi, Julian R. ORCID: https://orcid.org/0000-0002-7994-5239, Perkins, Caroline D. and Weightman, Andrew J. ORCID: https://orcid.org/0000-0002-6671-2209 1997. Using microcosms to study gene transfer in aquatic habitats. FEMS Microbiology Ecology 23 (2) , pp. 81-94. 10.1111/j.1574-6941.1997.tb00393.x |