Frantz, Renate, Gwozdzinski, Konrad, Gisch, Nicolas, Doijad, Swapnil Prakash, Hudel, Martina, Wille, Maria, Abu Mraheil, Mobarak, Schwudke, Dominik, Imirzalioglu, Can, Falgenhauer, Linda, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Chakraborty, Trinad and Weinert, Emily 2023. A Single Residue within the MCR-1 Protein Confers Anticipatory Resilience. Microbiology Spectrum 11 (3) , e03592-22. 10.1128/spectrum.03592-22 |
Malik, Rainer, Beaufort, Nathalie, Frerich, Simon, Gesierich, Benno, Georgakis, Marios K, Rannikmäe, Kristiina, Ferguson, Amy C, Haffner, Christof, Traylor, Matthew, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Sudlow, Cathie L M and Dichgans, Martin 2021. Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities. Brain 144 (9) , 2670–2682. 10.1093/brain/awab253 |
Schmidt, Nina, Irle, Inga, Ripkens, Kamilla, Lux, Vanda, Nelles, Jasmin, Johannes, Christian, Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196, Greenow, Kirsty, Amir, Sarah, Campioni, Mara, Baldi, Alfonso, Oka, Chio, Kawaichi, Masashi, Clarke, Alan R. and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2016. Epigenetic silencing of serine protease HTRA1 drives polyploidy. BMC Cancer 16 , 399. 10.1186/s12885-016-2425-8 |
Poepsel, Simon, Sprengel, Andreas, Sacca, Barbara, Kaschani, Farnusch, Kaiser, Markus, Gatsogiannis, Christos, Raunser, Stefan, Clausen, Tim and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2015. Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nature Chemical Biology 11 (11) , pp. 862-869. 10.1038/nchembio.1931 |
Beaufort, Nathalie, Scharrer, Eva, Lux, Vanda, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Haffner, Christof and Dichgans, Martin 2015. Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 112 (14) , E1694. 10.1073/pnas.1501817112 |
Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Kaschani, Farnusch and Kaiser, Markus 2015. Chemical proteomics versus Leishmaniasis. Chemistry & Biology 22 (3) , pp. 309-310. 10.1016/j.chembiol.2015.03.001 |
Beaufort, Nathalie, Scharrer, Eva, Kremmer, Elisabeth, Lux, Vanda, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Huber, Robert, Houlden, Henry, Werring, David, Haffner, Christof and Dichgans, Martin 2014. Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America 111 (46) , 16496. 10.1073/pnas.1418087111 |
Thompson, Natalie J., Merdanovic, Melisa, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, van Duijn, Esther and Heck, Albert J. R. 2014. Substrate occupancy at the onset of oligomeric transitions of DegP. Structure 22 (2) , pp. 281-290. 10.1016/j.str.2013.11.010 |
Mastny, Markus, Heuck, Alexander, Kurzbauer, Robert, Heiduk, Anja, Boisguerin, Prisca, Volkmer, Rudolf, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Rodrigues, Christopher D. A., Rudner, David Z. and Clausen, Tim 2013. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. Cell 155 (3) , pp. 647-658. 10.1016/j.cell.2013.09.050 |
Gloeckl, Sarina, Ong, Vanissa A., Patel, Pooja, Tyndall, Joel D. A., Timms, Peter, Beagley, Kenneth W., Allan, John A., Armitage, Charles W., Turnbull, Lynne, Whitchurch, Cynthia B., Merdanovic, Melisa, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Powers, James C., Oleksyszyn, Jozef, Verdoes, Martijn, Bogyo, Matthew and Huston, Wilhelmina M. 2013. Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis. Molecular Microbiology 89 (4) , pp. 676-689. 10.1111/mmi.12306 |
Stolze, Sara C., Meltzer, Michael, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Kaiser, Markus 2013. Ahp cyclodepsipeptides: the Impact of the Ahp residue on the "Canonical Inhibition" of S1 serine proteases. ChemBioChem 14 (11) , pp. 1301-1308. 10.1002/cbic.201300180 |
Merdanovic, Melisa, Mönig, Timon, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Kaiser, Markus 2013. Diversity of allosteric regulation in proteases. ACS Chemical Biology 8 (1) , pp. 19-26. 10.1021/cb3005935 |
Nigro, A., Menon, R., Bergamaschi, A., Clovis, Y. M., Baldi, A., Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Comi, G., De Pietri Tonelli, D., Farina, C., Martino, G. and Muzio, L. 2012. MiR-30e and miR-181d control Radial Glia cell proliferation via HtrA1 modulation. Cell Death and Disease 3 , e360. 10.1038/cddis.2012.98 |
Tiaden, Andre N., Klawitter, Marina, Lux, Vanda, Mirsaidi, Ali, Bahrenberg, Gregor, Glanz, Stephan, Quero, Lilian, Liebscher, Thomas, Wuertz, Karin, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Richards, Peter J. 2012. Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. Journal of Biological Chemistry 287 (25) , pp. 21335-21345. 10.1074/jbc.M112.341032 |
Lütticke, Christiane, Hauske, Patrick, Lewandrowski, Urs, Sickmann, Albert, Kaiser, Markus and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2012. E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe-Phe bonds. Molecular BioSystems 8 (6) , pp. 1775-1782. 10.1039/c2mb05506f |
Stolze, Sara C., Meltzer, Michael, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Kaiser, Markus 2012. Development of a solid-phase approach to the natural product class of Ahp-containing cyclodepsipeptides. European Journal of Organic Chemistry 2012 (8) , pp. 1616-1625. 10.1002/ejoc.201101757 |
Weski, Juliane, Meltzer, Michael, Spaan, Lina, Mönig, Timon, Oeljeklaus, Julian, Hauske, Patrick, Vouilleme, Lars, Volkmer, Rudolf, Boisguerin, Prisca, Boyd, Dana, Huber, Robert, Kaiser, Markus and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2012. Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease. Chembiochem 13 (3) , pp. 402-408. 10.1002/cbic.201100643 |
Malet, Hélène, Canellas, Flavia, Sawa, Justyna, Yan, Jun, Thalassinos, Konstantinos, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Clausen, Tim and Saibil, Helen R. 2012. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Nature Structural & Molecular Biology 19 (2) , pp. 152-157. 10.1038/nsmb.2210 |
Tiaden, André N, Breiden, Maike, Mirsaidi, Ali, Weber, Fabienne A., Bahrenberg, Gregor, Glanz, Stephan, Cinelli, Paolo, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Richards, Peter J. 2012. Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein. Stem Cells 30 (10) , pp. 2271-2282. 10.1002/stem.1190 |
Weski, Juliane and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2012. Genetic analysis of 15 protein folding factors and proteases of the escherichia coli cell envelope. Journal of Bacteriology 194 (12) , pp. 3225-3233. 10.1128/JB.00221-12 |
Merdanovic, Melisa, Clausen, Tim, Kaiser, Markus, Huber, Robert and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2011. Protein quality control in the bacterial periplasm. Annual Review of Microbiology 65 (1) , pp. 149-168. 10.1146/annurev-micro-090110-102925 |
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Wu, Junchen, Zawistowski, Adam, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Yi, Tao and Schmuck, Carsten 2011. Peptide functionalized polydiacetylene liposomes act as a gluorescent turn-on sensor for bacterial Lipopolysaccharide. Journal of the American Chemical Society 133 (25) , pp. 9720-9723. 10.1021/ja204013u |
Kley, Juliane, Schmidt, Bastian, Boyanov, Boril, Stolt-Bergner, Peggy C., Kirk, Rebecca, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Knopf, Ronit R., Naveh, Leah, Adam, Zach and Clausen, Tim 2011. Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure. Nature Structural & Molecular Biology 18 (6) , pp. 728-731. 10.1038/nsmb.2055 |
Truebestein, Linda, Tennstaedt, Annette, Mönig, Timon, Krojer, Tobias, Canellas, Flavia, Kaiser, Markus, Clausen, Tim and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2011. Substrate-induced remodeling of the active site regulates human HTRA1 activity. Nature Structural & Molecular Biology 18 (3) , pp. 386-388. 10.1038/nsmb.2013 |
Clausen, Tim, Kaiser, Markus, Huber, Robert and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2011. HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews Molecular Cell Biology 12 (3) , pp. 152-162. 10.1038/nrm3065 |
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Campioni, Mara, Severino, Anna, Manente, Lucrezia, Tuduce, Ioana L., Toldo, Stefano, Caraglia, Michele, Crispi, Stefania, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, He, Xiaoping, Maguire, Jacie, De Falco, Maria, De Luca, Antonia, Shridhar, Viji and Baldi, Alfonso 2010. The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein. Molecular Cancer Research 8 (9) , pp. 1248-1260. 10.1158/1541-7786.MCR-09-0473 |
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Meltzer, Michael, Hasenbein, Sonja, Mamant, Nicolette, Merdanovic, Melisa, Poepsel, Simon, Hauske, Patrick, Kaiser, Markus, Huber, Robert, Krojer, Tobias, Clausen, Tim and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2009. Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Research in Microbiology 160 (9) , pp. 660-666. 10.1016/j.resmic.2009.07.012 |
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Krojer, Tobias, Sawa, Justyna, Schäfer, Eva, Saibil, Helen R., Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Clausen, Tim 2008. Structural basis for the regulated protease and chaperone function of DegP. Nature 453 (7197) , pp. 885-890. 10.1038/nature07004 |
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Baldi, Alfonso, Mottolese, Marcella, Vincenzi, Bruno, Campioni, Mara, Mellone, Pasquale, Di Marino, Mariapia, di Crescenzo, Vincenzo G., Visca, Paolo, Menegozzo, Simona, Spugnini, Enrico P., Citro, Gennaro, Ceribelli, Anna, Mirri, Alessandra, Chien, Jeremy, Shridhar, Viji, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Santini, Mario and Facciolo, Francesco 2008. The serine protease HtrA1 is a novel prognostic factor for human mesothelioma. Pharmacogenomics 9 (8) , pp. 1069-1077. 10.2217/14622416.9.8.1069 |
Launay, S., Maubert, E., Lebeurrier, N., Tennstaedt, A., Campioni, M., Docagne, F., Gabriel, C., Dauphinot, L., Potier, M. C., Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Baldi, A. and Vivien, D. 2008. HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival. Cell Death and Differentiation 15 (9) , pp. 1408-1416. 10.1038/cdd.2008.82 |
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Severino, Anna, Campioni, Mara, Straino, Stefania, Salloum, Fadi N., Schmidt, Nina, Herbrand, Ulrike, Frede, Stilla, Toietta, Gabriele, Di Rocco, Giuliana, Bussani, Rossana, Silvestri, Furio, Piro, Maddalena, Liuzzo, Giovanna, Biasucci, Luigi M., Mellone, Pasquale, Feroce, Florinda, Capogrossi, Maurizio, Baldi, Feliciano, Fandrey, Joachim, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Crea, Filippo, Abbate, Antonio and Baldi, Alfonso 2007. Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy. Journal of the American College of Cardiology 50 (11) , p. 1029. 10.1016/j.jacc.2007.06.006 |
Eser, Markus, Henrichs, Tanja, Boyd, Dana and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2007. Target‐directed proteolysis In vivo. Methods in Enzymology 421 , pp. 68-83. 10.1016/S0076-6879(06)21008-5 |
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Henrichs, Tanja, Mikhaleva, Natasha, Conz, Charlotte, Deuerling, Elke, Boyd, Dana, Zelazny, Adrian, Bibi, Eitan, Ban, Nenad and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2005. Target-directed proteolysis at the ribosome. Proceedings of the National Academy of Sciences of the USA , pp. 4246-4251. 10.1073/pnas.0408520102 |
Grau, S., Baldi, A., Bussani, R., Tian, X., Stefanescu, R., Przybylski, M., Richards, P., Jones, S. A., Shridhar, V., Clausen, T. and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2005. Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proceedings of the National Academy of Sciences of the United States of America 102 (17) , pp. 6021-6026. 10.1073/pnas.0501823102 |
Tian, Xiaodan, Cecal, Roxana, McLaurin, JoAnne, Manea, Marilena, Stefanescu, Raluca, Grau, Sandra, Harnasch, Mona, Amir, Sarah, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, St George-Hyslop, Peter, Kohlmann, Markus and Przybylski, Michael 2005. Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry. European Journal of Mass Spectrometry 11 (1) , pp. 547-556. 10.1255/ejms.722 |
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Faber, Klaas Nico, Kram, Anita M., Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Veenhuis, Marten 2001. A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus protease. Journal of Biological Chemistry 276 (39) , pp. 36501-36507. 10.1074/jbc.M105828200 |
Steinke, A., Grau, S., Davidson, A., Hofmann, E. and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2001. Characterization of transmembrane segments 3, 4, and 5 of MalF by mutational analysis. Journal of Bacteriology 183 (1) , pp. 375-381. 10.1128/JB.183.1.375-381.2001 |
Uhland, K., Mondigler, M., Spiess, C., Prinz, W. and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2000. Determinants of translocation and folding of TreF, a trehalase of Escherichia coli. Journal of Biological Chemistry 275 (31) , pp. 23439-23445. 10.1074/jbc.M002793200 |