ORCA
Online Research @ Cardiff
Browse by All Cardiff Authors
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Up a levelNumber of items: 103.
Dolton, Garry, Bulek, Anna, Wall, Aaron, Thomas, Hannah, Hopkins, Jade R, Rius, Cristina, Galloway, Sarah A.E., Whalley, Thomas, Tan, Li Rong, Morin, Theo, Omidvar, Nader, Fuller, Anna, Topley, Katie, Hasan, Samiul, Jain, Shika, D’Souza, Nirupa, Hodges-Hoyland, Tom, Spiller, Owen B.  ORCID: https://orcid.org/0000-0002-9117-6911, Kronenberg-Versteeg, Deborah, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, van den Berg, Hugo A., Jones, Lucy C. ORCID: https://orcid.org/0000-0002-3872-4376, Peakman, Mark, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2024.
HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes.
Journal of Clinical Investigation
134
(18)
, e164535.
10.1172/JCI164535
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Hulin-Curtis, Sarah, Geary, James, MacLachlan, Bruce, Altmann, Danny, Baillon, Laury, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Greenshields-Watson, Alex, Hesketh, Sophie, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Jones, Ian, Lauder, Sarah, Mason, Georgina, Smart, Kathryn, Scourfield, Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard ORCID: https://orcid.org/0000-0002-6799-1182, Wall, Aaron, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Barclay, Wendy, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567
2024.
A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.
Cell Reports
43
(6)
, 114259.
10.1016/j.celrep.2024.114259
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Bates, Emily A., Davies, James A. ORCID: https://orcid.org/0000-0003-3569-4500, Vánová, Jana, Nestic, Davor, Meniel, Valerie S., Koushyar, Sarah, Cunliffe, Tabitha G., Mundy, Rosie M., Moses, Elise, Uusi-Kerttula, Hanni K., Baker, Alexander T. ORCID: https://orcid.org/0000-0001-8232-0531, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Majhen, Dragomira, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Chester, John D. ORCID: https://orcid.org/0000-0002-7830-3840 and Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761
2022.
Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10.
Molecular Therapy - Oncolytics
25
, pp. 43-56.
10.1016/j.omto.2022.03.007
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Man, Stephen ORCID: https://orcid.org/0000-0001-9103-1686, Redman, James E. ORCID: https://orcid.org/0000-0001-5492-2869, Cross, Deborah L., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Can, Ilona, Davies, Bethan, Hashimdeen, Shaikh Shimaz, Reid, Reiss, Llewellyn-Lacey, Sian, Miners, Kelly L., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Lissina, Anya, Brown, Paul E., Wooldridge, Linda, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369
2021.
Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells.
The Journal of Immunology
207
(4)
, pp. 1009-1017.
10.4049/jimmunol.2000756
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Knezevic, Lea, Dockree, Tamsin, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bridgeman, John S., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, van den Berg, Hugo A. and Wooldridge, Linda
2021.
CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.
Proceedings of the National Academy of Sciences
118
(29)
, e2019639118.
10.1073/pnas.2019639118
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Lanz, Anna-Lisa, Masi, Giulia, Porciello, Nicla, Cohnen, André, Cipria, Deborah, Prakaash, Dheeraj, Bálint, Štefan, Raggiaschi, Roberto, Galgano, Donatella, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Lepore, Marco, Dushek, Omer, Dustin, Michael L., Sansom, Mark S.P., Kalli, Antreas C. and Acuto, Oreste
2021.
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation.
Cell Reports
36
(2)
, 109375.
10.1016/j.celrep.2021.109375
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MacLachlan, Bruce J., Mason, Georgina H., Greenshields Watson, Alexander, Triebel, Frederic, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567
2021.
Molecular characterization of HLA class II binding to the LAG-3 T cell co-inhibitory receptor.
European Journal of Immunology
51
(2)
, pp. 331-341.
10.1002/eji.202048753
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Hopkins, Jade R., Crean, Rory M., Catici, Dragana A. M., Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Arcus, Vickery L., Van der Kamp, Marc W., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Pudney, Christopher R.
2020.
Peptide cargo tunes a network of correlated motions in human leukocyte antigens.
FEBS Journal
287
(17)
, pp. 3777-3793.
10.1111/febs.15278
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Bovay, Amandine, Zoete, Vincent, Rizkallah, Pierre J ORCID: https://orcid.org/0000-0002-9290-0369, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Delbreil, Philippe, Speiser, Daniel E, Cole, David K ORCID: https://orcid.org/0000-0003-0028-9396 and Fuertes Marraco, Silvia A
2020.
Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b214-222 by combinatorial peptide library screening.
Molecular Immunology
125
, pp. 43-50.
10.1016/j.molimm.2020.06.025
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Saeed, Mesha, Schooten, Erik, van Brakel, Mandy, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, ten Hagen, Timo L. M. and Debets, Reno
2020.
T Cells expressing a TCR-like antibody selected against the heteroclitic variant of a shared MAGE-A epitope do not recognise the cognate epitope.
Cancers
12
(5)
, 1255.
10.3390/cancers12051255
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Holland, Christopher J., Crean, Rory M., Pentier, Johanne M., de Wet, Ben, Lloyd, Angharad, Srikannathasan, Velupillai, Lissin, Nikolai, Lloyd, Katy A., Blicher, Thomas H., Conroy, Paul J., Hock, Miriam, Pengelly, Robert J., Spinner, Thomas E., Cameron, Brian, Potter, Elizabeth A., Jeyanthan, Anitha, Molloy, Peter E., Sami, Malkit, Aleksic, Milos, Liddy, Nathaniel, Robinson, Ross A., Harper, Stephen, Lepore, Marco, Pudney, Chris R., van der Kamp, Marc W., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Jakobsen, Bent K., Vuidepot, Annelise and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396
2020.
Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA.
Journal of Clinical Investigation
130
(5)
, 2673–2688.
10.1172/JCI130562
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Whalley, Thomas, Dolton, Garry, Brown, Paul E., Wall, Aaron, Wooldridge, Linda, van den Berg, Hugo, Fuller, Anna, Hopkins, Jade R., Crowther, Michael D., Attaf, Meriem, Knight, Robin R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533
2020.
GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope.
Frontiers in Immunology
11
, 296.
10.3389/fimmu.2020.00296
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Bagaev, Dmitry V, Vroomans, Renske M A, Samir, Jerome, Stervbo, Ulrik, Rius, Cristina, Dolton, Garry, Greenshields Watson, Alexander, Attaf, Meriem, Egorov, Evgeny S, Zvyagin, Ivan V, Babel, Nina, Cole, David K ORCID: https://orcid.org/0000-0003-0028-9396, Godkin, Andrew J ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Kesmir, Can, Chudakov, Dmitriy M, Luciani, Fabio and Shugay, Mikhail
2020.
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium.
Nucleic Acids Research
48
(D1)
, D1057-D1062.
10.1093/nar/gkz874
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MacLachlan, Bruce J., Dolton, Garry, Papakyriakou, Athanasios, Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea, Besneux, Matthieu, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Elliott, Tim, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567
2019.
Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.
Journal of Biological Chemistry
294
(52)
, pp. 20246-20258.
10.1074/jbc.RA119.009437
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Madura, Florian, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E. Joel, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2019.
TCR-induced alteration of primary MHC peptide anchor residue.
European Journal of Immunology
49
(7)
, pp. 1052-1066.
10.1002/eji.201948085
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Galloway, Sarah A. E., Dolton, Garry, Attaf, Meriem, Wall, Aaron, Fuller, Anna, Rius, Cristina, Bianchi, Valentina, Theaker, Sarah, Lloyd, Angharad, Caillaud, Marine E., Svane, Inge Marie, Donia, Marco, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2019.
Peptide super-agonist enhances T-cell responses to melanoma.
Frontiers in Immunology
10
, 319.
10.3389/fimmu.2019.00319
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Baker, Alexander T. ORCID: https://orcid.org/0000-0001-8232-0531, Greenshields-Watson, Alexander, Coughlan, Lynda, Davies, James A. ORCID: https://orcid.org/0000-0003-3569-4500, Uusi-Kerttula, Hanni, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761
2019.
Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions.
Nature Communications
10
, 741.
10.1038/s41467-019-08599-y
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Tungatt, Katie, Dolton, Garry, Morgan, Sophie B., Attaf, Meriem, Fuller, Anna, Whalley, Thomas, Hemmink, Johanneke D., Porter, Emily, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Montoya, Maria, Hammond, John A., Miles, John J., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Townsend, Alain, Bailey, Mick, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Charleston, Bryan, Tchilian, Elma and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2018.
Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.
PLoS Pathogens
14
(5)
, e1007017.
10.1371/journal.ppat.1007017
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Holland, Christopher J., MacLachlan, Bruce J., Bianchi, Valentina, Hesketh, Sophie J., Morgan, Richard, Vickery, Owen, Bulek, Anna M., Fuller, Anna, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wells, Stephen and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396
2018.
In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility.
Frontiers in Immunology
9
, 674.
10.3389/fimmu.2018.00674
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Bovay, Amandine, Zoete, Vincent, Dolton, Garry, Bulek, Anna M., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Fuller, Anna, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Michielin, Olivier, Speiser, Daniel E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Fuertes Marraco, Silvia A.
2018.
T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.
European Journal of Immunology
48
(2)
, pp. 258-272.
10.1002/eji.201747082
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Maciocia, Paul M., Wawrzyniecka, Patrycja A., Philip, Brian, Ricciardelli, Ida, Akarca, Ayse U., Onuoha, Shimobi C., Legut, Mateusz, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gritti, Giuseppe, Somja, Joan, Piris, Miguel A., Peggs, Karl S., Linch, David C., Marafioti, Teresa and Pule, Martin A.
2017.
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Nature Medicine
23
, pp. 1416-1423.
10.1038/nm.4444
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Lori, Madura, Florian, Holland, Christopher J., Bulek, Anna M., Bridgeman, John S., Miles, John J., Schauenburg, Andrea J. A., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Evavold, Brian D., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2017.
Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope.
Frontiers in Immunology
8
, 1503.
10.3389/fimmu.2017.01503
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Jones, Nicholas, Cronin, James G., Dolton, Garry, Panetti, Silvia, Schauenburg, Andrea, Galloway, Sarah A. E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Thornton, Catherine A. and Francis, Nigel J. ORCID: https://orcid.org/0000-0002-4706-4795
2017.
Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation.
Frontiers in Immunology
8
, 1516.
10.3389/fimmu.2017.01516
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Fuller, Anna, Wall, Aaron, Crowther, Michael D., Lloyd, Angharad, Zhurov, Alexei ORCID: https://orcid.org/0000-0002-5594-0740, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484
2017.
Thermal stability of heterotrimeric pMHC proteins as determined by circular dichroism spectroscopy.
Bio-protocol
7
(13)
, -.
10.21769/BioProtoc.2366
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MacLachlan, Bruce J., Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea J., Bianchi, Valentina, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Fuller, Anna and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396
2017.
Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens.
Journal of Visualized Experiments
(120)
, e54991.
10.3791/54991
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, van den Berg, Hugo A., Lloyd, Angharad, Crowther, Michael D., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Ekeruche-Makinde, Julia, Miles, John J., Bulek, Anna M., Dolton, Garry, Schauenburg, Andrea J., Wall, Aaron, Fuller, Anna, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Laugel, Bruno, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2017.
Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase.
Journal of Biological Chemistry
292
(3)
, pp. 802-813.
10.1074/jbc.M116.741603
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Bulek, Anna M., Dolton, Garry, Schauenberg, Andrea J., Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Rittase, William, Trimby, Andrew, Jothikumar, Prithiviraj, Fuller, Anna, Skowera, Ania, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Zhu, Cheng, Miles, John J., Peakman, Mark, Wooldridge, Linda, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2016.
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
Journal of Clinical Investigation
126
(6)
, pp. 2191-2204.
10.1172/JCI85679
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Bianchi, Valentina, Bulek, Anna, Fuller, Anna, Lloyd, Angharad, Attaf, Meriem, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Dolton, Garry, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396
2016.
A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen.
Journal of Biological Chemistry
291
(17)
, pp. 8951-8959.
10.1074/jbc.M115.707414
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Theaker, Sarah M., Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Greenshields-Watson, Alexander, Lloyd, Angharad, Trimby, Andrew R., Fuller, Anna, Miles, John James, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Dolton, Garry Michael
2016.
T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones.
Journal of Immunological Methods
430
, pp. 43-50.
10.1016/j.jim.2016.01.014
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Jones, Kimberley, Wockner, Leesa, Brennan, Rebekah M., Keane, Colm, Chattopadhyay, Pratip K., Roederer, Mario, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Hassan, Brekhna, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Gottlieb, David, Ritchie, David S., Seymour, John F., Vari, Frank, Crooks, Pauline, Burrows, Scott R. and Gandhi, Maher K.
2016.
The impact of HLA-class I and EBV-latency-II antigen-specific CD8+T-cells on the pathogenesis of EBV+ Hodgkin Lymphoma.
Clinical and Experimental Immunology
183
(2)
, pp. 206-220.
10.1111/cei.12716
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Raman, Marine C. C., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Simmons, Ruth, Donnellan, Zoe, Dukes, Joseph, Bossi, Giovanna, Le Provost, Gabrielle S., Todorov, Penio, Baston, Emma, Hickman, Emma, Mahon, Tara, Hassan, Namir, Vuidepot, Annelise, Sami, Malkit, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Jakobsen, Bent K.
2016.
Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Scientific Reports
6
, 18851.
10.1038/srep18851
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Tsai, M.-H., Muenchhoff, M., Adland, E., Carlqvist, A., Roider, J., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Carlson, J., Ndung'u, T. and Goulder, P. J. R.
2016.
Paediatric non-progression following grandmother-to-child HIV transmission.
Retrovirology
13
(1)
, p. 65.
10.1186/s12977-016-0300-y
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Dolton, Garry Michael, Tungatt, Katie, Lloyd, Angharad, Bianchi, Valentina, Theaker, Sarah M., Trimby, Andrew R., Holland, Christopher J., Donia, Marco, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Straten, Per Thor, Peakman, Mark, Svane, Inge Marie and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2015.
More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers.
Immunology
146
(1)
, pp. 11-22.
10.1111/imm.12499
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Wynn, Katherine, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Miles, John James, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2010.
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.
The Journal of Immunology
185
(4)
, pp. 2600-2610.
10.4049/jimmunol.1000629
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Wooldridge, Linda, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Lissina, Anna, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Hewitt, R. E., Laugel, Bruno Frederic, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Debets, R., Berrevoets, C., Miles, John James, Burrows, S. R., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2010.
MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
Journal of Immunology
184
(7)
, pp. 3357-3366.
10.4049/jimmunol.0902398
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Miles, John James, Bulek, Anna Marta, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gostick, Emma, Schauenburg, Andrea J. A., Dolton, Garry Michael, Venturi, Vanessa, Davenport, Miles P., Tan, Mai Ping, Burrows, Scott R., Wooldridge, Linda, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2010.
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.
PLoS Pathogens
6
(11)
, e1001198.
10.1371/journal.ppat.1001198
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Borbulevych, Oleg Y., Piepenbrink, Kurt H., Gloor, Brian E., Scott, Daniel R., Sommese, Ruth F., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Baker, Brian M.
2009.
T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.
Immunity
31
(6)
, pp. 885-896.
10.1016/j.immuni.2009.11.003
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Hoffman, M., Hickling, Steven, Filby, A., Wilburg, C., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Turner, A., Sims, S., McLean, Andrew, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Klenerman, P., Frater, J. and Phillips, R. E.
2009.
Novel tetramer technology for the detection of high affinity CD8 T cells [Conference poster abstract].
Retrovirology
6
(S3)
, P409.
10.1186/1742-4690-6-S3-P409
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Yuan, Fang, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Miles, John James, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Gao, George F., Jakobsen, Bent K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2009.
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
Journal of Biological Chemistry
284
(40)
, 27281-27289.
10.1074/jbc.M109.022509
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Choudhuri, K., Parker, M., Milicic, A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Shaw, M. K., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Stewart-Jones, G., Dong, T., Gould, K. G. and van der Merwe, P. A.
2009.
Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation.
Journal of Biological Chemistry
284
(38)
, pp. 26096-26105.
10.1074/jbc.M109.039966
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Horlock, Claire, Stott, Bryony, Dyson, Julian, Ogg, Graham, McPherson, Tess, Jones, Louise, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Stebbing, Justin and Savage, Philip
2009.
ELISPOT and functional T cell analyses using HLA mono-specific target cells.
Journal of Immunological Methods
350
(1-2)
, pp. 150-160.
10.1016/j.jim.2009.08.011
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Wooldridge, Linda, Lissina, Anna, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, van den Berg, Hugo A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2009.
Tricks with tetramers: how to get the most from multimeric peptide-MHC.
Immunology
126
(2)
, pp. 147-164.
10.1111/j.1365-2567.2008.02848.x
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Varela-Rohena, Angel, Molloy, Peter E., Dunn, Steven M., Li, Yi, Suhoski, Megan M., Carroll, Richard G., Milicic, Anita, Mahon, Tara, Sutton, Deborah H., Laugel, Bruno, Moysey, Ruth, Cameron, Brian J., Vuidepot, Annelise, Purbhoo, Marco A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Phillips, Rodney E., June, Carl H., Jakobsen, Bent K., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Riley, James L.
2008.
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.
Nature Medicine
14
(12)
, pp. 1390-1395.
10.1038/nm.1779
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Melenhorst, J. Joseph, Scheinberg, Phillip, Chattopadhyay, Pratip K., Lissina, Anna, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Wooldridge, Linda, van den Berg, Hugo A., Bornstein, Ethan, Hensel, Nancy F., Douek, Daniel C., Roederer, Mario, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Barrett, A. John and Price, David ORCID: https://orcid.org/0000-0001-9416-2737
2008.
Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers.
Journal of Immunological Methods
338
(1-2)
, pp. 31-39.
10.1016/j.jim.2008.07.008
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Dunn, Steven M., Sami, Malkit, Boulter, Jonathan M., Jakobsen, Bent K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2008.
T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding.
Molecular Immunology
45
(9)
, pp. 2700-2709.
10.1016/j.molimm.2007.12.009
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Laugel, Bruno Frederic, Berg, Hugo A. van den, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Wooldridge, Linda, Boulter, Jonathan M, Milicic, Anita, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135
2007.
Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotxic T lymphocyte activation and tetramer properties.
The Journal of Biological Chemistry
282
(33)
, pp. 23799-22810.
10.1074/jbc.M700976200
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Pumphrey, Nicholas J., Boulter, Jonathan M., Sami, Malkit, Bell, John I., Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Gao, George F., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Jakobsen, Bent K.
2007.
Human TCR-binding affinity is governed by MHC class restriction.
The Journal of Immunology
178
(9)
, pp. 5727-5734.
10.4049/jimmunol.178.9.5727
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Boulter, Jonathan M., Sami, Malkit, Vuidepot, Anne-lise, Glick, Meir, Gao, Feng, Bell, John I., Jakobsen, Bent K. and Gao, George F.
2007.
Computational design and crystal structure of an enhanced affinity mutant human CD8 αα coreceptor.
Proteins: Structure, Function and Bioinformatics
67
(1)
, pp. 65-74.
10.1002/prot.21176
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Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Hutchinson, Sarah L., Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno Frederic, Lissina, A., Oxenius, Annette, Boulter, Jonathan M., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135
2007.
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor.
European Journal of Immunology
37
(2)
, pp. 479-486.
10.1002/eji.200636243
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Gao, Feng, Watson, Neil I., Boulter, Jonathan M., Bell, John I., Sami, Malkit, Gao, George F. and Jakobsen, Bent K.
2006.
Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
European Journal of Immunology
36
(1)
, pp. 170-179.
10.1002/eji.200535424
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Wang, H. W., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Jiang, W. Z., Jin, H. T., Fu, N., Chen, Z. L. and Jin, N. Y.
2005.
Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120.
Clinical and Experimental Immunology
141
(1)
, pp. 72-80.
10.1111/j.1365-2249.2005.02826.x
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Sami, Malkit, Lissin, Nikolai M., Gao, Feng, Bell, John I., Boulter, Jonathan M., Glick, Meir, Vuidepot, Anne-Lise, Jakobsen, Bent K. and Gao, George F.
2005.
Crystallization and preliminary X-ray structural studies of a high-affinity CD8αα co-receptor to pMHC.
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
61
(3)
, pp. 285-287.
10.1107/S1744309105002988
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Xu, Yanhui, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Lou, Zhiyong, Liu, Yiwei, Qin, Lan, Li, Xu, Bai, Zhihong, Yuan, Fang, Rao, Zihe and Gao, George F.
2004.
Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein.
Protein Expression and Purification
38
(1)
, pp. 116-122.
10.1016/j.pep.2004.08.005
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Wang, Xiaojia, Xu, Yanhui, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Lou, Zhiyong, Liu, Yiwei, Rao, Zihe, Wang, Ming and Gao, George F.
2004.
Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein.
Acta Crystallographica Section D: Biological Crystallography
60
(9)
, pp. 1632-1635.
10.1107/S0907444904015872
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Zhou, Minghai, Xu, Yanhui, Lou, Zhiyong, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Li, Xiaojuan, Liu, Yiwei, Tien, Po, Rao, Zihe and Gao, George F.
2004.
Complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2Kd complexed with an HBV-core nonapeptide.
Acta Crystallographica Section D: Biological Crystallography
60
(8)
, pp. 1473-1475.
10.1107/S0907444904013587
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Yan, Huimin, Xiao, Gengfu, Zhang, Jiamin, Hu, Yuanyang, Yuan, Fang, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Zheng, Congyi and Gao, George F.
2004.
SARS coronavirus induces apoptosis in Vero E6 Cells.
Journal of Medical Virology
73
(3)
, pp. 323-331.
10.1002/jmv.20094
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Zhu, Jieqing, Xiao, Gengfu, Xu, Yanhui, Yuan, Fang, Zheng, Congyi, Liu, Yueyong, Yan, Huimin, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Bell, John I., Rao, Zihe, Tien, Po and Gao, George F.
2004.
Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors.
Biochemical and Biophysical Research Communications
319
(1)
, pp. 283-288.
10.1016/j.bbrc.2004.04.141
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Xu, Yanhui, Lou, Zhiyong, Liu, Yiwei, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Su, Nan, Qin, Lan, Li, Xu, Bai, Zhihong, Rao, Zihe and Gao, George F.
2004.
Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus.
Acta Crystallographica Section D: Biological Crystallography
60
(6)
, pp. 1161-1164.
10.1107/S0907444904009515
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Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Gao, George F.
2004.
CD8: adhesion molecule, co-receptor and immuno-modulator [Review].
Cellular and Molecular Immunology
1
(2)
, pp. 81-88.
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Xu, Yanhui, Gao, Shan, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Zhu, Junjie, Su, Nan, Wang, Hui, Gao, George F. and Rao, Zihe
2004.
Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses.
Biochemical and Biophysical Research Communications
315
(3)
, pp. 664-670.
10.1016/j.bbrc.2004.01.115
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Xu, Yanhui, Zhu, Jieqing, Liu, Yiwei, Lou, Zhiyong, Yuan, Fang, Liu, Yueyong, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Ni, Ling, Su, Nan, Qin, Lan, Li, Xu, Bai, Zhihong, Bell, John I., Pang, Hai, Tien, Po, Gao, George F. and Rao, Zihe
2004.
Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus.
Biochemistry
43
(44)
, pp. 14064-14071.
10.1021/bi049101q
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