Browse by Schools (complete)

, Hogan, Catherine

and Parker, Alan

2024. The αvβ6 integrin specific virotherapy, Ad5NULL-A20.FCU1, selectively delivers 2 potent “in-tumour” chemotherapy to Pancreatic Ductal Adenocarcinoma. British Journal of Cancer 131 , pp. 1694-1706. 10.1038/s41416-024-02869-3

de Paula do Nascimento, Roberto, Soto Rizzato, Julia, Polezi, Gabriele, Boughanem, Hatim, Williams, Non Gwenllian, Borguini, Galhardo, Cristina Pessanha de Araujo Santiago, Manuela, Roberto Marostica Junior, Mario and Parry, Lee

2024. Myrciaria jaboticaba fruit peel: Bioactive composition as determined by distinct harvest seasons and in vitro anti-cancer activity. Plants 13 (20) , 2907. 10.3390/plants13202907

Hill, Liam 2024. Unravelling the early responses to KrasG12D activation in the adult lung epithelium. PhD Thesis, Cardiff University.

Item availability restricted.

Lovatt, Charlotte, Williams, Megan, Gibbs, Alex, Mukhtar, Abdullahi, Morgan, Huw J., Lanfredini, Simone

, Olivero, Carlotta

, Spurlock, Gill, Davies, Sally, Philpott, Charlotte, Tovell, Hannah, Turnpenny, Peter, Baban, Dilair, Knight, Sam, Brems, Hilde, Sampson, Julian R.

, Legius, Eric, Upadhyaya, Meena and Patel, Girish K. 2024. Pigment epithelium derived factor drives melanocyte proliferation and migration in neurofibromatosis café au lait macules. Skin Health and Disease 4 (5) , e394. 10.1002/ski2.394

Padilha, Ana, Jones, Emma, Cutting, Scott, Godkin, Andrew

and Parry, Lee

2024. Regulatory T cells play a role in determining the tumourigenicity of the Intestinal Stem Cell Niche. Gastro Hep Advances 4 (2) , 100559. 10.1016/j.gastha.2024.09.014

Seaton, Gillian, Smith, Hannah, Brancale, Andrea, Westwell, Andrew D.

and Clarkson, Richard

2024. Multifaceted roles for BCL3 in cancer: a proto-oncogene comes of age. Molecular Cancer 23 (1) , 7. 10.1186/s12943-023-01922-8

Tornillo, Giusy, Warrington, Lauren, Kendrick, Howard, Higgins, Adam T.

, Hay, Trevor, Beck, Sam and Smalley, Matthew J.

2024. Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model. Disease Models and Mechanisms 17 (1) , dmm050211. 10.1242/dmm.050211

Vaiasicca, Salvatore, Melone, Gianmarco, James, David W, Quintela, Marcos, Xiao, Jing, Yao, Seydou, Finnell, Richard H, Conlan, Robert S, Francis, Lewis W and Corradetti, Bruna 2024. Transcriptomic analysis reveals the anti-cancer effect of gestational mesenchymal stem cell secretome. Stem Cells Translational Medicine 13 (7) , pp. 693-710. 10.1093/stcltm/szae024

2023

Almotiri, Alhomidi, Boyd, Ashleigh S. and Rodrigues, Neil P.

2023. Zeb1 Regulates the function of lympho-myeloid primed progenitors after transplantation. Biomolecules 13 (9) , 1386. 10.3390/biom13091386

Alshahrany, Nawal, Begum, Ayesha, Siebzehnrubl, Dorit, Jimenez-Pascual, Ana and Siebzehnrubl, Florian A.

2023. Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion. Cancer Letters 571 , 216349. 10.1016/j.canlet.2023.216349

Arana Echarri, Ainhoa, Struszczak, Lauren, Beresford, Mark, Campbell, John P., Jones, Robert H.

, Thompson, Dylan and Turner, James E. 2023. Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study. Frontiers in Physiology 14 , 1107070. 10.3389/fphys.2023.1107070

Bates, Emily A., Lovatt, Charlotte, Plein, Alice R., Davies, James A.

, Siebzehnrubl, Florian A.

and Parker, Alan L.

2023. Engineering adenoviral vectors with improved GBM selectivity. Viruses 15 (5) , 1086. 10.3390/v15051086

Brown, J.M.C., Zaben, M.

, Ormonde, C., Sharouf, F.

, Spencer, R., Bhatt, H., Siebzehnrubl, F.A.

and Gray, W.P.

2023. A high-density 3-dimensional culture model of human glioblastoma for rapid screening of therapeutic resistance. Biochemical Pharmacology 208 , 115410. 10.1016/j.bcp.2023.115410

Chan, Yee-Hung, Moss, Joe W. E.

, Williams, Jessica O., Ferekidis, Nele, Alshehri, Nouf, Hughes, Timothy R.

, Menendez Gonzalez, Juan B., Plummer, Sue F., Michael, Daryn R., Rodrigues, Neil P.

and Ramji, Dipak P.

2023. (+)-catechin attenuates multiple atherosclerosis-associated processes in vitro, modulates disease-associated risk factors in C57BL/6J mice and reduces atherogenesis in LDL receptor deficient mice by inhibiting inflammation and increasing markers of plaque stability. Molecular Nutrition & Food Research 67 (14) , 2200716. 10.1002/mnfr.202200716

Edmunds, Grace, Beck, Sam, Umakant Kale, Kedar, Spasic, Irena

, O'Neill, Dan, Brodbelt, David and Smalley, Matthew J

2023. Associations between dog breed and clinical features of mammary epithelial neoplasia in bitches: an epidemiological study of submissions to a single diagnostic pathology centre between 2008-2021. Journal of Mammary Gland Biology and Neoplasia 28 (6) 10.1007/s10911-023-09531-3

Jones, Robert

, Plummer, Ruth, Moreno, Victor, Carter, Louise, Roda, Desamparados, Garralda, Elena, Kristeleit, Rebecca, Sarker, Debashis, Arkenau, Tobias, Roxburgh, Patricia, Walter, Harriet S., Blagden, Sarah, Anthoney, Alan, Klencke, Barbara J., Kowalski, Mark M. and Banerji, Udai 2023. A Phase I/II trial of Oral SRA737 (a Chk1 Inhibitor) given in combination with low-dose gemcitabine in patients with advanced cancer. Clinical Cancer Research 29 (2) , pp. 331-340. 10.1158/1078-0432.CCR-22-2074

Kristeleit, Rebecca, Plummer, Ruth, Jones, Robert

, Carter, Louise, Blagden, Sarah, Sarker, Debashis, Arkenau, Tobias, Evans, Thomas R. Jeffry, Danson, Sarah, Symeonides, Stefan N., Veal, Gareth J., Klencke, Barbara J., Kowalski, Mark M. and Banerji, Udai 2023. A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer. British Journal of Cancer 10.1038/s41416-023-02279-x

Michael, D. R., Kerry-Smith, J., Webberley, T. S., Murphy, K.R., Plummer, S. F., Parry, L.

and Marchesi, J. R.

2023. Does flow culture impact upon gut-probiotic interactions: a comparison with static culture. Journal of Functional Foods 104 , 105519. 10.1016/j.jff.2023.105519

Moore, Joshua W., Dale, Trevor C.

and Woolley, Thomas E.

2023. Modelling polarity-driven laminar patterns in bilayer tissues with mixed signalling mechanisms. SIAM Journal on Applied Dynamical Systems 22 (4) , pp. 2945-2990. 10.1137/22M1522565

Ordonez, Liliana, Tornillo, Giusy, Kendrick, Howard, Hay, Trevor and Smalley, Matthew John

2023. NOTCH and AKT signalling interact to drive mammary tumour heterogeneity. Cancers 15 (17) , 4324. 10.3390/cancers15174324

Rastogi, Namrata, Gonzalez, Juan Bautista Menendez, Srivastava, Vikas, Alanazi, Bader, Alanazi, Rehab N., Hughes, Owen M., O'Neill, Niamh S., Gilkes, Amanda, Ashley, Neil, Deshpande, Sumukh, Andrews, Robert, Mead, Adam, Rodrigues, Neil

, Knapper, Steven

, Darley, Richard

and Tonks, Alex

2023. Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia. Leukemia 37 , pp. 276-287. 10.1038/s41375-022-01801-z

Sanz-Castillo, Belén, Hurtado, Begoña, Vara-Ciruelos, Diana, El Bakkali, Aicha, Hermida, Dario, Salvador-Barbero, Beatriz, Martínez-Alonso, Diego, González-Martínez, José, Santiveri, Clara, Campos-Olivas, Ramón, Ximénez-Embún, Pilar, Muñoz, Javier, Álvarez-Fernández, Mónica and Malumbres, Marcos 2023. The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. The EMBO Journal 42 (2) , e110833. 10.15252/embj.2022110833

Shorning, Boris, Trent, Neil, Griffiths, David F., Worzfeld, Thomas, Offermanns, Stefan, Smalley, Matthew J.

and Williamson, Magali 2023. Plexin-B1 mutation drives metastasis in prostate cancer mouse models. Cancer Research Communications 3 (3) , pp. 444-458. 10.1158/2767-9764.CRC-22-0480

Singh, Niharika, Siebzehnrubl, Florian A.

and Martinez Garay, Isabel

2023. Transcriptional control of embryonic and adult neural progenitor activity. Frontiers in Neuroscience 17 , 1217596. 10.3389/fnins.2023.1217596

Varney, Danielle, O'Neill, Dan, O'Neill, Maeve, Church, David, Stell, Anneliese, Beck, Sam, Smalley, Matthew J.

and Brodbelt, David 2023. Epidemiology of mammary tumours in bitches under veterinary care in the UK in 2016. Veterinary Record 193 (5) , e3054. 10.1002/vetr.3054

2022

Almotiri, Alhomidi, Abdelfattah, Ali and Rodrigues, Neil P.

2022. Flow cytometry analysis of hematopoietic stem/progenitor cells and mature blood cell subsets in atherosclerosis. Ramji, Dipak, ed. Atherosclerosis, Vol. 2419. Methods in Molecular Biology, Springer, pp. 583-595. (10.1007/978-1-0716-1924-7_36)

Anjos-Afonso, Fernando

, Buettner, Florian, Mian, Syed A., Rhys, Hefin, Perez-Lloret, Jimena, Garcia-Albornoz, Manuel, Rastogi, Namrata, Ariza-McNaughton, Linda and Bonnet, Dominique 2022. Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population. Nature Communications 13 , 2048. 10.1038/s41467-022-29675-w

Banerjee, Susana, Michalarea, Vasiliki, Ang, Joo Ern, Ingles Garces, Alvaro, Biondo, Andrea, Funingana, Ionut-Gabriel, Little, Martin, Ruddle, Ruth, Raynaud, Florence, Riisnaes, Ruth, Gurel, Bora, Chua, Sue, Tunariu, Nina, Porter, Joanna C., Prout, Toby, Parmar, Mona, Zachariou, Anna, Turner, Alison, Jenkins, Ben, McIntosh, Stuart, Ainscow, Edward, Minchom, Anna, Lopez, Juanita, de Bono, Johann, Jones, Robert

, Hall, Emma, Cook, Natalie, Basu, Bristi and Banerji, Udai 2022. A phase I trial of CT900, a novel α-folate receptor-mediated thymidylate synthase inhibitor, with expansion cohorts in patients with high grade serous ovarian cancer. Clinical Cancer Research 22 , 1268. 10.1158/1078-0432.CCR-22-1268

Bates, Emily A., Davies, James A.

, Vánová, Jana, Nestic, Davor, Meniel, Valerie S., Koushyar, Sarah, Cunliffe, Tabitha G., Mundy, Rosie M., Moses, Elise, Uusi-Kerttula, Hanni K., Baker, Alexander T.

, Cole, David K.

, Majhen, Dragomira, Rizkallah, Pierre J.

, Chester, John D.

and Parker, Alan L.

2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10. Molecular Therapy - Oncolytics 25 , pp. 43-56. 10.1016/j.omto.2022.03.007

D'Ambrogio, Joshua, Hill, Liam and Hogan, Catherine

2022. Cell competition: Clonal competition protects against early tumorigenesis. Current Biology 32 (1) , PR52-R54. 10.1016/j.cub.2021.11.029

Dimitriou, Pantelitsa, Li, Jin

, Tornillo, Giusy, Smalley, Matthew

and Barrow, David

2022. Droplet incubator: a new droplet-based model to investigate living cell-synthetic cell interactions. Presented at: MicroTAS 2022, Hangzhou, China, 23-27 October 2022.

Engel, Rebekah M., Jardé, Thierry, Oliva, Karen, Kerr, Genevieve, Chan, Wing Hei, Hlavca, Sara, Nickless, David, Archer, Stuart K., Yap, Raymond, Ranchod, Pravin, Bell, Stephen, Niap, Ann, Koulis, Christine, Chong, Ashley, Wilkins, Simon, Dale, Trevor C.

, Hollins, Andrew J.

, McMurrick, Paul J. and Abud, Helen E. 2022. Modeling colorectal cancer: A bio-resource of 50 patient-derived organoid lines. Journal of Gastroenterology and Hepatology 37 (5) , pp. 898-907. 10.1111/jgh.15818

Hidalgo, Manuel, Garcia-Carbonero, Rocio, Lim, Kian-Huat, Messersmith, Wells A., Garrido-Laguna, Ignacio, Borazanci, Erkut, Lowy, Andrew M., Medina Rodriguez, Laura, Laheru, Daniel, Salvador-Barbero, Beatriz, Malumbres, Marcos, Shields, David J., Grossman, Joseph E., Huang, Xin, Tammaro, Meggan, Martini, Jean-François, Yu, Yanke, Kern, Kenneth and Macarulla, Teresa 2022. A preclinical and phase Ib study of palbociclib plus nab-paclitaxel in patients with metastatic adenocarcinoma of the pancreas. Cancer Research Communications 2 (11) , 1326–1333. 10.1158/2767-9764.CRC-22-0072

Howell, Sacha J., Casbard, Angela

, Carucci, Margherita, Ingarfield, Kate, Butler, Rachel, Morgan, Sian, Meissner, Magdalena, Bale, Catherine, Bezecny, Pavel, Moon, Sarah, Twelves, Chris, Venkitaraman, Ramachandran, Waters, Simon, De Bruin, Elza C., Schiavon, Gaia, Foxley, Andrew and Jones, Robert H.

2022. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial. The Lancet Oncology 23 (7) , pp. 851-864. 10.1016/s1470-2045(22)00284-4

Koushyar, Sarah, Meniel, Valerie S., Phesse, Toby J.

2022. Exploring the Wnt pathway as a therapeutic target for prostate cancer. Biomolecules 12 (2) , 309. 10.3390/biom12020309

May, Stephanie, Greenow, Kirsty, Higgins, Adam

, Derrick, Anna, Taylor, Elaine, Pan, Pan, Konstantinou, Maria, Nixon, Colin, Woolley, Thomas

, Sansom, Owen, Wang, Li-Shu and Parry, Lee

2022. Modification of diet to reduce the stemness and tumourigenicity of murine and human intestinal cells. Molecular Nutrition & Food Research 66 (19) , 2200234. 10.1002/mnfr.202200234

Menendez-Gonzalez, Juan Bautista, Strange, Kathryn E., Bassetto, Marcella, Brancale, Andrea

, Rodrigues, Neil P.

and Ferla, Salvatore 2022. Ligand-based discovery of a novel GATA2 inhibitor targeting acute myeloid leukemia cells. Frontiers In Drug Discovery 2 , 1013229. 10.3389/fddsv.2022.1013229

Menendez-Gonzalez, Juan Bautista and Rodrigues, Neil P.

2022. Exploring the associations between clonal hematopoiesis of indeterminate potential, myeloid malignancy, and atherosclerosis. Ramji, Dipak, ed. Atherosclerosis, Vol. 2419. Methods in Molecular Biology, Springer, pp. 73-88. (10.1007/978-1-0716-1924-7_5)

Moore, Joshua W., Dale, Trevor C.

and Woolley, Thomas E.

2022. Polarity driven laminar pattern formation by lateral-inhibition in 2D and 3D bilayer geometries. IMA Journal of Applied Mathematics 87 (4) , pp. 568-606.

Morgan, Huw J., Rees, Elise, Lanfredini, Simone

, Powell, Kate A., Gore, Jasmine, Gibbs, Alex, Lovatt, Charlotte, Davies, Gemma E., Olivero, Carlotta

, Shorning, Boris Y., Tornillo, Giusy, Tonks, Alex

, Darley, Richard

, Wang, Eddie C.Y.

and Patel, Girish K. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132 (21) , e150750. 10.1172/JCI150750

Owen, Jasmine S., Clayton, Aled

2022. Cancer-associated fibroblast heterogeneity, activation and function: implications for prostate cancer. Biomolecules 13 (1) , 67. 10.3390/biom13010067

Parry, Lee

2022. Stemming the flow toward disease: A research profile of Lee Parry. eFood 3 (6) , e46. 10.1002/efd2.46

Petrik, David

, Jorgensen, Sara, Eftychidis, Vasileios and Siebzehnrubl, Florian A.

2022. Singular adult neural stem cells do not exist. Cells 11 (4) , 722. 10.3390/cells11040722

Routledge, Daniel, Rogers, Sally, Ono, Yosuke, Brunt, Lucy, Meniel, Valerie, Tornillo, Giusy, Ashktorab, Hassan, Phesse, Toby J

and Scholpp, Steffen 2022. The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer. eLife 11 , e77376. 10.7554/elife.77376

Saad, Fred, Thiery-Vuillemin, Antoine, Wiechno, Pawel, Alekseev, Boris, Sala, Nuria, Jones, Robert

, Kocak, Ivo, Chiuri, Vincenzo Emanuele, Jassem, Jacek, Fléchon, Aude, Redfern, Charles, Kang, Jinyu, Burgents, Joseph, Gresty, Christopher, Degboe, Arnold and Clarke, Noel W 2022. Patient-reported outcomes with olaparib plus abiraterone versus placebo plus abiraterone for metastatic castration-resistant prostate cancer: a randomised, double-blind, phase 2 trial. The Lancet Oncology 23 (10) , pp. 1297-1307. 10.1016/S1470-2045(22)00498-3

Siebzehnrubl, Florian A.

2022. Isolating and culturing of precursor cells from the adult human brain. Deleyrolle, Loic P., ed. Neural Progenitor Cells: Methods and Protocols, Vol. 2389. Methods in Molecular Biology, New York, NY: Springer, pp. 95-102. (10.1007/978-1-0716-1783-0_9)

Williams, Non G. and Parry, Lee

2022. Balancing the scales: Do healthy lifestyle choices offset the colorectal cancer risk of unhealthy choices? eFood 3 (6) , e45. 10.1002/efd2.45

Woolley, Thomas

, Hill, William and Hogan, Catherine

2022. Accounting for dimensional differences in stochastic domain invasion with applications to precancerous cell removal. Journal of Theoretical Biology 541 , 111024. 10.1016/j.jtbi.2022.111024

2021

Abdelfattah, Ali Mahmoud, Hughes-Davies, Antonia, Clayfield, Liam Daniel, Menendez-Gonzalez, Juan Bautista, Almotiri, Alhomidi, Alotaibi, Badi, Tonks, Alex

and Rodrigues, Neil P

2021. Gata2 haploinsufficiency promotes proliferation and functional decline of HSCs with myeloid bias during aging. Blood Advances 5 (20) , pp. 4285-4290. 10.1182/bloodadvances.2021004726

Almotiri, Alhomidi, Alzahrani, Hamed Ahmad A., Menendez-Gonzalez, Juan Bautista, Abdelfattah, Ali, Alotaibi, Badi, Saleh, Lubaid, Greene, Adelle, Georgiou, Mia R. F., Gibbs, Alex, Alsayari, Amani Salem, Taha, Sarab, Thomas, Leigh-Anne, Shah, Dhruv, Edkins, Sarah

, Giles, Peter J.

, Stemmler, Marc P., Brabletz, Simone, Brabletz, Thomas, Boyd, Ashleigh S., Siebzehnrubl, Florian

and Rodrigues, Neil P.

2021. Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. Journal of Clinical Investigation 131 (1) , e129115. 10.1172/JCI129115

Arana Echarri, Ainhoa, Beresford, Mark, Campbell, John P., Jones, Robert H.

, Butler, Rachel, Gollob, Kenneth J., Brum, Patricia C., Thompson, Dylan and Turner, James E. 2021. A phenomic perspective on factors influencing breast cancer treatment: integrating aging and lifestyle in blood and tissue biomarker profiling. Frontiers in Immunology 11 , 616188. 10.3389/fimmu.2020.616188

Castro, Jessica, Tornillo, Giusy, Ceada, Gerardo, Ramos-Neble, Beatriz, Bravo, Marlon, Ribo', Marc, Vilanova, Maria, Smalley, Matthew

and Benito, Antoni 2021. A nuclear-directed ribonuclease variant targets cancer stem cells and inhibits migration and invasion of breast cancer cells. Cancers 13 (17) , 4350. 10.3390/cancers13174350

Davies, James A.

, Marlow, Gareth

, Uusi-Kerttula, Hanni K., Seaton, Gillian, Piggott, Luke, Badder, Luned M., Clarkson, Richard W. E.

, Chester, John D.

and Parker, Alan L.

2021. Efficient intravenous tumor targeting using the αvβ6 integrin-selective precision virotherapy Ad5NULL-A20. Viruses 13 (5) , 864. 10.3390/v13050864

Dimitriou, Pantelitsa, Li, Jin

, Tornillo, Giusy, McCloy, Thomas and Barrow, David

2021. Droplet microﬂuidics for tumor drug-related studies and programmable artiﬁcial cells. Global Challenges 5 (7) , 2000123. 10.1002/gch2.202000123

Edmunds, Grace L., Smalley, Matthew J.

, Beck, Sam, Errington, Rachel J.

, Gould, Sara, Winter, Helen, Brodbelt, David and O'Neill, Dan 2021. Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study. Canine Medicine and Genetics 8 , 2. 10.1186/s40575-021-00100-7

Gupta, Bhavana, Errington, Adam C.

, Jimenez-Pascual, Ana, Eftychidis, Vasileios, Brabletz, Simone, Stemmler, Marc P., Brabletz, Thomas, Petrik, David

and Siebzehnrubl, Florian A.

2021. The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus. Cell Reports 36 (8) , 109588. 10.1016/j.celrep.2021.109588

Hill, William, Zaragkoulias, Andreas, Salvador-Barbero, Beatriz, Parfitt, Geraint

, Alatsatianos, Markella, Padilha, Ana, Porazinski, Sean, Woolley, Thomas E.

, Morton, Jennifer P., Sansom, Owen J.

and Hogan, Catherine

2021. EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neigbors in the adult pancreas. Current Biology 31 (12) , pp. 2550-2560. 10.1016/j.cub.2021.03.094

Jukes, Zoe, Freier, Anne, Glymenaki, Maria, Brown, Richard, Parry, Lee

, Want, Elizabeth, Vorkas, Panagiotis A. and Li, Jia V. 2021. Lipid profiling of mouse intestinal organoids for studying APC mutations. Bioscience Reports 41 (3) , BSR20202915. 10.1042/BSR20202915

Kermanizadeh, Ali, Jacobsen, Nicklas Raus, Murphy, Fiona, Parry, Lee

, Zhang, Haiyuan and Møller, Peter 2021. A review of the current state of nanomedicines for targeting and treatment of cancers - achievements and future challenges. Advanced Therapeutics 4 (2) , 2000186. 10.1002/adtp.202000186

Lawson, Hannah, Sepulveda, Catarina, van de Latemaat, Louie N., Durko, Jozef, Barile, Melania, Tavosanis, Andrea, Georges, Elise, Shmakova, Alena, Timms, Penny, Carter, Roderick N., Allen, Lewis, Campos, Joana, Vukovic, Milica, Guitart, Amelie V., Giles, Peter

, O'Shea, Marie, Vernimmen, Douglas, Morton, Nicholas M., Rodrigues, Neil P.

, Gottgens, Berthold, Schofield, Christopher J., Lengeling, Andreas, O'Carroll, Donal and Kranc, Kamil R. 2021. JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. Blood Advances 5 (3) , pp. 889-899. 10.1182/bloodadvances.2020002702

Lawson, Hannah, van de Lagemaat, Louie N., Barile, Melania, Tavosanis, Andrea, Durko, Jozef, Villacreces, Arnaud, Bellani, Aarushi, Mapperley, Christopher, Georges, Elise, Martins-Costa, Catarina, Sepulveda, Catarina, Allen, Lewis, Campos, Joana, Campbell, Kirsteen J., O'Carroll, Donal, Gottgens, Berthold, Cory, Suzanne, Rodrigues, Neil P.

, Guitart, Amelie V. and Kranc, Kamil R. 2021. CITED2 coordinates key haematopoietic regulatory pathways to maintain the HSC pool in both steady-state haematopoiesis and transplantation. Stem Cell Reports 16 (11) , pp. 2784-2797. 10.1016/j.stemcr.2021.10.001

Mian, Syed A., Dos Anjos-Afonso, Fernando

and Bonnet, Dominique 2021. Advances in human immune system mouse models for studying human hematopoiesis and cancer immunotherapy. Frontiers in Immunology 11 , 619236. 10.3389/fimmu.2020.619236

Moore, Joshua W., Lau, Zechariah, Kaouri, Katerina

, Dale, Trevor C.

and Woolley, Thomas E.

2021. A general computational framework for COVID-19 modelling with applications to testing varied interventions in education environments. COVID 1 (4) , pp. 674-703. 10.3390/covid1040055

Moss, Joe W. E.

, Williams, Jessica O., Al-Ahmadi, Wijdan, O'Morain, Victoria, Chan, Yee-Hung, Hughes, Timothy R.

, Menendez-Gonzalez, Juan B., Almotiri, Alhomidi, Plummer, Sue F., Rodrigues, Neil P.

, Michael, D. R. and Ramji, Dipak P.

2021. Protective effects of a unique combination of nutritionally active ingredients on risk factors and gene expression associated with atherosclerosis in C57BL/6J mice fed a high fat diet. Food and Function 12 (8) , pp. 3657-3671. 10.1039/D0FO02867C

O'Morain, Victoria L., Chan, Yee-Hung, Williams, Jessica O., Alotibi, Reem, Alahmadi, Alaa, Rodrigues, Neil P.

, Plummer, Sue F., Hughes, Timothy R., Michael, Daryn R. and Ramji, Dipak P.

2021. The Lab4P consortium of probiotics attenuates atherosclerosis in LDL receptor deficient mice fed a high fat diet and causes plaque stabilization by inhibiting inflammation and several pro-atherogenic processes. Molecular Nutrition & Food Research 65 (17) , 2100214. 10.1002/mnfr.202100214

Ordonez, Liliana D., Melchor, Lorenzo, Greenow, Kirsty R., Kendrick, Howard, Tornillo, Giusy, Bradford, James, Giles, Peter

and Smalley, Matthew J.

2021. Reproductive history determines ErbB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model. Disease Models and Mechanisms 14 (5) , dmm048736. 10.1242/dmm.048736

Pope, Iestyn

, Masia, Francesco

, Ewan, Kenneth

, Jimenez-Pascual, Ana, Dale, Trevor C.

, Siebzehnrubl, Florian A.

, Borri, Paola

and Langbein, Wolfgang

2021. Identifying subpopulations in multicellular systems by quantitative chemical imaging using label-free hyperspectral CARS microscopy. Analyst 146 (7) , pp. 2277-2291. 10.1039/D0AN02381G

Rastogi, Namrata, Baker, Sarah

, Man, Stephen

, Uger, Robert A., Wong, Mark, Coles, Steve J., Hodges, Marie, Gilkes, Amanda, Knapper, Steven

, Darley, Richard

and Tonks, Alex

2021. Use of an anti-CD200 blocking antibody improves immune responses to AML in vitro and in vivo. British Journal of Haematology 193 (1) , pp. 155-159. 10.1111/bjh.17125

Seligmann, Jenny F., Fisher, David J., Brown, Louise C., Adams, Richard A.

, Graham, Janet, Quirke, Philip, Richman, Susan D., Butler, Rachel, Domingo, Enric, Blake, Andrew, Yates, Emma, Braun, Michael, Collinson, Fiona, Jones, Rob

, Brown, Ewan, de Winton, Emma, Humphrey, Timothy C., Parmar, Mahesh, Kaplan, Richard, Wilson, Richard H., Seymour, Matthew and Maughan, Timothy S. 2021. Inhibition of WEE1 is effective in TP53- and RAS-mutant metastatic colorectal cancer: a randomized trial (FOCUS4-C) comparing adavosertib (AZD1775) with active monitoring. Journal of Clinical Oncology 39 (33) , pp. 3705-3715. 10.1200/JCO.21.01435

Soukupova, Jitka, Bordoni, Cinzia, Turnham, Daniel J.

, Yang, William W., Seaton, Gillian, Gruca, Aleksandra, French, Rhiannon, Lee, Kok Yung, Varnava, Athina, Piggott, Luke, Clarkson, Richard W. E.

, Westwell, Andrew D.

and Brancale, Andrea

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2018. Dual mechanisms of LYN kinase dysregulation drive aggressive behaviour in breast cancer cells. Cell Reports 25 (13) , pp. 3674-3692. 10.1016/j.celrep.2018.11.103

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2018. The central role of Wnt signaling and organoid technology in personalizing anticancer therapy. Progress in Molecular Biology and Translational Science 153 , pp. 299-319. 10.1016/bs.pmbts.2017.11.009

2017

Badder, Luned 2017. Developing stem-cell containing organoids as a pre-clinical model for colorectal cancer therapeutics. PhD Thesis, Cardiff University.

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Berenjeno, Inma M., Piñeiro, Roberto, Castillo, Sandra D., Pearce, Wayne, McGranahan, Nicholas, Dewhurst, Sally M., Meniel, Valerie, Birkbak, Nicolai J., Lau, Evelyn, Sansregret, Laurent, Morelli, Daniele, Kanu, Nnennaya, Srinivas, Shankar, Graupera, Mariona, Parker, Victoria E. R., Montgomery, Karen G., Moniz, Larissa S., Scudamore, Cheryl L., Phillips, Wayne A., Semple, Robert K., Clarke, Alan, Swanton, Charles and Vanhaesebroeck, Bart 2017. Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nature Communications 8 (1) , 1773. 10.1038/s41467-017-02002-4

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, Negrini, Massimo, Forbes, Stuart J, Terracciano, Luigi, Scarpa, Aldo, Patel, Tushar, Valeri, Nicola, Workman, Paul, Sansom, Owen and Braconi, Chiara 2017. Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut 66 (7) , pp. 1268-1277. 10.1136/gutjnl-2016-312278

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2017. Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers. British Journal of Pharmacology 174 (24) , pp. 4666-4683. 10.1111/bph.13890
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Flanagan, Dustin J., Barker, Nick, Nowell, Cameron, Clevers, Hans, Ernst, Matthias, Phesse, Toby J.

and Vincan, Elizabeth 2017. Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo. Disease Models and Mechanisms 10 (8) , pp. 971-980. 10.1242/dmm.029876

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2017. Notch signaling in the regulation of hematopoietic stem cell. Current Stem Cell Reports 10.1007/s40778-017-0090-8

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, Borgogna, Cinzia, Calati, Federica, Powell, Kathryn, Davies, Kelli-Jo, De Andrea, Marco, Harries, Sarah, Tang, Hiu, Pfister, Herbert, Gariglio, Marisa and Patel, Girish K 2017. HPV8 field cancerization in a transgenic mouse model is due to Lrig1+Keratinocyte stem cell expansion. Journal of Investigative Dermatology 137 (10) , pp. 2208-2216. 10.1016/j.jid.2017.04.039

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, Fisher, Oliver M., Read, Matthew, Guerra, Glen R., Haupt, Ygal, Cullinane, Carleen, Wiman, Klas G., Abrahmsen, Lars, Phillips, Wayne A. and Clemons, Nicholas J. 2017. Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation. Nature Communications 8 , 14844. 10.1038/ncomms14844

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Menendez Gonzalez, Juan Bautista 2017. Exploring the role of GATA2 in normal and malignant haematopoiesis. PhD Thesis, Cardiff University.

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Mohamed, Noha-Ehssan 2017. Characterizing the roles of APC2 protein in ovarian homeostasis and tumourigenesis. PhD Thesis, Cardiff University.

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Soady, Kelly J., Tornillo, Giusy, Kendrick, Howard, Meniel, Valerie, Olijnyk-Dallis, Daria, Morris, Joanna S., Stein, Torstein, Gusterson, Barry A., Isacke, Clare M. and Smalley, Matthew J.

2017. Receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis. Development 144 (20) , pp. 3777-3788. 10.1242/dev.149120

Tang, Hiu Kwan Carolyn, Lee, Doreen Yin Hui, Thompson, Ian, Ingram, John R.

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2016

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, Gowan, Sharon, De Haven Brandon, Alexis, Hewitt, Phllip, Hobbs, Stephen M., Kaufmann, Wolfgang, Mallinger, Aurélie, Raynaud, Florence, Roe, Toby, Rohdich, Felix, Schiemann, Kai, Simon, Stephanie, Schneider, Richard, Valenti, Melanie, Weigt, Stefan, Blagg, Julian, Blaukat, Andree, Dale, Trevor C.

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Schmidt, Nina, Irle, Inga, Ripkens, Kamilla, Lux, Vanda, Nelles, Jasmin, Johannes, Christian, Parry, Lee

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Ali, Ahmed Y., Yeo, Syn, Ellis, Sadie, Ade, Jamilla, Clarkson, Richard W. E.

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, Barker, Nick, Schwab, Renate H. M., Amin, Nancy, Malaterre, Jordane, Stange, Daniel E., Nowell, Cameron J., Currie, Scott A., Saw, Jarel T. S., Beuchert, Eva, Ramsay, Robert G., Sansom, Owen J., Ernst, Matthias, Clevers, Hans and Vincan, Elizabeth 2015. Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells. Stem Cell Reports 4 (5) , pp. 759-767. 10.1016/j.stemcr.2015.03.003

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, Currie, Erin, Rouault-Pierre, Kevin and Bonnet, Dominique 2015. Different motile behaviors of human hematopoietic stem versus progenitor cells at the osteoblastic niche. Stem Cell Reports 5 (5) , pp. 690-701. 10.1016/j.stemcr.2015.09.003

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, Lord, Christopher J. and Ashworth, Alan 2015. Whole exome DNA sequence analysis of Brca2 and Trp53 deficient mouse mammary gland tumours. Journal of Pathology 236 (2) , pp. 186-200. 10.1002/path.4517

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2015. Overview of genetically engineered mouse models of breast cancer used in translational biology and drug development. Current Protocols in Pharmacology 70 (1) , 70:14.36.1-14.36.14.. 10.1002/0471141755.ph1436s70

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, Mogford, S., Hart, C., Patel, G., Roberts, G., Matin, C. and Newcombe, R. 2015. Topical delivery of gabapentin (Gaba Gel™) for neuropathic pain: a proof of concept study. Presented at: Royal Pharmaceutical Society Annual Conference 2015, Birmingham, England, 13-14 September 2015. International Journal of Pharmacy Practice. , vol.23 (S2) Royal Pharmaceutical Society of Great Britain, pp. 46-47. 10.1111/ijpp.12213

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2015. Severe postherpetic neuralgia and other neuropathic pain syndromes alleviated by topical gabapentin. British Journal of Dermatology 173 (1) , pp. 300-302. 10.1111/bjd.13624

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, Matthews, James, Song, Fei, Hedley, Ann, Kalna, Gabriela, Ceteci, Fatih, Reed, Karen R.

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, Blyth, Karen and Stein, Torsten 2015. Annexin A8 identifies a subpopulation of transiently quiescent c-Kit positive luminal progenitor cells of the ductal mammary epithelium. Plos One 10 (3) , e0119718. 10.1371/journal.pone.0119718

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, Deb, S., Britt, K. L., Rizzitelli, A., Li, J., Harmey, J. H., Pouliot, N. and Anderson, R. L. 2015. Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer. Disease Models and Mechanisms 8 (3) , pp. 237-251. 10.1242/dmm.017830

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Lio, Ka Ian 2015. Characterising the role of Cbx3/HP1γ in normal intestinal homeostasis and tumourigenesis. PhD Thesis, Cardiff University.

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Mallinger, Aurélie, Crumpler, Simon, Pichowicz, Mark, Waalboer, Dennis, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Wood, Bozena, Smith, Elizabeth, Thai, Ching, Henley, Alan T., Georgi, Katrin, Court, William, Hobbs, Steve, Box, Gary, Ortiz-Ruiz, Maria-Jesus, Valenti, Melanie, De Haven Brandon, Alexis, TePoele, Robert, Leuthner, Birgitta, Workman, Paul, Aherne, Wynne, Poeschke, Oliver, Dale, Trevor Clive

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2015. Apc and p53 interaction in DNA damage and genomic instability in hepatocytes. Oncogene 34 , pp. 4118-4129. 10.1038/onc.2014.342

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2015. Protocols for analyzing the role of Paneth cells in regenerating the murine intestine using conditional cre-lox mouse models. Journal of Visualized Experiments (105) , e53429. 10.3791/53429

Pearson, Helen B.

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, Schlüter, Holger, Srikumar, Anuratha, Gödde, Nathan J., Woelwer, Christina B., Ryan, Andrew, Phillips, Wayne A., Ernst, Matthias, Kaur, Pritinder and Humbert, Patrick 2015. The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis. Molecular Cancer 14 , 169. 10.1186/s12943-015-0440-z

Piggott, Luke, Omidvar, Nader, Martí Pérez, Salvador, French, Rhiannon, Eberl, Matthias

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Rada, Patricia, Rojo, Ana I., Offergeld, Anika

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, Regadera, Javier and Cuadrado, Antonio 2015. WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Antioxidants & Redox Signaling 22 (7) , pp. 555-571. 10.1089/ars.2014.6040

Reed, Karen Ruth

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and Sansom, Owen J. 2015. Correction for Reed et al., B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 112 (10) , E1168. 10.1073/pnas.1502294112

Reed, Karen Ruth

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Sampurno, Shienny, Cross, Ryan, Pearson, Helen

, Kaur, Pritinder, Malaterre, Jordane and Ramsay, Robert G. 2015. Myb via TGFβ is required for collagen type 1 production and skin integrity. Growth Factors 33 (2) , pp. 102-112. 10.3109/08977194.2015.1016222

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2015. Application of an RNA amplification method for reliable single-cell transcriptome analysis. Biotechniques 59 (3) , pp. 137-148. 10.2144/000114331

Soady, Kelly J., Kendrick, Howard, Gao, Qiong, Tutt, Andrew, Zvelebil, Marketa, Ordonez, Liliana D., Quist, Jelmar, Tan, David Wei-Min, Isacke, Clare M., Grigoriadis, Anita and Smalley, Matthew J.

2015. Mouse mammary stem cells express prognostic markers for triple-negative breast cancer. Breast Cancer Research 17 , 31. 10.1186/s13058-015-0539-6

Takizawa, Itsuhiro, Lawrence, Mitchell G., Balanathan, Preetika, Rebello, Richard, Pearson, Helen B.

, Garg, Elika, Pedersen, John, Pouliot, Normand, Nadon, Robert, Watt, Matthew J., Taylor, Renea A., Humbert, Patrick, Topisirovic, Ivan, Larsson, Ola, Risbridger, Gail P. and Furic, Luc 2015. Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity. Oncotarget 6 (2) , pp. 604-616. 10.18632/oncotarget.2820

Tangudu, N. K., Verma, V. K., Clemons, T. D., Beevi, S. S., Hay, Trevor, Mahidhara, G., Raja, Meera, Nair, R. A., Alexander, L. E., Patel, A. B., Jose, J., Smith, N. M., Zdyrko, B., Bourdoncle, A., Luzinov, I., Iyer, K. S., Clarke, Alan Richard

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Tornillo, Giusy and Smalley, Matthew John

2015. ERrrr...Where are the progenitors? Hormone receptors and mammary cell heterogeneity. Journal of Mammary Gland Biology and Neoplasia 20 (1) , pp. 63-73. 10.1007/s10911-015-9336-1

Wölwer, Christina B., Pase, Luke B., Pearson, Helen B.

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2014

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, Decraene, C., Chiappetta, G., Piantedosi, F., Calabrese, C. and Zollo, M. 2014. H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC. Oncotarget 5 (14) , pp. 5736-5749. 10.18632/oncotarget.2169

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2014. PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. The Journal of Pathology 233 (1) , pp. 27-38. 10.1002/path.4312

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2014. Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency. Oncogene 33 , pp. 4089-4096. 10.1038/onc.2013.371

Griessinger, E., Anjos-Afonso, Fernando

, Pizzitola, I., Rouault-Pierre, K., Vargaftig, J., Taussig, D., Gribben, J., Lassailly, F. and Bonnet, Dominique 2014. A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: A new tool to decipher their chemoresistance and self-renewal mechanisms. Stem Cells Translational Medicine 3 (4) , pp. 520-529. 10.5966/sctm.2013-0166

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, Waring, Paul M., Montgomery, Karen G., Kinross, Kathryn M., Mills, Kevin, Roh, Vincent, Heath, Joan K., Ramsay, Robert G., Ernst, Matthias and Phillips, Wayne A. 2014. Physiological expression of the PI3K-activating mutationPik3caH1047Rcombines withApcloss to promote development of invasive intestinal adenocarcinomas in mice. Biochemical Journal 458 (2) , pp. 251-258. 10.1042/BJ20131412

Hickman, John A., Graeser, Ralph, de Hoogt, Ronald, Vidic, Suzana, Brito, Catarina, Gutekunst, Matthias, van der Kuip, Heiko, consortium, IMI PREDECT and Smalley, Matthew John

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Krzystyniak, Joanna 2014. Epigenetic modulation of intestinal homeostasis and tumorigenesis by Brm SWI/SNF chromatin remodelling factor. PhD Thesis, Cardiff University.

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Marsh Durban, Victoria

, Jansen, Marnix, Davies, Emma Jane, Morsink, Folkert H., Offerhaus, G. Johan A. and Clarke, Alan Richard

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2014. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. Journal of Pathology 233 (2) , pp. 124-137. 10.1002/path.4345

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, Kirsch, David G., Provero, Paolo, Poli, Valeria, Ramsay, Robert G., Sieber, Oliver, Burgess, Antony W., Huszar, Dennis, Vincan, Elizabeth and Ernst, Matthias 2014. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration. Science Signaling 7 (345) , ra92. 10.1126/scisignal.2005411

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, Rouault-Pierre, K., Lassailly, F., Tettamanti, S., Spinelli, O., Biondi, A., Biagi, E. and Bonnet, D. 2014. Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo. Leukemia 28 , pp. 1596-1605. 10.1038/leu.2014.62

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, Abud, Helen E., Cengia, Louise H., Corbin, Jason, Mifsud, Sandra, Di Rago, Ladina, Metcalf, Donald, Ernst, Matthias, Dewson, Grant, Roberts, Andrew W., Alexander, Warren S., Murphy, James M., Ekert, Paul G., Masters, Seth L., Vaux, David L., Croker, Ben A., Gerlic, Motti and Silke, John 2014. RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell 157 (5) , pp. 1175-1188. 10.1016/j.cell.2014.04.019

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Sarkisian, Matthew R., Siebzehnrubl, Dorit, Hoang-Minh, Lan, Deleyrolle, Loic, Silver, Daniel J., Siebzehnrubl, Florian

, Guadiana, Sarah M., Srivinasan, Gayathri, Semple-Rowland, Susan, Harrison, Jeffrey K., Steindler, Dennis A. and Reynolds, Brent A. 2014. Detection of primary cilia in human glioblastoma. Journal of Neuro-Oncology 117 (1) , pp. 15-24. 10.1007/s11060-013-1340-y

Stuart, E., Buchert, M., Putoczki, T., Thiem, S., Farid, R., Elzer, J., Huszar, D., Waring, P. M., Phesse, Toby

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Suhalim, Jeffrey L., Parfitt, Geraint J

, Xie, Yilu, De Paiva, Cintia S., Pflugfelder, Stephen C., Shah, Tejas N., Potma, Eric O., Brown, Donald J. and Jester, James V. 2014. Effect of desiccating stress on mouse meibomian gland function. Ocular Surface 12 (1) , pp. 59-68. 10.1016/j.jtos.2013.08.002

Tanguay, J. S., Wheeler, P., Button, M., Stevens, R., Shaw, Paul

, Brewster, A., Hanna, L. and Lester, J. F. 2014. Limited stage small cell lung cancer (LS SCLC) South East Wales experience. Lung Cancer 88 (Supp 1) , S66. 10.1016/S0169-5002(14)70180-1

Tornillo, Giusy and Cabodi, Sara 2014. 3D mammary colony-forming cell assay. Bio-Protocol 4 (7)

Vedam-Mai, Vinata, Gardner, Bronwen, Okun, Michael S., Siebzehnrubl, Florian

, Kam, Monica, Aponso, Palingu, Steindler, Dennis A., Yachnis, Anthony T., Neal, Dan, Oliver, Brittany U., Rath, Sean J., Faull, Richard L. M., Reynolds, Brent A. and Curtis, Maurice A. 2014. Increased precursor cell proliferation after deep brain stimulation for Parkinson's disease: a human study. PLoS ONE 9 (3) , e88770. 10.1371/journal.pone.0088770

2013

Anjos-Afonso, Fernando

, Currie, Erin, Palmer, Hector G., Foster, Katie E., Taussig, David C. and Bonnet, Dominique 2013. CD34− cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures. Cell Stem Cell 13 (2) , pp. 161-174. 10.1016/j.stem.2013.05.025

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Cater, Michael A., Pearson, Helen B.

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Shorning, Boris and Clarke, Alan Richard

2011. LKB1 loss of function studied in vivo. FEBS Letters 585 (7) , pp. 958-966. 10.1016/j.febslet.2011.01.019

Shorning, Boris, Griffiths, David Francis Rees and Clarke, Alan Richard

2011. Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS ONE 6 (1) , e16209. 10.1371/journal.pone.0016209

Siebzehnrubl, Florian

, Reynolds, B. A., Vescovi, A., Steindler, D. A. and Deleyrolle, L. P. 2011. The origins of glioma: E pluribus unum? GLIA 59 (8) , pp. 1135-1147. 10.1002/glia.21143

Siebzehnrubl, Florian

, Vedam-Mai, Vinata, Azari, Hassan, Reynolds, Brent A. and Deleyrolle, Loic P. 2011. Isolation and characterization of adult neural stem cells. Filippi, Marie-Dominique and Geiger, Hartmut, eds. Stem Cell Migration, Vol. 750. Methods in Molecular Biology, Springer, pp. 61-77. (10.1007/978-1-61779-145-1_4)

Steffenhagen, Carolin, Kraus, Sabrina, Dechant, Franz-Xaver, Kandasamy, Mahesh, Lehner, Bernadette, Poehler, Anne-Maria, Furtner, Tanja, Siebzehnrubl, Florian

, Couillard-Despres, Sebastien, Strauss, Olaf, Aigner, Ludwig and Rivera, Francisco J. 2011. Identity, fate and potential of cells grown as neurospheres: species matters. Stem Cell Reviews and Reports 7 (4) , pp. 815-835. 10.1007/s12015-011-9251-9

Thomas, Rhian Sara, Clarke, Alan Richard

, Duance, Victor Colin

and Blain, Emma Jane

2011. Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Research and Therapy 13 (6) , R203. 10.1186/ar3536

Vargaftig, J., Taussig, D. C., Griessinger, E., Anjos-Afonso, Fernando

, Lister, T. A., Cavenagh, J., Oakervee, H., Gribben, J. and Bonnet, Dominique 2011. Frequency of leukemic initiating cells does not depend on the xenotransplantation model used. Leukemia 26 (4) , pp. 858-860. 10.1038/leu.2011.250

Wansbury, Olivia, Mackay, Alan, Kogata, Naoko, Mitsopoulos, Costas, Kendrick, Howard, Davidson, Kathryn, Ruhrberg, Christiana, Reis- Filho, Jorge, Smalley, Matthew John

, Zvelebil, Marketa and Howard, Beatrice 2011. Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment. Breast Cancer Research 13 (4) , R79. 10.1186/bcr2928

Young, Madeleine and Clarke, Alan Richard

2011. Expanding the p53 toolkit: A new platform for rapid engineering of the p53 locus in vivo [Note]. Cell Cycle 10 (14) , p. 2249. 10.4161/cc.10.14.16205

2010

Ashton, Gabrielle H., Morton, Jennifer P., Myant, Kevin, Phesse, Toby

, Ridgway, Rachel A., Marsh Durban, Victoria

, Wilkins, Julie A., Athineos, Dimitris, Muncan, Vanesa, Kemp, Richard, Neufeld, Kristi, Clevers, Hans, Brunton, Valerie, Winton, Douglas J., Wang, Xiaoyan, Sears, Rosalie C., Clarke, Alan Richard

, Frame, Margaret C. and Sansom, Owen J.

2010. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental Cell 19 (2) , pp. 259-269. 10.1016/j.devcel.2010.07.015

Buchert, Michael, Athineos, Dimitris, Abud, Helen E., Burke, Zoe D., Faux, Maree C., Samuel, Michael S., Jarnicki, Andrew G., Winbanks, Catherine E., Newton, Ian P, Meniel, Valerie, Suzuki, Hiromu, Stacker, Steven A., Näthke, Inke S., Tosh, David, Huelsken, Joerg, Clarke, Alan Richard

, Heath, Joan K., Sansom, Owen J.

and Ernst, Matthias 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-Catenin pathway in vivo. PLOS Genetics 6 (1) , e1000816. 10.1371/journal.pgen.1000816

Cole, Alicia M., Myant, Kevin, Reed, Karen Ruth

, Ridgway, Rachel A., Athineos, Dimitris, Van den Brink, Gijs, Muncan, Vanesa, Clevers, Hans, Clarke, Alan Richard

, Sicinski, Peter and Sansom, Owen J.

2010. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Research 70 (20) , pp. 8149-8158. 10.1158/0008-5472.CAN-10-0315

Cole, Alicia, Ridgway, Rachel, Derkits, Sahra, Parry, Lee

, Barker, Nick, Clevers, Hans, Clarke, Alan Richard

and Sansom, Owen 2010. p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Molecular Medicine 2 (11) , pp. 472-486. 10.1002/emmm.201000101

Coras, Roland, Siebzehnrubl, Florian

, Pauli, Elisabeth, Huttner, Hagen B., Njunting, Marleisje, Kobow, Katja, Villmann, Carmen, Hahnen, Eric, Neuhuber, Winfried, Weigel, Daniel, Buchfelder, Michael, Stefan, Hermann, Beck, Heinz, Steindler, Dennis A. and Bluemcke, Ingmar 2010. Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. Brain 133 (11) , pp. 3359-3372. 10.1093/brain/awq215

De Navascues Melero, Joaquin

and Modolell, Juan 2010. The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. Mechanisms of Development 127 (9-12) , pp. 393-406. 10.1016/j.mod.2010.05.001

Evers, Bastiaan, Speksnijder, Ewoud N., Schut, Eva, Ciampricotti, Metamia, Smalley, Matthew John

, Derksen, Patrick W. B., Jonkers, Jos and de Visser, Karin E. 2010. A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis. Journal of Pathology 220 (1) , pp. 34-44. 10.1002/path.2655

Ewan, Kenneth Burnside Ramsay

, Pajak, Bozena, Stubbs, M., Todd, H., Barbeau, O., Quevedo, C., Botfield, H., Young, R., Ruddle, R., Samuel, L., Battersby, Alysia Agnes, Raynaud, F., Allen, Nicholas Denby

, Wilson, Samuel, Latinkic, Branko

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2010. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Research 70 (14) , pp. 5963-5973. 10.1158/0008-5472.CAN-10-1028

Ghafoor, Sana Z. A., MacRae, Eva A., Harding, Keith Gordon and Patel, Girish Khandubhai 2010. Symmetrical peripheral digital gangrene following severe Plasmodium falciparum malaria-induced disseminated intravascular coagulopathy. International Wound Journal 7 (5) , pp. 418-422. 10.1111/j.1742-481X.2010.00697.x

Jiang, Wen Guo

, Ye, Lin

, Patel, Girish Khandubhai and Harding, Keith Gordon 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues and the biological influence on human keratinocytes. Wound Repair and Regeneration 18 (6) , pp. 594-604. 10.1111/j.1524-475X.2010.00630.x

Jiang, Wen Guo

, Ye, Lin

, Patel, Girish Khandubhai and Harding, Keith Gordon 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins, in human wound tissues and the cellular impact of WAVEs on keratinocytes [Abstract]. Wound Repair and Regeneration 18 (6) , A84. 10.1111/j.1524-475X.2010.00633.x

Kajita, Mihoko, Hogan, Catherine

, Harris, Andrew R., Dupre-Crochet, Sophie, Itasaki, Nobue, Kawakami, Koichi, Charras, Guillaume, Tada, Masazumi and Fujita, Yasuyuki 2010. Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. Journal of Cell Science 123 (2) , pp. 171-180. 10.1242/jcs.057976

Minhas, Uzma, Sanders, Andrew James

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2010. Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract]. Wound Repair and Regeneration 18 (6) , A89. 10.1111/j.1524-475X.2010.00633.x

Molyneux, Gemma, Geyer, Felipe, Magnay, Fiona-Ann, McCarthy, Afshan, Kendrick, Howard, Natrajan, Rachael, MacKay, Alan, Grigoriadis, Anita, Tutt, Andrew, Ashworth, Alan, Reis-Filho, Jorge and Smalley, Matthew John

2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7 (3) , pp. 403-417. 10.1016/j.stem.2010.07.010

Patel, Girish Khandubhai and Harding, Keith Gordon 2010. Nicorandil ulcer: moves beyond the mucosa. Annals of the Royal College of Surgeons of England 92 (6) , pp. 451-452. 10.1308/003588410X12699663905195

Patel, Girish Khandubhai, Davies, Wendy L., Price, Patricia Elaine and Harding, Keith Gordon 2010. Ulcerated tophaceous gout. International Wound Journal 7 (5) , pp. 423-427. 10.1111/j.1742-481X.2010.00700.x

Porazinski, Sean, Wang, Huijia and Furutani-Seiki, Makoto 2010. Microinjection of medaka embryos for use as a model genetic organism. Journal of Visualized Experiments (46) , e1937. 10.3791/1937

Poulin, L. F., Salio, M., Griessinger, E., Anjos-Afonso, F.

, Craciun, L., Chen, J. -L., Keller, A. M., Joffre, O., Zelenay, S., Nye, E., Le Moine, A., Faure, F., Donckier, V., Sancho, D., Cerundolo, V., Bonnet, D. and Reis e Sousa, C. 2010. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8 + dendritic cells. Journal of Experimental Medicine 207 (6) , pp. 1261-1271. 10.1084/jem.20092618

Rangaraj, Aravindan, Ye, Lin

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2010. The role of Bik1 (BCL-2 interaction killer) in wound healing [Abstract]. Wound Repair and Regeneration 18 (6) , A92. 10.1111/j.1524-475X.2010.00633.x

Rangaraj, Aravindan, Ye, Lin

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2010. The molecular and cellular roles of Psoriasin (S100A4) in human cutaneous wound healing [Abstract]. Wound Repair and Regeneration 18 (6) , A92. 10.1111/j.1524-475X.2010.00633.x

Smalley, Matthew John

2010. Isolation, culture and analysis of mouse mammary epithelial cells. Ward, Andrew and Tosh, David, eds. Mouse cell culture : methods and protocols, Methods in Molecular Biology, vol. 633. New York: Springer-Verlag, pp. 139-170. (10.1007/978-1-59745-019-5_11)

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2009

Alexander, Caroline M., Puchalski, Joel, Klos, Kristine S., Badders, Nisha, Ailles, Laurie, Kim, Carla F., Dirks, Peter and Smalley, Matthew John

2009. Separating stem cells by flow cytometry: reducing variability for solid tissues. Cell Stem Cell 5 (6) , pp. 579-583. 10.1016/j.stem.2009.11.008

Barker, Nick, Ridgway, Rachel A., Van Es, Johan H., Van De Wetering, Marc, Begthel, Harry, Van Den Born, Maaike, Danenberg, Esther, Clarke, Alan Richard

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Bollrath, Julia, Phesse, Toby

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Britt, Kara L., Kendrick, Howard, Regan, Joseph L., Molyneux, Gemma, Magnay, Fiona-Ann, Ashworth, Alan and Smalley, Matthew John

2009. Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells. Breast Cancer Research 11 (2) , R20. 10.1186/bcr2245

Burke, Zoé D., Reed, Karen Ruth

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Greenow, Kirsty Rhian, Clarke, Alan Richard

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2009. Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. Oncogene 28 (11) , pp. 1443-1453. 10.1038/onc.2008.482

Grigoriadis, Anita, Oliver, Gavin, Tanney, Austin, Kendrick, Howard, Smalley, Matthew John

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Pearson, Helen B.

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2009. K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Research 69 (1) , pp. 94-101. 10.1158/0008-5472.CAN-08-2895

Phesse, Toby

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2009. Normal stem cells in cancer prone epithelial tissues. British Journal of Cancer 100 (2) , pp. 221-227. 10.1038/sj.bjc.6604850

Rivera, Francisco J., Siebzehnrubl, Florian

, Kandasamy, Mahesh, Couillard-Despres, Sebastien, Caioni, Massimiliano, Poehler, Anne-Maria, Berninger, Benedikt, Sandner, Beatrice, Bogdahn, Ulrich, Goetz, Magdalena, Bluemcke, Ingmar, Weidner, Norbert and Aigner, Ludwig 2009. Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures. Cellular Physiology and Biochemistry 24 (3-4) , pp. 317-324. 10.1159/000233256

Ruzov, Alexey, Shorning, Boris, Mortusewicz, Oliver, Dunican, Donncha S., Leonhardt, Heinrich and Meehan, Richard R. 2009. MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. Development 136 (13) , pp. 2277-2286. 10.1242/dev.032227

Shorning, Boris, Zabkiewicz, Joanna

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2009. Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS ONE 4 (1) , e4264. 10.1371/journal.pone.0004264

Siebzehnrubl, Florian

, Jeske, Ina, Mueller, Dorit, Buslei, Rolf, Coras, Roland, Hahnen, Eric, Huttner, Hagen B., Corbeil, Denis, Kaesbauer, Johanna, Appl, Thomas, von Hoersten, Stephan and Bluemcke, Ingmar 2009. Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells. Brain Pathology 19 (3) , pp. 399-408. 10.1111/j.1750-3639.2008.00189.x

Smith, Paul James, Furon, Emeline, Wiltshire, Marie, Campbell, Lee, Feeney, Graham P., Snyder, R. D. and Errington, Rachel Jane

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Tipping, A. J., Pina, C., Castor, A., Hong, D., Rodrigues, Neil

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Weiss, S., Siebzehnrubl, Florian

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2008

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2008. The potential for targeting oncogenic WNT/beta-catenin signaling in therapy. Current Drug Targets 9 (7) , pp. 532-547. 10.2174/138945008784911787

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2008. Investigating h-Prune activation of Wnt signalling in breast cancer. Breast Cancer Research 10 (s2) , p. 10. 10.1186/bcr1899

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Kadri, Hachemi, Dale, Trevor Clive

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2008. The design, synthesis and antitumour evaluation of novel small molecule inhibitors of the Dishevelled PDZ domain [Poster Presentation/Abstract]. EJC Supplements 6 (12) , p. 137. 10.1016/S1359-6349(08)72370-X

Kendrick, Howard, Regan, Joseph, Magnay, Fiona-Ann, Grigoriadis, Anita, Mitsopoulos, Costas, Zvelebil, Marketa and Smalley, Matthew John

2008. Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics 9 (1) , 591. 10.1186/1471-2164-9-591

Lindeman, Geoffrey, Visvader, Jane, Smalley, Matthew John

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Marsh Durban, Victoria

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2008. Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nature Genetics 40 (12) , pp. 1436-1444. 10.1038/ng.256

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2008. Highway to heaven: mammary gland development and differentiation. Breast Cancer Research 10 (5) , pp. 305-307. 10.1186/bcr2147

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2008. Development and characterisation of novel mouse models of human prostate cancer. PhD Thesis, Cardiff University.

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2007

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2003. Wnt-Cadherin connections in normal and neoplastic mammary epithelium. Journal of Mammary Gland Biology and Neoplasia 8 (4) , pp. 435-447. 10.1023/B:JOMG.0000017430.12210.37

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2002

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2002. lkB kinase alpha: a link in the chain of the mammary cycle. Breast Cancer Research 4 , 173. 10.1186/bcr446

Cullingworth, Jan, Hooper, Martin L., Harrison, David J., Mason, John O., Sirard, Christian, Patek, Charles E. and Clarke, Alan Richard

2002. Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes. Oncogene 21 (30) , pp. 4696-4701. 10.1038/sj.onc.1205673

Ding, Yanning and Dale, Trevor Clive

2002. Wnt signal transduction: kinase cogs in a nano-machine? Trends in Biochemical Sciences 27 (7) , pp. 327-329. 10.1016/S0968-0004(02)02137-0

Feng, Gui Jie, Cavalli, Antonella and Milligan, Graeme 2002. Engineering a V2 vasopressin receptor agonist- and regulator of G-protein-signaling-sensitive G protein. Analytical Biochemistry 300 (2) , pp. 212-220. 10.1006/abio.2001.5448

Franca-Koh, Jonathan, Yeo, Margaret, Fraser, Elizabeth, Young, Neville and Dale, Trevor Clive

2002. The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP. Journal of Biological Chemistry , pp. 43844-43848. 10.1074/jbc.M207265200

Fraser, Elizabeth, Young, N., Dajani, R., Franca-Koh, J., Ryves, William Jonathan, Williams, R. S. B., Yeo, M., Webster, M.-T., Richardson, C., Smalley, Matthew John

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2002. Identification of the Axin and Frat binding region of glycogen synthase kinase-3. Journal of Biological Chemistry 277 (3) , pp. 2176-2185. 10.1074/jbc.M109462200

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2002. Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene 21 (42) , pp. 6446-6457. 10.1038/sj.onc.1205892

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Morse, Nerys R., Meniel, Valerie and Waters, Raymond 2002. Photoreactivation of UV-induced cyclobutane primidine dimers in the MFA2 gene of S. cerevisiae. Nucleic Acids Research 30 (8) , pp. 1799-1807. 10.1093/nar/30.8.1799

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, Wilson, Stephen W. and Stemple, Derek L. 2001. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes & Development 15 (11) , pp. 1427-1434. 10.1101/gad.194301

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2001. Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. Human Molecular Genetics 10 (25) , pp. 2899-9205. 10.1093/hmg/10.25.2899

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Patel, Girish Khandubhai and Anstey, Alexander Vincent

2001. Rifampicin-induced lupus erythematosus. Clinical and Experimental Dermatology 26 (3) , pp. 260-262. 10.1046/j.1365-2230.2001.00809.x

Patel, Girish, Taylor, D. and Anstey, Alexander Vincent

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2001. Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in ApcMin/+ and ApcMin/+, Msh2-/- mice. Cancer Research 61 , pp. 7060-7064.

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, Toft, Neil J., Winton, Douglas J. and Clarke, Alan Richard

2001. Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner. Oncogene 20 (27) , pp. 3580-3584. 10.1038/sj.onc.1204449

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2001. Wnt signaling and mammary tumorigenesis. Journal of Mammary Gland Biology and Neoplasia 6 (1) , pp. 37-52.

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, Leiper, K., Tootle, R., McCloskey, P., O'Hare, M. J. and Hodgson, H. 2001. Immortalisation of human hepatocytes by temperature-sensitive SV40 large-T antigen. In Vitro Cellular and Developmental Biology - Animal 37 (3) , pp. 166-168. 10.1290/1071-2690(2001)037<0166:IOHHBT>2.0.CO;2

Strathdee, Gordon, Sansom, Owen J.

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2001. Oral uracil-tegafur: an alternative to intravenous 5-fluorouracil? Expert Opinion on Pharmacotherapy 2 (9) , pp. 1495-1505. 10.1517/14656566.2.9.1495

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and Harper, Peter Stanley 2000. Randomized trial of a specialist genetic assessment service for familial breast cancer. Journal of the National Cancer Institute 92 (16) , pp. 1345-1351. 10.1093/jnci/92.16.1345

Chapman, Rachel S., Duff, Eleanor K., Lourenco, Paula C., Tonner, Elizabeth, Flint, David J., Clarke, Alan Richard

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, Dombkowski, David, Stier, Sebastian and Scadden, David T. 2000. Stem cell repopulation efficiency but not pool size is governed by p27 (kip1). Nature Medicine 6 , pp. 1235-1240. 10.1038/81335

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, Shen, Hongmei, Yang, Yong-Guang, Dombkowski, David, Sykes, Megan and Scadden, David T. 2000. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287 (5459) , pp. 1804-1808. 10.1126/science.287.5459.1804

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2000. Manipulating the germline: Its impact on the study of carcinogenesis. Carcinogenesis 21 (3) , pp. 435-441. 10.1093/carcin/21.3.435

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, Heeley, JoannaLL., Chapman, Rachel, Aillet, Fabienne, Hay, Ronald T., Wyllie, Andrew and Watson, Christine J. 2000. NF-kappa B inhibits apoptosis in murine mammary epithelia. Journal of Biological Chemistry 275 (17) , pp. 12737-12742. 10.1074/jbc.275.17.12737

Gordon, K., Binas, B., Chapman, R. S., Kurian, K. M., Clarkson, Richard W. E.

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MacKenzie, Alasdair, Payne, Catherine, Boyle, Shelagh, Clarke, Alan Richard

and Quinn, John P. 2000. The human preprotachykinin-A gene promoter has been highly conserved and can drive human-like marker gene expression in the adult mouse CNS. Molecular and Cellular Neuroscience 16 (5) , pp. 620-630. 10.1006/mcne.2000.0902

Naylor, S., Smalley, Matthew John

, Robertson, D., Gusterson, B. A., Edwards, P. A. and Dale, Trevor Clive

2000. Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium. Journal of Cell Science 113 (12) , pp. 2129-2138.

Nunez, Fatima, Chipchase, Michael D., Clarke, Alan Richard

and Melton, David W. 2000. Nucleotide excision repair gene (ERCC1) deficiency causes G2 arrest in hepatocytes and a reduction in liver binucleation: The role of p53 and p21. Faseb Journal 14 (9) , pp. 1073-1082.

Parry, Lee

, Maynard, Julie Helen, Patel, Amit, Hodges, Angela, von Deimling, Andreas, Sampson, Julian Roy

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2000. Molecular analysis of the TSC1 and TSC2 tumour suppressor genes in sporadic glial and glioneuronal tumours. Human Genetics 107 (4) , pp. 350-356. 10.1007/s004390000390

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2000. P53 null mice: damaging the hypothesis? Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 452 (2) , pp. 149-162. 10.1016/S0027-5107(00)00089-0

Sarkar, L., Cobourne, M., Naylor, S., Smalley, Matthew John

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and Sharpe, P. T. 2000. Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proceedings of the National Academy of Sciences of the United States of America 97 (9) , pp. 4520-4524. 10.1073/pnas.97.9.4520

Toft, Neil J., Sansom, Owen J., Brookes, Roger A., Arends, Mark J., Wood, Michelle, Margison, Geoffrey P., Winton, Douglas J. and Clarke, Alan Richard

2000. In vivo administration of O6-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine. Carcinogenesis 21 (4) , pp. 593-598.

Webster, M. T., Rozycka, M., Sara, Elizabeth, Davis, E., Smalley, Matthew John

, Young, N., Dale, Trevor Clive

and Wooster, R. 2000. Sequence variants of the Axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. Genes Chromosomes and Cancer 28 (4) , pp. 443-453. 10.1002/1098-2264(200008)28:4<443::AID-GCC10>3.0.CO;2-D

1999

Feng, Gui-Jie, Goodridge, Helen S., Harnett, Margaret M., Wei, Xiao Qing, Nikolaev, Andrei V., Higson, Adrian P. and Liew, Foo -Y. 1999. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. Journal of Immunolgy 163 (12) , pp. 6403-6412.

Smalley, Matthew John