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Number of items: 76.

Ferreira, Lucas Coral, de Souza Galaverna, Renan, McBride, Tom, Costa e Silva, Rodrigo, Browne, Duncan L.

and Pastre, Julio Cezar 2025. Fast and scalable continuous flow synthesis of butenolides and coumarins. Reaction Chemistry and Engineering 10 (5) , pp. 1108-1113. 10.1039/d4re00567h

Yu, Cihang, Leitch, Jamie A., Gierlichs, Lukas, Das, Sampurna, Porch, Adrian

, Melen, Rebecca L.

and Browne, Duncan L.

2024. Use of microwave dielectric spectroscopy for the In Actu assessment of frustrated Lewis Pair encounter complexes. Journal of the American Chemical Society 146 (29) , 19809–19817. 10.1021/jacs.4c02736

Williams, Matthew T. J., Morrill, Louis C.

and Browne, Duncan L.

2023. Nickel‐catalyzed intramolecular alkene difunctionalization by ball‐milling. Advanced Synthesis & Catalysis 365 (9) , pp. 1477-1484. 10.1002/adsc.202300188

Del Vecchio, Antonio, Smallman, Harry R., Morvan, Jennifer, McBride, Tom, Browne, Duncan L.

and Mauduit, Marc 2022. Challenges arising from continuous-flow olefin metathesis. Angewandte Chemie International Edition 61 (47) , e202209564. 10.1002/anie.202209564

Jones, Andrew C., Williams, Matthew T. J., Morrill, Louis C.

and Browne, Duncan L.

2022. Mechanical activation of zero-valent metal reductants for nickel-catalyzed cross-electrophile coupling. ACS Catalysis 12 (21) , pp. 13681-13689. 10.1021/acscatal.2c03117

Williams, Matthew T. J., Morrill, Louis C.

and Browne, Duncan L.

2022. Mechanochemical organocatalysis: do high enantioselectivities contradict what we might expect? ChemSusChem 15 (2) , e202102157. 10.1002/cssc.202102157

Nicholson, William I., Howard, Joseph L., Magri, Giuseppina, Seastram, Alex C., Khan, Adam, Bolt, Robert R. A., Morrill, Louis C.

, Richards, Emma

and Browne, Duncan L.

2021. Ball-milling-enabled reactivity of manganese metal. Angewandte Chemie International Edition 60 (43) , pp. 23128-23133. 10.1002/anie.202108752

Nicholson, William I., Barreteau, Fabien, Leitch, Jamie A., Payne, Riley, Priestley, Ian, Godineau, Edouard, Battilocchio, Claudio and Browne, Duncan L.

2021. Direct amidation of esters by ball milling**. Angewandte Chemie International Edition 60 (40) , pp. 21868-21874. 10.1002/anie.202106412

Morvan, Jennifer, McBride, Tom, Curbet, Idriss, Colombel-Rouen, Sophie, Roisnel, Thierry, Crévisy, Christophe, Browne, Duncan L.

and Mauduit, Marc 2021. Continuous flow Z-stereoselective Olefin Metathesis: development and applications in the synthesis of pheromones and macrocyclic odorant molecules. Angewandte Chemie International Edition 60 (36) , pp. 19685-19690. 10.1002/anie.202106410

Jones, Andrew C., Nicholson, William I., Leitch, Jamie A. and Browne, Duncan L.

2021. A ball-milling-enabled cross-electrophile coupling. Organic Letters 23 (16) , 6337–6341. 10.1021/acs.orglett.1c02096

Riley, William, Jones, Andrew C., Singh, Kuldip, Browne, Duncan L.

and Stuart, Alison M. 2021. Accessing novel fluorinated heterocycles with the hypervalent fluoroiodane reagent by solution and mechanochemical synthesis. Chemical Communications 57 (60) , pp. 7406-7409. 10.1039/D1CC02587B

Schotten, Christiane, Leprevost, Samy K., Yong, Low Ming, Hughes, Colan E., Harris, Kenneth D. M.

and Browne, Duncan L.

2020. Comparison of the thermal stabilities of diazonium salts and their corresponding triazenes. Organic Process Research and Development 24 (10) , pp. 2336-2341. 10.1021/acs.oprd.0c00162

Jones, Andrew C., Nicholson, William I., Smallman, Harry R. and Browne, Duncan L.

2020. A robust Pd-catalyzed C–S cross-coupling process enabled by ball-milling. Organic Letters 22 (19) , pp. 7433-7438. 10.1021/acs.orglett.0c02418

Yin, JieXiang, Stark, Roderick T., Fallis, Ian A.

and Browne, Duncan L.

2020. A mechanochemical zinc-mediated barbier-type allylation reaction under ball-milling conditions. Journal of Organic Chemistry 85 (4) , pp. 2347-2354. 10.1021/acs.joc.9b02876

Nicholson, William I., Seastram, Alex C., Iqbal, Saqib A., Reed-Berendt, Benjamin G., Morrill, Louis C.

and Browne, Duncan L.

2020. N-Heterocyclic carbene acyl anion organocatalysis by ball-milling. ChemSusChem 13 (1) , pp. 131-135. 10.1002/cssc.201902346

Allen, Benjamin D. W., Mishra, Deepak, Seastram, Alex C., McBride, Tom, Wirth, Thomas

, Browne, Duncan L.

and Morrill, Louis C.

2019. Manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols via alkoxy radicals. Organic Letters 21 (22) , pp. 9241-9246. 10.1021/acs.orglett.9b03652

Galaverna, Renan, McBride, Tom, Pastre, Julio C. and Browne, Duncan L.

2019. Exploring the generation and use of acylketenes with continuous flow processes. Reaction Chemistry and Engineering 4 (9) , pp. 1559-1564. 10.1039/C9RE00072K

Cao, Qun

, Stark, Roderick, Fallis, Ian

and Browne, Duncan L.

2019. A ball-milling enabled Reformatsky reaction. ChemSusChem 12 (12) , pp. 2554-2557. 10.1002/cssc.201900886

Laudadio, Gabriele, Barmpoutsis, Efstathios, Schotten, Christiane, Struik, Lisa, Govaerts, Sebastian, Browne, Duncan L.

and Noël, Timothy 2019. Sulfonamide synthesis through electrochemical oxidative coupling of amines and thiols. Journal of the American Chemical Society 141 (14) , pp. 5664-5668. 10.1021/jacs.9b02266

Cao, Qun

, Nicholson, William I., Jones, Andrew C. and Browne, Duncan L.

2019. Robust Buchwald-Hartwig amination enabled by ball-milling. Organic and Biomolecular Chemistry 17 (7) , pp. 1722-1726. 10.1039/C8OB01781F

Carden, Jamie, Gierlichs, Lukas, Wass, Duncan

, Browne, Duncan

and Melen, Rebecca

2019. Unlocking the catalytic potential of tris(3,4,5-trifluorophenyl)borane with microwave irradiation. Chemical Communications 55 (3) , pp. 318-321. 10.1039/C8CC09459D

Howard, Joseph L., Brand, Michael C. and Browne, Duncan L.

2018. Switching chemoselectivity: using mechanochemistry to alter reaction kinetics. Angewandte Chemie International Edition 57 (49) , pp. 16104-16108. 10.1002/anie.201810141

Galaverna, Renan, Fernandes, Lucas P., Browne, Duncan L.

and Pastre, Julio C. 2018. Continuous flow processing as a tool for the generation of terpene-derived monomer libraries. Reaction Chemistry and Engineering 4 (2) , pp. 362-367. 10.1039/C8RE00237A

Schotten, Christiane, Howard, Joseph L., Jenkins, Robert L., Codina, Anna and Browne, Duncan L.

2018. A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring. Tetrahedron 74 (38) , pp. 5503-5509. 10.1016/j.tet.2018.05.070

Cao, Qun

, Howard, Joseph L., Crawford, Deborah E., James, Stuart L. and Browne, Duncan L.

2018. Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder. Green Chemistry 20 (19) , pp. 4443-4447. 10.1039/C8GC02036A

Cao, Qun

, Howard, Joseph L., Wheatley, Emilie and Browne, Duncan L.

2018. Mechanochemical activation of zinc and application to Negishi cross-coupling. Angewandte Chemie International Edition 57 (35) , pp. 11339-11343. 10.1002/anie.201806480

Howard, Joseph L., Sagatov, Yerbol and Browne, Duncan L.

2018. Mechanochemical electrophilic fluorination of liquid beta-ketoesters. Tetrahedron 74 (25) , pp. 3118-3123. 10.1016/j.tet.2017.11.066

Howard, Joseph, Cao, Qun

and Browne, Duncan

2018. Mechanochemistry as an emerging tool for molecular synthesis: what can it offer? Chemical Science 9 (12) , pp. 3080-3094. 10.1039/C7SC05371A

Schotten, Christiane, Leist, Lisa G. T., Semrau, Anna Lisa and Browne, Duncan L.

2018. A machine-assisted approach for the preparation of follow-on pharmaceutical compound libraries. Reaction Chemistry and Engineering 3 (2) , pp. 210-215. 10.1039/C8RE00010G

Howard, Joseph L., Nicholson, William, Sagatov, Yerbol and Browne, Duncan L.

2017. One-pot multistep mechanochemical synthesis of fluorinated pyrazolones. Beilstein Journal of Organic Chemistry 13 , pp. 1950-1956. 10.3762/bjoc.13.189

Jürgens, Sophie, Scalcon, Valeria, Estrada-Ortiz, Natalia, Folda, Alessandra, Tonolo, Federica, Jandl, Christian, Browne, Duncan L.

, Rigobello, Maria Pia, Kühn, Fritz E. and Casini, Angela

2017. Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes. Bioorganic & Medicinal Chemistry 10.1016/j.bmc.2017.08.001

Wilkins, Lewis C., Howard, Joseph L., Burger, Stefan, Frentzel-Beyme, Louis, Browne, Duncan L.

and Melen, Rebecca L.

2017. Exploring multistep continuous-flow hydrosilylation reactions catalyzed by tris(pentafluorophenyl)borane. Advanced Synthesis and Catalysis 359 (15) , pp. 2580-2584. 10.1002/adsc.201700349

Groves, Lara M., Schotten, Christiane, Beames, Joseph

, Platts, James A.

, Coles, Simon J., Horton, Peter N., Browne, Duncan L.

and Pope, Simon J. A.

2017. From ligand to phosphor: rapid, machine-assisted synthesis of substituted iridium(III) pyrazolate complexes with tuneable luminescence. Chemistry - A European Journal 23 (39) , pp. 9407-9418. 10.1002/chem.201701551

Howard, Joseph L., Sagatov, Yerbol, Repusseau, Laura, Schotten, Christiane and Browne, Duncan L.

2017. Controlling reactivity through liquid assisted grinding: the curious case of mechanochemical fluorination. Green Chemistry 12 , pp. 2798-2802. 10.1039/C6GC03139K

Howard, Joseph L., Schotten, Christiane and Browne, Duncan L.

2017. Continuous flow synthesis of antimalarials: opportunities for distributed autonomous chemical manufacturing. Reaction Chemistry and Engineering 2 (3) , pp. 281-287. 10.1039/C7RE00034K

Browne, Duncan L

, Howard, Joseph L and Schotten, Christiane 2017. Continuous flow processing as a tool for medicinal chemical synthesis. Comprehensive Medicinal Chemistry III, Elsevier, pp. 135-185. (10.1016/B978-0-12-409547-2.12288-7)

Schotten, Christiane, Aldmairi, Abdul Hadi

, Sagatov, Yerbol, Shepherd, Martyn and Browne, Duncan L.

2016. Protected diazonium salts: a continuous-flow preparation of triazenes including the anticancer compounds dacarbazine and mitozolomide. Journal of Flow Chemistry 6 (3) , pp. 218-225. 10.1556/1846.2016.00025

Browne, Duncan L.

and Richardson, Paul 2016. Fluorination Approaches. Blakemore, D, Doyle, P, Fobian, Y and Thurston, D, eds. Synthetic Methods in Drug Discovery: Volume 2, Vol. 2. Synthetic Methods in Drug Discovery, Cambridge, UK: Royal Society of Chemistry, (10.1039/9781782627913-00263)

Browne, Duncan L.

, Ley, Steven V., Poh, Jian-Siang, Blakemore, David C., Meroni, Francesca, García-Ruiz, Cristina and Zuniga, Andrea 2016. Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation. Organic & Biomolecular Chemistry 14 (25) , pp. 5983-5991. 10.1039/C6OB00970K

Howard, Joseph L., Schotten, Christiane, Alston, Stephen T. and Browne, Duncan L.

2016. Preparation of difluoromethylthioethers through difluoromethylation of disulfides using TMS-CF2H. Chemical Communications 52 , pp. 8448-8451. 10.1039/C6CC02693A

Poh, Jian-Siang, Browne, Duncan L.

and Ley, Steven V. 2016. A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. Reaction Chemistry and Engineering 2016 (1) , pp. 101-105. 10.1039/C5RE00082C

Browne, Duncan L.

2015. Flow chemistry. Green Processing and Synthesis 4 (3) , p. 253. 10.1515/gps-2015-0027

Schotten, Christiane, Plaza, Dorota, Manzini, Simone, Nolan, Steven P., Ley, Steven V., Browne, Duncan L.

and Lapkin, Alexei 2015. Continuous flow metathesis for direct valorization of food waste: an example of cocoa butter triglyceride. ACS Sustainable Chemistry & Engineering 3 (7) , pp. 1453-1459. 10.1021/acssuschemeng.5b00397

Zhou, Yating, Guo, Fang, Hughes, Colan Evan, Browne, Duncan L.

, Peskett, Thomas R. and Harris, Kenneth David Maclean

2015. Discovery of new metastable polymorphs in a family of urea co-crystals by solid-state mechanochemistry. Crystal Growth and Design 15 (6) , pp. 2901-2907. 10.1021/acs.cgd.5b00331

Deadman, Benjamin J., Browne, Duncan L.

, Baxendale, Ian R. and Ley, Steven V. 2015. Back pressure regulation of slurry-forming reactions in continuous flow. Chemical Engineering & Technology 38 (2) , pp. 259-264. 10.1002/ceat.201400445

Browne, Duncan L.

2015. Cluster preface: progress in organo-fluorine chemistry. Synlett 26 (01) , pp. 33-35. 10.1055/s-0034-1379721

Newby, James A., Blaylock, D. Wayne, Witt, Paul M., Pastre, Julio C., Zacharova, Marija K., Ley, Steven V. and Browne, Duncan L.

2014. Design and application of a low-temperature continuous flow chemistry platform. Organic Process Research and Development 18 (10) , pp. 1211-1220. 10.1021/op500213j

Newby, James A., Blaylock, D. Wayne, Witt, Paul M., Turner, Richard M., Heider, Patrick L., Harji, Bashir H., Browne, Duncan L.

and Ley, Steven V. 2014. Reconfiguration of a continuous flow platform for extended operation: application to a cryogenic fluorine-directedortho-lithiation reaction. Organic Process Research and Development 18 (10) , pp. 1221-1228. 10.1021/op500221s

Kabeshov, Mikhail A., Musio, Biagia, Murray, Philip R. D., Browne, Duncan L.

and Ley, Steven V. 2014. Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology. Organic Letters 16 (17) , pp. 4618-4621. 10.1021/ol502201d

Browne, Duncan

2014. The Trifluoromethylating Sandmeyer Reaction: a method for transforming C[BOND]N into C[BOND]CF3. Angewandte Chemie - International Edition 53 (6) , pp. 1482-1484. 10.1002/anie.201308997

Newby, James A., Huck, Lena, Blaylock, D. Wayne, Witt, Paul M., Ley, Steven V. and Browne, Duncan L.

2014. Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor. Chemistry - a European Journal 20 (1) , pp. 263-271. 10.1002/chem.201303736

Allwood, Daniel, Browne, Duncan L.

and Ley, Steven V. 2014. Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor: Ethyl 1-Benzyl-trans-5-(trifluoromethyl)pyrrolidine-3-carboxylate. Organic Syntheses 91 , pp. 162-174.

Pastre, Julio C., Browne, Duncan L.

and Ley, Steven V. 2013. Flow chemistry syntheses of natural products. Chemical Society Reviews 42 (23) , pp. 8849-8869. 10.1039/c3cs60246j

Murray, Philip R. D., Browne, Duncan L.

, Pastre, Julio C., Butters, Chris, Guthrie, Duncan and Ley, Steven V. 2013. Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen. Organic Process Research and Development 17 (9) , pp. 1192-1208. 10.1021/op4001548

Pastre, Julio C., Browne, Duncan L.

, O'Brien, Matthew and Ley, Steven V. 2013. Scaling up of continuous flow processes with gases using a tube-in-tube reactor: inline titrations and fanetizole synthesis with ammonia. Organic Process Research and Development 17 (9) , pp. 1183-1191. 10.1021/op400152r

Ley, Steven V., Ingham, Richard J., O'Brien, Matthew and Browne, Duncan L.

2013. Camera-enabled techniques for organic synthesis. Beilstein Journal of Organic Chemistry 9 , pp. 1051-1072. 10.3762/bjoc.9.118

Ley, Steven, Nakayama, Keiji, Browne, Duncan L.

and Baxendale, Ian 2013. Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor. Synlett 24 (10) , pp. 1298-1302. 10.1055/s-0033-1338455

Tran, Gaël, Meier, Robin, Harris, Lawrence, Browne, Duncan L.

and Ley, Steven V. 2012. Synthesis and use of a trifluoromethylated azomethine ylide precursor. Journal of Organic Chemistry 77 (24) , pp. 11071-11078. 10.1021/jo302052m

Browne, Duncan L.

, Wright, Steven, Deadman, Benjamin J., Dunnage, Samantha, Baxendale, Ian R., Turner, Richard M. and Ley, Steven V. 2012. Continuous flow reaction monitoring using an on-line miniature mass spectrometer. Rapid Communications in Mass Spectrometry 26 (17) , pp. 1999-2010. 10.1002/rcm.6312

O'Brien, Matthew, Koos, Peter, Browne, Duncan L.

and Ley, Steven V. 2012. A prototype continuous-flow liquid–liquid extraction system using open-source technology. Organic & Biomolecular Chemistry 10 (35) , pp. 7031-7036. 10.1039/c2ob25912e

Koos, Peter, Browne, Duncan L.

and Ley, Steven V. 2012. Continuous stream processing: a prototype magnetic field induced flow mixer. Green Processing and Synthesis 1 (1) , pp. 11-18. 10.1515/greenps-2011-0501

Cranwell, Philippa B., O'Brien, Matthew, Browne, Duncan L.

, Koos, Peter, Polyzos, Anastasios, Peña-López, Miguel and Ley, Steven V. 2012. Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration. Organic & Biomolecular Chemistry 10 (30) , pp. 5774-5779. 10.1039/c2ob25407g

Ley, Steven, Browne, Duncan L.

, O'Brien, Matthew, Koos, Peter, Cranwell, Philippa and Polyzos, Anastasios 2012. Continuous-flow processing of gaseous ammonia using a teflon AF-2400 tube-in-tube reactor: synthesis of thioureas and in-line titrations. Synlett 23 (09) , pp. 1402-1406. 10.1055/s-0031-1290963

Browne, Duncan L.

, Baxendale, Ian R. and Ley, Steven V. 2011. Piecing together the puzzle: understanding a mild, metal free reduction method for the large scale synthesis of hydrazines. Tetrahedron 67 (52) , pp. 10296-10303. 10.1016/j.tet.2011.09.146

Browne, Duncan L.

, Baumann, Marcus, Harji, Bashir H., Baxendale, Ian R. and Ley, Steven V. 2011. A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures. Organic Letters 13 (13) , pp. 3312-3315. 10.1021/ol2010006

Browne, Duncan L.

, Deadman, Benjamin J., Ashe, Robert, Baxendale, Ian R. and Ley, Steven V. 2011. Continuous flow processing of slurries: evaluation of an agitated cell reactor. Organic Process Research and Development 15 (3) , pp. 693-697. 10.1021/op2000223

Crossley, James A., Kirkham, James D., Browne, Duncan L.

and Harrity, Joseph P.A. 2010. On the use of 2-(trimethylsilyl)iodobenzene as a benzyne precursor. Tetrahedron Letters 51 (50) , pp. 6608-6610. 10.1016/j.tetlet.2010.10.052

Crossley, James A. and Browne, Duncan L.

2010. An alkynyliodide cycloaddition strategy for the construction of iodoisoxazoles. Journal of Organic Chemistry 75 (15) , pp. 5414-5416. 10.1021/jo1011174

Crossley, James A. and Browne, Duncan L.

2010. Cycloaddition of benzynes and nitrile oxides: synthesis of benzisoxazoles. Tetrahedron Letters 51 (17) , pp. 2271-2273. 10.1016/j.tetlet.2010.02.103

Browne, Duncan L.

and Harrity, Joseph P. A. 2010. Recent developments in the chemistry of sydnones. Tetrahedron 66 (3) , pp. 553-568. 10.1016/j.tet.2009.10.085

Browne, Duncan L.

, Taylor, John B., Plant, Andrew and Harrity, Joseph P. A. 2010. Alkyne [3 + 2] cycloadditions of iodosydnones toward functionalized 1,3,5-trisubstituted pyrazoles. Journal of Organic Chemistry 75 (3) , pp. 984-987. 10.1021/jo902514v

Foster, Robert S., Huang, Jianhui, Vivat, Jérôme F., Browne, Duncan L.

and Harrity, Joseph P. A. 2009. A divergent strategy to the withasomnines. Organic & Biomolecular Chemistry 7 (19) , pp. 4052-4056. 10.1039/b910632d

Browne, Duncan L.

, Vivat, Jérôme F., Plant, Andrew, Gomez-Bengoa, Enrique and Harrity, Joseph P. A. 2009. Investigation of the scope and regiochemistry of alkynylboronate cycloadditions with sydnones. Journal of the American Chemical Society 131 (22) , pp. 7762-7769. 10.1021/ja902460n

Browne, Duncan L.

, Taylor, John B., Plant, Andrew and Harrity, Joseph P. A. 2009. Cross coupling of bromo sydnones: development of a flexible route toward functionalized pyrazoles. Journal of Organic Chemistry 74 (1) , pp. 396-400. 10.1021/jo802240e

Delaney, Patrick M., Browne, Duncan L.

, Adams, Harry, Plant, Andrew and Harrity, Joseph P.A. 2008. A 2-pyrone cycloaddition route to functionalised aromatic boronic esters. Tetrahedron 64 (5) , pp. 866-873. 10.1016/j.tet.2007.08.118

Browne, Duncan L.

, Helm, Matthew D., Plant, Andrew and Harrity, Joseph P.A. 2007. A sydnone cycloaddition route to pyrazole boronic esters. Angewandte Chemie - International Edition 46 (45) , pp. 8656-8658. 10.1002/anie.200703767

This list was generated on Sat Nov 8 11:08:09 2025 GMT.