ORCA
Online Research @ Cardiff
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Up a levelNumber of items: 132.
Raju, Vidya, Reddy, Revanth, Javan, Arzhang Cyrus, Hajihossainlou, Behnam, Weissleder, Ralph, Guiseppi-Elie, Anthony, Kurabayashi, Katsuo, Jones, Simon A.  ORCID: https://orcid.org/0000-0001-7297-9711 and Faghih, Rose T.
2025.
Tracking inflammation status for improving patient prognosis: A review of current methods, unmet clinical needs and opportunities.
Biotechnology Advances
82
, 108592.
10.1016/j.biotechadv.2025.108592
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Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Tyrrell, Victoria J., Burston, James J., Johnson, Sam R. C., Aldrovandi, Maceler, Alvarez-Jarreta, Jorge, Inglis, Rossa, Leonard, Adam, Fice, Lydia, Costales, Jeremie, Vidal-Puig, Antonio, Protty, Majd, Guy, Carol, Andrews, Robert, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Cossins, Ben C., Cardus Figueras, Ana, Carobbio, Stefania, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and O’Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460
2025.
12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation.
Proceedings of the National Academy of Sciences
122
(36)
, e2502640122.
10.1073/pnas.2502640122
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Culling, Toby, Bertorelli, Claire, Strang, Angela, Oram, Shaun, Faggian, Federica, Sharma, Simran, Ridgway, Anouk, Zaher, Summia, Labeta, Mario ORCID: https://orcid.org/0000-0001-5750-6983, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Davies, Luke C., Watkins, John ORCID: https://orcid.org/0000-0003-3262-6588, Siddall, Kate, Keeping, Vikki, Simpson, Kathryn, Bray, Maryanne, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Bell, Sarah F. and Collis, Rachel E.
2025.
Maternal physiological parameters and routine laboratory tests to screen for maternal sepsis: an observational cohort study.
International Journal of Obstetric Anesthesia
63
, 104683.
10.1016/j.ijoa.2025.104683
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Rose‐John, Stefan and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711
2025.
More and more pleiotropy within the IL ‐6 family of cytokines.
The FEBS Journal
292
(3)
, pp. 519-522.
10.1111/febs.17355
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Odd, David ORCID: https://orcid.org/0000-0002-6416-4966, Sabir, Hemmen, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Gale, Chris and Chakkarapani, Ela
2024.
Risk factors for infection and outcomes in infants with neonatal encephalopathy: a cohort study.
Pediatric Research
96
, pp. 785-791.
10.1038/s41390-024-03157-9
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Millrine, David, Cardus Figueras, Ana, Uceda Fernandez, Javier, Andrews, Robert, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Cossins, Benjamin, Rice, Christopher M., Li, Jasmine, Tyrrell, Victoria, McLeod, Louise, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, O'Donnell, Valerie ORCID: https://orcid.org/0000-0003-4089-8460, Taylor, Philip ORCID: https://orcid.org/0000-0003-0163-1421, Turner, Stephen J., Jenkins, Brendan J., Jones, Gareth, Topley, Nicholas, Williams, Nigel ORCID: https://orcid.org/0000-0003-1177-6931 and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711
2023.
Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements.
The Journal of Immunology
211
(2)
, pp. 274-286.
10.4049/jimmunol.2300114
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L, Marsden, Morgan, Chapman, Lucy, Cardus Figueras, Anna, Scott, Jake, Andrews, Robert, Clare, Simon, Kriukova, Valeriia V, Lupyr, Ksenia R, Britanova, Olga V, Withers, David R, Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Chudakov, Dmitriy M, Price, David A ORCID: https://orcid.org/0000-0001-9416-2737 and Humphreys, Ian R ORCID: https://orcid.org/0000-0002-9512-5337
2023.
Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1.
eLife
12
, e79165.
10.7554/eLife.79165
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Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151, Rice, Christopher M., Fernandez, Javier U. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711
2023.
Tracking the host response to infection in peritoneal models of acute resolving inflammation.
Jenkins, B.J., ed.
Inflammation and Cancer,
Vol. 2691.
Methods in Molecular Biology,
New York:
Springer,
pp. 81-95.
(10.1007/978-1-0716-3331-1_7)
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Karhunen, Ville, Gill, Dipender, Huang, Jian, Bouras, Emmanouil, Malik, Rainer, Ponsford, Mark J, Ahola-Olli, Ari, Papadopoulou, Areti, Palaniswamy, Saranya, Sebert, Sylvain, Wielscher, Matthias, Auvinen, Juha, Veijola, Juha, Herzig, Karl-Heinz, Timonen, Markku, Keinänen-Kiukaanniemi, Sirkka, Dichgans, Martin, Salmi, Marko, Jalkanen, Sirpa, Lehtimäki, Terho, Salomaa, Veikko, Raitakari, Olli, Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Hovingh, G Kees, Tsilidis, Konstantinos K, Järvelin, Marjo-Riitta and Dehghan, Abbas
2023.
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study.
BMJ Medicine
2
(1)
, e000157.
10.1136/bmjmed-2022-000157
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Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151, Jenkins, Robert H ORCID: https://orcid.org/0000-0001-8500-9044, Hughes, Stuart T O and Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711
2022.
Making sense of IL-6 signalling cues in pathophysiology.
FEBS Letters
596
(5)
, pp. 567-588.
10.1002/1873-3468.14201
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Heise, Denise, Derrac Soria, Alicia, Hansen, Selina, Dambietz, Christine, Akbarzadeh, Mohammad, Berg, Anna F., Waetzig, Georg H., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Dvorsky, Radovan, Ahmadian, Mohammad R., Scheller, Jürgen and Moll, Jens M.
2021.
Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits TH17 cell expansion.
Science Signaling
14
(696)
, eabc3480.
10.1126/scisignal.abc3480
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Davies, Ruth, Williams, Jessica, Sime, Katie, Jin, Hyun-Sun, Thompson, Charlotte, Jordan, Lauren, Lang, Derek, Halcox, Julian P, Ellins, Elizabeth ORCID: https://orcid.org/0000-0001-5164-6416, Jones, Gareth, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609
2021.
The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis.
Rheumatology
60
(6)
, pp. 2852-2861.
10.1093/rheumatology/keaa725
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Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and Hunter, Christopher A.
2021.
Is IL-6 a key cytokine target for therapy in COVID-19?
Nature Reviews Immunology
21
(6)
, 337–339.
10.1038/s41577-021-00553-8
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Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Bryant, Clare, Lloyd, Clare M, McInnes, Iain and O'Neill, Luke
2020.
A vision for cytokine biology with 20/20 clarity.
Function
2
(1)
, zqaa042.
10.1093/function/zqaa042
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Ponsford, Mark J., Gkatzionis, Apostolos, Walker, Venexia M., Grant, Andrew J., Wootton, Robyn E., Moore, Luke S.P., Fatumo, Segun, Mason, Amy M., Zuber, Verena, Willer, Cristen, Rasheed, Humaira, Brumpton, Ben, Hveem, Kristian, Kristian Damås, Jan, Davies, Neil, Olav Åsvold, Bjørn, Solligård, Erik, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Burgess, Stephen, Rogne, Tormod and Gill, Dipender
2020.
Cardiometabolic traits, sepsis, and severe COVID-19.
Circulation
142
(18)
, 1791–1793.
10.1161/CIRCULATIONAHA.120.050753
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Lucchesi, Davide, Coleby, Rachel, Pontarini, Elena, Prediletto, Edoardo, Rivellese, Felice, Hill, David G., Derrac Soria, Alicia, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Sutcliffe, Nurhan, Tappuni, Anwar R., Pitzalis, Costantino, Jones, Gareth W. ORCID: https://orcid.org/0000-0001-7297-9711 and Bombardieri, Michele
2020.
Impaired IL‐27 mediated control of CD4+ T cell function impacts on ectopic lymphoid structure formation in patients with Sjögren's Syndrome.
Arthritis and Rheumatology
72
(9)
, pp. 1559-1570.
10.1002/art.41289
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Harbour, Stacey N., DiToro, Daniel F., Witte, Steven J., Zindl, Carlene L., Gao, Min, Schoeb, Trenton R., Jones, Gareth W., Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Hatton, Robin D. and Weaver, Casey T.
2020.
Th17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.
Science Immunology
5
(49)
, eaaw2262.
10.1126/sciimmunol.aaw2262
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Twohig, Jason P., Cardus Figueras, Ana, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C., Derrac Soria, Alicia, Lewis, Myles J., Townsend, Michael J., Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151, Li, Jasmine, Hill, David G., Uceda Fernandez, Javier, Liu, Xiao, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Pepper, Christopher J., Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Pitzalis, Costantino, Tiganis, Tony, Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931, Jones, Gareth W. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711
2019.
Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells.
Nature Immunology
20
, pp. 458-470.
10.1038/s41590-019-0350-0
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Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Takeuchi, Tsutomu, Aletaha, Daniel, Smolen, Josef, Choy, Ernest H ORCID: https://orcid.org/0000-0003-4459-8609 and McInnes, Iain
2019.
Interleukin 6: the biology behind the therapy.
Considerations in Medicine
2
10.1136/conmed-2018-000005
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Takeuchi, Tsutomu, Smolen, Josef S., Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Aletaha, Daniel, McInnes, Iain and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711
2019.
Considering new lessons about the use of IL-6 inhibitors in arthritis.
BMJ Considerations in Medicine
2
(1)
, pp. 7-11.
10.1136/conmed-2018-000002
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Smolen, Josef S., Aletaha, Daniel, Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Takeuchi, Tsutomu and McInnes, Iain
2019.
Targeting IL-6: a review of data.
BMJ Considerations in Medicine
2
(1)
, pp. 12-18.
10.1136/conmed-2018-000003
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Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Aletaha, Daniel, Takeuchi, Tsutomu, McInnes, Iain and Smolen, Josef S
2019.
IL-6: To immunity and beyond.
BMJ Considerations in Medicine
2
(1)
, pp. 19-23.
10.1136/conmed-2018-000004
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Rivellese, Felice, Mauro, Daniele, Nerviani, Alessandra, Pagani, Sara, Fossati-Jimack, Liliane, Messemaker, Tobias, Kurreeman, Fina, Toes, Rene, Rauber, Simon, Schett, Georg, Jones, Gareth, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Rossi, Francesca, de Paulis, Amato, Marone, Gianni, El Shikh, Mohey Eldin and Humby, Frances
2018.
Mast cells in early rheumatoid arthritis associate with disease severity and support B-cell autoantibody production.
Annals of the Rheumatic Diseases
77
(12)
, pp. 1773-1781.
10.1136/annrheumdis-2018-213418
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Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and Jenkins, Brendan J.
2018.
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer.
Nature Reviews Immunology
18
, pp. 773-789.
10.1038/s41577-018-0066-7
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Jones, Gareth, Hill, David, Cardus Figueras, Ana and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711
2018.
IL-27 - a double agent in the IL-6 family.
Clinical and Experimental Immunology
193
(1)
, pp. 37-46.
10.1111/cei.13116
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Fernandez, Javier Uceda, Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151 and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711
2018.
Tracking competent host defence to chronic inflammation: An In Vivo model of peritonitis.
Jenkins, Brendan J., ed.
Inflammation and Cancer,
Vol. 1725.
Methods in Molecular Biology,
New York, NY:
Springer,
pp. 65-75.
(10.1007/978-1-4939-7568-6_6)
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Stacey, Maria A., Clare, Simon, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Abdul-Karim, Juneid, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Fielding, Ceri A. ORCID: https://orcid.org/0000-0002-5817-3153, Smith, Sarah E., Wash, Rachael S., Gimeno Brias, Silvia, Stack, Gabrielle, Notley, George, Cambridge, Emma L., Isherwood, Christopher, Speak, Anneliese O., Johnson, Zoe, Ferlin, Walter, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Kellam, Paul and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337
2017.
The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis.
Journal of Clinical Investigation
127
(4)
, pp. 1463-1474.
10.1172/JCI84889
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Catar, Rusan, Witowski, Janusz, Zhu, Nan, Lücht, Christian, Derrac Soria, Alicia, Uceda Fernandez, Javier, Chen, Lei, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Fielding, Ceri A., Rudolf, Andras, Topley, Nicholas, Dragun, Duska and Jörres, Achim
2017.
IL-6 trans-signaling links inflammation with angiogenesis in the peritoneal membrane.
Journal of the American Society of Nephrology
28
(4)
, pp. 1188-1199.
10.1681/ASN.2015101169
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Dutzan, Nicolas, Abusleme, Loreto, Bridgeman, Hayley, Greenwell-Wild, Teresa, Zangerle-Murray, Tamsin, Fife, Mark E., Bouladoux, Nicolas, Linley, Holly, Brenchley, Laura, Wemys, Kelly, Calderon, Gloria, Hong, Bo-Young, Break, Timothy J., Bowdish, Dawn M. E., Lionakis, Michail S., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Trinchieri, Giorgio, Diaz, Patricia I., Belkaid, Yasmine and Konkel, Joanne E.
2017.
On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier.
Immunity
46
(1)
, pp. 133-147.
10.1016/j.immuni.2016.12.010
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Lauder, Sarah N., Tyrrell, Victoria J., Allen-Redpath, Keith, Aldrovandi, MacEler, Gray, David, Collins, Peter ORCID: https://orcid.org/0000-0002-6410-1324, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 and O'Donnell, Valerie ORCID: https://orcid.org/0000-0003-4089-8460
2017.
Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo.
Wellcome Open Research
2
(1)
10.12688/wellcomeopenres.10308.1
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Stacey, Maria, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana Filipa, Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Weaver, Casey, Carlesso, Gianluca, Clare, Simon, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Jones, Gareth W. and Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337
2016.
Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence.
Plos Pathogens
12
(12)
, e1006050.
10.1371/journal.ppat.1006050
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Jones, Gareth, Hill, David and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711
2016.
Understanding immune cells in tertiary lymphoid organ development: it is all starting to come together.
Frontiers in Immunology
7
, pp. 1-13.
10.3389/fimmu.2016.00401
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Davies, Ruth, Iacono, Daniela, Jordan, Lauren, Williams, Jessica O., Sime, Katie, Rawlings, Charlotte, Lang, Derek, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609
2016.
Serum Vascular Cell Adhesion Molecule 1 levels are associated with vascular Dysfunction and increased cardiovascular risk in an animal model and patients with Rheumatoid Arthritis.
Rheumatology
55
(Supp 1)
, p. 54.
10.1093/rheumatology/kew102.004
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Harvey, Ann K, Lelos, Mariah Jillian ORCID: https://orcid.org/0000-0001-7102-055X, Greenhill, Claire J., Jones, Ashley, Clinch, Susanne, Newton, Michael, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Wyatt, Sean Lee ORCID: https://orcid.org/0000-0002-0572-234X, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2016.
Novel application of behavioral assays allows dissociation of joint pathology from systemic extra-articular alterations induced by inflammatory arthritis.
Journal of Rheumatic Diseases and Treatment
2
(2)
, 033.
10.23937/2469-5726/1510033
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Liu, Xiang, Jones, Gareth W., Choy, Ernest H. ORCID: https://orcid.org/0000-0003-4459-8609 and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711
2016.
The biology behind interleukin-6 targeted
interventions.
Current Opinion in Rheumatology
28
(2)
, pp. 152-160.
10.1097/BOR.0000000000000255
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Lacroix, Marine, Rousseau, François, Guilhot, Florence, Malinge, Pauline, Magistrelli, Giovanni, Herren, Suzanne, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Jones, Gareth Wyn, Scheller, Jürgen, Lissilaa, Rami, Kosco-Vilbois, Marie, Johnson, Zoë, Buatois, Vanessa and Ferlin, Walter
2015.
Novel insights into IL-6 cis- and trans-signaling pathways by differentially manipulating the assembly of the IL-6 signaling complex.
Journal of Biological Chemistry
290
, pp. 26943-26953.
10.1074/jbc.M115.682138
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Jones, Gareth W., Bombardieri, Michele, Greenhill, Claire J., McLeod, Louise, Nerviani, Alessandra, Rocher-Ros, Vidalba, Cardus, Anna, Williams, Anwen S. ORCID: https://orcid.org/0000-0001-6118-020X, Pitzalis, Costantino, Jenkins, Brendan J. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711
2015.
Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis.
Journal of Experimental Medicine
212
(11)
, pp. 1793-1802.
10.1084/jem.20132307
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Beyer, Christian, Huang, Jingang, Beer, Jürgen, Zhang, Yun, Palumbo-Zerr, Katrin, Zerr, Pawel, Distler, Alfiya, Dees, Clara, Maier, Christiane, Munoz, Louis, Krönke, Gerhard, Uderhardt, Stefan, Distler, Oliver, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan, Oravecz, Tamas, Schett, Georg and Distler, Jörg HW
2015.
Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages.
Annals of the Rheumatic Diseases
74
(6)
, pp. 1317-1324.
10.1136/annrheumdis-2013-204401
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Hunter, Christopher A. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2015.
IL-6 as a keystone cytokine in health and disease.
Nature Immunology
16
(5)
, pp. 448-457.
10.1038/ni.3153
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Rosser, Elizabeth C., Oleinika, Kristine, Tonon, Silvia, Doyle, Ronan, Bosma, Anneleen, Carter, Natalie A., Harris, Kathryn A., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Klein, Nigel and Mauri, Claudia
2014.
Regulatory B cells are induced by gut microbiota- driven interleukin-1β and interleukin-6 production.
Nature Medicine
20
, pp. 1334-1339.
10.1038/nm.3680
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Garbers, Christoph, Monhasery, Niloufar, Aparicio-Siegmund, Samadhi, Lokau, Juliane, Baran, Paul, Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan and Scheller, Jürgen
2014.
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
Biochimica et Biophysica Acta - Molecular Basis of Disease
1842
(9)
, pp. 1485-1494.
10.1016/j.bbadis.2014.05.018
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Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul Nazeer, Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, Luke A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2014.
Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction.
Arthritis Research and Therapy
16
(4)
, 419.
10.1186/s13075-014-0419-y
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Pitzalis, Costantino, Jones, Gareth Wyn, Bombardieri, Michele and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2014.
Ectopic lymphoid-like structures in infection, cancer and autoimmunity.
Nature Reviews Immunology
14
(7)
, pp. 447-462.
10.1038/nri3700
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Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153 and Jones, Gareth Wyn
2014.
Interleukin-6 in renal disease and therapy.
Nephrology Dialysis Transplantation
30
(4)
, pp. 564-574.
10.1093/ndt/gfu233
|
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Lauder, Sarah Nicol, Jones, Emma, Smart, Kathryn, Bloom, Anja Constanze, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hindley, James P., Ondondo, Beatrice, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004
2013.
Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology.
European Journal of Immunology
43
(10)
, pp. 2613-2625.
10.1002/eji.201243018
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Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Harvey, Ann, Moideen, Abdul Nazeer, Collins, Fraser, Bloom, Anja Constanze, Coll, R., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, L. A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2013.
Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract].
Cytokine
63
(3)
, p. 267.
10.1016/j.cyto.2013.06.105
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Davies, Luke Cynlais, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Jenkins, Stephen J., Liao, Chia-Te, Scurr, Martin John ORCID: https://orcid.org/0000-0002-4120-0688, Brombacher, Frank, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Allen, Judith E., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421
2013.
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.
Nature Communications
4
, 1886.
10.1038/ncomms2877
|
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Orr, Selinda Jane, Burg, Ashley R., Chan, Tim, Quigley, Laura, Jones, Gareth Wyn, Ford, Jill W., Hodge, Deborah, Razzook, Catherine, Sarhan, Joseph, Jones, Yava L., Whittaker, Gillian C., Boelte, Kimberly C., Lyakh, Lyudmila, Cardone, Marco, O'Connor, Geraldine M., Tan, Cuiyan, Li, Hongchuan, Anderson, Stephen K., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Zhang, Weiguo, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Trinchieri, Giorgio and McVicar, Daniel W.
2013.
LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
PLoS Pathogens
9
(5)
, e1003357.
10.1371/journal.ppat.1003357
|
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Choy, Ernest Ho Sing ORCID: https://orcid.org/0000-0003-4459-8609, Kavanaugh, A. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2013.
The problem of choice: current biologic agents and future prospects in RA [review].
Nature Reviews Rheumatology
9
(3)
, pp. 154-163.
10.1038/nrrheum.2013.8
|
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Chakraborty, Mallinath, McGreal, Eamon Patrick, Davies, Philip Lloyd, Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627
2013.
Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity.
Neonatology
104
(3)
, pp. 161-167.
10.1159/000351015
|
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McDonald, Jacqueline U., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Brown, Gordon D., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421
2012.
Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation.
PLoS ONE
7
(9)
, e45781.
10.1371/journal.pone.0045781
|
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O'Connor, Richard A., Floess, Stefan, Huehn, Jochen, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Anderton, Stephen M.
2012.
Foxp3+Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production.
European Journal of Immunology
42
(5)
, pp. 1174-1179.
10.1002/eji.201142216
|
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Jones, Gareth Wyn, Greenhill, Claire J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Nowell, Mari Ann, Jenkins, Brian J. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2012.
Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract].
Rhuematology
51
(s3)
, pp. 43-44.
10.1093/rheumatology/kes117
|
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Jones, Gareth Wyn, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Nowell, Mari Ann, Jenkins, Brian J. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2011.
Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B- cell responses [Abstract].
Arthritis and Rheumatism
63
(s10)
, S978-S978.
10.1002/art.33310
|
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Smale, Shaun, Carty, Sara Madelaine, Goodfellow, Rhian Mair, Choy, Ernest Ho-Sing ORCID: https://orcid.org/0000-0003-4459-8609, Rose-John, Stefan, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Williams, Anwen SIan ORCID: https://orcid.org/0000-0001-6118-020X
2011.
Inhibiting IL-6 trans-signalling with soluble gp130Fc potently reduces the incidence and severity of collagen-induced experimental arthritis [Abstract].
Arthritis and Rheumatism
63
(s10)
, S446-S447.
|
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Colmont, Chantal Sophie, Raby, Anne-Catherine ORCID: https://orcid.org/0000-0002-5354-5835, Dioszeghy, Vincent, Le Bouder, Emmanuel, Foster, Thomas Lloyd, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Labeta, Mario Oscar ORCID: https://orcid.org/0000-0001-5750-6983, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153 and Topley, Nicholas
2011.
Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors.
Nephrology Dialysis Transplantation
26
(12)
, pp. 4079-4090.
10.1093/ndt/gfr217
|
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McDonald, Jacqueline U., Cortini, Andrea, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Fossati-Jimack, Liliane, Ling, Guang Sheng, Lewis, Kimberley, Dewitt, Sharon ORCID: https://orcid.org/0000-0001-8169-8241, Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Brown, Gordon D., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, Botto, Marina and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421
2011.
In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils.
The FASEB Journal
25
(6)
, pp. 1972-1982.
10.1096/fj.10-178517
|
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Jones, Gareth Wyn, Stumhofer, Jason S., Foster, Tom, Twohig, Jason Peter, Hertzog, Paul, Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Christopher A., Jenkins, Brendan J., Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2011.
Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
The FASEB Journal
25
(1)
, pp. 409-419.
10.1096/fj.10-166843
|
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Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Osario, Fabiola, Robinson, Matthew J., Davies, Luke Cynlais, Dierkes, Nicola, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Reis e Sousa, Caetano and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421
2011.
Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells.
European Journal of Immunology
41
(2)
, pp. 356-365.
10.1002/eji.201040962
|
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Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Davies, Luke Cynlais, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421
2011.
Macrophage heterogeneity and acute inflammation.
European Journal of Immunology
41
(9)
, pp. 2503-2508.
10.1002/eji.201141743
|
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Kennedy, Catherine L., Najdovska, Meri, Jones, Gareth Wyn, McLeod, Louise, Hughes, Norman R., Allison, Cody, Huey Ooi, Chia, Tan, Patrick, Ferrero, Richard L., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Dev, Anouk, Sievert, William, Bhathal, Prithi S. and Jenkins, Brendan J.
2011.
The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17.
The Journal of Pathology
225
(2)
, pp. 255-264.
10.1002/path.2933
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Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Scheller, Jürgen and Rose-John, Stefan
2011.
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.
Journal of Clinical Investigation
121
(9)
, pp. 3375-3383.
10.1172/JCI57158
|
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McGreal, Eamon Patrick, Chakraborty, Mallinath, Winter, Vicki T., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Coalson, Jacqueline J. and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627
2011.
Dynamic expression of IL-6 trans-signalling molecules in the lungs of preterm baboons undergoing mechanical ventilation.
Neonatology
100
(2)
, pp. 130-138.
10.1159/000322148
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Stumhofer, Jason S., Tait, Elia D., III, William J. Quinn, Hosken, Nancy, Spudy, Björn, Goenka, Radhika, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, O'Hara, Aisling C., Chen, Yi, Jones, Michael L., Saris, Christiaan J. M., Rose-John, Stefan, Cua, Daniel J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Elloso, Merle M., Grötzinger, Joachim, Cancro, Michael P., Levin, Steven D. and Hunter, Christopher A.
2010.
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Nature Immunology
11
(12)
, pp. 1119-1126.
10.1038/ni.1957
|
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Jones, Gareth Wyn, Stumhofer, J. S., Foster, T., Twohig, Jason Peter, Hertzog, P., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Catherine, Jenkins, Brian J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964
2010.
Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract].
Immunology
131
(s1)
, p. 102.
10.1111/j.1365-2567.2010.03390.x
|
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Lissilaa, Rami, Buatois, Vanessa, Magistrelli, Giovanni, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth Wyn, Herren, Suzanne, Shang, Limin, Malinge, Pauline, Guilhot, Florence, Chatel, Laurence, Hatterer, Eric, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Kosco-Vilbois, Marie H. and Ferlin, Walter G.
2010.
Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity.
The Journal of Immunology
185
(9)
, pp. 5512-5521.
10.4049/jimmunol.1002015
|
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Jones, Gareth Wyn, McLoughlin, Rachel Mary, Hammond, Victoria Jayne, Parker, Clare Rhian, Williams, John, Malhotra, Raj, Scheller, Jurgen, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2010.
Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
The Journal of Immunology
184
(4)
, pp. 2130-2139.
10.4049/jimmunol.0901528
|
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Jones, Gareth Wyn, McLoughlin, R. M., Hammond, Victoria Jayne, Parker, Clare R., Williams, John D., Malhotra, R., Scheller, J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2010.
Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Journal of Immunology
184
(4)
, pp. 2130-2139.
|
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Page, Charlotte E., Smale, Shaun, Carty, Sara Madelaine, Amos, Nick, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Richards, Peter James, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X
2010.
Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis.
Arthritis Research & Therapy
12
(2)
, R49.
10.1186/ar2960
|
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Leggate, Melanie, Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Nimmo, Myra N.
2010.
The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling.
Cell Stress and Chaperones
15
(6)
, pp. 827-833.
10.1007/s12192-010-0192-z
|
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McGreal, Eamon Patrick, Davies, Philip Lloyd, Powell, Wendy ORCID: https://orcid.org/0000-0002-4670-1406, Rose-John, Stefan, Spiller, Owen Bradley ORCID: https://orcid.org/0000-0002-9117-6911, Doull, Iolo John Manley, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627
2010.
Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.
Biochimica et Biophysica Acta - Molecular Basis of Disease
1802
(7-8)
, pp. 649-658.
10.1016/j.bbadis.2010.04.005
|
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|
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Page, Charlotte E., Smale, Shaun, Carty, Sara Madelaine, Amos, Nick, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Richards, Peter J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X
2010.
Interferon-gamma inhibits interleukin-1 beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis.
Arthritis Research and Therapy
12
(2)
, R49.
|
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Cash, Hannes, Relle, Manfred, Menke, Julia, Brochhausen, Christoph, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas, Galle, Peter R. and Schwarting, Andreas
2009.
Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus.
The Journal of Rheumatology
37
(1)
, pp. 60-70.
10.3899/jrheum.090194
|
|
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Nowell, Mari Ann, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Carty, Sara Madelaine, Scheller, Jurgen, Hayes, Anthony Joseph, Jones, Gareth Wyn, Richards, Peter James, Slinn, Simon James, Ernst, Matthias, Jenkins, Brendan J., Topley, Nicholas, Rose-John, Stephen and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2009.
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.
Journal of Immunology
182
(1)
, pp. 613-622.
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Morgan, Alwena Haf, Dioszeghy, Vincent, Maskrey, Benjamin, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Clark, Stephen Robert ORCID: https://orcid.org/0000-0001-5907-9671, Mathie, Sara A., Lloyd, Clare M., Kuhn, Hartmut, Topley, Nicholas, Coles, Barbara, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460
2009.
Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease.
Journal of Biological Chemistry
284
(32)
, pp. 21185-21191.
10.1074/jbc.M109.021634
|
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Raby, Anne-Catherine ORCID: https://orcid.org/0000-0002-5354-5835, Le Bouder, Emmanuel, Colmont, Chantal Sophie, Davies, James Anthony ORCID: https://orcid.org/0000-0003-3569-4500, Richards, Peter, Coles, Barbara, George, Christopher H., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Topley, Nicholas and Labeta, Mario Oscar ORCID: https://orcid.org/0000-0001-5750-6983
2009.
Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering.
The Journal of Immunology
183
(1)
, pp. 506-517.
10.4049/jimmunol.0802909
|
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Jones, Gareth Wyn, Stumhofer, J. S., Newton, Zarabeth, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Ernst, M., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Catherine, Jenkins, Brian J., Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2008.
TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract].
Immunology
125
(s1)
, p. 62.
10.1111/j.1365-2567.2008.02974.x
|
|
|
|
Rabe, B., Chalaris, A., Adams, N., Paliga, K., Lange, H., Laskay, T., Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Waetzig, G. H., Seegert, D., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Sina, C., Rose-John, Stefan and Schelle, J.
2008.
The role of IL6-transsignaling in acute and chronic inflammation [Abstract].
Cytokine
43
(3)
, p. 244.
10.1016/j.cyto.2008.07.073
|
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Jenkins, Brendan J., Nadjovska, Meri, Greenhill, Claire, McLeod, Louise, Tye, Hazel, Kennedy, Catherine, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Topley, Nicholas, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Ernst, Matthias and Hertzog, Paul J.
2008.
Differential roles of IL-6 and IL-11 in inflammation and tumorigenesis [Abstract].
Cytokine
43
(3)
, p. 243.
10.1016/j.cyto.2008.07.069
|
|
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Hams, Emily ORCID: https://orcid.org/0000-0002-9745-3246, Colmont, Chantal Sophie, Dioszeghy, Vincent, Hammond, Victoria Jayne, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2008.
Oncostatin M receptor-β signaling limits monocytic cell recruitment in acute inflammation.
Journal of Immunology
181
(3)
, pp. 2174-2180.
|
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Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, McLoughlin, Rachel Mary, McLeod, Louise, Colmont, Chantal Sophie, Najdovska, Meri, Grail, Dianne, Ernst, Matthias, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas and Jenkins, Brendan J.
2008.
IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.
Journal of Immunology
181
(3)
, pp. 2189-2195.
|
|
|
|
Hams, Emily, Colmont, Chantal S., Dioszeghy, Vincent, Hammond, Victoria Jayne, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2008.
Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation.
Journal of Immunology
181
(3)
, pp. 2174-2180.
|
|
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|
Morton, Jonathan, Coles, Barbara, Wright, Kate Louise, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Morrow, Jason D., Terry, Erin S., Anning, Peter, Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676, Dioszeghy, Vincent, Kuhn, Hartmut, Chaitidis, Pavlos, Hobbs, Adrian J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460
2008.
Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN -dependent iNOS expression in the vasculature of healthy mice.
Blood
111
(10)
, pp. 5187-5194.
10.1182/blood-2007-10-117283
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|
|
Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004
2008.
Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells.
PLoS Pathogens
4
(2)
, e1000006.
10.1371/journal.ppat.1000006
|
|
|
|
Rabe, Bjorn, Chalaris, Athena, May, Ulrike, Waetzig, Georg H., Seegert, Dirk, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan and Scheller, Jurgen
2008.
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Blood
111
(3)
, pp. 1021-1028.
10.1182/blood-2007-07-102137
|
|
|
|
Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Jones, Gareth Wyn, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Nowell, Mari Ann
2008.
Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression.
Immunology Endocrine & Metabolic Agents in Medicinal Chemistry
8
(3)
, pp. 235-246.
|
|
|
|
Dioszeghy, Vincent, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Maskrey, Benjamin H., Colmont, Chantal Sophie, Topley, Nicholas, Chaitidis, Pavlos, Kühn, Hartmut, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460
2008.
12/15-lipoxygenase regulates the inflammatory response to bacterial products in vivo.
The Journal of Immunology
181
(9)
, pp. 6514-6524.
|
|
|
|
Rabe, B., Chalaris, Athena, May, Ulrike, Paliga, Krzysztof, Lange, Hans, Laskay, Tamas, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Waetzig, Georg H., Seegert, Dirk, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan and Scheller, J.
2007.
IL6/sIL6R-transsignaling controls innate and aquired immunity [Abstract].
Cytokine
39
(1)
, p. 34.
10.1016/j.cyto.2007.07.129
|
|
|
|
Hams, Emily, Dioszechy, Vincent, Colmont, Chantal Sophie, Hammond, Victoria Jayne, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2007.
Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract].
Cytokine
39
(1)
, p. 14.
10.1016/j.cyto.2007.07.053
|
|
|
|
Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Richards, Peter James, Thomas, Eleri, Carty, Sara Madelaine, Nowell, Mari Ann, Goodfellow, Rhian Mair, Dent, Colin Michael, Williams, Bryan Davies, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Topley, Nicholas
2007.
Interferon-γ protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints.
Arthritis & Rheumatism
56
(7)
, pp. 2244-2254.
10.1002/art.22732
|
|
|
|
Carty, Sara Madelaine, Nowell, Mari Ann, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Williams, B. D. and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X
2007.
Combination therapy with etanercept and sgp130 for rheumatoid arthritis is more effective than monotherapy [Abstract].
Rheumatology
46
(s1)
, I18-I18.
10.1093/rheumatology/kem1007
|
|
|
|
Dimitrov, Stoyan, Lange, Tanja, Benedict, Christian, Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Scheller, Jurgen, Rose-John, Stefan and Born, Jan
2006.
Sleep enhances IL-6 trans-signaling in humans.
The FASEB Journal
20
(12)
, pp. 2174-2176.
10.1096/fj.06-5754fje
|
|
|
|
Carty, Sara Madelaine, Nowell, Mari Ann, Goodfellow, Rhian Mair, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Williams, B. D. and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X
2006.
TINFa and IL-6/slL-6R interactions regulate the magnitude and the phenotype of synovial Leucocyte infiltration in rheumatoid arthritis [Abstract].
Arthritis and Rheumatism
54
(9)
, S597-S597.
|
|
|
|
Nowell, Mari Ann, Richards, Peter James, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Ognjanovic, Simona, Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Bryant-Greenwood, Gillian and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2006.
Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis.
Arthritis & Rheumatism
54
(7)
, pp. 2084-2095.
10.1002/art.21942
|
|
|
|
Monslow, Jamie, Williams, John David, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Michael, Daryn Robert, Foka, Pelagia, Kift-Morgan, Ann Patricia, Luo, Dong Dong, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Craig, Kathrine Jane, Topley, Nicholas, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 and Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435
2006.
Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene.
The Journal of Biological Chemistry
281
(26)
, pp. 18043-18050.
10.1074/jbc.M510467200
|
|
|
|
Peake, N. J., Khawaja, K., Myers, A., Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rowan, A. D., Cawston, T. E. and Foster, H. E.
2006.
Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor.
Rheumatology
45
(12)
, pp. 1485-1489.
10.1093/rheumatology/kel154
|
|
|
|
Richards, Peter James, Nowell, Mari Ann, Horiuchi, Sankichi, McLoughlin, Rachel Mary, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Grau, Sandra, Yamamoto, Naoki, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Rose-John, Stefan, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2006.
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.
Arthritis & Rheumatism
54
(5)
, pp. 1662-1672.
10.1002/art.21818
|
|
|
|
Grau, Sandra, Richards, Peter J., Kerr, Briedgeen, Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877, Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Junker, Uwe, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Clausen, Tim and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X
2006.
The role of human HtrA1 in arthritic disease.
The Journal of Biological Chemistry
281
(10)
, pp. 6124-6129.
10.1074/jbc.M500361200
|
|
|
|
Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, McLoughlin, Rachel Mary, Colmont, Chantal Sophie, Kovaleva, Marina, Harris, Dean Anthony, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2005.
Viral IL-6 blocks neutrophil infiltration during acute inflammation.
The Journal of Immunology
175
(6)
, pp. 4024-4029.
|
|
|
|
McLoughlin, Rachel Mary, Jenkins, Brendan J., Grail, Dianne, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Parker, Clare R., Ernst, Matthias, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2005.
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.
Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490
102
(27)
, pp. 9589-9594.
10.1073/pnas.0501794102
|
|
|
|
Carty, S. M., Nowell, Mari Ann, Goodfellow, Rhian Mair, Topley, Nicholas, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Williams, B. D. and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X
2005.
Interleukin 6 (IL-6) signalling in rheumatoid arthritis.
Rheumatology
44
, I38-I38.
|
|
|
|
McLoughlin, Rachel Mary, Hurst, Suzanne Maria, Nowell, Mari Ann, Harris, Dean Anthony, Horiuchi, Sankichi, Morgan, Llinos Wyn, Yamamoto, Naoki, Wilkinson, Thomas S., Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2004.
Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms.
The Journal of Immunology
172
, pp. 5676-83.
|
|
|
|
Nowell, Mari Ann, Richards, Peter James, Horiuchi, Sankichi, Yamamoto, Naoki, Rose-John, Stefan, Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2003.
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130.
The Journal of Immunology
171
(6)
, pp. 3202-3209.
|
|
|
|
McLoughlin, Rachel Mary, Witowski, Janusz, Robson, Rachel L., Wilkinson, Thomas S., Hurst, Suzanne Maria, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Williams, John David, Rose-John, Stefan, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Topley, Nicholas
2003.
Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
The Journal of Clinical Investigation
112
(4)
, pp. 598-607.
10.1172/JCI200317129
|
|
|
|
Robson, Rachel L., McLoughlin, Rachel Mary, Witowski, Janusz, Loetscher, Pius, Wilkinson, Thomas S., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Topley, Nicholas
2001.
Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo.
The Journal of Immunology
167
(2)
, pp. 1028-1038.
|
|
|
|
Hurst, Suzanne Maria, Wilkinson, Thomas S., McLoughlin, Rachel Mary, Jones, Suzanne, Horiuchi, Sankichi, Yamamoto, Naoki, Rose-John, Stefan, Fuller, Gerald M., Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2001.
IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Immunity
14
(6)
, pp. 705-714.
10.1016/S1074-7613(01)00151-0
|
|
|