Zelek, Wioleta M. and Morgan, B. Paul
2022.
Targeting complement in neurodegeneration: challenges, risks, and strategies.
Trends in Pharmacological Sciences
43
(8)
, pp. 615-628.
10.1016/j.tips.2022.02.006
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Carpanini, Sarah M., Torvell, Megan, Bevan, Ryan J., Byrne, Robert A. J., Daskoulidou, Nikoleta, Saido, Takaomi C., Taylor, Philip R., Hughes, Timothy R., Zelek, Wioleta M. and Morgan, B. Paul
2022.
Terminal complement pathway activation drives synaptic Loss in Alzheimer’s disease models.
Acta Neuropathologica Communications
10
, 99.
10.1186/s40478-022-01404-w
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Fielding, Ceri Alan, Sabberwal, Pragati, Williamson, James C., Greenwood, Edward J.D., Crozier, Thomas WM, Zelek, Wioleta, Seow, Jeffrey, Graham, Carl, Huettner, Isabella, Edgeworth, Jonathan D., Price, David A., Morgan, Paul B., Ladell, Kristin, Eberl, Matthias, Humphreys, Ian R., Merrick, Blair, Doores, Katie, Wilson, Sam J., Lehner, Paul J., Wang, Eddie C.Y. and Stanton, Richard J.
2022.
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies.
eLife
11
10.7554/eLife.74489
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Lewis, Lisa A, Gulati, Sunita, Zelek, Wioleta M., Morgan, B. Paul, Song, Wen-Chao, Zheng, Bo, Nowak, Nancy, DeOliveira, Rosane B., Sanchez, Bryan, DeSouza Silva, Leandro, Schuurman, Janine, Beurskens, Frank, Ram, Sanjay and Rice, Peter A
2022.
Efficacy of an experimental gonococcal lipooligosaccharide mimitope vaccine requires terminal complement.
The Journal of Infectious Diseases
225
(10)
, 1861–1864.
10.1093/infdis/jiab630
Item availability restricted. |
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Kolka, Cathryn M., Webster, Julie, Lepletier, Ailin, Winterford, Clay, Brown, Ian, Richards, Renee S., Zelek, Wioleta M., Cao, Yilang, Khamis, Ramlah, Shanmugasundaram, Karthik B., Wuethrich, Alain, Trau, Matt, Brosda, Sandra, Barbour, Andrew, Shah, Alok K., Eslick, Guy D., Clemons, Nicholas J., Morgan, B. Paul and Hill, Michelle M.
2022.
C5b-9 membrane attack complex formation and extracellular vesicle shedding in Barrett's esophagus and esophageal adenocarcinoma.
Frontiers in Immunology
13
, 842023.
10.3389/fimmu.2022.842023
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Scurr, Martin, Zelek, Wioleta, Lippiatt, George, Somerville, Michelle, Burnell, Stephanie, Capitani, Lorenzo, Davies, Kate, Lawton, Helen, Tozer, Thomas, Rees, Tara, Roberts, Kerry, Evans, Mererid, Jackson, Amanda, Young, Charlotte, Fairclough, Lucy, Tighe, Paddy, Wills, Mark, Westwell, Andrew, Morgan, Bryan Paul, Gallimore, Awen and Godkin, Andrew
2022.
Whole blood-based measurement of SARS-CoV-2-specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid organ cancers.
Immunology
165
(2)
, pp. 250-259.
10.1111/imm.13433
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Syrimi, Eleni, Fennell, Eanna, Richter, Alex, Vrljicak, Pavle, Stark, Richard, Ott, Sascha, Murray, Paul G., Al-Abadi, Eslam, Chikermane, Ashish, Dawson, Pamela, Hackett, Scott, Jyothish, Deepthi, Kanthimathinathan, Hari Krishnan, Monaghan, Sean, Nagakumar, Prasad, Scholefield, Barnaby R., Welch, Steven, Khan, Naeem, Faustini, Sian, Davies, Kate, Zelek, Wioleta M., Kearns, Pamela and Taylor, Graham S.
2021.
The immune landscape of SARS-CoV-2-associated multisystem inflammatory syndrome in children (MIS-C) from acute disease to recovery.
iScience
24
(11)
, 103215.
10.1016/j.isci.2021.103215
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Zelek, Wioleta
2021.
Measuring total classical pathway and activities of individual components of the mouse complement pathway.
Bio-protocol
11
(19)
, e4175.
10.21769/BioProtoc.4175
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Mc Mahon, O., Hallam, T. M., Patel, S., Harris, C. L., Menny, A., Zelek, W. M., Widjajahakim, R., Java, A., Cox, T., Tzoumas, N., Steel, D. H. W., Shuttleworth, V. G., Smith-Jackson, K., Brocklebank, V., Griffiths, H., Cree, A. J., Atkinson, J. P., Lotery, A. J., Bubeck, D., Morgan, B. P., Marchbank, K. J., Seddon, J. M. and Kavanagh, D.
2021.
The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade.
Human Molecular Genetics
30
(13)
, pp. 1188-1199.
10.1093/hmg/ddab086
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Webster, Julie A., Wuethrich, Alain, Shanmugasundaram, Karthik B., Richards, Renee S., Zelek, Wioleta M., Shah, Alok K., Gordon, Louisa G., Kendall, Bradley J., Hartel, Gunter, Morgan, B. Paul, Trau, Matt and Hill, Michelle M.
2021.
Development of EndoScreen chip, a microfluidic pre-endoscopy triage test for esophageal adenocarcinoma.
Cancers
13
(12)
, 2865.
10.3390/cancers13122865
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Moat, Stuart James, Zelek, Wiola M., Carne, Emily, Ponsford, Mark J., Bramhall, Kathyryn, Jones, Sara, El-Shanawany, Tariq, Wise, Matthew J., Thomas, Annette, George, Chloe, Fegan, Christopher, Steven, Rachael, Webb, Russell, Weeks, Ian, Morgan, Brian Paul and Jolles, Stephen
2021.
Development of a high throughput SARS-CoV-2 antibody testing pathway using dried blood spot specimens.
Annals of Clinical Biochemistry
58
(2)
10.1177/0004563220981106
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Murrell, Isa, Forde, Donall, Zelek, Wioleta, Tyson, Linda, Chichester, Lisa, Palmer, Nicki, Jones, Rachel, Morgan, B. Paul and Moore, Catherine
2021.
Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study.
PLoS ONE
16
(1)
, e0245382.
10.1371/journal.pone.0245382
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Buckland, Matthew S., Galloway, James B., Fhogartaigh, Caoimhe Nic, Meredith, Luke, Provine, Nicholas M., Bloor, Stuart, Ogbe, Ane, Zelek, Wioleta M., Smielewska, Anna, Yakovleva, Anna, Mann, Tiffeney, Bergamaschi, Laura, Turner, Lorinda, Mescia, Frederica, Toonen, Erik J. M., Hackstein, Carl-Philipp, Akther, Hossain Delowar, Vieira, Vinicius Adriano, Ceron-Gutierrez, Lourdes, Periselneris, Jimstan, Kiani-Alikhan, Sorena, Grigoriadou, Sofia, Vaghela, Devan, Lear, Sara E., Török, M. Estée, Hamilton, William L., Stockton, Joanne, Quick, Josh, Nelson, Peter, Hunter, Michael, Coulter, Tanya I., Devlin, Lisa, Bradley, John R., Smith, Kenneth G. C., Ouwehand, Willem H., Estcourt, Lise, Harvala, Heli, Roberts, David J., Wilkinson, Ian B., Screaton, Nick, Loman, Nicholas, Doffinger, Rainer, Lyons, Paul A., Morgan, B. Paul, Goodfellow, Ian G., Klenerman, Paul, Lehner, Paul J., Matheson, Nicholas J. and Thaventhiran, James E. D.
2020.
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report.
Nature Communications
11
(1)
, 6385.
10.1038/s41467-020-19761-2
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Zelek, Wioleta M. and Morgan, B. Paul
2020.
Monoclonal antibodies capable of inhibiting complement downstream of C5 in multiple species.
Frontiers in Immunology
11
(11)
, 612402.
10.3389/fimmu.2020.612402
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Zelek, Wioleta Milena, Fathalla, Dina, Morgan, Angharad, Touchard, Samuel, Loveless, Samantha, Tallantyre, Emma, Robertson, Neil P. and Morgan, B. Paul
2020.
Cerebrospinal fluid complement system biomarkers in demyelinating disease.
Multiple Sclerosis
26
(14)
, pp. 1929-1937.
10.1177/1352458519887905
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Zelek, Wioleta M., Cole, Jade, Ponsford, Mark J., Harrison, Richard A., Schroeder, Ben E., Webb, Nicholas, Jolles, Stephen, Fegan, Christopher, Morgan, Matt, Wise, Matt P. and Morgan, B. Paul
2020.
Complement inhibition with the C5 blocker LFG316 in severe COVID-19.
American Journal of Respiratory and Critical Care Medicine
202
(9)
, pp. 1304-1308.
10.1164/rccm.202007-2778LE
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Zelek, Wioleta M., Menzies, Georgina E., Brancale, Andrea, Stockinger, Brigitta and Morgan, B. Paul
2020.
Characterising the original anti-C5 function-blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5.
Immunology
161
(2)
, pp. 103-113.
10.1111/imm.13228
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Zelek, Wioleta
2019.
Targeting the terminal pathway in
complement – driven disease.
PhD Thesis,
Cardiff University.
Item availability restricted. |
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Zelek, Wioleta M., Xie, Long, Morgan, B. Paul and Harris, Claire L. 2019. Compendium of current complement therapeutics. Molecular Immunology 114 , pp. 341-352. 10.1016/j.molimm.2019.07.030 |
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Zelek, Wioleta M., Taylor, Philip R. and Morgan, B. Paul
2019.
Development and characterisation of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species.
Immunology
157
(4)
, pp. 283-295.
10.1111/imm.13083
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Zelek, Wioleta M., Watkins, Lewis M., Howell, Owain W., Evans, Rhian, Loveless, Sam, Robertson, Neil P., Beenes, Marijke, Willems, Loek, Brandwijk, Ricardo and Morgan, B. Paul
2019.
Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59.
Multiple Sclerosis
25
(4)
, pp. 523-531.
10.1177/1352458518758927
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Kopczynska, Maja, Zelek, Wioleta, Touchard, Samuel, Gaughran, Fiona, Di Forti, Marta, Mondelli, Valeria, Murray, Robin, O'Donovan, Michael and Morgan, B. Paul
2019.
Complement system biomarkers in first episode psychosis.
Schizophrenia Research
204
, pp. 16-22.
10.1016/j.schres.2017.12.012
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Zelek, Wioleta M., Harris, Claire L. and Morgan, Bryan Paul 2018. Extracting the barbs from complement assays: Identification and optimisation of a safe substitute for traditional buffers. Immunobiology 223 (12) , pp. 744-749. 10.1016/j.imbio.2018.07.016 |
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Zelek, Wioleta M., Stott, Matthew, Walters, David, Harris, Claire L. and Morgan, B. Paul
2018.
Characterising a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis.
Immunology
155
(3)
, pp. 396-403.
10.1111/imm.12982
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Kopczynska, Maja, Zelek, Wioleta, Vespa, Simone, Touchard, Samuel, Wardle, Mark, Loveless, Samantha, Thomas, Rhys H., Hamandi, Khalid and Morgan, B. Paul 2018. Complement system biomarkers in epilepsy. Seizure - European Journal of Epilepsy 60 , pp. 1-7. 10.1016/j.seizure.2018.05.016 |
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Boshra, Hani, Zelek, Wioleta M., Hughes, Timothy R., Rodriguez de Cordoba, Santiago and Morgan, B. Paul 2018. Absence of CD59 in guinea pigs: Analysis of the Cavia porcellus genome suggests the evolution of a CD59 pseudogene. Journal of Immunology 200 (1) , pp. 327-335. 10.4049/jimmunol.1701238 |
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