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Number of items: 208.

Thomas, Sophie R., Yang, Wenjie, Morgan, David J.

, Davies, Thomas E., Li, Jiao Jiao, Fischer, Roland A., Huang, Jun, Dimitratos, Nikolaos and Casini, Angela

2022. Bottom-up synthesis of water-soluble gold nanoparticles stabilized by N-Heterocyclic carbenes: From structural characterization to applications. Chemistry - A European Journal 28 (56) , e202201575. 10.1002/chem.202201575

Bonsignore, Riccardo, Thomas, Sophie R., Rigoulet, Mathilde, Jandl, Christian, Pöthig, Alexander, Bourissou, Didier, Barone, Giampaolo and Casini, Angela

2021. C-C Cross-Couplings from a Cyclometalated Au(III) CN Complex: Mechanistic Insights and synthetic developments. Chemistry - A European Journal 27 (57) , pp. 14322-14334. 10.1002/chem.202102668

Pimpao, Catarina, Wragg, Darren, Bonsignore, Riccardo, Aikman, Brech, Pedersen, Per Amstrup, Leoni, Stefano

, Soveral, Graça and Casini, Angela

2021. Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations. Metallomics 13 (9) , mfab053. 10.1093/mtomcs/mfab053

Casini, Angela

and Thomas, Sophie R. 2021. The beauty of gold: knowledge of mechanisms leads to different applications of organogold compounds in medicine and catalysis. Chemistry Letters 50 (8) , pp. 1516-1522. 10.1246/cl.210238

Thomas, Sophie R. and Casini, Angela

2021. N-Heterocyclic carbenes as “smart” gold nanoparticle stabilizers: state-of-the art and perspectives for biomedical applications. Journal of Organometallic Chemistry 938 , 121743. 10.1016/j.jorganchem.2021.121743

Wragg, Darren, Casini, Angela

and Leoni, Stefano

2020. Harvesting free energy landscapes in biological systems. Presented at: International Conference on Bio and Nanomaterials, MSC Cruise, Mediterranean Sea, Italy, 28 Sept - 3 Oct 2019. Published in: Piotto, Stefano, Concilio, Simona, Sessa, Lucia and Rossi, Federico eds. Advances in Bionanomaterials II. Lecture Notes in Bioengineering Springer, pp. 64-77. 10.1007/978-3-030-47705-9_7

Thomas, Sophie R. and Casini, Angela

2020. Gold compounds for catalysis and metal-mediated transformations in biological systems. Current Opinion in Chemical Biology 55 , pp. 103-110. 10.1016/j.cbpa.2019.12.007

Bonsignore, Riccardo

, Thomas, Sophie, Klooster, Wim, Coles, Simon, Bourissou, Didier, Jenkins, Robert, Barone, Giampaolo and Casini, Angela

2020. Carbon-Phosphorus coupling from C^N cyclometalated Au(III) complexes. Chemistry - A European Journal 26 (19) , pp. 4226-4231. 10.1002/chem.201905392

Oberkofler, Jens, Aikman, Brech, Bonsignore, Riccardo

, Pöthig, Alexander, Platts, James

, Casini, Angela

and Kühn, Fritz E. 2020. Exploring the reactivity and biological effects of heteroleptic N-Heterocyclic carbene gold(I)-Alkynyl complexes. European Journal of Inorganic Chemistry 2020 (11-12) , pp. 1040-1051. 10.1002/ejic.201901043

Meier-Menches, Samuel M., Aikman, Brech, Döllerer, Daniel, Klooster, Wim T., Coles, Simon J., Santi, Nicolò

, Luk, Louis

, Casini, Angela

and Bonsignore, Riccardo

2020. Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands. Journal of Inorganic Biochemistry 202 , 110844. 10.1016/j.jinorgbio.2019.110844

Estrada-Ortiz, Natalia, Lopez-Gonzales, Elena, Woods, Ben, Stürup, Stefan, de Graaf, Inge A. M., Groothuis, Geny M. M. and Casini, Angela

2019. Ex vivo toxicological evaluation of experimental anticancer gold(I) complexes with lansoprazole-type ligands. Toxicology Research 8 (6) , pp. 885-895. 10.1039/C9TX00149B

Woods, Ben, Dollerer, Daniel, Aikman, Brech, Wenzel, Margot

, Sayers, Edward J.

, Kühn, Fritz E., Jones, Arwyn T.

and Casini, Angela

2019. Highly luminescent metallacages featuring bispyridyl ligands functionalised with BODIPY for imaging in cancer cells. Journal of Inorganic Biochemistry 199 , 110781. 10.1016/j.jinorgbio.2019.110781

Wragg, Darren, de Almeida, Andreia

, Casini, Angela

and Leoni, Stefano

2019. Unveiling the mechanisms of aquaglyceroporin-3 water and glycerol permeation by metadynamics. Chemistry - A European Journal 25 (37) , pp. 8713-8718. 10.1002/chem.201902121

Wenzel, Margot

, Bonsignore, Riccardo

, Thomas, Sophie, Bourissou, Didier, Barone, Giampaolo and Casini, Angela

2019. Cyclometalated AuIII complexes for cysteine arylation in zinc finger protein domains: towards controlled reductive elimination. Chemistry - A European Journal 25 (32) , pp. 7628-7634. 10.1002/chem.201901535

Pöthig, Alexander and Casini, Angela

2019. Recent developments of supramolecular metal-based structures for applications in cancer therapy and imaging. Theranostics 9 (11) , pp. 3150-3169. 10.7150/thno.31828

Casini, Angela

and Crowley, James D. 2019. Editorial: supramolecular metal-based entities for biomedical and biological applications. Frontiers in Chemistry 7 , -. 10.3389/fchem.2019.00293

Wenzel, Margot N.

, Woods, Benjamin and Casini, Angela

2019. Supramolecular metal-based structures for applications in cancer therapy [Chapter 9]. Casini, A., Vessieres, A. and Meier-Menches, S., eds. Metal-based Anticancer Agents, Metallobiology, Royal Society of Chemistry, pp. 215-245. (10.1039/9781788016452-00215)

Mazzei, Luca, Wenzel, Margot N.

, Cianci, Michele, Palombo, Marta, Casini, Angela

and Ciurli, Stefano 2019. Inhibition mechanism of urease by Au(III) compounds unveiled by x-ray diffraction analysis. ACS Medicinal Chemistry Letters 10 (4) , pp. 564-570. 10.1021/acsmedchemlett.8b00585

Pinho, Jacinta, Amaral, Joana, Castro, Rui, Rodrigues, Cecilia, Casini, Angela

, Soveral, Graca and Gaspar, Manuela 2019. Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models. Nanomedicine 14 (7) 10.2217/nnm-2018-0388

Woods, Ben, Wenzel, Margot N.

, Williams, Thomas, Thomas, Sophie R., Jenkins, Robert L. and Casini, Angela

2019. Exo-functionalized metallacages as host-guest systems for the anticancer drug Cisplatin. Frontiers in Chemistry 7 (68) 10.3389/fchem.2019.00068

van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y.O., Zuidema, J., Steendam, R., Klose, Matthias H.M., Meier-Menches, Samuel M., Casini, Angela

, Horvatovich, P.L., Sijbrandi, N.J., Frijlink, H.W., Hinrichs, W.L.J., Poelstra, K., Beljaars, L. and Olinga, P. 2019. The antifibrotic potential of a sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitor. Journal of Controlled Release 296 , pp. 250-257. 10.1016/j.jconrel.2018.12.039

Wenzel, Margot N.

, Mósca, Andreia F., Graziani, Valentina, Aikman, Brech, Thomas, Sophie R., De Almeida, Andreia

, Platts, James A.

, Re, Nazzareno, Coletti, Cecilia, Marrone, Alessandro, Soveral, Graça and Casini, Angela

2019. Insights into the mechanisms of aquaporin-3 inhibition by gold(III) complexes: the importance of non-coordinative adduct formation. Inorganic Chemistry 58 (3) , -. 10.1021/acs.inorgchem.8b03233

Han, Jiaying, Permentier, Hjalmar, Bischoff, Rainer, Groothuis, Geny, Casini, Angela

and Horvatovich, Péter 2019. Imaging of protein distribution in tissues using mass spectrometry: An interdisciplinary challenge. Trends in Analytical Chemistry 112 , pp. 13-28. 10.1016/j.trac.2018.12.016

Casini, Angela

, Bonsignore, Riccardo

and Oberkofler, Jens 2018. Organometallic gold-based anticancer therapeutics. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier, pp. 1-10. (10.1016/B978-0-12-409547-2.14350-1)

Han, Jiaying, Rader, Andreas, Reichart, Florian, Aikman, Brech, Wenzel, Margot Nina

, Woods, Ben, Weinmüller, Michael, Ludwig, Beatrice S., Sturup, Stefan, Groothuis, Geny M.M., Permentier, Hjalmar P., Bischoff, Rainer, Kessler, Horst, Horvatovich, Péter and Casini, Angela

2018. Bioconjugation of supramolecular metallacages to integrin ligands for targeted delivery of cisplatin. Bioconjugate Chemistry 29 (11) , pp. 3856-3865. 10.1021/acs.bioconjchem.8b00682

Carboni, Silvia, Zucca, Antonio, Stoccoro, Sergio, Maiore, Laura, Arca, Massimiliano, Ortu, Fabrizio, Artner, Christian, Keppler, Bernhard K., Meier-Menches, Samuel M., Casini, Angela

and Cinellu, Maria Agostina 2018. New variations on the theme of gold(III) C^N^N cyclometalated complexes as anticancer agents: Synthesis and biological characterization. Inorganic Chemistry 10.1021/acs.inorgchem.8b02604

Aikman, Brech, Wenzel, Margot

, Mósca, Andreia, De Almeida, Andreia

, Klooster, Wim, Coles, Simon, Soveral, Graça and Casini, Angela

2018. Gold(III) pyridine-benzimidazole complexes as aquaglyceroporin inhibitors and antiproliferative agents. Inorganics 6 (4) , 123. 10.3390/inorganics6040123

Mósca, Andreia F., De Almeida, Andreia

, Wragg, Darren, Martins, Ana P., Sabir, Farzana, Leoni, Stefano

, Moura, Teresa F., Prista, Catarina, Casini, Angela

and Soveral, Graça 2018. Molecular basis of Aquaporin-7 permeability regulation by pH. Cells 7 (11) , 207. 10.3390/cells7110207

Wragg, Darren, De Almeida, Andreia

, Bonsignore, Riccardo

, Kühn, Fritz E., Leoni, Stefano

and Casini, Angela

2018. On the mechanism of Gold/NHC compounds binding to DNA G-quadruplexes: combined metadynamics and biophysical methods. Angewandte Chemie International Edition 57 (44) , pp. 14524-14528. 10.1002/anie.201805727

Spreckelmeyer, Sarah, van der Zee, Margot, Bertrand, Benoît, Bodio, Ewen, Stürup, Stefan and Casini, Angela

2018. Relevance of copper and organic cation transporters in the activity and transport mechanisms of an anticancer cyclometallated gold(III) compound in comparison to cisplatin. Frontiers in Chemistry 6 , 377. 10.3389/fchem.2018.00377

Boscutti, Giulia, Nardon, Chiara, Marchiò, Luciano, Crisma, Marco, Biondi, Barbara, Dalzoppo, Daniele, Dalla Via, Lisa, Formaggio, Fernando, Casini, Angela

and Fregona, Dolores 2018. Anticancer gold(III) peptidomimetics: from synthesis to in vitro and ex vivo biological evaluation. ChemMedChem 13 (11) , pp. 1131-1145. 10.1002/cmdc.201800098

Aikman, Brech, De Almeida, Andreia

, Meier-Menches, Samuel M. and Casini, Angela

2018. Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents. Metallomics 10 (5) , pp. 696-712. 10.1039/C8MT00072G

Jürgens, Sophie, E. Kühn, Fritz and Casini, Angela

2018. Cyclometalated complexes of platinum and gold with biological properties: state-of-the-art and future perspectives. Current Medicinal Chemistry 25 (4) , pp. 437-461. 10.2174/0929867324666170529125229

Casini, Angela

2018. Medicinal chemistry of gold anticancer metallodrugs. Sigel, Astrid, Sigel, Helmut, Freisinger, Eva and Sigel, Roland K. O., eds. Metallo-Drugs: Development and Action of Anticancer Agents, Vol. 18. Metal Ions in Life Sciences, Walter de Gruyter GmbH, pp. 199-217.

Wenzel, Margot

, Meier-Menches, Samuel, Williams, Thomas, Rämisch, Eberhard, Barone, Giampaolo and Casini, Angela

2017. Selective targeting of PARP-1 zinc finger recognition domains with Au(III) organometallics. Chemical Communications 54 (6) , pp. 611-614. 10.1039/C7CC08406D

Wenzel, Margot

and Casini, Angela

2017. Mass spectrometry as a powerful tool to study therapeutic metallodrugs speciation mechanisms: current frontiers and perspectives. Coordination Chemistry Reviews 352 , pp. 432-460. 10.1016/j.ccr.2017.02.012

Casini, Angela

, Woods, Benjamin and Wenzel, Margot

2017. The promise of self-assembled 3D supramolecular coordination complexes for biomedical applications. Inorganic Chemistry 56 (24) , pp. 14715-14729. 10.1021/acs.inorgchem.7b02599

Karaca, Özden, Scalcon, Valeria, Meier-Menches, Samuel M., Bonsignore, Riccardo

, Brouwer, Jurriaan M. J. L., Tonolo, Federica, Folda, Alessandra, Rigobello, Maria Pia, Kühn, Fritz E. and Casini, Angela

2017. Characterization of hydrophilic gold(I) N-Heterocyclic Carbene (NHC) complexes as potent TrxR inhibitors using biochemical and mass spectrometric approaches. Inorganic Chemistry 10.1021/acs.inorgchem.7b02345

Casini, Angela

, Orvig, Chris and Correia, João D. G. 2017. Frontiers in radionuclide imaging and therapy, a chemical journey from naturally radioactive elements to targeted theranostic agents. Dalton Transactions 46 , pp. 14433-14434. 10.1039/C7DT90181J

Graziani, Valentina, Marrone, Alessandro, Re, Nazzareno, Coletti, Cecilia, Platts, James A.

and Casini, Angela

2017. A multilevel theoretical study to disclose the binding mechanisms of gold(III) bipyridyl compounds as selective aquaglyceroporin inhibitors. Chemistry - a European Journal 23 (55) , pp. 13802-13813. 10.1002/chem.201703092

Boorsma, Carian E., van der Veen, T. Anienke, Putri, Kurnia S. S., De Almeida, Andreia

, Draijer, Christina, Mauad, Thais, Fejer, Gyorgy, Brandsma, Corry-Anke, van den Berge, Maarten, Bossé, Yohan, Sin, Don, Hao, Ke, Reithmeier, Anja, Andersson, Göran, Olinga, Peter, Timens, Wim, Casini, Angela

and Melgert, Barbro N. 2017. A potent tartrate resistant acid phosphatase inhibitor to study the function of TRAP in alveolar macrophages. Scientific Reports 7 (1) , 12570. 10.1038/s41598-017-12623-w

Casini, Angela

, Estrada-Ortiz, Natalia, Gabbiani, Chiara, Guarra, Federica, Groothuis, Geny, de Graaf, Inge, de Jager, Marina and Marchetti, Lorella 2017. Anticancer gold N-heterocyclic carbene complexes: a comparative in vitro and ex vivo study. ChemMedchem 12 (17) , pp. 1429-1435. 10.1002/cmdc.201700316

Jürgens, Sophie, Scalcon, Valeria, Estrada-Ortiz, Natalia, Folda, Alessandra, Tonolo, Federica, Jandl, Christian, Browne, Duncan L.

, Rigobello, Maria Pia, Kühn, Fritz E. and Casini, Angela

2017. Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes. Bioorganic & Medicinal Chemistry 10.1016/j.bmc.2017.08.001

Karaca, Özden, Meier-Menches, Samuel, Casini, Angela

and Kühn, Fritz E. 2017. On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging. Chemical Communications 59 , pp. 8249-8260. 10.1039/C7CC03074F

Jürgens, Sophie and Casini, Angela

2017. Mechanistic insights into gold organometallic compounds and their biomedical application [Correction]. Chimia 71 (5) , p. 308. 10.2533/chimia.2017.308

De Almeida, Andreia

, Mosca, Andreia F., Wragg, Darren, Wenzel, Margot

, Kavanagh, Paul, Barone, Giampaolo, Leoni, Stefano

, Soveral, Graca and Casini, Angela

2017. The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods. Chemical Communications 53 (27) , pp. 3830-3833. 10.1039/C7CC00318H

Hahn, Eva, Estrada-Ortiz, Natalia, Han, Jiaying, Ferreira, Vera F. C., Kapp, Tobias, Correia, Joao D. G., Casini, Angela

and Kühn, Fritz E. 2017. Functionalization of Ruthenium(II) terpyridine complexes with cyclic RGD peptides to target integrin receptors in cancer cells. European Journal of Inorganic Chemistry 2017 (12) , pp. 1667-1672. 10.1002/ejic.201601094

Medrano, M. Angeles, Morais, Mauricio D.S., Ferreira, Vera, Correia, João D. G., Paulo, Antonio Rocha, Do Santos, Isabel, Navarro-Ranninger, Carmen, Alvarez-Valdes, Amparo, Casini, Angela

, Mendes, Filipa and Gomez Quiroga, Adoracion 2017. Non-conventional trans-platinum complexes functionalized with RDG peptides: chemical and cytototoxicity studies. European Journal of Inorganic Chemistry 12 , pp. 1835-1840. 10.1002/ejic.201700072

Jürgens, Sophie and Casini, Angela

2017. Mechanistic insights into gold organometallic compounds and their biomedical applications. Chimia 71 (3) , pp. 92-101. 10.2533/chimia.2017.92

Han, J., Schmidt, A., Zhang, T., Permentier, H., Groothuis, G. M. M., Bischoff, R., Kühn, F. E., Horvatovich, P. and Casini, A.

2017. Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications. Chemical Communications 53 (8) , pp. 1405-1408. 10.1039/C6CC08937B

Soveral, Graça and Casini, Angela

2017. Aquaporin modulators: a patent review (2010-2015). Expert Opinion on Therapeutic Patents 27 (1) , pp. 49-62. 10.1080/13543776.2017.1236085

Casini, Angela

, Miller, Jessica J., Gomes, Luiza M.F. and Storr, Tim 2017. The interaction of metal compounds with protein targets: new tools in medicinal chemistry and chemical biology. Encyclopedia of Inorganic and Bioinorganic Chemistry, Wiley, (10.1002/9781119951438)

University of Groningen 2017. Gold(III) compounds as tartrate resistant acid phosphatase inhibitors, and therapeutic uses thereof. WO2017058012 (A1). [Patent].

Spreckelmeyer, Sarah, Estrada-Ortiz, Natalia, Prins, Gerian G. H., van der Zee, Margot, Gammelgaard, Bente, Stürup, Stefan, de Graaf, Inge A. M., Groothuis, Geny M. M. and Casini, Angela

2017. On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent. Metallomics 2017 (9) , pp. 1786-1795. 10.1039/C7MT00271H

Muenzner, Julienne K, Biersack, Bernhard, Albrecht, Alexander, Rehm, Tobias, Lacher, Ulrike, Milius, Wolfgang, Casini, Angela

, Zhang, Jing-Jing, Ott, Ingo, Brabec, Viktor, Stuchlikova, Olga, Andronache, Ion C, Schuppan, Detlef, Kaps, Leonard and Schobert, Rainer 2016. Ferrocenyl-coupled n-heterocyclic carbene complexes of gold(i): a successful approach to multinuclear anticancer drugs. Chemistry - a European Journal 22 (52) , pp. 18953-18962. 10.1002/chem.201604246

Khan, Rais Ahmad, De Almeida, Andreia

, Al-Farhan, Khalid, Alsalme, Ali, Casini, Angela

, Ghazzali, Mohamed and Reedijk, Jan 2016. Transition-metal norharmane compounds as possible cytotoxic agents: new insights based on a coordination chemistry perspective. Journal of Inorganic Biochemistry 165 , pp. 128-135. 10.1016/j.jinorgbio.2016.07.001

Kaiser, Felix, Schmidt, Andrea, Heydenreuter, Wolfgang, Altmann, Philipp Johannes, Casini, Angela

, Sieber, Stephan A. and Kühn, Fritz Elmar 2016. Self-assembled palladium and platinum coordination cages: Photophysical studies and anticancer activity. European Journal of Inorganic Chemistry 2016 (33) , pp. 5189-5196. 10.1002/ejic.201600811

Gabbiani, Chiara, Pratesi, Alessandro, Marchetti, Lorella, Casini, Angela

, Leoni, Piero, Pillozzi, Serena, Crociani, Olivia, Bartoli, Gianluca and Messori, Luigi 2016. Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells. Journal of Inorganic Biochemistry 163 , pp. 318-322. 10.1016/j.jinorgbio.2016.06.024

Citta, A., Scalcon, V., Göbel, P., Bertrand, B., Wenzel, Margot

, Folda, A., Rigobello, M. P., Meggers, E. and Casini, Angela

2016. Toward anticancer gold-based compounds targeting PARP-1: a new case study. RSC Advances 6 (82) , pp. 79147-79152. 10.1039/C6RA11606J

Schmidt, Andrea, Hollering, Manuela, Han, Jiaying, Casini, Angela

and Kühn, Fritz Elmar 2016. Self-assembly of highly luminescent heteronuclear coordination cages. Dalton Transactions 10.1039/C6DT02708C

Nave, Mariana, Castro, Rui E., Rodrigues, Cecília M. P., Casini, Angela

, Soveral, Graça and Gaspar, Maria Manuela 2016. Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells. Nanomedicine 11 (14) , pp. 1817-1830. 10.2217/nnm-2016-0086

Spinello, Angelo, De Almeida, Andreia

, Casini, Angela

and Barone, Giampaolo 2016. The inhibition of glycerol permeation through aquaglyceroporin-3 induced by mercury (II): A molecular dynamics study. Journal of Inorganic Biochemistry 160 , pp. 78-84. 10.1016/j.jinorgbio.2015.11.027

Meier, Samuel M., Gerner, Christopher, Keppler, Bernhard K., Cinellu, Maria Agostina and Casini, Angela

2016. Mass spectrometry uncovers molecular reactivities of coordination and organometallic gold (III) drug candidates in competitive experiments that correlate with their biological effects. Inorganic Chemistry 55 (9) , pp. 4248-4259. 10.1021/acs.inorgchem.5b03000

De Almeida, A.

, Martins, A. P., Mósca, A. F., Wijma, H. J., Prista, C., Soveral, G. and Casini, A.

2016. Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors? Molecular BioSystems 12 , pp. 1564-1573. 10.1039/C6MB00013D

Schmidt, Andrea, Hollering, Manuela, Drees, Markua, Casini, Angela

and Kühn, Fritz E. 2016. Supramolecular exo-functionalized palladium cages: fluorescent properties and biological activity. Dalton Transactions 45 , pp. 8556-8565. 10.1039/C6DT00654J

Bazzicalupi, Carla, Ferraroni, Marta, Papi, Francesco, Massai, Lara, Bertrand, Benoît, Messori, Luigi, Gratteri, Paola and Casini, Angela

2016. Determinants for tight and selective binding of a medicinal dicarbene gold(I) complex to a telomeric DNA G-quadruplex: a joint ESI MS and XRD investigation. Angewandte Chemie International Edition 55 (13) , pp. 4256-4259. 10.1002/anie.201511999

Wenzel, Margot, De Almeida, Andreia

, Bigaeva, Emilia, Kavanagh, Paul, Picquet, Michel, Le Gendre, Pierre, Bodio, Ewen and Casini, Angela

2016. New luminescent polynuclear metal complexes with anticancer properties: toward structure-activity relationships. Inorganic Chemistry 55 (5) , pp. 2544-2557. 10.1021/acs.inorgchem.5b02910

Schmidt, Andrea, Molano, Viviana, Hollering, Manuela, Pöthig, Alexander, Casini, Angela

and Kühn, Fritz E. 2016. Evaluation of new palladium cages as potential delivery systems for the anticancer drug cisplatin. Chemistry - a European Journal 22 (7) , pp. 2253-2256. 10.1002/chem.201504930

Tsitsa, Ifigenia, Tarushi, Alketa, Doukoume, Panagiota, Perdih, Franc, De Almeida, Andreia

, Papadopoulos, Athanasios, Kalogiannis, Stavros, Casini, Angela

, Turel, Iztok and Psomas, George 2016. Structure and biological activities of metal complexes of flumequine. RSC Advances 6 (23) , pp. 19555-19570. 10.1039/C5RA25776J

Folda, A, Scalcon, V, Ghazzali, M, Jaafar, M. H., Khan, R. A., Casini, Angela

, Citta, A, Bindoli, A, Rigobello, M. P., Al-Farhan, K, Alsalme, A and Reedijk, J 2015. Insights into the strong in-vitro anticancer effects for bis(triphenylphosphane)iminium compounds having perchlorate, tetrafluoridoborate and bis(chlorido)argentate anions. Journal of Inorganic Biochemistry 153 , pp. 346-354. 10.1016/j.jinorgbio.2015.08.030

Bertrand, Benoit, Citta, Anna, Franken, Inge L., Picquet, Michel, Folda, Alessandra, Scalcon, Valeria, Rigobello, Maria Pia, Le Gendre, Pierre, Casini, Angela

and Bodio, Ewen 2015. Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents. Journal of Biological Inorganic Chemistry 20 (6) , pp. 1005-1020. 10.1007/s00775-015-1283-1

Rajaratnam, R, Martin, E. K., Dorr, M, Harms, K, Casini, Angela

and Meggars, E 2015. Correlation between the stereochemistry and bioactivity in octahedral rhodium prolinato complexes. Inorganic Chemistry 54 (16) , pp. 8111-8120. 10.1021/acs.inorgchem.5b01349

Muenzner, Julienne K., Rehm, Tobias, Biersack, Bernhard, Casini, Angela

, de Graaf, Inge A. M., Worawutputtapong, Pawida, Noor, Awal, Kempe, Rhett, Brabec, Viktor, Kasparkova, Jana and Schobert, Rainer 2015. Adjusting the DNA interaction and anticancer activity of pt(ii) n-heterocyclic carbene complexes by steric shielding of the trans leaving group. Journal of Medicinal Chemistry 58 (15) , pp. 6283-6292. 10.1021/acs.jmedchem.5b00896

Bertrand, B, Spreckelmeyer, S, Bodio, E, Cocco, Fabio, Picquet, M, Richard, P, Le Gendre, P, Orvig, C, Cinellu, M.A. and Casini, Angela

2015. Exploring the potential of gold(iii) cyclometallated compounds as cytotoxic agents: variations on the C^N theme. Dalton Transactions 44 (26) , pp. 11911-11918. 10.1039/c5dt01023c

Jacques, Aurelie, Lebrun, Colette, Casini, Angela

, Kieffer, Isabelle, Proux, Olivier, Latour, Jean-Marc and Seneque, Olivier 2015. Reactivity of Cys4 zinc finger domains with gold(III) complexes: insights into the formation of "gold fingers". Inorganic Chemistry 54 (8) , pp. 4104-4113. 10.1021/acs.inorgchem.5b00360

Daum, Steffen, Chekhun, Vasiliy F., Todor, Igor N., Lukianova, Natalia Yu, Shvets, Yulia V., Sellner, Leopold, Putzker, Kerstin, Lewis, Joe, Zenz, Thorsten, de Graaf, Inge A. M., Groothuis, Geny M. M., Casini, Angela

, Zozulia, Oleksii, Hampel, Frank and Mokhir, Andriy 2015. Improved synthesis of N-benzylaminoferrocene-based prodrugs and evaluation of their toxicity and antileukemic activity. Journal of Medicinal Chemistry 58 (4) , pp. 2015-2024. 10.1021/jm5019548

Bertrand, Benoit, Bodio, Ewen, Richard, Philippe, Picquet, Michel, Le Gendre, Pierre and Casini, Angela

2015. Gold(I) N-heterocyclic carbene complexes with an "activable" ester moiety: possible biological applications. Journal of Organometallic Chemistry 775 , pp. 124-129. 10.1016/j.jorganchem.2014.03.020

Laskay, Ü. A., Garino, C., Tsybin, Y. O., Salassa, L. and Casini, Angela

2015. Gold finger formation studied by high-resolution mass spectrometry and in silico methods. Chemical Communications 51 (9) , pp. 1612-1615. 10.1039/C4CC07490D

Wenzel, Margot, Bigaeva, Emilia, Richard, Philippe, Le Gendre, Pierre, Picquet, Michel, Casini, Angela

and Bodio, Ewen 2014. New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one? Journal of Inorganic Biochemistry 141 , pp. 10-16. 10.1016/j.jinorgbio.2014.07.011

Serna, Ana, Galan-Cobo, Ana, Rodrigues, Claudia, Sanchez-Gomar, Ismael, Toledo-Aral, Juan Jose, Moura, Teresa F., Casini, Angela

, Soveral, Graca and Echevarria, Miriam 2014. Functional inhibition of aquaporin-3 with a gold-based compound induces blockage of cell proliferation. Journal of Cellular Physiology 229 (11) , pp. 1787-1801. 10.1002/jcp.24632

Khan, Rais Ahmad, Al-Farhan, Khalid, De Almeida, Andreia

, Alsalme, Ali, Casini, Angela

, Ghazzali, Mohamed and Reedijk, Jan 2014. Light-stable bis(norharmane)silver(I) compounds: synthesis, characterization and antiproliferative effects in cancer cells. Journal of Inorganic Biochemistry 140 , pp. 1-5. 10.1016/j.jinorgbio.2014.06.019

De Almeida, Andreia

, Soveral, Graca and Casini, Angela

2014. Gold compounds as aquaporin inhibitors: new opportunities for therapy and imaging. MedChemComm 5 , pp. 1444-1453. 10.1039/C4MD00265B

Spreckelmeyer, Sarah, Orvig, Chris and Casini, Angela

2014. Cellular transport mechanisms of Cytotoxic metallodrugs: an overview beyond cisplatin. Molecules 19 (10) , pp. 15584-15610. 10.3390/molecules191015584

Hahn, Eva M., Casini, Angela

and Kuehn, Fritz E. 2014. Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals. Coordination Chemistry Reviews 276 , pp. 97-111. 10.1016/j.ccr.2014.05.021

Schmidt, Andrea, Casini, Angela

and Kuehn, Fritz E. 2014. Self-assembled M2L4 coordination cages: synthesis and potential applications. Coordination Chemistry Reviews 275 , pp. 19-36. 10.1016/j.ccr.2014.03.037

Bertrand, Benoit, de Almeida, Andreia, van der Burgt, Evelien P.M., Picquet, Michel, Citta, Anna, Folda, Alessandra, Rigobello, Maria Pia, Le Gendre, Pierre, Bodio, Ewen and Casini, Angela

2014. New Gold(I) organometallic compounds with biological activity in cancer cells. European Journal of Inorganic Chemistry 2014 (27) , pp. 4532-4536. 10.1002/ejic.201402248

Khan, Rais Ahmad, Khalid, Al-Farhan, De Almeida, Andreia

, Alsalme, Ali, Casini, Angela

, Ghazzali, Mohamed and Reedijk, Jan 2014. Silver(I) bis(norharmane) compounds: synthesis, 3D structures and cytostatic properties. Journal of Biological Inorganic Chemistry 19 , S799.

Bertrand, Benoit, De Almeida, Andreia

, van der Burgt, Evelien P.M., Citta, Anna, Folda, Alessandra, Bodio, Ewen, Picquet, Michel, Rigobello, Maria Pia, Le Gendre, Pierre and Casini, Angela

2014. Fluorescent organometallic gold(I) N-heterocyclic carbene complexes: synthesis and biological activities. Journal of Biological Inorganic Chemistry 19 , S792.

Serratice, M, Bertrand, B, Janssen, E.F.J., Hemelt, E, Zucca, A, Cocco, Fabio, Cinellu, M.A. and Casini, Angela

2014. Gold(i) compounds with lansoprazole-type ligands: Synthesis, characterization and anticancer properties in vitro. Medchemcomm 5 (9) , pp. 1418-1422. 10.1039/c4md00241e

Madeira, Ana, De Almeida, Andreia

, de Graaf, Chris, Camps, Marta, Zorzano, Antonio, Moura, Teresa F., Casini, Angela

and Soveral, Graca 2014. A gold coordination compound as a chemical probe to unravel aquaporin-7 function. ChemBioChem 15 (10) , pp. 1487-1494. 10.1002/cbic.201402103

De March, Matteo, Demitri, Nicola, De Zorzi, Rita, Casini, Angela

, Gabbiani, Chiara, Guerri, Annalisa, Messori, Luigi and Geremia, Silvano 2014. Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition. Journal of Inorganic Chemistry 135 , pp. 58-67. 10.1016/j.jinorgbio.2014.02.015

Rubbiani, Riccardo, Salassa, Luca, De Almeida, Andreia

, Casini, Angela

and Ott, Ingo 2014. Cytotoxic gold(I) N-heterocyclic carbene complexes with phosphane ligands as potent enzyme inhibitors. ChemMedChem 9 (6) , pp. 1205-1210. 10.1002/cmdc.201400056

Frik, M., Jimenez, J., Vasilevski, V., Carreira, M., De Almeida, Andreia

, Gascon, E., Benoit, F., Sanau, M., Casini, Angela

and Contel, M. 2014. Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents. Inorganic Chemistry Frontiers 1 (3) , pp. 231-241. 10.1039/c4qi00003j

Bertrand, Benoit, Stefan, Loic, Pirrotta, Marc, Monchaud, David, Bodio, Ewen, Richard, Philippe, Le Gendre, Pierre, Warmerdam, Elena, de Jager, Marina H., Groothuis, Geny M. M., Picquet, Michel and Casini, Angela

2014. Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties. Inorganic Chemistry 53 (4) , pp. 2296-2303. 10.1021/ic403011h

Bertrand, Benoit and Casini, Angela

2014. A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds. Dalton Transactions 43 (11) , pp. 4209-4219. 10.1039/C3DT52524D

Cinellu, M. A., Ott, I and Casini, Angela

2014. Gold organometallics with biological properties. Bioorganometallic Chemistry: Applications in Drug Discovery, Biocatalysis, and Imaging, Wiley Blackwell, pp. 117-140. (10.1002/9783527673438.ch04)

De Almeida, Andreia

, Oliveira, Bruno L., Correia, Joao D.G., Soveral, Graca and Casini, Angela

2013. Emerging protein targets for metal-based pharmaceutical agents: an update. Coordination Chemistry Reviews 257 (19-20) , pp. 2689-2704. 10.1016/j.ccr.2013.01.031

Martins, Ana Paula, Ciancetta, Antonella, De Almeida, Andreia

, Marrone, Alessandro, Re, Nazzareno, Soveral, Graca and Casini, Angela

2013. Aquaporin inhibition by gold(III) compounds: new insights. ChemMedChem 8 (7) , pp. 1086-1092. 10.1002/cmdc.201300107

Lease, Nicholas, Vasilevski, Vadim, Carreira, Monica, De Almeida, Andreia

, Sanau, Mercedes, Hirva, Pipsa, Casini, Angela

and Contel, Maria 2013. Potential anticancer heterometallic Fe-Au and Fe-Pd agents: initial mechanistic insights. Journal of Medicinal Chemistry 56 (14) , pp. 5806-5818. 10.1021/jm4007615

Avanti, Christina, Hinrichs, Wouter L. J., Casini, Angela

, Eissens, Anko C., Van Dam, Annie, Kedrov, Alexej, Driessen, Arnold J. M., Frijlink, Henderik W. and Permentier, Hjalmar P. 2013. The formation of oxytocin dimers is suppressed by the zinc-aspartate-oxytocin complex. Journal of Pharmaceutical Sciences 102 (6) , pp. 1734-1741. 10.1002/jps.23546

Contel, Maria, Vasileuski, Vadim, Lease, Nicholas, Carreira, Monica, De Almeida, Andreia

, Sanau, Mercedes, Jimenez, Josefina, Gascon, Elena and Casini, Angela

2013. Iminophosphorane d(8) transition metal complexes as potential anticancer agents via a non-cisplatin mode of action. Abstracts of Papers of the American Chemical Society 245

De Luca, Anastasia, Hartinger, Christian G., Dyson, Paul J., Lo Bello, Mario and Casini, Angela

2013. A new target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin. Journal of Inorganic Biochemistry 119 , pp. 38-42. 10.1016/j.jinorgbio.2012.08.006

Guidi, Francesca, Modesti, Alessandra, Landini, Ida, Nobili, Stefania, Mini, Enrico, Bini, Luca, Puglia, Michele, Casini, Angela

, Dyson, Paul J., Gabbiani, Chiara and Messori, Luigi 2013. The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics. Journal of Inorganic Biochemistry 118 , pp. 94-99. 10.1016/j.jinorgbio.2012.10.003

Tasan, Semra, Zava, Olivier, Bertrand, Benoit, Bernhard, Claire, Goze, Christine, Picquet, Michel, Le Gendre, Pierre, Harvey, Pierre, Denat, Franck, Casini, Angela

and Bodio, Ewen 2013. BODIPY-phosphane as a versatile tool for easy access to new metal-based theranostics. Dalton Transactions 42 (17) , pp. 6102-6109. 10.1039/C2DT32055J

Hartinger, Christian G., Groessl, Michael, Meier, Samuel M., Casini, Angela

and Dyson, Paul J. 2013. Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs. Chemical Society Reviews 42 (14) , pp. 6186-6199. 10.1039/C3CS35532B

Citta, Anna, Schuh, Esther, Mohr, Fabian, Folda, Alessandra, Massimino, Maria Lina, Bindoli, Alberto, Casini, Angela

and Rigobello, Maria Pia 2013. Fluorescent silver(I) and gold(I)-N-heterocyclic carbene complexes with cytotoxic properties: mechanistic insights. Metallomics 5 (8) , pp. 1006-1015. 10.1039/C3MT20260G

Casini, Angela

and Reedijk, Jan 2012. Interactions of anticancer Pt compounds with proteins: An overlooked topic in medicinal inorganic chemistry? Chemical Science 3 (11) , pp. 3135-3144. 10.1039/C2SC20627G

Schuh, Esther, Pflueger, Carolin, Citta, Anna, Folda, Alessandra, Rigobello, Maria Pia, Bindoli, Alberto, Casini, Angela

and Mohr, Fabian 2012. Gold(I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents. Journal of Medicinal Chemistry 55 (11) , pp. 5518-5528. 10.1021/jm300428v

Martins, Ana Paula, Marrone, Alessandro, Ciancetta, Antonella, Galan Cobo, Ana, Echevarria, Miriam, Moura, Teresa F., Re, Nazzareno, Casini, Angela

and Soveral, Graca 2012. Targeting aquaporin function: potent inhibition of aquaglyceroporin-3 by a gold-based compound. Plos One 7 (5) , e37435. 10.1371/journal.pone.0037435

Casini, Angela

2012. Exploring the mechanisms of metalbased pharmacological agents via an integrated approach. Journal of Inorganic Biochemistry 109 , pp. 97-106. 10.1016/j.jinorgbio.2011.12.007

Messori, Luigi, Cubo, Leticia, Gabbiani, Chiara, Alvarez-Valdes, Amparo, Michelucci, Elena, Pieraccini, Giuseppe, Rios-Luci, Carla, Leon, Leticia G., Padron, Jose M., Navarro-Ranninger, Carmen, Casini, Angela

and Quiroga, Adoracion G. 2012. Reactivity and biological properties of a series of cytotoxic PtI2(amine)(2) complexes, either cis or trans configured. Inorganic Chemistry 51 (3) , pp. 1717-1726. 10.1021/ic202036c

Komeda, Seiji and Casini, Angela

2012. Next-generation anticancer metallodrugs. Current Topics in Medicinal Chemistry 12 (3) , pp. 219-235. 10.2174/156802612799078964

Serratrice, Maria, Edafe, Fabio, Mendes, Filipa, Scopelliti, Rosario, Zakeeruddin, Shaik Mohammed, Graetzel, Michael, Santos, Isabel, Cinellu, Maria Agostina and Casini, Angela

2012. Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1. Dalton Transactions 41 (11) , pp. 3287-3293. 10.1039/C2DT11913G

Stepanenko, Iryna N., Casini, Angela

, Edafe, Fabio, Novak, Maria S., Arion, Vladimir B., Dyson, Paul J., Jakupec, Michael A. and Keppler, Bernhard K. 2011. Conjugation of organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance Cytotoxicity in Cancer Cells. Inorganic Chemistry 50 (24) , pp. 12669-12679. 10.1021/ic201801e

Gabbiani, Chiara, Casini, Angela

, Kelter, Gerhard, Cocco, Fabio, Cinellu, Maria Agostina, Fiebig, Heinz-Herbert and Messori, Luigi 2011. Mechanistic studies on two dinuclear organogold(III) compounds showing appreciable antiproliferative properties and a high redox stability. Metallomics 3 (12) , pp. 1318-1323. 10.1039/C1MT00113B

Casini, Angela

and Messori, Luigi 2011. Molecular mechanisms and proposed targets for selected anticancer gold compounds. Current Topics in Medicinal Chemistry 11 (21) , pp. 2647-2660. 10.2174/156802611798040732

Vergara, Elena, Cerrada, Elena, Clavel, Catherine, Casini, Angela

and Laguna, Mariano 2011. Thiolato gold(I) complexes containing water-soluble phosphane ligands: a characterization of their chemical and biological properties. Dalton Transactions 40 (41) , pp. 10927-10935. 10.1039/C1DT10892A

Wenzel, Margot, Bertrand, Benoit, Eymin, Marie-Joelle, Comte, Virginie, Harvey, Jennifer A., Richard, Philippe, Groessl, Michael, Zava, Olivier, Amrouche, Hedi, Harvey, Pierre D., Le Gendre, Pierre, Picquet, Michel and Casini, Angela

2011. Multinuclear cytotoxic metallodrugs: physicochemical characterization and biological properties of novel heteronuclear gold-titanium complexes. Inorganic Chemistry 50 (19) , pp. 9472-9480. 10.1021/ic201155y

Nowak-Sliwinska, Patrycja, van Beijnum, Judy R., Casini, Angela

, Nazarov, Alexey A., Wagnieres, Georges, van den Bergh, Hubert, Dyson, Paul J. and Griffioen, Arjan W. 2011. Organometallic ruthenium(II) arene compounds with antiangiogenic activity. Journal of Medicinal Chemistry 54 (11) , pp. 3895-3902. 10.1021/jm2002074

Mendes, Filipa, Groessl, Michael, Nazarov, Alexey A., Tsybin, Yury O., Sava, Gianni, Santos, Isabel, Dyson, Paul J. and Casini, Angela

2011. Metal-based inhibition of poly(ADP-ribose) polymerase: the guardian angel of DNA. Journal of Medicinal Chemistry 54 (7) , pp. 2196-2206. 10.1021/jm2000135

Muegge, Carolin, Rothenburger, Claudia, Beyer, Antje, Goerls, Helmar, Gabbiani, Chiara, Casini, Angela

, Michelucci, Elena, Landini, Ida, Nobili, Stefania, Mini, Enrico, Messori, Luigi and Weigand, Wolfgang 2011. Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(II) compounds with sulfur and phosphorus donors. Dalton Transactions 40 (9) , pp. 2006-2016. 10.1039/C0DT00845A

Snelders, Dennis J. M., Casini, Angela

, Edafe, Fabio, van Koten, Gerard, Gebbink, Robertus J. M. Klein and Dyson, Paul J. 2011. Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties. Journal of Organometallic Chemistry 696 (5) , pp. 1108-1116. 10.1016/j.jorganchem.2010.11.025

Ang, Wee Han, Casini, Angela

, Sava, Gianni and Dyson, Paul J. 2011. Organometallic ruthenium-based antitumor compounds with novel modes of action. Journal of Organometallic Chemistry 696 (5) , pp. 989-998. 10.1016/j.jorganchem.2010.11.009

Gabbiani, Chiara, Mastrobuoni, Guido, Sorrentino, Francesca, Dani, Barbara, Rigobello, Maria Pia, Bindoli, Alberto, Cinellu, Maria Agostina, Pieraccini, Giuseppe, Messori, Luigi and Casini, Angela

2011. Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(III) compounds studied with combined mass spectrometry and biochemical assays. MedChemComm 2 (1) , pp. 50-54. 10.1039/C0MD00181C

Casini, Angela

, Temperini, Claudia, Gabbiani, Chiara, Supuran, Claudiu T. and Messori, Luigi 2010. The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins. ChemMedChem 5 (12) , pp. 1989-1994. 10.1002/cmdc.201000331

Messori, Luigi, Casini, Angela

, Gabbiani, Chiara, Michelucci, Elena, Cubo, Leticia, Rios-Luci, Carla, Padron, Jose M., Navarro-Ranninger, Carmen and Quiroga, Adoracion G. 2010. Cytotoxic profile and peculiar reactivity with biomolecules of a novel "rule-breaker" iodidoplatinum(II) complex. ACS Medicinal Chemistry Letters 1 (8) , pp. 381-385. 10.1021/ml100081e

Pelletier, Frederic, Comte, Virginie, Massard, Alexandre, Wenzel, Margot, Toulot, Stephanie, Richard, Philippe, Picquet, Michel, Le Gendre, Pierre, Zava, Olivier, Edafe, Fabio, Casini, Angela

and Dyson, Paul J. 2010. Development of bimetallic titanocene-ruthenium-arene complexes as anticancer agents: relationships between structural and biological properties. Journal of Medicinal Chemistry 53 (19) , pp. 6923-6933. 10.1021/jm1004804

Cinellu, Maria A., Maiore, Laura, Manassero, Mario, Casini, Angela

, Arca, Massimiliano, Fiebig, Heinz-Herbert, Kelter, Gerhard, Michelucci, Elena, Pieraccini, Giuseppe, Gabbiani, Chiara and Messori, Luigi 2010. [Au-2(phen(2Me))2(mu-O)2](PF6)2, a novel dinuclear gold(III) complex showing excellent antiproliferative properties. ACS Medicinal Chemistry Letters 1 (7) , pp. 336-339. 10.1021/ml100097f

Cubo, Leticia, Groessl, Michael, Dyson, Paul J., Quiroga, Adoracion G., Navarro-Ranninger, Carmen and Casini, Angela

2010. Proteins as possible targets for cytotoxic trans-platinum(II) complexes with aliphatic amine ligands: further exceptions to the DNA paradigm. ChemMedChem 5 (8) , pp. 1335-1343. 10.1002/cmdc.201000104

Casini, Angela

, Edafe, Fabio, Erlandsson, Mikael, Gonsalvi, Luca, Ciancetta, Antonella, Re, Nazzareno, Ienco, Andrea, Messori, Luigi, Peruzzini, Maurizio and Dyson, Paul J. 2010. Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT. Dalton Transactions 39 (23) , pp. 5556-5563. 10.1039/C003218B

Vergara, Elena, Cerrada, Elena, Casini, Angela

, Zava, Olivier, Laguna, Mariano and Dyson, Paul J. 2010. Antiproliferative activity of gold(I) alkyne complexes containing water-soluble phosphane ligands. Organometallics 29 (11) , pp. 2596-2603. 10.1021/om100300a

Nobili, Stefania, Mini, Enrico, Landini, Ida, Gabbiani, Chiara, Casini, Angela

and Messori, Luigi 2010. Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies. Medicinal Research Reviews 30 (3) , pp. 550-580. 10.1002/med.20168

Gras, Michael, Therrien, Bruno, Suess-Fink, Georg, Casini, Angela

, Edafe, Fabio and Dyson, Paul J. 2010. Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand. Journal of Organometallic Chemistry 695 (8) , pp. 1119-1125. 10.1016/j.jorganchem.2010.01.020

Casini, Angela

, Diawara, Mariam Celine, Scopelliti, Rosario, Zakeeruddin, Shaik Mohammed, Graetzel, Michael and Dyson, Paul J. 2010. Synthesis, characterisation and biological properties of gold(III) compounds with modified bipyridine and bipyridylamine ligands. Dalton Transactions 39 (9) , pp. 2239-2245. 10.1039/B921019A

Groessl, Michael, Terenghi, Mattia, Casini, Angela

, Elviri, Lisa, Lobinski, Ryszard and Dyson, Paul J. 2010. Reactivity of anticancer metallodrugs with serum proteins: new insights from size exclusion chromatography-ICP-MS and ESI-MS. Journal of Analytical Atomic Spectrometry 25 (3) , pp. 305-313. 10.1039/B922701F

Mura, Pasquale, Camalli, Mercedes, Casini, Angela

, Gabbiani, Chiara and Messori, Luigi 2010. Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B. Journal of Inorganic Chemistry 104 (2) , pp. 111-117. 10.1016/j.jinorgbio.2009.10.002

Vergara, Elena, Casini, Angela

, Sorrentino, Francesca, Zava, Olivier, Cerrada, Elena, Rigobello, Maria Pia, Bindoli, Alberto, Laguna, Mariano and Dyson, Paul J. 2010. Anticancer therapeutics that target selenoenzymes: synthesis, characterization, in vitro cytotoxicity, and thioredoxin reductase inhibition of a series of gold(I) complexes containing hydrophilic phosphine ligands. ChemMedChem 5 (1) , pp. 96-102. 10.1002/cmdc.200900370

Innocenti, Massimo, Salvietti, Emanuele, Guidotti, Martina, Casini, Angela

, Bellandi, Silvano, Foresti, Maria Luisa, Gabbiani, Chiara, Pozzi, Andrea, Zatta, Paolo and Messori, Luigi 2010. Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta{1-42}: an AFM study. Journal of Alzheimer's Disease 19 (4) , pp. 1323-1329. 10.3233/JAD-2010-1338

Casini, Angela

, Hartinger, Christian G., Nazaroy, Alexey A. and Dyson, Paul J. 2010. Organometallic antitumour agents with alternative modes of action. Jaouen, Gerard and Metzler-Nolte, Nils, eds. Medicinal Organometallic Chemistry, Topics in Organometallic Chemistry, vol. 32. Springer, pp. 57-80. (10.1007/978-3-642-13185-1_3)

Spencer, John, Casini, Angela

, Zava, Olivier, Rathnam, Rajendra P., Velhanda, Santosh K., Pfeffer, Michel, Callear, Samantha K., Hursthouse, Michael B. and Dyson, Paul J. 2009. Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles. Dalton Transactions (48) , pp. 10731-10735. 10.1039/B912096C

Cubo, Leticia, Casini, Angela

, Gabbiani, Chiara, Mastrobuoni, Guido, Messori, Luigi, Jimenez-Barbero, Jesus, Navarro-Ranninger, Carmen and Quiroga, Adoracion G. 2009. Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands. Chemistry - A European Journal 15 (36) , pp. 9139-9146. 10.1002/chem.200901090

Casini, Angela

, Karotki, Andrei, Gabbiani, Chiara, Rugi, Francesco, Vasak, Milan, Messori, Luigi and Dyson, Paul J. 2009. Reactivity of an antimetastatic organometallicruthenium compound with metallothionein-2: relevance to the mechanism of action. Metallomics 1 (5) , pp. 434-441. 10.1039/B909185H

Casini, Angela

, Kelter, Gerhard, Gabbiani, Chiara, Cinellu, Maria Agostina, Minghetti, Giovanni, Fregona, Dolores, Fiebig, Heinz-Herbert and Messori, Luigi 2009. Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic study. Journal of Biological Inorganic Chemistry 14 (7) , pp. 1139-1149. 10.1007/s00775-009-0558-9

Bindoli, Alberto, Rigobello, Maria Pia, Scutari, Guido, Gabbiani, Chiara, Casini, Angela

and Messori, Luigi 2009. Thioredoxin reductase: a target for gold compounds acting as potential anticancer drugs. Coordination Chemistry Reviews 253 (11-12) , pp. 1692-1707. 10.1016/j.ccr.2009.02.026

Casini, Angela

, Gabbiani, Chiara, Michelucci, Elena, Pieraccini, Giuseppe, Moneti, Gloriano, Dyson, Paul J. and Messori, Luigi 2009. Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound. Journal of Biological Inorganic Chemistry 14 (5) , pp. 761-770. 10.1007/s00775-009-0489-5

Gabbiani, Chiara, Messori, Luigi, Cinellu, Maria A., Casini, Angela

, Mura, Pasquale, Sannella, Anna R., Severini, Carlo, Majori, Giancarlo, Bilia, Anna R. and Vincieri, Franco F. 2009. Outstanding plasmodicidal properties within a small panel of metallic compounds: hints for the development of new metal-based antimalarials. Journal of Inorganic Biochemistry 103 (2) , pp. 310-312. 10.1016/j.jinorgbio.2008.10.004

Grossi, Cristina, Francese, Simona, Casini, Angela

, Rosi, Maria Cristina, Luccarini, Ilaria, Fiorentini, Anna, Gabbiani, Chiara, Messori, Luigi, Moneti, Gloriano and Casamenti, Fiorella 2009. Clioquinol decreases amyloid-β burden and reduces working memory impairment in a transgenic mouse model of alzheimer's disease. Journal of Alzheimer's Disease 17 (2) , pp. 423-440. 10.3233/JAD-2009-1063

Hartinger, Christian G., Casini, Angela

, Duhot, Celine, Tsybin, Yury O., Messori, Luigi and Dyson, Paul J. 2008. Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: relevance to antitumour activity. Journal of Inorganic Biochemistry 102 (12) , pp. 2136-2141. 10.1016/j.jinorgbio.2008.08.002

Casini, Angela

, Gabbiani, Chiara, Sorrentino, Francesca, Rigobello, Maria Pia, Bindoli, Alberto, Geldbach, Tifimann J., Marrone, Alessandro, Re, Nazzareno, Hartinger, Christian G., Dyson, Paul J. and Messori, Luigi 2008. Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium (II)-arene compounds. Journal of Medicinal Chemistry 51 (21) , pp. 6773-6781. 10.1021/jm8006678

Ascone, Isabella, Messori, Luigi, Casini, Angela

, Gabbiani, Chiara, Balerna, Antonella, Dell'Unto, Francesca and Castellano, Agostina Congiu 2008. Exploiting soft and hard X-ray absorption spectroscopy to characterize metallodrug/protein interactions: the binding of [trans-RuCl4(Im)(dimethylsulfoxide)][ImH] (Im = imidazole) to bovine serum albumin. Inorganic Chemistry 47 (19) , pp. 8629-8634. 10.1021/ic8001477

Chiellini, Chiara, Casini, Angela

, Cochet, Olivia, Gabbiani, Chiara, Ailhaud, Gerard, Dani, Christian, Messori, Luigi and Amri, Ez-Zoubir 2008. The influence of auranofin, a clinically established antiarthritic gold drug, on bone metabolism: analysis of its effects on human multipotent adipose-derived stem cells, taken as a model. Chemistry & Biodiversity 5 (8) , pp. 1513-1520. 10.1002/cbdv.200890140

Gabbiani, Chiara, Casini, Angela

, Mastrobuoni, Guido, Kirshenbaum, Noam, Moshel, Ofra, Pieraccini, Giuseppe, Moneti, Gloriano, Messori, Luigi and Gibson, Dan 2008. Peculiar mechanistic and structural features of the carboplatin-cytochrome c system revealed by ESI-MS analysis. Journal of Biological Inorganic Chemistry 13 (5) , pp. 755-764. 10.1007/s00775-008-0361-z

Casini, Angela

, Guerri, Annalisa, Gabbiani, Chiara and Messori, Luigi 2008. Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: new insights from X-ray diffraction and mass spectrometry studies. Journal of Inorganic Biochemistry 102 (5-6) , pp. 995-1006. 10.1016/j.jinorgbio.2007.12.022

Gabbiani, Chiara, Casini, Angela

, Messori, Luigi, Guerri, Annalisa, Cinellu, Maria Agostina, Mlnghetti, Giovanni, Corsini, Maddalena, Rosani, Claudia, Zanello, Piero and Arca, Massimiliano 2008. Structural characterization, solution studies, and DFT calculations on a series of binuclear gold(III) oxo complexes: relationships to biological properties. Inorganic Chemistry 47 (7) , pp. 2368-2379. 10.1021/ic701254s

Sannella, Anna Rosa, Casini, Angela

, Gabbiani, Chiara, Messori, Luigi, Bilia, Anna Rita, Vincieri, Francesco Franco, Majori, Giancarlo and Severini, Carlo 2008. New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: mechanistic and pharmacological implications. FEBS Letters 582 (6) , pp. 844-847. 10.1016/j.febslet.2008.02.028

Muniz-Miranda, Maurizio, Pagliai, Marco, Cardini, Gianni, Messori, Luigi, Bruni, Bruno, Casini, Angela

, Di Vaira, Massimo and Schettino, Vincenzo 2008. A multi-technique approach to predicting the molecular structure of cuprizone in the gas phase and in the crystalline state. CrystEngComm 10 (4) , pp. 416-422. 10.1039/B715131D

Drago, Denise, Bettella, Mikol, Bolognin, Silvia, Cendron, Laura, Scancar, Janez, Milacic, Radmila, Ricchelli, Fernanda, Casini, Angela

, Messori, Luigi, Tognon, Giuseppe and Zatta, Paolo 2008. Potential pathogenic role of β-amyloid1-42-aluminum complex in Alzheimer's disease. The International Journal of Biochemistry and Cell Biology 40 (4) , pp. 731-746. 10.1016/j.biocel.2007.10.014

Mura, Pasquale, Camalli, Mercedes, Bindoli, Alberto, Sorrentino, Francesca, Casini, Angela

, Gabbiani, Chiara, Corsini, Maddalena, Zanello, Piero, Rigobello, Maria Pia and Messori, Luigi 2007. Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound. Journal of Medicinal Chemistry 50 (24) , pp. 5871-5874. 10.1021/jm0708578

Pratesi, Alessandro, Zanello, Piero, Giorgi, Gianluca, Messori, Luigi, Laschi, Franco, Casini, Angela

, Corsini, Maddalena, Gabbiani, Chiara, Orfei, Marco, Rosani, Claudia and Ginanneschi, Mauro 2007. New copper(II)/cyclic tetrapeptide system that easily oxidizes to copper(III) under atmospheric oxygen. Inorganic Chemistry 46 (24) , pp. 10038-10040. 10.1021/ic701411y

Casini, Angela

, Mastrobuoni, Guido, Terenghi, Mattia, Gabbiani, Chiara, Monzani, Enrico, Moneti, Gloriano, Casella, Luigi and Messori, Luigi 2007. Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome c. Journal of Biological Inorganic Chemistry 12 (8) , pp. 1107-1117. 10.1007/s00775-007-0280-4

Casini, Angela

, Gabbiani, Chiara, Mastrobuoni, Guido, Pellicani, Raffaella Zoe, Intini, Francesco Paolo, Arnesano, Fabio, Natile, Giovanni, Moneti, Gloriano, Francese, Simona and Messori, Luigi 2007. Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer Platinum(II) iminoethers with horse heart cytochrome c. Biochemistry 46 (43) , pp. 12220-12230. 10.1021/bi701516q

Casini, Angela

, Mastrobuoni, Guido, Ang, Wee Han, Gabbiani, Chiara, Pieraccini, Giuseppe, Moneti, Gloriano, Dyson, Paul J. and Messori, Luigi 2007. ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes. ChemMedChem 2 (5) , pp. 631-635. 10.1002/cmdc.200600258

Ciani, Laura, Casini, Angela

, Gabbiani, Chiara, Ristori, Sandra, Messori, Luigi and Martini, Giacomo 2007. DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques. Biophysical Chemistry 127 (3) , pp. 213-220. 10.1016/j.bpc.2007.02.003

Gabbiani, Chiara, Casini, Angela

and Messori, Luigi 2007. Gold(III) compounds as anticancer drugs. Gold Bulletin 40 (1) , pp. 73-81. 10.1007/BF03215296

Sannella, Anna Rosa, Messori, Luigi, Casini, Angela

, Vincieri, Franco Francesco, Bilia, Anna Rita, Majori, Giancarlo and Severini, Carlo 2007. Antimalarial properties of green tea. Biochemical and Biophysical Research Communications 353 (1) , pp. 177-181. 10.1016/j.bbrc.2006.12.005

Cini, Renzo, Defazio, Sandra, Tamasi, Gabriella, Casolaro, Mario, Messori, Luigi, Casini, Angela

, Morpurgo, Margherita and Hursthouse, Michael 2007. fac-{Ru(CO)3}2+-core complexes and design of metal-based drugs. Synthesis, structure, and reactivity of Ru-thiazole derivative with serum proteins and absorption-release studies with acryloyl and silica hydrogels as carriers in physiological media. Inorganic Chemistry 46 (1) , pp. 79-92. 10.1021/ic060755s

Hartinger, Christian G., Ang, Wee Han, Casini, Angela

, Messori, Luigi, Keppler, Bernhard K. and Dyson, Paul J. 2007. Mass spectrometric analysis of ubiquitin-platinum interactions of leading anticancer drugs: MALDI versus ESI. Journal of Analytical Atomic Spectrometry 22 (8) , pp. 960-967. 10.1039/B703350H

Casini, Angela

, Mastrobuoni, Guido, Temperini, Claudia, Gabbiani, Chiara, Francese, Simona, Moneti, Gloriano, Supuran, Claudiu T., Scozzafava, Andrea and Messori, Luigi 2007. ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme. Chemical Communications (2) , pp. 156-158. 10.1039/B611122J

Messori, Luigi, Casini, Angela

, Gabbiani, Chiara, Sorace, Lorenzo, Muniz-Miranda, Maurizio and Zatta, Paolo 2007. Unravelling the chemical nature of copper cuprizone. Dalton Transactions (21) , pp. 2112-2114. 10.1039/B701896G

Casini, Angela

, Cinellu, Maria Agostina, Minghetti, Giovanni, Gabbiani, Chiara, Coronnello, Marcella, Mini, Enrico and Messori, Luigi 2006. Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligands. Journal of Medicinal Chemistry 49 (18) , pp. 5524-5531. 10.1021/jm060436a

Casini, Angela

, Gabbiani, Chiara, Mastrobuoni, Guido, Messori, Luigi, Moneti, Gloriano and Pieraccini, Giuseppe 2006. Exploring metallodrug-protein interactions by ESI mass spectrometry: the reaction of anticancer platinum drugs with horse heart cytochrome c. ChemMedChem 1 (4) , pp. 413-417. 10.1002/cmdc.200500079

Svastova, E., Hulikova, A., Rafajova, M., Zat'ovicova, M., Gibadulinova, A., Casini, Angela

, Cecchi, A., Scozzafava, A., Supuran, C.T., Pastorek, J. and Pastorekova, S. 2004. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Letters 577 (3) , pp. 439-445. 10.1016/j.febslet.2004.10.043

Zimmerman, S., Innocenti, A., Casini, Angela

, Ferry, J.G., Scozzafava, A. and Supuran, C.T. 2004. Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides. Bioorganic & Medicinal Chemistry Letters 14 (24) , pp. 6001-6006. 10.1016/j.bmcl.2004.09.085

Supuran, C. T., Casini, Angela

, Mastrolorenzo, A. and Scozzafava, A. 2004. COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents. Mini-Reviews in Medicinal Chemistry 4 (6) , pp. 625-632.

Innocenti, A., Casini, Angela

, Alcaro, M.C., Papini, A.M., Scozzafava, A and Supuran, C.T. 2004. Carbonic anhydrase inhibitors: The first on-resin screening of a 4-sulfamoylphenylthiourea library. Journal of Medicinal Chemistry 47 (21) , pp. 5224-5229. 10.1021/jm049692i

Lehtonen, J. M., Parkkila, S., Vullo, D., Casini, Angela

, Scozzafava, A. and Supuran, C. T. 2004. Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design. Bioorganic & Medicinal Chemistry Letters 14 (14) , pp. 3757-3762. 10.1016/j.bmcl.2004.04.106

Dogne, JM, de Leval, X, Hanson, J, Frederich, M, Lambermont, B, Ghuysen, A, Casini, Angela

, Masereel, B, Ruan, KH, Pirotte, B and Kolh, P 2004. New developments on thromboxane and prostacyclin modulators - Part I: Thromboxane modulators. Current Medicinal Chemistry 11 (10) , pp. 1223-1241.

de Leval, X, Ilies, M, Casini, Angela

, Dogne, JM, Scozzafava, A, Masini, E, Mincione, F, Starnotti, M and Supuran, CT 2004. Carbonic anhydrase inhibitors: Synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. Journal of Medicinal Chemistry 47 (11) , pp. 2796-2804. 10.1021/jm031116j

Pastorekova, S, Casini, Angela

, Scozzafava, A, Vullo, D, Pastorek, J and Supuran, CT 2004. Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX. Bioorganic and Medicinal Chemistry Letters 14 (4) , pp. 869-873. 10.1016/j.bmcl.2003.12.029

Abbate, F, Casini, Angela

, Scozzafava, A and Supuran, CT 2004. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide. Bioorganic and Medicinal Chemistry Letters 14 (9) , pp. 2357-2361. 10.1016/j.bmcl.2004.01.096

Lehtonen, J, Shen, BR, Vihinen, M, Casini, Angela

, Scozzafava, A, Supuran, CT, Parkkila, AK, Saarnio, J, Kivela, AJ, Waheed, A, Sly, WS and Parkkila, S 2004. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. Journal of Biological Chemistry 279 (4) , pp. 2719-2727. 10.1074/jbc.M308984200

Abbate, F, Casini, Angela

, Owa, T, Scozzafava, A and Supuran, C. T. 2004. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Biorganic and Medicinal Chemistry Letters 14 (1) , pp. 217-223. 10.1016/j.bmcl.2003.09.062

Abbate, F, Winum, J. Y., Potter, B. V. L, Casini, Angela

, Montero, J. L., Scozzafava, A and Supuran, C. T. 2004. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase. Biorganic and Medicinal Chemistry Letters 14 (1) , pp. 231-234. 10.1016/j.bmcl.2003.09.064

Winum, J. Y., Casini, Angela

, Mincione, F, Starnotti, M, Montero, J. L., Scozzafava, A and Supuran, C. T. 2004. Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits. Biorganic and Medicinal Chemistry Letters 14 (1) , pp. 225-229. 10.1016/j.bmcl.2003.09.063

Abbate, F, Coetzee, A, Casini, Angela

, Ciattini, S, Scozzafava, A and Supuran, CT 2004. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride. Bioorganic and Medicinal Chemistry Letters 14 (2) , pp. 337-341. 10.1016/j.bmcl.2003.11.014

Bonnac, L, Innocenti, A, Winum, JY, Casini, Angela

, Montero, JL, Scozzafava, A, Barragan, V and Supuran, CT 2004. Carbonic anhydrase inhibitors: Aliphatic N-phosphorylated sulfamates - A novel zinc-anchoring group leading to nanomolar inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 19 (3) , pp. 275-278. 10.1080/14756360410001689522

Winum, J. Y., Vullo, D, Casini, Angela

, Montero, J. L., Scozzafava, A and Supuran, C. T. 2003. Carbonic anhydrase inhibitors: Inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic Isozymes I and II with aliphatic sulfamates. Journal of Medicinal Chemistry 46 (25) , pp. 5471-5477. 10.1021/jm030911u

Casini, Angela

, Scozzafava, A, Mincione, F, Menabuoni, L, Starnotti, M and Supuran, C. T. 2003. Carbonic anhydrase inhibitors: Topically acting antiglaucoma sulfonamides incorporating esters and amides of 3-and 4-carboxybenzolamide. Biorganic and Medicinal Chemistry Letters 13 (17) , pp. 2867-2873. 10.1016/S0960-894X(03)00580-8

Mastrolorenzo, A., Zuccati, G., Massi, D., Gabrielli, M. G., Casini, Angela

, Scozzafava, A. and Supuran, C. T. 2003. Immunohistochemical study of carbonic anhydrase isozymes in human skin. European Journal of Dermatology 13 (5) , pp. 440-444.

Supuran, C. T., Casini, Angela

and Scozzafava, A 2003. Protease inhibitors of the sulfonamide type: Anticancer, antiinflammatory, and antiviral agents. Medicinal Research Reviews 23 (5) , pp. 535-558. 10.1002/med.10047

Casini, Angela

, Caccia, S, Scozzafava, A and Supuran, C. T. 2003. Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of Isozymes I and II. Biorganic and Medicinal Chemistry Letters 13 (16) , pp. 2765-2768. 10.1016/S0960-894X(03)00507-9

Casini, Angela

, Abbate, F., Scozzafava, A. and Supuran, C. T. 2003. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide - Two heads are better than one? Biorganic and Medicinal Chemistry Letters 13 (16) , pp. 2759-2763. 10.1016/S0960-894X(03)00508-0

Abbate, F., Casini, Angela

, Scozzafava, A. and Supuran, C. T. 2003. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 18 (4) , pp. 303-308. 10.1080/1475636031000119337

Winum, J. Y., Vullo, D, Casini, Angela

, Montero, J. L., Scozzafava, A and Supuran, C. T. 2003. Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors. Journal of Medicinal Chemistry 46 (11) , pp. 2197-2204. 10.1021/jm021124k

Casini, Angela

, Antel, J, Abbate, F, Scozzafava, A, David, S, Waldeck, H, Schafer, S and Supuran, C. T. 2003. Carbonic anhydrase inhibitors: SAR and x-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with Isozymes I, II and IV. Biorganic and Medicinal Chemistry Letters 13 (5) , pp. 841-845. 10.1016/S0960-894X(03)00029-5

Casini, Angela

, Winum, JY, Montero, JL, Scozzafava, A and Supuran, CT 2003. Carbonic anhydrase inhibitors: Inhibition of cytosolic isozymes I and II with sulfamide derivatives. Bioorganic & Medicinal Chemistry Letters 13 (5) , pp. 837-840. 10.1016/S0960-894X(03)00028-3

Supuran, CT, Scozzafava, A and Casini, Angela

2003. Carbonic anhydrase inhibitors. Medicinal Research Reviews 23 (2) , pp. 146-189. DOI: 10.1002/med.10025

Maestrelli, F., Mura, P., Casini, Angela

, Mincione, F., Scozzafava, A. and Supuran, C.T. 2002. Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents. Journal of Pharmaceutical Sciences 91 (10) , pp. 2211-2219. 10.1002/jps.10215

Casini, Angela

, Scozzafava, A and Supuran, CT 2002. Cysteine-modifying agents: A possible approach for effective anticancer and antiviral drugs. Environmental Health Perspectives 110 , pp. 801-806.

Casini, Angela

, Scozzafava, A and Supuran, CT 2002. Sulfonamide derivatives with protease inhibitory action as anticancer, anti-inflammatory and antiviral agents. Expert Opinion on Therapeutic Patents 12 (9) , pp. 1307-1327. 10.1517/13543776.12.9.1307

Scozzafava, A, Casini, Angela

and Supuran, CT 2002. Targeting cysteine residues of biomolecules: New approaches for the design of antiviral and anticancer drugs. Current Medicinal Chemistry 9 (12) , pp. 1167-1185. 10.2174/0929867023370077#sthash.8XxGycVL.dpuf

Casini, Angela

, Mincione, F, Vullo, D, Menabuoni, L, Scozzafava, A and Supuran, CT 2002. Carbonic anhydrase inhibitors with strong topical antiglaucoma properties incorporating a 4-(2-aminopyrimidin-4-yl-amino)-benzenesulfonamide scaffold. Journal of Enzyme Inhibition and Medicinal Chemistry 17 (1) , pp. 9-18. 10.1080/14756360290018602

Casini, Angela

, Scozzafava, Andrea, Mastrolorenzo, Antonio and Supuran, Claudiu T. 2002. Sulfonamides and sulfonylated derivatives as anticancer agents. Current Cancer Drug Targets 2 (1) , pp. 55-75. 10.2174/1568009023334060

Casini, Angela

, Scozzafava, A, Mincione, F, Menabuoni, L and Supuran, CT 2002. Carbonic anhydrase inhibitors: Synthesis of water soluble sulfonamides incorporating a 4-sulfamoylphenylmethylthiourea scaffold, with potent intraocular pressure lowering properties. Journal of Enzyme Inhibition and Medicinal Chemistry 17 (5) , pp. 333-343. 10.1080/1475636021000010950

Mincione, Francesco, Starnotti, Michele, Menabuoni, Luca, Scozzafava, Andrea, Casini, Angela

and Supuran, Claudiu. T 2001. Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties. Biorganic and Medicinal Chemistry Letters 11 (13) , pp. 1787-1791. 10.1016/S0960-894X(01)00303-1

Casini, Angela

, Messori, Luigi, Orioli, Pierluigi, Gielen, Marcel, Kemmer, Martine and Willem, Rudolph 2001. Interactions of two cytotoxic organotin(IV) compounds with calf thymus DNA. Journal of Inorganic Biochemistry 85 (4) , pp. 297-300. 10.1016/S0162-0134(01)00215-X

Messori, L, Casini, Angela

, Vullo, D, Haroutiunian, S.G, Dalian, E.B and Orioli, P 2000. Effects of two representative antitumor ruthenium(III) complexes on thermal denaturation profiles of DNA. Inorganica Chimica Acta 303 (2) , pp. 283-286. 10.1016/S0020-1693(99)00528-9

Gallori, Enzo, Vettori, Cristina, Alessio, Enzo, Vilchez, Francisco Gonzalez, Vilaplana, Rosario, Orioli, Pierluigi, Casini, Angela

and Messori, Luigi 2000. DNA as a possible target for antitumor ruthenium(111) complexes - A spectroscopic and molecular biology study of the interactions of two representative antineoplastic ruthenium(111) complexes with DNA. Archives of biochemistry and biophysics 376 (1) , pp. 156-162. 10.1006/abbi.1999.1654

This list was generated on Sat Nov 1 15:06:47 2025 GMT.