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Number of items: 37.

Zhang, Luyao, Xing, Yanpeng, Wang, Pai, Gu, Jianlei, Peng, Jian, Huang, Juan, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Hu, Youjia, Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2025. Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice. Frontiers in Endocrinology 16 , 1630979. 10.3389/fendo.2025.1630979
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269 and Hanna, Stephanie J. 2025. Mini review: Interleukin-32 as a key mediator of type 1 diabetes pathogenesis. Frontiers in Immunology 16 , 1641698. 10.3389/fimmu.2025.1641698
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Jenkins, Benjamin, Jenkins, Yasmin, Ponce-Garcia, Fernando, Moscrop, Chloe, Perry, Iain, Hitchings, Matthew, Uribe, Alejandro, Bernuzzi, Federico, Eastham, Simon, Cronin, James, Berisha, Ardena, Howell, Alexandra, Davies, Joanne, Blagih, Julianna, Veale, Douglas, Davies, Luke, Niphakis, Micah, Finlay, David, Sinclair, Linda, Cravatt, Benjamin, Hogan, Andrew, Nathan, James, Fearon, Ursula, Sumpton, David, Vande Voorde, Johan, Dias do Vale, Goncalo, McDonald, Jeffrey, Jones, Gareth, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Vincent, Emma and Jones, Nicholas 2025. ABHD11 inhibition drives sterol metabolism to modulate T cell effector function 2 and alleviate autoimmunity. [Online]. bioRxiv: openRxiv. Available at: https://doi.org/10.1101/2025.03.19.643996
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Haq, N., Toczyska, K. W., Wilson, M. E., Jacobs, M., Zhao, Min, Lei, Y., Shen, Z., Pearson, J. A. ORCID: https://orcid.org/0000-0002-2867-2269, Persaud, S. J., Pullen, T. J. and Bewick, G. A. 2024. Reformed islets: a long-term primary cell platform for exploring mouse and human islet biology. Cell Death Discovery 10 , 480. 10.1038/s41420-024-02234-6
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Wang, Pai, Yang, Xin, Zhang, Luyao, Sha, Sha, Huang, Juan, Peng, Jian, Gu, Jianlei, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Hu, Youjia, Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Wang, Quan and Wen, Li 2024. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 15 (1) , 4232. 10.1038/s41467-024-48611-8
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Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Hu, Youjia, Peng, Jian, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2024. TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model. Frontiers in Immunology 15 , 1333967. 10.3389/fimmu.2024.1333967
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Peng, Jian, Huang, Juan, Yu, Xiaoqing, Tai, Ningwen, Hu, Youjia, Sha, Sha, Flavell, Richard A., Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2023. NLRP6 deficiency expands a novel CD103 + B cell population that confers immune tolerance in NOD mice. Frontiers in Immunology 14 , 1147925. 10.3389/fimmu.2023.1147925
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Boldison, Joanne, Hopkinson, Jessica R., Davies, Joanne, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Leete, Pia, Richardson, Sarah, Morgan, Noel G. and Wong, F. Susan 2022. Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes. Diabetologia 66 (3) , pp. 551-566. 10.1007/s00125-022-05839-7
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Ding, Heyuan, Hu, Changyun, Peng, Jian, Galuppo, Brittany, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Caprio, Sonia, Santoro, Nicola and Wen, Li 2022. IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans. Diabetologia 65 (8) , pp. 1398-1411. 10.1007/s00125-022-05711-8
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Chan, Karl, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269 2022. Circadian rhythms and pancreas physiology: A review. Frontiers in Endocrinology 13 , 920261. 10.3389/fendo.2022.920261
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, McKinney, Eoin F. and Walker, Lucy S. K. 2022. 100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes. Immunotherapy Advances 10.1093/immadv/ltab024
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Huang, Juan, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Wen, Li and Zhou, Zhiguang 2022. Innate immunity in latent autoimmune diabetes in adults (LADA). Diabetes/Metabolism Research and Reviews 38 (1) , e3480. 10.1002/dmrr.3480
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Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Voisey, Alexander Christopher ORCID: https://orcid.org/0000-0001-6906-9397, Boest Bjerg, Kathrine, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2021. Circadian rhythm modulation of microbes during health and infection. Frontiers in Microbiology 12 , 721004. 10.3389/fmicb.2021.721004
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Huang, Juan, Tan, Qiyuan, Tai, Ningwen, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Li, Yangyang, Chao, Chen, Zhang, Lucy, Peng, Jian, Xing, Yanpeng, Zhang, Luyao, Hu, Youjia, Zhou, Zhiguang, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2021. IL-10 deficiency accelerates type 1 diabetes development via modulation of innate and adaptive immune cells and gut microbiota in BDC2.5 NOD mice. Frontiers in Immunology 12 , 702955. 10.3389/fimmu.2021.702955
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Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2021. Inflammasomes and type 1 diabetes. Frontiers in Immunology 12 , 686956. 10.3389/fimmu.2021.686956
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Thayer, Terri C., Davies, Joanne, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Hanna, Stephanie J., Wen, Li and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70 (2) , pp. 529-537. 10.2337/db19-1050

Sha, Sha, Pearson, James A ORCID: https://orcid.org/0000-0002-2867-2269, Peng, Jian, Hu, Youjia, Huang, Juan, Xing, Yanpeng, Zhang, Luyao, Zhu, Ying, Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Chen, Li and Wen, Li 2021. TLR9-deficiency in B cells promotes immune tolerance via IL-10 in a type 1 diabetes mouse model. Diabetes 70 (2) , pp. 504-515. 10.2337/db20-0373
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Huang, Juan, Peng, Jian, Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Efthimiou, Georgios, Hu, Youjia, Tai, Ningwen, Xing, Yanpeng, Zhang, Luyao, Gu, Jianlei, Jiang, Jianping, Zhao, Hongyu, Zhou, Zhiguang, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2021. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular and Molecular Immunology 18 , pp. 328-338. 10.1038/s41423-020-00590-8
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Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2020. Crosstalk between circadian rhythms and the microbiota. Immunology 161 (4) , pp. 278-290. 10.1111/imm.13278
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Li, Yangyang, Majewska-Szczepanik, Monika, Guo, Junhua, Zhang, Li, Liu, Yu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2020. Insulin-reactive T cells convert diabetogenic insulin-reactive VH125 B cells into tolerogenic cells by reducing germinal center T:B cell Interactions in NOD mice. Frontiers in Immunology 11 , 585886. 10.3389/fimmu.2020.585886
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Huang, Juan, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Peng, Jian, Hu, Youjia, Sha, Sha, Xing, Yanpeng, Huang, Gan, Li, Xia, Hu, Fang, Xie, Zhiguo, Xiao, Yang, Luo, Shuoming, Chao, Chen, Wong, Florence S. ORCID: https://orcid.org/0000-0002-2812-8845, Zhou, Zhiguang and Wen, Li 2020. Gut microbial metabolites alter IgA immunity in type 1 diabetes. JCI Insight 5 (10) , e135718. 10.1172/jci.insight.135718
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Tai, Ningwen, Ekanayake-Alper, Dilrukshi K., Peng, Jian, Hu, Youjia, Hager, Karl, Compton, Susan, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Smith, Peter C. and Wen, Li 2019. Norovirus changes susceptibility to type 1 diabetes by altering intestinal microbiota and immune cell functions. Frontiers in Immunology 10 , 2654. 10.3389/fimmu.2019.02654
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Kakabadse, Dimitri, Davies, Joanne, Peng, Jian, Warden-Smith, Jeremy, Cuff, Simone ORCID: https://orcid.org/0000-0002-0546-3579, Lewis, Mark, Camargo da Rosa, Larissa, Wen, Li and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2019. Altered gut microbiota activate and expand insulin B15-23-Reactive CD8+ T-Cells. Diabetes 68 (5) , pp. 1002-1013. 10.2337/db18-0487
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Liu, Mengju, Peng, Jian, Tai, Ningwen, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Hu, Changyun, Guo, Junhua, Hou, Lin, Zhao, Hongyu, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2018. Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes. Diabetologia 61 (11) , pp. 2333-2343. 10.1007/s00125-018-4705-0
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Gülden, Elke, Chao, Chen, Tai, Ningwen, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Peng, Jian, Majewska-Szczepanik, Monika, Zhou, Zhiguang, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2018. TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells. Journal of Autoimmunity 93 , pp. 57-65. 10.1016/j.jaut.2018.06.003
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Majewska-Szczepanik, Monika, Kowalczyk, Paulina, Biała, Dominika, Marcińska, Katarzyna, Strzępa, Anna, Woźniak, Dorota, Sura, Piotr, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Wen, Li and Szczepanik, Marian 2018. Cyclophosphamide-modified murine peritoneal macrophages induce CD4+ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression. Pharmacological Reports 70 (4) , pp. 796-803. 10.1016/j.pharep.2018.02.015

Tan, Qiyuan, Tai, Ningwen, Li, Yangyang, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Pennetti, Sean, Zhou, Zhiguang, Wong, Florence ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2018. Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice. JCI Insight 3 (1) , 95882. 10.1172/jci.insight.95882
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Li, Y. Y., Pearson, J. A. ORCID: https://orcid.org/0000-0002-2867-2269, Chao, C., Peng, J., Zhang, X., Zhou, Z., Liu, Y., Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, L. 2017. Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota. Journal of Autoimmunity 82 , pp. 85-95. 10.1016/j.jaut.2017.05.007
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Thayer, Terri C., Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, De Leenheer, Evy, Hanna, Stephanie J., Boldison, Joanne, Davies, Joanne ORCID: https://orcid.org/0000-0002-7369-6032, Tsui, Adrian, Ahmed, Sartaj, Easton, Peter, Siew, Lai Khai, Wen, Li and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65 (11) , pp. 3429-3439. 10.2337/db15-1649
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Gras, Stephanie, Van den berg, Hugo, Lissina, Anya, Llewellyn-Lacey, Sian, Willis, Mark ORCID: https://orcid.org/0000-0003-3024-6063, Dockree, Tamsin, McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Ekeruche-Makinde, Julia, Gostick, Emma, Robertson, Neil ORCID: https://orcid.org/0000-0002-5409-4909, Burrows, Scott, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Peakman, Mark, Skowera, Ania and Wooldridge, Linda 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6 , 35332. 10.1038/srep35332
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Thayer, Terri C., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, De Leenheer, Evy, Phillips, Amy, Davies, Joanne, Kakabadse, Dimitri, Miners, Kelly, Morgan, Peter ORCID: https://orcid.org/0000-0002-8555-3493, Wen, Li, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65 (6) , pp. 1679-1689. 10.2337/db15-1498
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Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2016. The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes. Journal of Autoimmunity 66 , pp. 76-88. 10.1016/j.jaut.2015.08.019

Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269 and Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845 2015. Identification of islet antigen-specific CD8 T cells using MHCI-peptide tetramer reagents in the non obese diabetic (NOD) mouse model of type 1 diabetes. Gillespie, Kathleen M., ed. Type-1 Diabetes, Vol. 1433. Methods in Molecular Biology, Springer, pp. 119-125. (10.1007/7651_2015_295)

Ye, Jody, Long, Anna E., Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Taylor, Hazel, Bingley, Polly J., Williams, Alistair J. K. and Gillespie, Kathleen M. 2015. Attenuated humoral responses in HLA-A*24-positive individuals at risk of type 1 diabetes. Diabetologia 58 (10) , pp. 2284-2287. 10.1007/s00125-015-3702-9

Hu, Changyun, Ding, Heyuan, Li, Yangyang, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Zhang, Xiaojun, Flavell, Richard A., Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2015. NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets. Proceedings of the National Academy of Sciences 112 (36) , pp. 11318-11323. 10.1073/pnas.1513509112

Motozono, Chihiro, Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, De Leenheer, Evy, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Trimby, Andrew, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290 (31) , pp. 18924-18933. 10.1074/jbc.M114.622522
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Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269 2014. Analysis of the repertoire of insulin-reactive CD8+ T cells. PhD Thesis, Cardiff University.
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