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Number of items: 9.

Hulin-Curtis, Sarah, Geary, James, MacLachlan, Bruce, Altmann, Danny, Baillon, Laury, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Greenshields-Watson, Alex, Hesketh, Sophie, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Jones, Ian, Lauder, Sarah, Mason, Georgina, Smart, Kathryn, Scourfield, Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard ORCID: https://orcid.org/0000-0002-6799-1182, Wall, Aaron, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Barclay, Wendy, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43 (6) , 114259. 10.1016/j.celrep.2024.114259
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Chen, Yuan, Mason, Georgina H., Scourfield, D. Oliver, Greenshields-Watson, Alexander, Haigh, Tracey A., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Long, Heather M., Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, MacLachlan, Bruce J. and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2023. Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity. Cell Reports 42 (8) , 112827. 10.1016/j.celrep.2023.112827
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Burnell, Stephanie E. A., Capitani, Lorenzo, MacLachlan, Bruce J., Mason, Georgina H., Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2021. Seven mysteries of LAG-3: a multi-faceted immune receptor of increasing complexity. Immunotherapy Advances 2 (1) , ltab025. 10.1093/immadv/ltab025
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MacLachlan, Bruce J., Mason, Georgina H., Greenshields Watson, Alexander, Triebel, Frederic, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2021. Molecular characterization of HLA class II binding to the LAG-3 T cell co-inhibitory receptor. European Journal of Immunology 51 (2) , pp. 331-341. 10.1002/eji.202048753
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Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L. ORCID: https://orcid.org/0000-0003-0889-964X, Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Godkin, Andrew J. ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew J. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) , 107885. 10.1016/j.celrep.2020.107885
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Besneux, Matthieu, Greenshields Watson, Alexander, Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, MacLachlan, Bruce J., Christian, Adam, Davies, Michael M., Hargest, Rachel ORCID: https://orcid.org/0000-0001-9830-3832, Phillips, Simon, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2019. The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design. Cancer Immunology, Immunotherapy 68 , pp. 247-256. 10.1007/s00262-018-2266-1
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Holland, Christopher J., MacLachlan, Bruce J., Bianchi, Valentina, Hesketh, Sophie J., Morgan, Richard, Vickery, Owen, Bulek, Anna M., Fuller, Anna, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wells, Stephen and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9 , 674. 10.3389/fimmu.2018.00674
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MacLachlan, Bruce J., Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea J., Bianchi, Valentina, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Fuller, Anna and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2017. Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens. Journal of Visualized Experiments (120) , e54991. 10.3791/54991
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MacLachlan, Bruce James 2016. Molecular characterisation of CD4+ T cell responses to tumour antigens. PhD Thesis, Cardiff University.
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