Browse by All Cardiff Authors

Jorgensen, Sara K. M., Surridge-Smith, May, Jones, Kimberley, Maletínská, Lenka, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X and Petrik, David ORCID: https://orcid.org/0000-0003-3026-0770 2025. Anti-obesity compounds, Semaglutide and LiPR, and PrRP do not change the proportion of human and mouse POMC+ neurons. PLoS ONE 20 (8) , e0329268. 10.1371/journal.pone.0329268

Maguire, Emily, Winston, Jincy, Ellwood, Sarah, O'Donoghue, Rachel, Shaw, Bethany, Castillo Morales, Atahualpa, Keat, Samuel, Evans, Alexandra, Marshall, Rachel, Luckcuck, Lauren, Brown, Laura, Salis, Elisa, Leonenko, Ganna ORCID: https://orcid.org/0000-0001-8025-661X, Denning, Nicola, Allen, Nicholas ORCID: https://orcid.org/0000-0003-4009-186X, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Webber, Caleb ORCID: https://orcid.org/0000-0001-8063-7674, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Sims, Rebecca ORCID: https://orcid.org/0000-0002-3885-1199, Cowley, Sally A., Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Carpanini, Sarah M., Hall-Roberts, Hazel and EADB Consortium 2025. Modeling common Alzheimer’s disease with high and low polygenic risk in human iPSC: A large-scale research resource. Stem Cell Reports 20 (8) , 102570. 10.1016/j.stemcr.2025.102570

Murillo, Alvaro, Alpaugh, Melanie, Larin, Meghan, Randall, Emma L, Heraty, Laura, Durairaj, Ruban Rex, Aston, Alys N, Taylor, Alysha S, Monteys, Alex Mas, Stöberl, Nina, Heuchan, Aeverie ER, Aeschlimann, Pascale, Bhattacharyya, Soumyasree, Allen, Nicholas D ORCID: https://orcid.org/0000-0003-4009-186X, Puymirat, Jack, Davidson, Beverly L, Cicchetti, Francesca, Lelos, Mariah J ORCID: https://orcid.org/0000-0001-7102-055X and Dion, Vincent ORCID: https://orcid.org/0000-0003-4953-7637 2024. I001 Cas9 nickase-mediated contraction of CAG repeats in Huntington’s disease. Journal of Neurology, Neurosurgery and Psychiatry 95 (Suppl) , A141-A142. 10.1136/jnnp-2024-EHDN.283

Stöberl, Nina, Donaldson, Jasmine ORCID: https://orcid.org/0000-0001-6699-0674, Binda, Caroline S., McAllister, Branduff, Hall-Roberts, Hazel, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Massey, Thomas H. ORCID: https://orcid.org/0000-0002-9804-2131 and Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X 2023. Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia. Scientific Reports 13 , 20477. 10.1038/s41598-023-46852-z

Indrigo, Marzia, Morella, Ilaria ORCID: https://orcid.org/0000-0001-5691-5400, Orellana, Daniel, d'Isa, Raffaele, Papale, Alessandro ORCID: https://orcid.org/0000-0002-8794-0171, Parra, Riccardo, Gurgone, Antonia, Lecca, Daniela, Cavaccini, Anna, Tigaret, Cezar M. ORCID: https://orcid.org/0000-0001-5848-6697, Cagnotto, Alfredo, Jones, Kimberley, Brooks, Simon ORCID: https://orcid.org/0000-0001-9853-6177, Ratto, Gian Michele, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Lelos, Mariah J. ORCID: https://orcid.org/0000-0001-7102-055X, Middei, Silvia, Giustetto, Maurizio, Carta, Anna R., Tonini, Raffaella, Salmona, Mario, Hall, Jeremy ORCID: https://orcid.org/0000-0003-2737-9009, Thomas, Kerrie ORCID: https://orcid.org/0000-0003-3355-9583, Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706 and Fasano, Stefania ORCID: https://orcid.org/0000-0002-3696-7139 2023. Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2. EMBO Molecular Medicine 15 (11) , e15984. 10.15252/emmm.202215984

Miguez, Andrés, Gomis, Cinta, Vila, Cristina, Monguió-Tortajada, Marta, Fernández-García, Sara, Bombau, Georgina, Galofré, Mireia, García-Bravo, María, Sanders, Phil, Fernández-Medina, Helena, Poquet, Blanca, Salado-Manzano, Cristina, Roura, Santiago, Alberch, Jordi, Segovia, José Carlos, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Borràs, Francesc E. and Canals, Josep M. 2023. Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease. Cellular and Molecular Life Sciences 80 (8) , 238. 10.1007/s00018-023-04882-w

Daskoulidou, Nikoleta, Shaw, Bethany, Torvell, Megan, Watkins, Lewis, Cope, Emma L., Carpanini, Sarah M., Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X and Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676 2023. Complement receptor 1 is expressed on brain cells and in the human brain. Glia 71 (6) , pp. 1522-1535. 10.1002/glia.24355

Somogyi, Aleksandra, Kirkham, Emily D., Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611, Winston, Jincy, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Mackrill, John J., Anderson, Karen E., Hawkins, Phillip T., Gardiner, Sian E., Waller-Evans, Helen ORCID: https://orcid.org/0000-0003-4133-6064, Sims, Rebecca ORCID: https://orcid.org/0000-0002-3885-1199, Boland, Barry and O'Neill, Cora 2023. The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system. Journal of Cell Science 136 (6) , jcs259875. 10.1242/jcs.259875

Ateaque, Sarah, Merkouris, Spyros, Wyatt, Sean ORCID: https://orcid.org/0000-0002-0572-234X, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Xie, Jia, DiStefano, Peter S., Lindsay, Ronald M. and Barde, Yves-Alain ORCID: https://orcid.org/0000-0002-7627-461X 2022. Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC. Journal of Neurochemistry 161 (6) , pp. 463-477. 10.1111/jnc.15617

Maguire, Emily, Menzies, Georgina E. ORCID: https://orcid.org/0000-0002-6600-6507, Phillips, Thomas, Sasner, Michael, Williams, Harriet M. ORCID: https://orcid.org/0000-0001-7571-1868, Czubala, Magdalena A. ORCID: https://orcid.org/0000-0001-9881-1095, Evans, Neil ORCID: https://orcid.org/0000-0002-5458-6065, Cope, Emma L., Sims, Rebecca ORCID: https://orcid.org/0000-0002-3885-1199, Howell, Gareth R., Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611, Williams, Julie ORCID: https://orcid.org/0000-0001-7571-1868, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X and Taylor, Philip R ORCID: https://orcid.org/0000-0003-0163-1421 2021. PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522. EMBO Journal 40 (17) , e105603. 10.15252/embj.2020105603

Goold, Robert, Hamilton, Joseph, Menneteau, Thomas, Flower, Michael, Bunting, Emma L., Aldous, Sarah G., Porro, Antonio, Vicente, José R., Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Wilkinson, Hilary, Bates, Gillian P., Sartori, Alessandro A., Thalassinos, Konstantinos, Balmus, Gabriel and Tabrizi, Sarah J. 2021. FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease. Cell Reports 36 (9) , 109649. 10.1016/j.celrep.2021.109649

Imm, Jennifer, Pishva, Ehsan, Ali, Muhammadd, Kerrigan, Talitha L., Jeffries, Aaron, Burrage, Joe, Glaab, Enrico, Cope, Emma L., Jones, Kimberley M., Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X and Lunnon, Katie 2021. Characterization of DNA methylomic signatures in induced pluripotent stem cells during neuronal differentiation. Frontiers in Cell and Developmental Biology 9 , 647981. 10.3389/fcell.2021.647981

Steg, Leonard C., Shireby, Gemma L., Imm, Jennifer, Davies, Jonathan P., Franklin, Alice, Flynn, Robert, Namboori, Seema C., Bhinge, Akshay, Jeffries, Aaron R., Burrage, Joe, Neilson, Grant W. A., Walker, Emma M., Perfect, Leo W., Price, Jack, McAlonan, Grainne, Srivastava, Deepak P., Bray, Nicholas J. ORCID: https://orcid.org/0000-0002-4357-574X, Cope, Emma L., Jones, Kimberley M., Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Pishva, Ehsan, Dempster, Emma L., Lunnon, Katie, Mill, Jonathan and Hannon, Eilis 2021. Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Molecular Brain 14 (1) , 98. 10.1186/s13041-021-00810-w

Comella-Bolla, Andrea, Orlandi, Javier G., Miguez, Andrés, Straccia, Marco, García-Bravo, María, Bombau, Georgina, Galofré, Mireia, Sanders, Phil, Carrere, Jordi, Segovia, José Carlos, Blasi, Joan, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Alberch, Jordi, Soriano, Jordi and Canals, Josep M. 2020. Human pluripotent stem cell-derived neurons are functionally mature in vitro and integrate into the mouse striatum following transplantation. Molecular Neurobiology 57 (6) , pp. 2766-2798. 10.1007/s12035-020-01907-4

Cook, Sophie R., Badell-Grau, Rafael A., Kirkham, Emily D., Jones, Kimberley M., Kelly, Brendan M., Winston, Jincy, Waller-Evans, Helen ORCID: https://orcid.org/0000-0003-4133-6064, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X and Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611 2020. Detrimental effect of zwitterionic buffers on lysosomal homeostasis in cell lines and iPSC-derived neurons. AMRC Open Research 2 , 21. 10.12688/amrcopenres.12903.1

Smith-Geater, Charlene, Hernandez, Sarah J., Lim, Ryan G., Adam, Miriam, Wu, Jie, Stocksdale, Jennifer T., Wassie, Brook T., Gold, Maxwell Philip, Wang, Keona Q., Miramontes, Ricardo, Kopan, Lexi, Orellana, Iliana, Joy, Shona, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Fraenkel, Ernest and Thompson, Leslie M. 2020. Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation. Stem Cell Reports 14 (3) , pp. 406-419. 10.1016/j.stemcr.2020.01.015

Baker, Emily, Sims, Rebecca ORCID: https://orcid.org/0000-0002-3885-1199, Leonenko, Ganna ORCID: https://orcid.org/0000-0001-8025-661X, Frizzati, Aura ORCID: https://orcid.org/0000-0002-7002-6180, Harwood, Janet, Grozeva, Detelina ORCID: https://orcid.org/0000-0003-3239-8415, Morgan, Kevin ORCID: https://orcid.org/0000-0003-4075-7676, Passmore, Peter, Holmes, Clives, Powell, John, Brayne, Carol, Gill, Michael, Mead, Simon, Bossu, Paola, Spalletta, Gianfranco, Goate, Alison, Crunchaga, Carlos, Maier, Wolfgang, Heun, Reinhard, Jessen, Frank, Peters, Oliver, Dichgans, Martin, Frolich, Lutz, Ramirez, Alfredo, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Hardy, John, Ivanov, Dobril ORCID: https://orcid.org/0000-0001-6271-6301, Hill, Matthew ORCID: https://orcid.org/0000-0001-6776-8709, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Allen, Nicholas ORCID: https://orcid.org/0000-0003-4009-186X, Morgan, Paul ORCID: https://orcid.org/0000-0003-4075-7676, Seshadri, Sudha, Schellenberg, Gerard, Amouvel, Philippe, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259 and Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483 2019. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease. PLoS ONE 14 (7) , e0218111. 10.1371/journal.pone.0218111

Garcia, Veronica J., Rushton, David J., Tom, Colton M., Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Svendsen, Clive N. and Mattis, Virginia B. 2019. Huntington's disease patient-derived astrocytes display electrophysiological impairments and reduced neuronal support. Frontiers in Neuroscience 13 , 669. 10.3389/fnins.2019.00669

Harwood, Janet C. ORCID: https://orcid.org/0000-0003-3124-5169, Kent, Nicholas A. ORCID: https://orcid.org/0000-0002-4114-1307, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X and Harwood, Adrian J. ORCID: https://orcid.org/0000-0003-3124-5169 2019. Nucleosome dynamics of human iPSC during neural differentiation. EMBO reports 20 (6) , e46960. 10.15252/embr.201846960

Telezhkin, Vsevolod ORCID: https://orcid.org/0000-0002-5054-8774, Straccia, Marco, Yarova, Polina, Pardo, Monica, Yung, Sun, Vinh, Ngoc-Nga, Hancock, Jane M., Barriga, Gerardo Garcia-Diaz, Brown, David A., Rosser, Anne E. ORCID: https://orcid.org/0000-0002-4716-4753, Brown, Jonathan T., Canals, Josep M., Randall, Andrew D., Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X and Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X 2018. Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflügers Archiv European Journal of Physiology 470 (9) , pp. 1359-1376. 10.1007/s00424-018-2155-7

Merkouris, Spyros, Barde, Yves-Alain ORCID: https://orcid.org/0000-0002-7627-461X, Binley, Kate E., Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Stepanov, Alexey V., Wu, Nicholas C., Grande, Geramie, Lin, Chih-Wei, Li, Meng ORCID: https://orcid.org/0000-0002-4803-4643, Nan, Xinsheng ORCID: https://orcid.org/0000-0002-0865-7934, Chacon-Fernandez, Pedro, DiStefano, Peter S., Lindsay, Ronald M., Lerner, Richard A. and Xie, Jia 2018. Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library. Proceedings of the National Academy of Sciences 115 (30) , E7023-E7032. 10.1073/pnas.1806660115

Haenseler, Walther, Sansom, Stephen N., Buchrieser, Julian, Newey, Sarah E., Moore, Craig S., Nicholls, Francesca J., Chintawar, Satyan, Schnell, Christian, Antel, Jack P., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Cader, M. Zameel, Wade-Martins, Richard, James, William S. and Cowley, Sally A. 2017. A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response. Stem Cell Reports 8 (6) , pp. 1727-1742. 10.1016/j.stemcr.2017.05.017

Lim, Ryan G., Salazar, Lisa L., Wilton, Daniel K., King, Alvin R., Stocksdale, Jennifer T., Sharifabad, Delaram, Lau, Alice L., Stevens, Beth, Reidling, Jack C., Winokur, Sara T., Casale, Malcolm S., Thompson, Leslie M., Pardo, Mónica, Díaz-Barriga, A. Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M., Kaye, Julia A., Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Kedaigle, Amanda J., Gipson, Theresa A., Yildirim, Ferah, Ng, Christopher W., Milani, Pamela, Housman, David E., Fraenkel, Ernest, Allen, Nicholas D. ORCID: https://orcid.org/0000-0003-4009-186X, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F., MacDonald, Marcy E., Akimov, Sergey S., Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A., Mattis, Virginia B., Tom, Colton M., Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv and Svendsen, Clive N. 2017. Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nature Neuroscience 20 (5) , pp. 648-660. 10.1038/nn.4532

Bowles, Kathryn R., Stone, Timothy C. ORCID: https://orcid.org/0000-0003-4591-9611, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 2017. SMAD transcription factors are altered in cell models of HD and regulate HTT expression. Cellular Signalling 31 , pp. 1-14. 10.1016/j.cellsig.2016.12.005

Kemp, Paul J ORCID: https://orcid.org/0000-0003-2773-973X, Rushton, David J., Yarova, Polina, Schnell, Christian, Geater, Charlene, Hancock, Jane M., Wieland, Annalena, Hughes, Alis, Badder, Luned, Cope, Emma Louise, Riccardi, Daniela ORCID: https://orcid.org/0000-0002-7322-3163, Randall, Andrew, Brown, Jonathan T., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Telezhkin, Vsevolod ORCID: https://orcid.org/0000-0002-5054-8774 2016. Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. The Journal of Physiology 594 (22) , pp. 6583-6594. 10.1113/JP270655

Howard-Jones, Rachel Anne ORCID: https://orcid.org/0000-0001-7200-3110, Cheung, O. K. Y., Glen, A., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996 2016. Integration-free reprogramming of lamina propria progenitor cells. Journal of Dental Research 95 (8) , pp. 882-888. 10.1177/0022034516637579

Telezhkin, Vsevolod, Schnell, Christian, Yarova, Polina L., Yung, Sun, Sanders, Philip, Cope, Emma, Hughes, Alis, Thompson, Belinda A, Geater, Charlene, Hancock, Jane M., Joy, Shona, Badder, Luned, Connor-Robson, Natalie ORCID: https://orcid.org/0000-0001-8350-6928, Comella, Andrea, Straccia, Marco, Bombau, Georgina, Brown, Jon T, Canals, Josep M., Randall, Andrew D., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X 2016. Forced cell-cycle exit and modulation of GABAA, CREB and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. American Journal of Physiology - Cell Physiology , ajpcell.00166.2015. 10.1152/ajpcell.00166.2015

Gee, Heon Yung, Sadowski, Carolin E., Aggarwal, Pardeep K., Porath, Jonathan D., Yakulov, Toma A., Schueler, Markus, Lovric, Svjetlana, Ashraf, Shazia, Braun, Daniela A., Halbritter, Jan, Fang, Humphrey, Airik, Rannar, Vega-Warner, Virginia, Cho, Kyeong Jee, Chan, Timothy A., Morris, Luc G. T., ffrench-Constant, Charles, Allen, Nicholas ORCID: https://orcid.org/0000-0003-4009-186X, McNeill, Helen, Büscher, Rainer, Kyrieleis, Henriette, Wallot, Michael, Gaspert, Ariana, Kistler, Thomas, Milford, David V., Saleem, Moin A., Keng, Wee Teik, Alexander, Stephen I., Valentini, Rudolph P., Licht, Christoph, Teh, Jun C., Bogdanovic, Radovan, Koziell, Ania, Bierzynska, Agnieszka, Soliman, Neveen A., Otto, Edgar A., Lifton, Richard P., Holzman, Lawrence B., Sibinga, Nicholas E. S., Walz, Gerd, Tufro, Alda and Hildebrandt, Friedhelm 2016. FAT1 mutations cause a glomerulotubular nephropathy. Nature Communications 7 , 10822. 10.1038/ncomms10822

Precious, Sophie V., Kelly, Claire M., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 2016. Can manipulation of differentiation conditions eliminate proliferative cells from a population of ES cell-derived forebrain cells? Neurogenesis 3 (1) , e1127311. 10.1080/23262133.2015.1127311

Straccia, Marco, Garcia-Diaz Barriga, Gerardo, Sanders, Phil, Bombau, Georgina, Carrere, Jordi, Mairal, Pedro Belio, Vinh, Ngoc-Nga, Yung, Sun, Kelly, Claire M., Svendsen, Clive N, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Arjomand, Jamshid, Schoenfeld, Ryan C., Alberch, Jordi, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 and Canals, Josep M. 2015. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Molecular Therapy - Methods & Clinical Development 2 , 15030. 10.1038/mtm.2015.30

Celiz, Adam D., Smith, James G. W., Patel, Asha K., Hook, Andrew L., Rajamohan, Divya, George, Vinoj T., Flatt, Luke, Patel, Minal J., Epa, Vidana C., Singh, Taranjit, Langer, Robert, Anderson, Daniel G., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Hay, David C., Winkler, David A., Barrett, David A., Davies, Martyn C., Young, Lorraine E., Denning, Chris and Alexander, Morgan R. 2015. Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation. Advanced Materials 27 (27) , pp. 4006-4012. 10.1002/adma.201501351

Martín-Flores, Núria, Romaní-Aumedes, Joan, Rué, Laura, Canal, Mercè, Sanders, Phil, Straccia, Marco, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Alberch, Jordi, Canals, Josep M., Pérez-Navarro, Esther and Malagelada, Cristina 2015. RTP801 is involved in mutant Huntingtin-induced cell death. Molecular Neurobiology 53 (5) , pp. 2857-2868. 10.1007/s12035-015-9166-6

Jones, Anna J., Gokhale, Paul J., Allison, Thomas F., Sampson, Barry, Athwal, Sharan, Grant, Simon, Andrews, Peter W., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Case, C. Patrick 2015. Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells. Scientific Reports 5 , 11694. 10.1038/srep11694

Mort, Matthew Edwin, Carlisle, Francesca ORCID: https://orcid.org/0000-0002-9734-113X, Waite, Adrian, Elliston, Lyn, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612 and Hughes, Alis 2015. Huntingtin exists as multiple splice forms in human brain. Journal of Huntington's Disease 4 (2) , pp. 161-171. 10.3233/JHD-150151

Rushton, David J., Mattis, Virginia B., Svendsen, Clive N., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X 2013. Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons. PLoS ONE 8 (11) , e81031. 10.1371/journal.pone.0081031

Mattis, V. B., Svendsen, S. P., Ebert, A., Svendsen, C. N., King, A. R., Casale, M., Winokur, S. T., Batugedara, G., Vawter, M., Donovan, P. J., Lock, L. F., Thompson, L. M., Atwal, R. S., Zhu, Y., Fossale, E., Gillis, T., Mysore, J., Li, J.-H., Seong, I. S., Shen, Y., Chen, X., Wheeler, V. C., MacDonald, M. E., Gusella, J. F., Akimov, S., Arbez, N., Juopperi, T., Ratovitski, T., Chiang, J. H., Kim, W. R., Chighladze, E., Watkin, E., Zhong, C., Makri, G., Cole, R. N., Margolis, R. L., Song, H., Ming, G., Ross, C. A., Kaye, J. A., Daub, A., Sharma, P., Mason, A. R., Finkbeiner, S., Rushton, David J., Brazier, Stephen Paul, Battersby, Alysia Agnes, Redfern, Amanda Jane, Tseng, Hsiu-Er, Harrison, Alexander William John, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Castiglioni, V., Onorati, M., Cattaneo, E., Yu, J., Thomson, J. A. and Arjomand, J. 2012. Induced pluripotent stem cells from patients with Huntington's Disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11 (2) , pp. 264-278. 10.1016/j.stem.2012.04.027

Wray, Selina, Self, Matthew, Lewis, Patrick A., Taanman, Jan-Willem, Ryan, Natalie S., Mahoney, Colin J., Liang, Yuying, Devine, Michael J., Sheerin, Una-Marie, Houlden, Henry, Morris, Huw Rees, Healy, Daniel, Marti-Masso, Jose-Felix, Preza, Elisavet, Barker, Suzanne, Sutherland, Margaret, Corriveau, Roderick A., D'Andrea, Michael, Schapira, Anthony H. V., Uitti, Ryan J., Guttman, Mark, Opala, Grzegorz, Jasinska-Myga, Barbara, Puschmann, Andreas, Nilsson, Christer, Espay, Alberto J., Slawek, Jaroslaw, Gutmann, Ludwig, Boeve, Bradley F., Boylan, Kevin, Stoessl, A. Jon, Ross, Owen A., Maragakis, Nicholas J., Van Gerpen, Jay, Gerstenhaber, Melissa, Gwinn, Katrina, Dawson, Ted M., Isacson, Ole, Marder, Karen S., Clark, Lorraine N., Przedborski, Serge E., Finkbeiner, Steven, Rothstein, Jeffrey D., Wszolek, Zbigniew K., Rossor, Martin N., Hardy, John, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2012. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS ONE 7 (8) , e43099. 10.1371/journal.pone.0043099

Feyeux, M., Bourgois-Rocha, F., Redfern, Amanda Jane, Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Lefort, N., Aubert, S., Bonnefond, C., Buiga, A., Ruiz, M., Deglon, N., Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Peschanski, M., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Perrier, A. L. 2012. Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells. Human Molecular Genetics 21 (17) , pp. 3883-3895. 10.1093/hmg/dds216

Patani, R., Hollins, Andrew John ORCID: https://orcid.org/0000-0002-0324-9376, Wishart, T. M., Puddifoot, C. A., Alvarez, S., de Lera, A. R., Wyllie, D. J. A., Compston, D. A. S., Pedersen, R. A., Gillingwater, T. H., Hardingham, G. E., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Chandran, S. 2011. Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state. Nature Communications 2 , 214. 10.1038/ncomms1216

Kelly, Claire, Precious, Sophie Victoria, Torres, Eduardo Miguel, Harrison, Alexander William John, Williams, Deborah, Scherf, Caroline, Weyrauch, Ulrike Marie, Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Penketh, Richard, Amso, Nazar Najib ORCID: https://orcid.org/0000-0002-8646-6623, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 2011. Medical terminations of pregnancy: A viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation 20 (4) , pp. 503-513. 10.3727/096368910X546580

Decembrini, Sarah, Cananzi, Mara, Gualdoni, Sara, Battersby, Alysia, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Pearson, Rachael A., Ali, Robin R., De Coppi, Paolo and Sowden, Jane C. 2011. Comparative Analysis of the Retinal Potential of Embryonic Stem Cells and Amniotic Fluid-Derived Stem Cells. Stem Cells and Development 20 (5) , pp. 851-863. 10.1089/scd.2010.0291

Hollins, Andrew John ORCID: https://orcid.org/0000-0002-0324-9376, Joy, S., Kelly, Claire M., Battersby, Alysia Agnes, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 2011. Transplantation of differentiated human embryonic stem cells into a Huntington's Disease model: The challenges of generating neural cells suitable for replacement therapy in neurodegenerative disease. Cell Transplantation 20 (4) , pp. 563-564.

Ewan, Kenneth Burnside Ramsay ORCID: https://orcid.org/0000-0001-6622-9009, Pajak, Bozena, Stubbs, M., Todd, H., Barbeau, O., Quevedo, C., Botfield, H., Young, R., Ruddle, R., Samuel, L., Battersby, Alysia Agnes, Raynaud, F., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Wilson, Samuel, Latinkic, Branko ORCID: https://orcid.org/0000-0003-4952-123X, Workman, P., McDonald, E., Blagg, J., Aherne, W. and Dale, Trevor Clive ORCID: https://orcid.org/0000-0002-4880-9963 2010. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Research 70 (14) , pp. 5963-5973. 10.1158/0008-5472.CAN-10-1028

Odeh, H, Hunker, K. L., Belyantseva, I. A., Azaiez, H., Avenarius, M. R., Zheng, L. L., Peters, L. M., Gagnon, L. H., Hagiwara, N., Skynner, M. J., Brilliant, M. H., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Riazuddin, S., Johnson, K. R., Raphael, Y., Najmabadi, H., Friedman, T. B., Bartles, J. R., Smith, R. J. H. and Kohrman, D. C. 2010. Mutations in Grxcr1 Are The Basis for Inner Ear Dysfunction in the Pirouette Mouse. American Journal of Human Genetics 86 (2) , pp. 148-160. 10.1016/j.ajhg.2010.01.016

Wilkinson, William James, Gadeberg, H.C., Harrison, A. W. J., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Riccardi, Daniela ORCID: https://orcid.org/0000-0002-7322-3163 and Kemp, Paul J ORCID: https://orcid.org/0000-0003-2773-973X 2009. Carbon monoxide is a rapid modulator of recombinant and native P2X(2) ligand-gated ion channels. British Journal of Pharmacology 158 (3) , pp. 862-871. 10.1111/j.1476-5381.2009.00354.x

Kelly, Claire M, Precious, Sophie Victoria, Scherf, Caroline, Penketh, Richard, Amso, Nazar Najib ORCID: https://orcid.org/0000-0002-8646-6623, Battersby, Alysia Agnes, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 2009. Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression. Nature Methods 6 (4) , pp. 271-273. 10.1038/nmeth.1308

Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2009. Telomere length maintenance in stem cell populations. Biochimica et Biophysica Acta-Molecular Basis of Disease 1792 (4) , pp. 324-328. 10.1016/j.bbadis.2009.02.004

Patani, R., Compston, A., Puddifoot, C.A., Wyllie, D. J. A., Hardingham, G. E., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Chandran, S. 2009. Activin/nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. PLoS ONE 4 (10) , e7327. 10.1371/journal.pone.0007327

Bilican, B., Fiore-Heriche, C., Compston, A., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Chandran, S. 2008. Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level. PLoS ONE 3 (8) , e2863. 10.1371/journal.pone.0002863

Chandran, S, Caldwell, M and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2008. Introduction: stem cells and brain repair. Philosophical Transactions of the Royal Society B-Biological Sciences 363 ((1489)) , pp. 5-7. 10.1098/rstb.2006.2008

Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2008. Temporal and epigenetic regulation of neurodevelopmental plasticity. Philosophical Transactions of the Royal Society B - Biological Sciences 363 (1489) , pp. 23-28. 10.1098/rstb.2006.2010

Wilkinson, William J., Hanne, G., Harrison, Alexander William John, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Riccardi, Daniela ORCID: https://orcid.org/0000-0002-7322-3163 and Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X 2008. Carbon monoxide is a rapid modulator of recombinant and native P2X2 ligand-gated ion channels [Abstract]. Purinergic Signalling 4 (S1) , p. 26. 10.1007/s11302-008-9116-0

Battersby, Alysia, Jones, Robert D., Lilley, Kathryn S., McFarlane, Ramsay J., Braig, Henk R., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Wakeman, Jane A. 2007. Comparative proteomic analysis reveals differential expression of Hsp25 following the directed differentiation of mouse embryonic stem cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773 (2) , pp. 147-156. 10.1016/j.bbamcr.2006.08.030

Joannides, A. J., Webber, D. J., Raineteau, O., Kelly, Claire, Irvine, K.-A., Watts, C., Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Blakemore, W. F., Compston, A., Caldwell, M. A., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Chandran, S. 2007. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain 130 (5) , pp. 1263-1275. 10.1093/brain/awm070

Nikoletopoulou, Vassiliki, Plachta, Nicolas, Allen, Nicolas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Pinto, Luisa, Götz, Magdalena and Barde, Yves-Alain 2007. Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6. Cell Stem Cell 1 (5) , pp. 529-540. 10.1016/j.stem.2007.08.011

Bouhon, Isabelle A., Joannides, Alexis, Kato, Hidemasa, Chandran, Siddharthan and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2006. Embryonic stem cell derived neural progenitors display temporal restriction to neural patterning. Stem Cells 24 (8) , pp. 1908-1913. 10.1634/stemcells.2006-0031

Joannides, Alexis, Fiore-Hériché, Christelle, Westmore, Kristine, Caldwell, Maeve, Compston, Alastair, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Chandran, Siddharthan 2006. Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion. Stem Cells 24 (2) , pp. 230-235. 10.1634/stemcells.2005-0243

Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2006. Help for huntington's: stem cells for neurodegenerative disease. The Biochemist 28 , pp. 19-24.

Joannides, Alexis J., Fiore-Hériché, Christelle, Battersby, Alysia A., Athauda-Arachchi, Pandula, Bouhon, Isabelle A., Williams, Lydia, Westmore, Kristine, Kemp, Paul J. ORCID: https://orcid.org/0000-0003-2773-973X, Compston, Alastair, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and Chandran, Siddharthan 2006. A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Stem Cells 25 (3) , pp. 731-737. 10.1634/stemcells.2006-0562

Calo, Laura, Spillantini, Maria Grazia, Nicoletti, F. and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2005. Nurr1 co-localizes with EphB1 receptors in the developing ventral midbrain, and its expression is enhanced by the EphB1 ligand, ephrinB2. Journal of Neurochemistry 92 (2) , pp. 235-245. 10.1111/j.1471-4159.2004.02853.x

Bouhon, Isabelle A., Kato, Hidemasa, Chandran, Sidharthan and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2005. Neural differentiation of mouse embryonic stem cells in chemically defined medium. Brain Research Bulletin 68 (1-2) , pp. 62-75. 10.1016/j.brainresbull.2005.08.022

Stopps, M., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Barrett, R., Choudhury, H. I., Jarolimek, W., Johnson, M., Kuenzi, F. M., Maubach, K. A., Nagano, N. and Seabrook, G. R. 2004. Design and application of a novel brain slice system that permits independent electrophysiological recordings from multiple slices. Journal of Neuroscience Methods 132 (2) , pp. 137-148. 10.1016/j.jneumeth.2003.08.015

Odeh, Hana, Hagiwara, Nobuko, Skynner, Michael, Mitchem, Kristina L., Beyer, Lisa A., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Brilliant, Murray H., Lebart, M.C., Dolan, David F., Raphael, Yehoash and Kohrman, David C. 2004. Characterization of two transgene insertional mutations at pirouette, a mouse deafness locus. Audiology and Neuro-Otology 9 (5) , p. 303. 10.1159/000080701

Chandran, Siddharthan, Kato, Hidemasa, Gerreli, Dianne, Compston, Alastair, Svendsen, Clive N. and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2003. FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway. Development Vol 13 (26) , pp. 6599-6609. 10.1242/dev.00871

Ciani, Lorenza, Patel, Anjila, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X and ffrench-Constant, Charles 2003. Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype. Molecular and Cellular Biology 23 (10) , pp. 3575-3582. 10.1128/MCB.23.10.3575-3582.2003

Zou, Xiangang, Piper, Tony A., Smith, J. A., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Xian, Jian and Bruggemann, Marianne 2003. Block in development at the pre-B-II to immature B cell stage in mice without lgk and iga light chain. The Journal of Immunology 170 (3) , pp. 1354-1361.

Erven, Alexandra, Skynner, Michael J., Okumura, Katsuzumi, Takebayashi, Shin-ichiro, Brown, Steve D. M., Steel, Karen P. and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2002. A novel stereocilia defect in sensory hair cells of the deaf mouse mutant Tasmanian devil. European Journal of Neuroscience 16 (8) , pp. 1433-1441. 10.1046/j.1460-9568.2002.02213.x

Ma, Dan, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Van Bergen, Yfke C. H., Jones, Camilla M. E., Baum, Michael J., Keverne, E. Barry and Brennan, Peter A. 2002. Selective ablation of olfactory receptor neurons without functional impairment of vomeronasal receptor neurons in OMP-ntr transgenic mice. European Journal of Neuroscience 16 (12) , pp. 2317-2323. 10.1046/j.1460-9568.2002.02303.x

Isles, Anthony Roger ORCID: https://orcid.org/0000-0002-7587-5712, Baum, M. J., Ma, D., Szeto, A., Keverne, E. B. and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2002. A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice. Proceedings of the Royal Society B: Biological Sciences 269 (1492) , pp. 665-670. 10.1098/rspb.2001.1911

Mooslehner, K. A., Chan, P. M., Xu, W. M., Liu, L. Z., Smadja, C., Humby, Trevor ORCID: https://orcid.org/0000-0002-1840-1799, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Wilkinson, Lawrence Stephen ORCID: https://orcid.org/0000-0002-9337-6124 and Emson, P. C. 2001. Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism. Molecular and Cellular Biology 21 (16) , pp. 5321-5331. 10.1128/MCB.21.16.5321-5331.2001

Isles, Anthony Roger ORCID: https://orcid.org/0000-0002-7587-5712, Baum, Michael J., Ma, Dan, Keverne, Eric B. and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2001. Genetic imprinting: urinary odour preferences in mice. Nature 409 (6822) , pp. 783-784. 10.1038/35057323

Isles, Anthony Roger ORCID: https://orcid.org/0000-0002-7587-5712, Ma, Dan, Milsom, Chloe, Skynner, Michael J., Cui, Wei, Clark, John, Keverne, Eric B. and Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X 2001. Conditional ablation of neurones in transgenic mice. Journal of Neurobiology 47 (3) , pp. 183-193. 10.1002/neu.1026

Cui, Wei, Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Skynner, Michael, Gusterson, Barry and Clark, A. John 2001. Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain. Glia 34 (4) , pp. 272-282. 10.1002/glia.1061