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Number of items: 26.

Rizzo, Siân, Varache, Mathieu ORCID: https://orcid.org/0000-0001-7166-2253, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 and Ferguson, Elaine L. ORCID: https://orcid.org/0000-0002-0125-0234 2024. Modification of the antibiotic, colistin, with dextrin causes enhanced cytotoxicity and triggers apoptosis in myeloid leukemia. International Journal of Nanomedicine 19 , pp. 5419-5437. 10.2147/IJN.S449185
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Varache, Mathieu ORCID: https://orcid.org/0000-0001-7166-2253, Rizzo, Siân, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Newbury, Lucy, Mason, Anna, Liao, Chia-Te, Chiron, Emilie, Bourdiec, Nathan, Jones, Adam, Fraser, Donald J. ORCID: https://orcid.org/0000-0003-0102-9342, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820 and Ferguson, Elaine L. ORCID: https://orcid.org/0000-0002-0125-0234 2024. Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo. RSC Pharmaceutics 1 , pp. 68-79. 10.1039/D3PM00014A
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Birch, Ditlev, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Christensen, Malene V., Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Franzyk, Henrik and Nielsen, Hanne M. 2023. Stereoisomer-dependent membrane association and capacity for insulin delivery facilitated by Penetratin. Pharmaceutics 15 (6) , 1672. 10.3390/pharmaceutics15061672
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Daniele, Raffaella, Brazzale, Chiara, Arpac, Busra, Tognetti, Francesco, Pesce, Cristiano, Malfanti, Alessio, Sayers, Edward ORCID: https://orcid.org/0000-0002-2621-1119, Mastrotto, Francesca, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Salmaso, Stefano and Caliceti, Paolo 2023. Influence of folate-targeted gold nanoparticles on subcellular localization and distribution into lysosomes. Pharmaceutics 15 (3) , 864. 10.3390/pharmaceutics15030864
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Aikman, Brech, Bonsignore, Riccardo, Woods, Ben, Doellerer, Daniel, Scotti, Riccardo, Schmidt, Claudia, Heidecker, Alexandra A., Pöthig, Alexander, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 and Casini, Angela 2022. Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies. Dalton Transactions 51 (19) , pp. 7476-7490. 10.1039/D2DT00337F
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Sayers, Edward John ORCID: https://orcid.org/0000-0002-2621-1119, Palmer, Iwan, Hope, Lucy, Hope, Paul, Watson, Peter ORCID: https://orcid.org/0000-0003-0250-7852 and Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 2022. Fluid-phase endocytosis and lysosomal degradation of bovine lactoferrin in lung cells. Pharmaceutics 14 (4) , 855. 10.3390/pharmaceutics14040855
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Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Barlow, Victoria L., Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 and Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 2022. Quantitative subcellular analysis of cyclic cell-penetrating peptide EJP18 in nonadherent cells. Cell Penetrating Peptides, Vol. 2383. Methods in Molecular Biology book series, Springer, pp. 211-228. (10.1007/978-1-0716-1752-6_14)

Padalino, Gilda, El-Sakkary, Nelly, Liu, Lawrence J., Liu, Chenxi, Harte, Danielle S.G., Barnes, Rachel E., Sayers, Edward ORCID: https://orcid.org/0000-0002-2621-1119, Forde-Thomas, Josephine, Whiteland, Helen, Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868, Ferla, Salvatore, Johnson, George, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Caffrey, Conor R., Chalmers, Iain, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Hoffmann, Karl F. 2021. Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. European Journal of Medicinal Chemistry 226 , 113823. 10.1016/j.ejmech.2021.113823
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Nödling, Alexander, Mills, Emily M., Li, Xuefei, Cardella, Davide, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Wu, Shih-Hsiung, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2020. Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes. Chemical Communications 56 (34) , pp. 4672-4675. 10.1039/C9CC07931A
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Wymant, Jennifer Mary, Sayers, Edward John ORCID: https://orcid.org/0000-0002-2621-1119, Muir, Duncan and Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 2020. Strategic trastuzumab mediated crosslinking driving concomitant HER2 and HER3 endocytosis and degradation in breast cancer. Journal of Cancer 11 (11) , pp. 3288-3302. 10.7150/jca.32470
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Giannakopoulou, Naya, Williams, Joseph B., Moody, Paul R. ORCID: https://orcid.org/0000-0002-0191-2912, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Magnusson, Johannes P., Pope, Iestyn ORCID: https://orcid.org/0000-0002-4104-0389, Payne, Lukas, Alexander, Cameron, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Langbein, Wolfgang ORCID: https://orcid.org/0000-0001-9786-1023, Watson, Peter ORCID: https://orcid.org/0000-0003-0250-7852 and Borri, Paola ORCID: https://orcid.org/0000-0002-7873-3314 2020. Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells. Nanoscale 12 (7) , pp. 4622-4635. 10.1039/C9NR08512B
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Eissa, N.G., Sayers, E.J. ORCID: https://orcid.org/0000-0002-2621-1119, Birch, D., Patel, S.G., Tsai, Y.-H. ORCID: https://orcid.org/0000-0003-0589-5088, Nielsen, H. Mørck and Jones, Arwyn ORCID: https://orcid.org/0000-0003-2781-8905 2020. EJP18 peptide derived from the juxtamembrane domain of epidermal growth factor receptor represents a novel membrane-active cell-penetrating peptide. Biochemical Journal 477 (1) , pp. 45-60. 10.1042/BCJ20190452
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Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Peel, Samantha E., Schantz, Anna, England, Richard M., Beano, Maya, Bates, Stephanie M., Desai, Arpan S., Puri, Sanyogitta, Ashford, Marianne B. and Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 2019. Endocytic profiling of cancer cell models reveals critical factors influencing lipid nanoparticle mediated mRNA delivery and protein expression. Molecular Therapy 27 (11) , pp. 1950-1962. 10.1016/j.ymthe.2019.07.018
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Woods, Ben, Dollerer, Daniel, Aikman, Brech, Wenzel, Margot ORCID: https://orcid.org/0000-0001-6411-1816, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Kühn, Fritz E., Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 and Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 2019. Highly luminescent metallacages featuring bispyridyl ligands functionalised with BODIPY for imaging in cancer cells. Journal of Inorganic Biochemistry 199 , 110781. 10.1016/j.jinorgbio.2019.110781
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Lorenzer, Cornelia, Streußnig, Sonja, Tot, Emilia, Winkler, Anna-Maria, Merten, Hannes, Brandl, Fabian, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Watson, Peter ORCID: https://orcid.org/0000-0003-0250-7852, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Zangemeister-Wittke, Uwe, Plückthun, Andreas and Winkler, Johannes 2019. Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing. European Journal of Pharmaceutics and Biopharmaceutics 141 , pp. 37-50. 10.1016/j.ejpb.2019.05.015
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Patel, Sanjay G., Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, He, Lin, Narayan, Rohan, Williams, Thomas L., Mills, Emily M., Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2019. Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines. Scientific Reports 9 (1) , -. 10.1038/s41598-019-42456-8
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He, L., Sayers, E. J. ORCID: https://orcid.org/0000-0002-2621-1119, Watson, P. ORCID: https://orcid.org/0000-0003-0250-7852 and Jones, A. T. ORCID: https://orcid.org/0000-0003-2781-8905 2018. Contrasting roles for actin in the cellular uptake of cell penetrating peptide conjugates. Scientific Reports 8 (1) , 7318. 10.1038/s41598-018-25600-8
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Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Magnusson, Johannes P., Moody, Paul R. ORCID: https://orcid.org/0000-0002-0191-2912, Mastrotto, Francesca, Conte, Claudia, Brazzale, Chiara, Borri, Paola ORCID: https://orcid.org/0000-0002-7873-3314, Caliceti, Paolo, Watson, Peter ORCID: https://orcid.org/0000-0003-0250-7852, Mantovani, Giuseppe, Aylott, Jonathan, Salmaso, Stefano, Jones, Arwyn T ORCID: https://orcid.org/0000-0003-2781-8905 and Alexander, Cameron 2018. Switching of macromolecular ligand display by thermoresponsive polymers mediates endocytosis of multi-conjugate nanoparticles. Bioconjugate Chemistry 29 (4) , pp. 1030-1046. 10.1021/acs.bioconjchem.7b00704
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Roberts-Dalton, H. D. ORCID: https://orcid.org/0000-0003-4331-6067, Cocks, A., Falcon-Perez, J. M., Sayers, E. J. ORCID: https://orcid.org/0000-0002-2621-1119, Webber, J. P. ORCID: https://orcid.org/0000-0003-4772-3014, Watson, P. ORCID: https://orcid.org/0000-0003-0250-7852, Clayton, A. ORCID: https://orcid.org/0000-0002-3087-9226 and Jones, A. T. ORCID: https://orcid.org/0000-0003-2781-8905 2017. Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic. Nanoscale 9 (36) , pp. 13693-13706. 10.1039/C7NR04128D
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Wymant, Jennifer, Moody, P., Sayers, Edward ORCID: https://orcid.org/0000-0002-2621-1119 and Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 2017. Poster 433: Receptor-antibody clustering induced endocytosis of HER2 has therapeutic potential in breast cancer. Presented at: EACR-AACR-SIC Special Conference 2017: The Challenges of Optimising Immuno and Targeted Therapies From Cancer Biology to the Clinic, Florence, Italy, 24-27 June 2017.
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Moody, Paul R. ORCID: https://orcid.org/0000-0002-0191-2912, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Magnusson, Johannes P., Alexander, Cameron, Borri, Paola ORCID: https://orcid.org/0000-0002-7873-3314, Watson, Peter ORCID: https://orcid.org/0000-0003-0250-7852 and Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 2015. Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes. Molecular Therapy 23 (12) , pp. 1888-1898. 10.1038/mt.2015.178
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Bahnsen, Jesper Soborg, Franzyk, Henrik, Sayers, Edward John ORCID: https://orcid.org/0000-0002-2621-1119 and Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 2015. Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections. Pharmaceutical Research 32 (5) , pp. 1546-1556. 10.1007/s11095-014-1550-9
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Sayers, Edward John ORCID: https://orcid.org/0000-0002-2621-1119, Cleal, Kez, Eissa, Noura Gamal, Watson, Peter Duncan ORCID: https://orcid.org/0000-0003-0250-7852 and Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 2014. Distal phenylalanine modification for enhancing cellular delivery of fluorophores, proteins and quantum dots by cell penetrating peptides. Journal of Controlled Release 195 , pp. 55-62. 10.1016/j.jconrel.2014.07.055
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Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 and Sayers, Edward John ORCID: https://orcid.org/0000-0002-2621-1119 2012. Cell entry of cell penetrating peptides and tales of tails wagging dogs. Journal of Controlled Release 161 (2) , pp. 582-591. 10.1016/j.jconrel.2012.04.003

Sayers, Edward John ORCID: https://orcid.org/0000-0002-2621-1119 2012. An encoded microwell array for multi-image analysis of cells. PhD Thesis, Cardiff University.
Item availability restricted.
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Watkins, Catherine Louise, Sayers, Edward John ORCID: https://orcid.org/0000-0002-2621-1119, Allender, Christopher John, Barrow, David Anthony ORCID: https://orcid.org/0000-0003-2096-7262, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 and Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 2011. Co-operative membrane disruption between cell-penetrating peptide and cargo: implications for the therapeutic use of the Bcl-2 converter peptide D-NuBCP-9-r8. Molecular Therapy 19 (12) , pp. 2124-2132. 10.1038/mt.2011.175

This list was generated on Fri Dec 5 09:03:00 2025 GMT.


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