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Number of items: 43.

Smith-Jackson, Kate, Walsh, Patrick, Zelek, Wioleta M., Hoyler, Thomas, Martinic, Marianne M., Thompson, Gemma, Gibson, Beth, Connelly, Chloe, Pappworth, Isabel Y., Murphy, Mark J., Kavanagh, David and Marchbank, Kevin J. 2025. The membrane attack complex drives thrombotic microangiopathy in complement mediated atypical hemolytic uremic syndrome. Kidney International 10.1016/j.kint.2024.12.016
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Zelek, Wioleta M., Bevan, Ryan J. ORCID: https://orcid.org/0000-0002-2557-2887, Nimo, Jacqui M., Dewilde, Maarten, De Strooper, Bart and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2025. Targeting novel anti‐complement drugs to the brain reduces complement activation and synapse loss, and improves cognition in a mouse model of dementia. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 20 (S6) 10.1002/alz.090708
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Zelek, Wioleta M., Bevan, Ryan J. ORCID: https://orcid.org/0000-0002-2557-2887, Nimmo, Jacqui, Dewilde, Maarten, De Strooper, Bart and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2024. Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model. Brain 10.1093/brain/awae278
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Kharnaf, Mousa, Zafar, Farhan, Hogue, Spencer, Rosenfeldt, Leah, Cantrell, Rachel L., Sharma, Bal Krishan, Pearson, Amelia, Sprague, Cassandra, Leino, Daniel, Abplanalp, William A., Zelek, Wioleta M., McCrae, Keith R., Shim, Young Jun, Morales, David, Tweddell, James, Qualls, Joseph E. and Palumbo, Joseph S. 2024. Factor XII promotes the thromboinflammatory response in a rat model of veno-arterial extracorporeal membrane oxygenation. The Journal of Thoracic and Cardiovascular Surgery 168 (2) , E37-E53. 10.1016/j.jtcvs.2023.08.045
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Zelek, Wioleta M. 2024. Is Long COVID a complement dysregulation disease? Clinical Chemistry 10.1093/clinchem/hvae088
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Zelek, Wioleta M., Bevan, Ryan J. ORCID: https://orcid.org/0000-0002-2557-2887 and Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 2024. Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia. Brain, Behavior, and Immunity 118 , pp. 355-363. 10.1016/j.bbi.2024.03.017
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Nimmo, Jacqui, Byrne, Robert A.J., Daskoulidou, Nikoleta, Watkins, Lewis M., Carpanini, Sarah M., Zelek, Wioleta M. and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2024. The complement system in neurodegenerative diseases. Clinical Science 138 (6) , pp. 387-412. 10.1042/cs20230513
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Baillie, Kirsten, Davies, Helen E., Keat, Samuel B. K., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Jones, Samantha A., Mellou, Ermioni, Toonen, Erik J. M., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 and Zelek, Wioleta M. 2024. Complement dysregulation is a prevalent and therapeutically amenable feature of long COVID. Med 5 (3) , pp. 239-253. 10.1016/j.medj.2024.01.011
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Kodosaki, Eleftheria, Watkins, W. John ORCID: https://orcid.org/0000-0003-3262-6588, Loveless, Sam ORCID: https://orcid.org/0000-0002-5124-4115, Kreft, Karim L., Richards, Aidan, Anderson, Valerie, Hurler, Lisa, Robertson, Neil P. ORCID: https://orcid.org/0000-0002-5409-4909, Zelek, Wioleta M. and Tallantyre, Emma C. ORCID: https://orcid.org/0000-0002-3760-6634 2024. Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes. Journal of Neuroinflammation 21 (1) , 52. 10.1186/s12974-024-03036-4
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Daskoulidou, Nikoleta, Carpanini, Sarah, Zelek, Wioleta and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2024. Involvement of complement in Alzheimer's Disease: From genetics through pathology to therapeutic strategies. Ellenbroek, Bart A., Barnes, Thomas R. E., Andersen, Susan L., Paulus, Martin P. and Olivier, Jocelien, eds. Current Topics in Behavioral Neurosciences, Springer, Berlin, Heidelberg, pp. 1-22. (10.1007/7854_2024_524)

Kamegai, Naoki, Kim, Hangsoo, Suzuki, Yasuhiro, Fukui, Sosuke, Kojima, Hiroshi, Maruyama, Shoichi, Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676, Zelek, Wioleta Milena and Mizuno, Masashi 2023. Complement terminal pathway inhibition reduces peritoneal injuries in a rat peritonitis model. Clinical & Experimental Immunology 214 (2) , pp. 209-218. 10.1093/cei/uxad088
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Veteleanu, Aurora, Stevenson-Hoare, Joshua, Keat, Samuel, Daskoulidou, Nikoleta, Zetterberg, Henrik, Heslegrave, Amanda, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Sims, Rebecca ORCID: https://orcid.org/0000-0002-3885-1199, Zelek, Wioleta M., Carpanini, Sarah M. and Morgan, Bryan Paul 2023. Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels. Journal of Neuroinflammation 20 (1) , 169. 10.1186/s12974-023-02850-6
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Zelek, Wioleta M. and Harrison, Richard A. 2023. Complement and COVID-19: Three years on, what we know, what we don't know, and what we ought to know. Immunobiology 228 (3) , 152393. 10.1016/j.imbio.2023.152393
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Veteleanu, Aurora, Pape, Sarah, Davies, Kate ORCID: https://orcid.org/0000-0002-9807-1231, Kodosaki, Eleftheria, Hye, Abdul, Zelek, Wioleta M., Strydom, Andre and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2023. Complement dysregulation and Alzheimer's disease in Down syndrome. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 19 (4) , pp. 1383-1392. 10.1002/alz.12799
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Goff, L M, Davies, K, Zelek, W M, Kodosaki, E, Hakim, O, Lockhart, S, O'Rahilly, S and Morgan, B P 2023. Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity. Clinical & Experimental Immunology 212 (1) 10.1093/cei/uxad011
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Siggins, Matthew K., Davies, Kate ORCID: https://orcid.org/0000-0002-9807-1231, Fellows, Rosie, Thwaites, Ryan S., Baillie, J. Kenneth, Semple, Malcolm G., Openshaw, Peter J.M., Zelek, Wioleta, Harris, Claire L. and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2023. Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19. Immunology 168 (3) , pp. 473-492. 10.1111/imm.13585
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Lekova, Eleonora, Zelek, Wioleta M., Gower, David, Spitzfaden, Claus, Osuch, Isabelle H., John-Morris, Elen, Stach, Lasse, Gormley, Darren, Sanderson, Andrew, Bridges, Angela, Wear, Elizabeth R., Petit-Frere, Sebastien, Burden, Michael N., Priest, Richard, Wattam, Trevor, Kitchen, Semra J., Feeney, Maria, Davis, Susannah, Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 and Nichols, Eva-Maria 2022. Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients. Frontiers in Immunology 13 , 968206. 10.3389/fimmu.2022.968206
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Zelek, Wioleta M. and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2022. Targeting complement in neurodegeneration: challenges, risks, and strategies. Trends in Pharmacological Sciences 43 (8) , pp. 615-628. 10.1016/j.tips.2022.02.006
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Carpanini, Sarah M., Torvell, Megan, Bevan, Ryan J. ORCID: https://orcid.org/0000-0002-2557-2887, Byrne, Robert A. J., Daskoulidou, Nikoleta, Saido, Takaomi C., Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Hughes, Timothy R. ORCID: https://orcid.org/0000-0003-2348-3490, Zelek, Wioleta M. and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2022. Terminal complement pathway activation drives synaptic Loss in Alzheimer’s disease models. Acta Neuropathologica Communications 10 , 99. 10.1186/s40478-022-01404-w
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Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Sabberwal, Pragati, Williamson, James C., Greenwood, Edward J.D., Crozier, Thomas WM, Zelek, Wioleta, Seow, Jeffrey, Graham, Carl, Huettner, Isabella, Edgeworth, Jonathan D., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Morgan, Paul B. ORCID: https://orcid.org/0000-0003-4075-7676, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Merrick, Blair, Doores, Katie, Wilson, Sam J., Lehner, Paul J., Wang, Eddie C.Y. ORCID: https://orcid.org/0000-0002-2243-4964 and Stanton, Richard J. ORCID: https://orcid.org/0000-0002-6799-1182 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 10.7554/eLife.74489
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Lewis, Lisa A, Gulati, Sunita, Zelek, Wioleta M., Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676, Song, Wen-Chao, Zheng, Bo, Nowak, Nancy, DeOliveira, Rosane B., Sanchez, Bryan, DeSouza Silva, Leandro, Schuurman, Janine, Beurskens, Frank, Ram, Sanjay and Rice, Peter A 2022. Efficacy of an experimental gonococcal lipooligosaccharide mimitope vaccine requires terminal complement. The Journal of Infectious Diseases 225 (10) , 1861–1864. 10.1093/infdis/jiab630
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Kolka, Cathryn M., Webster, Julie, Lepletier, Ailin, Winterford, Clay, Brown, Ian, Richards, Renee S., Zelek, Wioleta M., Cao, Yilang, Khamis, Ramlah, Shanmugasundaram, Karthik B., Wuethrich, Alain, Trau, Matt, Brosda, Sandra, Barbour, Andrew, Shah, Alok K., Eslick, Guy D., Clemons, Nicholas J., Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 and Hill, Michelle M. 2022. C5b-9 membrane attack complex formation and extracellular vesicle shedding in Barrett's esophagus and esophageal adenocarcinoma. Frontiers in Immunology 13 , 842023. 10.3389/fimmu.2022.842023
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Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Zelek, Wioleta, Lippiatt, George, Somerville, Michelle, Burnell, Stephanie, Capitani, Lorenzo, Davies, Kate, Lawton, Helen, Tozer, Thomas, Rees, Tara, Roberts, Kerry, Evans, Mererid, Jackson, Amanda, Young, Charlotte, Fairclough, Lucy, Tighe, Paddy, Wills, Mark, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2022. Whole blood-based measurement of SARS-CoV-2-specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid organ cancers. Immunology 165 (2) , pp. 250-259. 10.1111/imm.13433
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Syrimi, Eleni, Fennell, Eanna, Richter, Alex, Vrljicak, Pavle, Stark, Richard, Ott, Sascha, Murray, Paul G., Al-Abadi, Eslam, Chikermane, Ashish, Dawson, Pamela, Hackett, Scott, Jyothish, Deepthi, Kanthimathinathan, Hari Krishnan, Monaghan, Sean, Nagakumar, Prasad, Scholefield, Barnaby R., Welch, Steven, Khan, Naeem, Faustini, Sian, Davies, Kate ORCID: https://orcid.org/0000-0002-9807-1231, Zelek, Wioleta M., Kearns, Pamela and Taylor, Graham S. 2021. The immune landscape of SARS-CoV-2-associated multisystem inflammatory syndrome in children (MIS-C) from acute disease to recovery. iScience 24 (11) , 103215. 10.1016/j.isci.2021.103215
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Zelek, Wioleta 2021. Measuring total classical pathway and activities of individual components of the mouse complement pathway. Bio-protocol 11 (19) , e4175. 10.21769/BioProtoc.4175
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Mc Mahon, O., Hallam, T. M., Patel, S., Harris, C. L., Menny, A., Zelek, W. M., Widjajahakim, R., Java, A., Cox, T., Tzoumas, N., Steel, D. H. W., Shuttleworth, V. G., Smith-Jackson, K., Brocklebank, V., Griffiths, H., Cree, A. J., Atkinson, J. P., Lotery, A. J., Bubeck, D., Morgan, B. P. ORCID: https://orcid.org/0000-0003-4075-7676, Marchbank, K. J., Seddon, J. M. and Kavanagh, D. 2021. The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade. Human Molecular Genetics 30 (13) , pp. 1188-1199. 10.1093/hmg/ddab086
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Webster, Julie A., Wuethrich, Alain, Shanmugasundaram, Karthik B., Richards, Renee S., Zelek, Wioleta M., Shah, Alok K., Gordon, Louisa G., Kendall, Bradley J., Hartel, Gunter, Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676, Trau, Matt and Hill, Michelle M. 2021. Development of EndoScreen chip, a microfluidic pre-endoscopy triage test for esophageal adenocarcinoma. Cancers 13 (12) , 2865. 10.3390/cancers13122865
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Moat, Stuart James, Zelek, Wiola M., Carne, Emily, Ponsford, Mark J., Bramhall, Kathyryn, Jones, Sara, El-Shanawany, Tariq, Wise, Matthew J., Thomas, Annette, George, Chloe, Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621, Steven, Rachael, Webb, Russell, Weeks, Ian ORCID: https://orcid.org/0000-0002-6362-2929, Morgan, Brian Paul and Jolles, Stephen 2021. Development of a high throughput SARS-CoV-2 antibody testing pathway using dried blood spot specimens. Annals of Clinical Biochemistry 58 (2) 10.1177/0004563220981106
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Murrell, Isa, Forde, Donall, Zelek, Wioleta, Tyson, Linda, Chichester, Lisa, Palmer, Nicki, Jones, Rachel, Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 and Moore, Catherine 2021. Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study. PLoS ONE 16 (1) , e0245382. 10.1371/journal.pone.0245382
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Buckland, Matthew S., Galloway, James B., Fhogartaigh, Caoimhe Nic, Meredith, Luke, Provine, Nicholas M., Bloor, Stuart, Ogbe, Ane, Zelek, Wioleta M., Smielewska, Anna, Yakovleva, Anna, Mann, Tiffeney, Bergamaschi, Laura, Turner, Lorinda, Mescia, Frederica, Toonen, Erik J. M., Hackstein, Carl-Philipp, Akther, Hossain Delowar, Vieira, Vinicius Adriano, Ceron-Gutierrez, Lourdes, Periselneris, Jimstan, Kiani-Alikhan, Sorena, Grigoriadou, Sofia, Vaghela, Devan, Lear, Sara E., Török, M. Estée, Hamilton, William L., Stockton, Joanne, Quick, Josh, Nelson, Peter, Hunter, Michael, Coulter, Tanya I., Devlin, Lisa, Bradley, John R., Smith, Kenneth G. C., Ouwehand, Willem H., Estcourt, Lise, Harvala, Heli, Roberts, David J., Wilkinson, Ian B., Screaton, Nick, Loman, Nicholas, Doffinger, Rainer, Lyons, Paul A., Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676, Goodfellow, Ian G., Klenerman, Paul, Lehner, Paul J., Matheson, Nicholas J. and Thaventhiran, James E. D. 2020. Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report. Nature Communications 11 (1) , 6385. 10.1038/s41467-020-19761-2
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Zelek, Wioleta M. and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2020. Monoclonal antibodies capable of inhibiting complement downstream of C5 in multiple species. Frontiers in Immunology 11 (11) , 612402. 10.3389/fimmu.2020.612402
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Zelek, Wioleta Milena, Fathalla, Dina, Morgan, Angharad ORCID: https://orcid.org/0000-0003-4075-7676, Touchard, Samuel, Loveless, Samantha ORCID: https://orcid.org/0000-0002-5124-4115, Tallantyre, Emma ORCID: https://orcid.org/0000-0002-3760-6634, Robertson, Neil P. ORCID: https://orcid.org/0000-0002-5409-4909 and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2020. Cerebrospinal fluid complement system biomarkers in demyelinating disease. Multiple Sclerosis 26 (14) , pp. 1929-1937. 10.1177/1352458519887905
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Zelek, Wioleta M., Cole, Jade, Ponsford, Mark J., Harrison, Richard A., Schroeder, Ben E., Webb, Nicholas, Jolles, Stephen, Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621, Morgan, Matt ORCID: https://orcid.org/0000-0003-4075-7676, Wise, Matt P. and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2020. Complement inhibition with the C5 blocker LFG316 in severe COVID-19. American Journal of Respiratory and Critical Care Medicine 202 (9) , pp. 1304-1308. 10.1164/rccm.202007-2778LE
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Zelek, Wioleta M., Menzies, Georgina E. ORCID: https://orcid.org/0000-0002-6600-6507, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Stockinger, Brigitta and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2020. Characterising the original anti-C5 function-blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5. Immunology 161 (2) , pp. 103-113. 10.1111/imm.13228
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Zelek, Wioleta 2019. Targeting the terminal pathway in complement – driven disease. PhD Thesis, Cardiff University.
Item availability restricted.
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Zelek, Wioleta M., Xie, Long, Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 and Harris, Claire L. 2019. Compendium of current complement therapeutics. Molecular Immunology 114 , pp. 341-352. 10.1016/j.molimm.2019.07.030
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Zelek, Wioleta M., Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2019. Development and characterisation of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species. Immunology 157 (4) , pp. 283-295. 10.1111/imm.13083
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Zelek, Wioleta M., Watkins, Lewis M., Howell, Owain W., Evans, Rhian, Loveless, Sam ORCID: https://orcid.org/0000-0002-5124-4115, Robertson, Neil P. ORCID: https://orcid.org/0000-0002-5409-4909, Beenes, Marijke, Willems, Loek, Brandwijk, Ricardo and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2019. Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59. Multiple Sclerosis 25 (4) , pp. 523-531. 10.1177/1352458518758927
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Kopczynska, Maja, Zelek, Wioleta, Touchard, Samuel, Gaughran, Fiona, Di Forti, Marta, Mondelli, Valeria, Murray, Robin, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379 and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2019. Complement system biomarkers in first episode psychosis. Schizophrenia Research 204 , pp. 16-22. 10.1016/j.schres.2017.12.012
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Zelek, Wioleta M., Harris, Claire L. and Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 2018. Extracting the barbs from complement assays: Identification and optimisation of a safe substitute for traditional buffers. Immunobiology 223 (12) , pp. 744-749. 10.1016/j.imbio.2018.07.016
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Zelek, Wioleta M., Stott, Matthew, Walters, David, Harris, Claire L. and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2018. Characterising a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis. Immunology 155 (3) , pp. 396-403. 10.1111/imm.12982
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Kopczynska, Maja, Zelek, Wioleta, Vespa, Simone, Touchard, Samuel, Wardle, Mark, Loveless, Samantha ORCID: https://orcid.org/0000-0002-5124-4115, Thomas, Rhys H., Hamandi, Khalid and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2018. Complement system biomarkers in epilepsy. Seizure - European Journal of Epilepsy 60 , pp. 1-7. 10.1016/j.seizure.2018.05.016
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Boshra, Hani, Zelek, Wioleta M., Hughes, Timothy R. ORCID: https://orcid.org/0000-0003-2348-3490, Rodriguez de Cordoba, Santiago and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2018. Absence of CD59 in guinea pigs: Analysis of the Cavia porcellus genome suggests the evolution of a CD59 pseudogene. Journal of Immunology 200 (1) , pp. 327-335. 10.4049/jimmunol.1701238

This list was generated on Thu Mar 13 06:08:45 2025 GMT.


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