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Number of items: 51.

Amratia, Pragati S., Kerr-Jones, Lauren E., Chapman, Lucy, Marsden, Morgan, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Stanton, Richard J. ORCID: https://orcid.org/0000-0002-6799-1182 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2024. Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection. mBio 15 (8) , e03152-23. 10.1128/mbio.03152-23
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Whiteside, Sarah K., Grant, Francis M., Alvisi, Giorgia, Clarke, James, Tang, Leqi, Imianowski, Charlotte J., Zhang, Baojie, Evans, Alexander C., Wesolowski, Alexander J., Conti, Alberto G., Yang, Jie, Lauder, Sarah N., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Dooley, James, Burton, Oliver, Liston, Adrian, Alloisio, Marco, Voulaz, Emanuele, Langhorne, Jean, Okkenhaug, Klaus, Lugli, Enrico and Roychoudhuri, Rahul 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8 (90) , eabo5558. 10.1126/sciimmunol.abo5558
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281 2023. The association of microbial infection and adaptive immune cell activation in Alzheimer's disease. Discovery Immunology 2 (1) , kyad015. 10.1093/discim/kyad015
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Knezevic, Lea, Wachsmann, Tassilo L.A., Francis, Ore, Dockree, Tamsin, Bridgeman, John S., Wouters, Anne, de Wet, Ben, Cole, David K., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, McLaren, James E., Gostick, Emma, Ladell, Kristin, Llewellyn-Lacey, Sian, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, van den Berg, Hugo A., Tabi, Zsuzsanna, Sessions, Richard B., Heemskerk, Mirjam H.M. and Wooldridge, Linda 2023. High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs. Journal of Biological Chemistry 299 (8) , 104981. 10.1016/j.jbc.2023.104981
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L, Marsden, Morgan, Chapman, Lucy, Cardus Figueras, Anna, Scott, Jake, Andrews, Robert, Clare, Simon, Kriukova, Valeriia V, Lupyr, Ksenia R, Britanova, Olga V, Withers, David R, Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Chudakov, Dmitriy M, Price, David A ORCID: https://orcid.org/0000-0001-9416-2737 and Humphreys, Ian R ORCID: https://orcid.org/0000-0002-9512-5337 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12 , e79165. 10.7554/eLife.79165
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Clement, M. ORCID: https://orcid.org/0000-0002-9280-5281, Forbester, J. L., Marsden, M., Sabberwal, P., Sommerville, M. S., Wellington, D., Dimonte, S., Clare, S., Harcourt, K., Yin, Z., Nobre, L., Antrobus, R., Jin, B., Chen, M., Makvandi-Nejad, S., Lindborg, J. A., Strittmatter, S. M., Weekes, M. P., Stanton, R. J. ORCID: https://orcid.org/0000-0002-6799-1182, Dong, T. and Humphreys, I. R. ORCID: https://orcid.org/0000-0002-9512-5337 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13 (1) , 5294. 10.1038/s41467-022-32587-4
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Dimonte, Sandra, Gimeno-Brias, Silvia, Marsden, Morgan, Chapman, Lucy, Sabberwal, Pragati, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2021. Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses. Immunology 164 (2) , pp. 279-291. 10.1111/imm.13368
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Forbester, Jessica, Marsden, Morgan, Sabberwal, Pragati, Wellington, Danielle, Dimonte, Sandra, Clare, Simon, Harcourt, Katherine, Yin, Zixi, Nobre, Luis, Antrobus, Robin, Jin, Boquan, Chen, Meixin, Makvandi-Nejad, Shokouh, Lindborg, Jane, Strittmatter, Stephen, Weekes, Michael, Stanton, Richard ORCID: https://orcid.org/0000-0002-6799-1182, Dong, Tao and Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.07.23.453513

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Knezevic, Lea, Dockree, Tamsin, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bridgeman, John S., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, van den Berg, Hugo A. and Wooldridge, Linda 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118 (29) , e2019639118. 10.1073/pnas.2019639118
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Forbester, Jessica L., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wellington, Dannielle, Yeung, Amy, Dimonte, Sandra, Marsden, Morgan, Chapman, Lucy, Coomber, Eve L., Tolley, Charlotte, Lees, Emily, Hale, Christine, Clare, Simon, Udalova, Irina, Dong, Tao, Dougan, Gordon and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2020. IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models. Journal of Virology 94 (9) , e00121-20. 10.1128/JVI.00121-20
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Thompson, Aiysha, Davies, Luke C., Liao, Chia-Te, da Fonseca, Diogo M., Griffiths, James S., Andrews, Robert, Jones, Adam V., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Brown, Gordon D., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 and Orr, Selinda J. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15 (6) , e1007850. 10.1371/journal.ppat.1007850
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Smith, S. E., Busse, D. C., Binter, S., Weston, S., Diaz Soria, C., Laksono, B. M., Clare, S., Van Nieuwkoop, S., Van den Hoogen, B. G., Clement, M. ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, M., Humphreys, I. R. ORCID: https://orcid.org/0000-0002-9512-5337, Marsh, M., de Swart, R. L., Wash, R. S., Tregoning, J. S. and Kellam, P. 2019. Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane. Journal of Virology 93 (6) , e02003-18. 10.1128/JVI.02003-18
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McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Miners, Kelly L., Llewellyn-Lacey, Sian, Grant, Emma J., Rubina, Anzelika, Gimeno Brias, Silvia, Gostick, Emma, Stacey, Maria A., Orr, Selinda J., Stanton, Richard J. ORCID: https://orcid.org/0000-0002-6799-1182, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (3) , pp. 943-955. 10.4049/jimmunol.1701757
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2019. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Frontiers in Immunology 10 , 78. 10.3389/fimmu.2019.00078
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Gimeno Brias, Silvia, Marsden, Morgan, Forbester, Jessica, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Brandt, Cordelia, Harcourt, Katherine, Kane, Leanne, Chapman, Lucy, Clare, Simon and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2018. Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PLoS ONE 13 (5) , e0197596. 10.1371/journal.pone.0197596
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Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Makinde, Julia, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Gras, Stephanie, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Burrows, Scott R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4) , pp. 1569-1580. 10.1172/JCI91512
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Lissina, Anna, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ilander, Mette, Andersson, Emma I., Lewis, Catherine S., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Herman, Andrew, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Llewellyn-Lacey, Sian, Miners, Kelly L., Gostick, Emma, Melenhorst, J. Joseph, Barrett, A. John, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Mustjoki, Satu and Wooldridge, Linda 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8 (1) , 2534. 10.1038/s41598-017-18062-x
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Sowerby, John M., Thomas, David C., Clare, Simon, Espéli, Marion, Guerrero, Jose A., Hoenderdos, Kim, Harcourt, Katherine, Marsden, Morgan, Abdul-Karim, Juneid, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Antrobus, Robin, Umrania, Yagnesh, Barton, Philippa R., Flint, Shaun M., Juss, Jatinder K., Condliffe, Alison M., Lyons, Paul A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Chilvers, Edwin R., Ouwehand, Willem H., Dougan, Gordon and Smith, Kenneth G. C. 2017. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation 127 (9) , pp. 3521-3526. 10.1172/JCI91684
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Stacey, Maria A., Clare, Simon, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Abdul-Karim, Juneid, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Fielding, Ceri A. ORCID: https://orcid.org/0000-0002-5817-3153, Smith, Sarah E., Wash, Rachael S., Gimeno Brias, Silvia, Stack, Gabrielle, Notley, George, Cambridge, Emma L., Isherwood, Christopher, Speak, Anneliese O., Johnson, Zoe, Ferlin, Walter, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Kellam, Paul and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127 (4) , pp. 1463-1474. 10.1172/JCI84889
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, van den Berg, Hugo A., Lloyd, Angharad, Crowther, Michael D., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Ekeruche-Makinde, Julia, Miles, John J., Bulek, Anna M., Dolton, Garry, Schauenburg, Andrea J., Wall, Aaron, Fuller, Anna, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Laugel, Bruno, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292 (3) , pp. 802-813. 10.1074/jbc.M116.741603
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Dockree, Tamsin, Holland, Christopher J., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Van Den Berg, Hugo A., Gostick, Emma, Llewellyn-Lacey, Sian, Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686, Bailey, Mick, Burrows, Scott, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Wooldridge, Linda 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95 (1) , pp. 68-76. 10.1038/icb.2016.85
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Stacey, Maria, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana Filipa, Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Weaver, Casey, Carlesso, Gianluca, Clare, Simon, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Jones, Gareth W. and Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) , e1006050. 10.1371/journal.ppat.1006050
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Gras, Stephanie, Van den berg, Hugo, Lissina, Anya, Llewellyn-Lacey, Sian, Willis, Mark ORCID: https://orcid.org/0000-0003-3024-6063, Dockree, Tamsin, McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Ekeruche-Makinde, Julia, Gostick, Emma, Robertson, Neil ORCID: https://orcid.org/0000-0002-5409-4909, Burrows, Scott, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Peakman, Mark, Skowera, Ania and Wooldridge, Linda 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6 , 35332. 10.1038/srep35332
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Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Liu, Jie, Brown, Paul E., Miles, John J., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Llewellyn-Lacey, Sian, Dolton, Garry, Ekeruche-Makinde, Julia, Lissina, Anya, Schauenburg, Andrea J., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Burrows, Scott R., Roederer, Mario, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and van den Berg, Hugo A. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94 (6) , pp. 573-582. 10.1038/icb.2016.12
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Patin, Emmanuel, Jones, Adam V., Thompson, Aiysha, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Liao, Chia-Te, Griffiths, James S., Wallace, Leah, Bryant, Clare E., Lang, Roland, Rosenstiel, Philip, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Jones, Gareth Wyn and Orr, Selinda Jane 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197 (1) , pp. 208-221. 10.4049/jimmunol.1501204
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Neller, Michelle A., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Matthews, Katherine K., Gostick, Emma, Pentier, Johanne, Dolton, Garry Michael, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly Louise, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, van Baarle, Debbie, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Miles, John James 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp. 625-633. 10.1038/icb.2015.17
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Lauder, Sarah Nicol, Jones, Emma, Smart, Kathryn, Bloom, Anja Constanze, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hindley, James P., Ondondo, Beatrice, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43 (10) , pp. 2613-2625. 10.1002/eji.201243018
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van den Berg, Hugo A., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly, Laugel, Bruno, Llewellyn-Lacey, Sian, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gostick, Emma, Wooldridge, Linda, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bridgeman, John S. and Price, David ORCID: https://orcid.org/0000-0001-9416-2737 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4 , 250. 10.3389/fimmu.2013.00250
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Eukeruche-Makinde, Julia, Miles, John J., Van Den Berg, Hugo A., Skowera, Ania, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Dolton, Garry Michael, Schauenburg, Andrea, Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim M., Bulek, Anna, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Dockree, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Burrows, Scott, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Ekeruche, Julia, Miles, John James, van den Berg, Hugo A., Skowera, Ania, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Dolton, Garry Michael, Schauenburg, Andrea J. A., Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim Michelle, Bulek, Anna Marta, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Williams, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Burrows, Scott R., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281 2013. The role of the CD8 co-receptor in CD8+ T-cell activation. PhD Thesis, Cardiff University.
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Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Wooldridge, Linda, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575

Ekeruche-Makinde, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409
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Ekeruche, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John James, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry Michael, Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Laugel, Bruno, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2) , pp. 139-148. 10.1111/j.1365-2567.2012.03625.x

Wooldridge, Linda, Ekeruche, Julia, van den Berg, Hugo A., Skowera, Anna, Miles, John James, Tan, Mai Ping, Dolton, Garry Michael, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Llewellyn-Lacey, Sian, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Peakman, Mark and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287 (2) , pp. 1168-1177. 10.1074/jbc.M111.289488
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Iglesias, M. C., Almeida, J. R., Fastenackels, S., van Bockel, D. J., Hashimoto, M., Venturi, V., Gostick, E., Urrutia, A., Wooldridge, L., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Gras, S., Wilmann, P. G., Autran, B., Moris, A., Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Davenport, M. P., Takiguchi, M., Brander, C., Douek, D. C., Kelleher, A. D., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Appay, V. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118 (8) , pp. 2138-2149. 10.1182/blood-2011-01-328781

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Miles, John James, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Laugel, Bruno Frederic, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wooldridge, Linda, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90 (6) , pp. 1089-1099. 10.1189/jlb.0611316

Iglesias, Maria Candela, Almeida, Jorge R., Fastenackels, Solene, van Bockel, David J., Hashimoto, Masao, Venturi, Vanessa, Gostick, Emma, Urrutia, Alejandra, Wooldridge, Linda, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Gras, Stephanie, Wilmann, Pascal G., Autran, Brigitte, Moris, Arnaud, Rossjohn, Jamie, Davenport, Miles P., Takiguchi, Masafumi, Brander, Christian, Douek, Daniel C., Kelleher, Anthony D., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Appay, Victor 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118 (8) , pp. 2138-2149. 10.1182/blood-2011-01-328781

Li, Na, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Michael, Daryn Robert, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153 and Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 2010. ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages. The Journal of Immunology 185 (5) , pp. 3041-3048. 10.4049/jimmunol.1000993

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Wynn, Katherine, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Miles, John James, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185 (4) , pp. 2600-2610. 10.4049/jimmunol.1000629

Wooldridge, Linda, Laugel, Bruno Frederic, Ekeruche, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, van den Berg, Hugo A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. CD8 controls T cell cross-reactivity. The Journal of Immunology 185 (8) , pp. 4625-4632. 10.4049/jimmunol.1001480

Wooldridge, Linda, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Lissina, Anna, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Hewitt, R. E., Laugel, Bruno Frederic, Gostick, Emma, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Debets, R., Berrevoets, C., Miles, John James, Burrows, S. R., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184 (7) , pp. 3357-3366. 10.4049/jimmunol.0902398

Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Shore, Angharad M., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Hewamana, Saman, Jones, Catrin M., Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Pepper, Christopher John and Brewis, Ian Andrew 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3 (3) , pp. 359-369. 10.1002/prca.200800137

Lissina, Anna, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Skowera, Ania, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Seggewiss, Ruth, van den Berg, Hugo A., Gostick, Emma, Gallagher, Kathleen, Jones, Emma, Melenhorst, J. Joseph, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Peakman, Mark, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340 (1) , pp. 11-24. 10.1016/j.jim.2008.09.014
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Hewamana, Saman, Alghazal, Suhair Alkailani, Lin, Thet Thet, Clement, Matthew ORCID: https://orcid.org/0000-0002-9280-5281, Jenkins, Christopher, Guzman, Monica L., Jordan, Craig T., Neelakantan, Sundar, Crooks, Peter A., Burnett, Alan Kenneth, Pratt, Guy, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Rowntree, Clare, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 and Pepper, Christopher John 2008. The NF-κB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood 111 (9) , pp. 4681-4689. 10.1182/blood-2007-11-125278

Weichsel, Ralf, Dix, Carolin, Wooldridge, Linda, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Fenton-May, Angharad, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Zezula, Josef, Greiner, Elizabeth, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Einsele, Hermann and Seggewiss, Ruth 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Research 14 (8) , pp. 2484-2491. 10.1158/1078-0432.CCR-07-4393

White, Paul Charles ORCID: https://orcid.org/0000-0002-6562-4696, Shore, A. M., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Soeiro, I., Lam, E. W.-F. and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 2006. Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene 25 (15) , pp. 2170-2180. 10.1038/sj.onc.1209255

Breslin, Elaine M., White, Paul ORCID: https://orcid.org/0000-0002-6562-4696, Shore, Angharad M., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281 and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 2005. LY294002 and rapamycin co-operate to inhibit T-cell proliferation. British Journal of Pharmacology 144 (6) , pp. 791-800. 10.1038/sj.bjp.0706061

Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Preece, Anna Charlotte, Morris, D. W., Spurlock, Gillian, Bray, Nicholas John ORCID: https://orcid.org/0000-0002-4357-574X, Stephens, Mark Keith, Norton, Nadine ORCID: https://orcid.org/0000-0002-3848-4288, Williams, Hywel John ORCID: https://orcid.org/0000-0001-7758-0312, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Dwyer, Sarah Lynne, Curran, Catherine, Wilkinson, Jennifer Camilla, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Waddington, J. L., Gill, M., Corvin, A. P., Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 2004. Identification in two independent samples of a novel schizophrenia risk haplotype of the dystobrevin binding protein gene (DTNBP1). Archives of general psychiatry 61 (4) , pp. 336-344. 10.1001/archpsyc.61.4.336

This list was generated on Thu Mar 13 07:22:06 2025 GMT.


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