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Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase.
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Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells.
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van den Berg, Hugo A., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly, Laugel, Bruno, Llewellyn-Lacey, Sian, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gostick, Emma, Wooldridge, Linda, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bridgeman, John S. and Price, David ORCID: https://orcid.org/0000-0001-9416-2737
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| Lloyd, Angharad, Vickery, Owen N. and Laugel, Bruno 2013. Beyond the antigen receptor: editing the genome of T-Cells for cancer adoptive cellular therapies. Frontiers in Immunology 4 , 221. 10.3389/fimmu.2013.00221 |
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Challier, John, Bruniquel, Denis, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Laugel, Bruno
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Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity.
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Laugel, Bruno, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
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The molecular determinants of CD8 co-receptor function.
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Laugel, Bruno Frederic, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wooldridge, Linda, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
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The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.
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Laugel, Bruno Frederic, Berg, Hugo A. van den, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Wooldridge, Linda, Boulter, Jonathan M, Milicic, Anita, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135
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Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotxic T lymphocyte activation and tetramer properties.
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Wooldridge, Linda, Lissina, Anna, Vernazza, Jonathan, Gostick, Emma, Laugel, Bruno Frederic, Hutchinson, Sarah L., Mirza, Fareed, Dunbar, P. Rod, Boulter, Jonathan M., Glick, Meir, Cerundolo, Vincenzo, Berg, Hugo A. van den, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135
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Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Hutchinson, Sarah L., Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno Frederic, Lissina, A., Oxenius, Annette, Boulter, Jonathan M., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
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Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor.
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Wooldridge, Linda, Scriba, Thomas J., Milicic, Anita, Laugel, Bruno Frederic, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Phillips, Rodney E. and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135
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Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers.
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Wooldridge, Linda, Berg, Hugo A. van den, Glick, Meir, Gostick, Emma, Laugel, Bruno Frederic, Hutchinson, Sarah L., Milicic, Anita, Brenchley, Jason M., Douek, Daniel C., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135
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Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.
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