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Pritchard, Manon F. ORCID: https://orcid.org/0000-0002-5135-4744, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Adams, Jennifer Y.M., Menzies, Georgina ORCID: https://orcid.org/0000-0002-6600-6507, Khan, Saira, Tondervik, Anne, Sletta, Havard, Olav, Aarstad, Skjåk-Bræk, Gudmund, McKenna, Stephen, Buurma, Niklaas J. ORCID: https://orcid.org/0000-0003-0260-5057, Farnell, Damian J.J. ORCID: https://orcid.org/0000-0003-0662-1927, Rye, Philip D., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2023. Structure–activity relationships of low molecular weight alginate oligosaccharide therapy against Pseudomonas aeruginosa. Biomolecules 13 (9) , 1366. 10.3390/biom13091366 |
Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Adams, Jennifer Y.M., Quoraishi, Sadik, Py, Charlene, Oger, Anais, Gazze, Salvatore A., Francis, Lewis W., von Ruhland, Christopher, Owens, David, Rye, Philip D., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Pritchard, Manon F. ORCID: https://orcid.org/0000-0002-5135-4744 and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2023. Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms. Frontiers in Cellular and Infection Microbiology 13 , 1122340. 10.3389/fcimb.2023.1122340 |
Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Cullen, Jason K., Boyle, Glen M., De Ridder, Tom, Yap, Pei-Yi, Xue, Wenya, Pierce, Carly J., Pritchard, Manon F., Menzies, Georgina E. ORCID: https://orcid.org/0000-0002-6600-6507, Abdulkarim, Muthanna, Adams, Jennifer Y. M., Stokniene, Joana, Francis, Lewis W., Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X, Johns, Jenny, Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Jones, Adam V., Parsons, Peter G., Reddell, Paul and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2022. Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds. Science Translational Medicine 14 (662) 10.1126/scitranslmed.abn3758 |
Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Abdulkarim, Muthanna, Stokniene, Joana, Yang, Qui E., Walsh, Timothy R. ORCID: https://orcid.org/0000-0003-4315-4096, Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2021. Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking. npj Biofilms and Microbiomes 7 , 13. 10.1038/s41522-020-00172-6 |
Stokniene, Joana, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Aarstad, Olav A., Aachmann, Finn L., Rye, Philip D., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 and Ferguson, Elaine L. ORCID: https://orcid.org/0000-0002-0125-0234 2020. Bi-functional alginate oligosaccharide–polymyxin conjugates for improved treatment of multidrug-resistant gram-negative bacterial infections. Pharmaceutics 12 (11) , 1080. 10.3390/pharmaceutics12111080 |
Yang, Qiu E., MacLean, Craig, Papkou, Andrei, Pritchard, Manon ORCID: https://orcid.org/0000-0002-5135-4744, Powell, Lydia ORCID: https://orcid.org/0000-0002-8641-0160, Thomas, David ORCID: https://orcid.org/0000-0001-7319-5820, Andrey, Diego O., Li, Mei, Spiller, Brad ORCID: https://orcid.org/0000-0002-9117-6911, Yang, Wang and Walsh, Timothy R. ORCID: https://orcid.org/0000-0003-4315-4096 2020. Compensatory mutations modulate the competitiveness and dynamics of plasmid-mediated colistin resistance in Escherichia coli clones. ISME Journal 14 , pp. 861-865. 10.1038/s41396-019-0578-6 |
Jack, Alison A., Nordli, Henriette R., Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Farnell, Damian J. J. ORCID: https://orcid.org/0000-0003-0662-1927, Pukstad, Brita, Rye, Philip D., Thomas, David W., Chinga-Carrasco, Gary and Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 2019. Cellulose nanofibril formulations incorporating a low molecular weight alginate oligosaccharide modify bacterial biofilm development. Biomacromolecules 20 (8) , pp. 2953-2961. 10.1021/acs.biomac.9b00522 |
Varache, Mathieu ORCID: https://orcid.org/0000-0001-7166-2253, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Aarstad, Olav A., Williams, Thomas L., Wenzel, Margot N. ORCID: https://orcid.org/0000-0001-6411-1816, Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 and Ferguson, Elaine L. ORCID: https://orcid.org/0000-0002-0125-0234 2019. Polymer masked-unmasked protein therapy: Identification of the active species after amylase-activation of dextrin-colistin conjugates. Molecular Pharmaceutics 16 (7) , pp. 3199-3207. 10.1021/acs.molpharmaceut.9b00393 |
Ferguson, Elaine L ORCID: https://orcid.org/0000-0002-0125-0234, Naseer, Sameza, Powell, Lydia C ORCID: https://orcid.org/0000-0002-8641-0160, Hardwicke, Joseph, Young, Fraser I ORCID: https://orcid.org/0000-0003-0779-3835, Zhu, Bangfu, Liu, Qian, Song, Bing ORCID: https://orcid.org/0000-0001-9356-2333 and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2018. Controlled release of Dextrin-conjugated growth factors to support growth and differentation of neural stem cells. Stem Cell Research 33 , pp. 69-78. 10.1016/j.scr.2018.10.008 |
Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Pritchard, Manon F. ORCID: https://orcid.org/0000-0002-5135-4744, Ferguson, Elaine L. ORCID: https://orcid.org/0000-0002-0125-0234, Powell, Kate A. ORCID: https://orcid.org/0000-0002-8641-0160, Patel, Shree U., Rye, Phil D., Sakellakou, Stavroula-Melina, Buurma, Niklaas J. ORCID: https://orcid.org/0000-0003-0260-5057, Brilliant, Charles D., Copping, Jack M., Menzies, Georgina E. ORCID: https://orcid.org/0000-0002-6600-6507, Lewis, Paul D., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2018. Targeted disruption of the extracellular polymeric network of pseudomonas aeruginosa biofilms by alginate oligosaccharides. npj Biofilms and Microbiomes 4 , 13. 10.1038/s41522-018-0056-3 |
Jack, Alison A., Khan, Saira, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Pritchard, Manon F. ORCID: https://orcid.org/0000-0002-5135-4744, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Sadh, Hina, Sutton, Lucy, Cavaliere, Alessandra, Florence, Hannah, Rye, Philip D., Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 and Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 2018. Alginate Oligosaccharide-Induced Modification of the lasI-lasR and rhlI-rhlR Quorum Sensing Systems in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 62 (5) , e02318-17. 10.1128/AAC.02318-17 |
Yang, Qiu, Li, Mei, Spiller, Owen B. ORCID: https://orcid.org/0000-0002-9117-6911, Andrey, Diego O., Hinchliffe, Philip, Li, Hui, MacLean, Craig, Niumsup, Pannika, Powell, Lydia ORCID: https://orcid.org/0000-0002-8641-0160, Pritchard, Manon ORCID: https://orcid.org/0000-0002-5135-4744, Papkou, Andrei, Shen, Yingbo, Portal, Edward, Sands, Kirsty, Spencer, James, Tansawai, Uttapoln, Thomas, David ORCID: https://orcid.org/0000-0001-7319-5820, Wang, Shaolin, Wang, Yang, Shen, Jianzhong and Walsh, Timothy 2017. Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms. Nature Communications 8 , 2054. 10.1038/s41467-017-02149-0 |
Pritchard, Manon ORCID: https://orcid.org/0000-0002-5135-4744, Jack, Alison, Powell, Lydia ORCID: https://orcid.org/0000-0002-8641-0160, Sadh, Hina, Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 and Rye, Philip D 2017. Alginate Oligosaccharides modify hyphal infiltration of Candida albicans in an in vitro model of invasive Human Candidosis. Journal of Applied Microbiology 123 (3) , pp. 625-636. 10.1111/jam.13516 |
Pritchard, Manon F. ORCID: https://orcid.org/0000-0002-5135-4744, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Jack, Alison A., Powell, Kate ORCID: https://orcid.org/0000-0002-8641-0160, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Florance, Hannah, Forton, Julian, Rye, Philip D., Dessen, Arne, Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2017. A low-molecular-weight alginate oligosaccharide disrupts pseudomonal microcolony formation and enhances antibiotic effectiveness. Antimicrobial Agents and Chemotherapy 61 (9) , e00762-17. 10.1128/AAC.00762-17 |
Pritchard, Manon F. ORCID: https://orcid.org/0000-0002-5135-4744, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Khan, Saira, Griffiths, Peter C., Mansour, Omar T., Schweins, Ralf, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Buurma, Niklaas J. ORCID: https://orcid.org/0000-0003-0260-5057, Dempsey, Christopher E., Wright, Chris J., Rye, Philip D., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 and Ferguson, Elaine L. ORCID: https://orcid.org/0000-0002-0125-0234 2017. The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Scientific Reports 7 , 44731. 10.1038/srep44731 |
Pritchard, Manon F. ORCID: https://orcid.org/0000-0002-5135-4744, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Menzies, Georgina E. ORCID: https://orcid.org/0000-0002-6600-6507, Lewis, Paul D., Hawkins, Karl, Wright, Chris, Doull, Iolo, Walsh, Timothy R., Onsoyen, Edvar, Dessen, Arne, Myrvold, Rolf, Rye, Philip D., Myrset, Astrid H., Stevens, Howard N. E., Hodges, Lee A., MacGregor, Gordon, Neilly, James B., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2016. A new class of safe oligosaccharide polymer therapy to modify the mucus barrier of chronic respiratory disease. Molecular Pharmaceutics 13 (3) , pp. 863-872. 10.1021/acs.molpharmaceut.5b00794 |
Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Khan, Saira, Chinga-Carrasco, Gary, Wright, Chris J., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 and Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 2016. An investigation of Pseudomonas aeruginosa biofilm growth on novel nanocellulose fiber dressings. Carbohydrate Polymers 137 , pp. 191-197. 10.1016/j.carbpol.2015.10.024 |
Rees, Adam, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Chinga-Carrasco, Gary, Gethin, David T., Syverud, Kristin, Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 and Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 2015. 3D bioprinting of carboxymethylated-periodate oxidized nanocellulose constructs for wound dressing applications. BioMedical Research International 2015 , pp. 1-7. 10.1155/2015/925757 |
Tondervik, Anne, Sletta, Havard, Klinkenberg, Geir, Emanuel, Charlotte, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Pritchard, Manon F. ORCID: https://orcid.org/0000-0002-5135-4744, Khan, Saira, Craine, Keiron M., Onsoyen, Edvar, Rye, Phil D., Wright, Chris, Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 and Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 2014. Alginate oligosaccharides inhibit fungal cell growth and potentiate the activity of anti-fungals against Candida and Aspergillus spp. PLoS ONE , e112518. 10.1371/journal.pone.0112518 |
Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Pritchard, Manon F. ORCID: https://orcid.org/0000-0002-5135-4744, Emanuel, Charlotte, Onsøyen, Edvar, Rye, Philip D., Wright, Chris J., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 and Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 2014. A nanoscale characterization of the interaction of a novel alginate oligomer with the cell surface and motility of pseudomonas aeruginosa. American Journal of Respiratory Cell and Molecular Biology 50 (3) , pp. 483-492. 10.1165/rcmb.2013-0287OC |
Gethin, D. T., Rees, A., Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Chinga-Carrasco, G., Claypole, T., Deganello, D., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Thomas, D. W. and Syverud, K. 2014. Studies on the 3D printing of nanocellulose structures. Advances in Printing and Media Technology XLI (1 A2) , pp. 91-95. |
Roberts, Jessica Louise, Khan, Saira, Emanuel, Charlotte, Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Pritchard, Manon ORCID: https://orcid.org/0000-0002-5135-4744, Onsøyen, E., Myrvold, R., Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 2013. An in vitro study of alginate oligomer therapies on oral biofilms. Journal of Dentistry 41 (10) , pp. 892-899. 10.1016/j.jdent.2013.07.011 |
Powell, Lydia C. ORCID: https://orcid.org/0000-0002-8641-0160, Sowedan, Ahmed, Khan, Saira, Wright, Chris J., Hawkins, Karl, Onsøyen, Edvar, Myrvold, Rolf, Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117 and Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 2013. The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms. Biofouling 29 (4) , pp. 413-421. 10.1080/08927014.2013.777954 |