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Number of items at this level: 308.


Abdelfattah, Ali Mahmoud, Hughes-Davies, Antonia, Clayfield, Liam Daniel, Menendez-Gonzalez, Juan Bautista, Almotiri, Alhomidi, Alotaibi, Badi, Tonks, Alex and Rodrigues, Neil P 2021. Gata2 haploinsufficiency promotes proliferation and functional decline of HSCs with myeloid bias during aging. Blood Advances 10.1182/bloodadvances.2021004726

Abraham, Thomas, Barbier, Michaël, Jaensch, Steffen, Cornelissen, Frans, Vidic, Suzana, Gjerde, Kjersti, de Hoogt, Ronald, Graeser, Ralph, Gustin, Emmanuel, Chong, Yolanda T. and Smalley, Matthew J. 2016. Ellipsoid segmentation model for analyzing light-attenuated 3D confocal image stacks of fluorescent multi-cellular spheroids. PLoS ONE 11 (6) , e0156942. 10.1371/journal.pone.0156942

Adams, G. B., Chabner, K. T., Foxall, R. T., Weibrecht, K. W., Rodrigues, Neil, Dombkowski, D., Fallon, R., Poznansky, M. C. and Scadden, D. T. 2002. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood 101 (1) , pp. 45-51. 10.1182/blood-2002-02-0486

Alexander, Caroline M., Puchalski, Joel, Klos, Kristine S., Badders, Nisha, Ailles, Laurie, Kim, Carla F., Dirks, Peter and Smalley, Matthew John 2009. Separating stem cells by flow cytometry: reducing variability for solid tissues. Cell Stem Cell 5 (6) , pp. 579-583. 10.1016/j.stem.2009.11.008

Almotiri, Alhomidi, Alzahrani, Hamed Ahmad A., Menendez-Gonzalez, Juan Bautista, Abdelfattah, Ali, Alotaibi, Badi, Saleh, Lubaid, Greene, Adelle, Georgiou, Mia R. F., Gibbs, Alex, Alsayari, Amani Salem, Taha, Sarab, Thomas, Leigh-Anne, Shah, Dhruv, Edkins, Sarah, Giles, Peter J., Stemmler, Marc P., Brabletz, Simone, Brabletz, Thomas, Boyd, Ashleigh S., Siebzehnrubl, Florian and Rodrigues, Neil P. 2021. Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. Journal of Clinical Investigation 131 (1) , e129115. 10.1172/JCI129115

Anjos-Afonso, Fernando and Bonnet, Dominique 2006. Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment. Blood 109 (3) , pp. 1298-1306. 10.1182/blood-2006-06-030551

Anjos-Afonso, Fernando and Bonnet, Dominique 2007. Flexible and dynamic organization of bone marrow stromal compartment. British Journal of Haematology 139 (3) , pp. 373-384. 10.1111/j.1365-2141.2007.06827.x

Anjos-Afonso, Fernando and Bonnet, Dominique 2008. Isolation, culture, and differentiation potential of mouse marrow stromal cells. Current Protocols in Stem Cell Biology 10.1002/9780470151808.sc02b03s7

Anjos-Afonso, Fernando and Bonnet, Dominique 2011. Prospective identification and isolation of murine bone marrow derived multipotent mesenchymal progenitor cells. Best Practice & Research Clinical Haematology 24 (1) , pp. 13-24. 10.1016/j.beha.2010.11.003

Anjos-Afonso, Fernando, Currie, Erin, Palmer, Hector G., Foster, Katie E., Taussig, David C. and Bonnet, Dominique 2013. CD34− cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures. Cell Stem Cell 13 (2) , pp. 161-174. 10.1016/j.stem.2013.05.025

Anjos-Afonso, Fernando, Siapati, Elena K. and Bonnet, Dominique 2004. In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions. Journal of Cell Science 117 (23) , pp. 5655-5664. 10.1242/jcs.01488

Annakesavan, Anita, Patel, Girish Khandubhai and Harding, Keith Gordon 2011. Recurrence of diffuse large B cell lymphoma presenting as a chronic non healing wound - case report [Abstract]. Wound Repair and Regeneration 19 (2) , A10. 10.1111/j.1524-475X.2010.00670.x

Ashton, Gabrielle H., Morton, Jennifer P., Myant, Kevin, Phesse, Toby, Ridgway, Rachel A., Marsh Durban, Victoria, Wilkins, Julie A., Athineos, Dimitris, Muncan, Vanesa, Kemp, Richard, Neufeld, Kristi, Clevers, Hans, Brunton, Valerie, Winton, Douglas J., Wang, Xiaoyan, Sears, Rosalie C., Clarke, Alan Richard, Frame, Margaret C. and Sansom, Owen J. 2010. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental Cell 19 (2) , pp. 259-269. 10.1016/j.devcel.2010.07.015


Badder, Luned 2017. Developing stem-cell containing organoids as a pre-clinical model for colorectal cancer therapeutics. PhD Thesis, Cardiff University.
Item availability restricted.

Badder, Luned M., Hollins, Andrew J., Herpers, Bram, Yan, Kuan, Ewan, Kenneth B., Thomas, Mairian, Shone, Jennifer R., Badder, Delyth A., Naven, Marc, Ashelford, Kevin E., Hargest, Rachel, Clarke, Alan R., Esdar, Christina, Buchstaller, Hans-Peter, Treherne, J. Mark, Boj, Sylvia, Ramezanpour, Bahar, Wienke, Dirk, Price, Leo S., Shaw, Paul H. and Dale, Trevor C. 2020. 3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors. PLoS ONE 15 (8) , e0235319. 10.1371/journal.pone.0235319

Barker, Nick, Ridgway, Rachel A., Van Es, Johan H., Van De Wetering, Marc, Begthel, Harry, Van Den Born, Maaike, Danenberg, Esther, Clarke, Alan Richard, Sansom, Owen J. and Clevers, Hans 2009. Crypt stem cells as the cells-of-origin of intestinal cancer [Letter]. Nature 457 (7229) , pp. 608-611. 10.1038/nature07602

Berenjeno, Inma M., Piñeiro, Roberto, Castillo, Sandra D., Pearce, Wayne, McGranahan, Nicholas, Dewhurst, Sally M., Meniel, Valerie, Birkbak, Nicolai J., Lau, Evelyn, Sansregret, Laurent, Morelli, Daniele, Kanu, Nnennaya, Srinivas, Shankar, Graupera, Mariona, Parker, Victoria E. R., Montgomery, Karen G., Moniz, Larissa S., Scudamore, Cheryl L., Phillips, Wayne A., Semple, Robert K., Clarke, Alan, Swanton, Charles and Vanhaesebroeck, Bart 2017. Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nature Communications 8 (1) , 1773. 10.1038/s41467-017-02002-4

Bosanquet, David C., Davies, Wendy L., May, Kenneth, Harding, Keith Gordon and Patel, Girish Khandubhai 2011. Acute generalised exanthematous pustulosis following intravitreal Ranibizumab. International Wound Journal 8 (3) , pp. 317-319. 10.1111/j.1742-481X.2011.00799.x

Brain, Katherine Emma, Gray, Jonathon, Norman, Paul, France, Elizabeth, Anglim, Cathy, Barton, Garry, Parsons, Evelyn Patricia, Clarke, Alan Richard, Sweetland, Helen Margaret, Tischkowitz, Marc, Myring, Jenny, Stansfield, Kate, Webster, David, Gower-Thomas, Kate, Daoud, Raouf, Gateley, Chris, Montpenny, Ian, Singhal, Hemant, Branston, Lucy, Sampson, Julian Roy, Roberts, Elizabeth, Newcombe, Robert Gordon, Cohen, David, Rogers, Cerilan, Mansel, Robert Edward and Harper, Peter Stanley 2000. Randomized trial of a specialist genetic assessment service for familial breast cancer. Journal of the National Cancer Institute 92 (16) , pp. 1345-1351. 10.1093/jnci/92.16.1345

Britt, K., Ashworth, A. and Smalley, Matthew John 2007. Pregnancy and the risk of breast cancer. Endocrine-Related Cancer 14 (4) , pp. 907-933. 10.1677/ERC-07-0137

Buchert, Michael, Athineos, Dimitris, Abud, Helen E., Burke, Zoe D., Faux, Maree C., Samuel, Michael S., Jarnicki, Andrew G., Winbanks, Catherine E., Newton, Ian P, Meniel, Valerie, Suzuki, Hiromu, Stacker, Steven A., Näthke, Inke S., Tosh, David, Huelsken, Joerg, Clarke, Alan Richard, Heath, Joan K., Sansom, Owen J. and Ernst, Matthias 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-Catenin pathway in vivo. PLOS Genetics 6 (1) , e1000816. 10.1371/journal.pgen.1000816

Burke, Zoé D., Reed, Karen Ruth, Phesse, Toby, Sansom, Owen J., Clarke, Alan Richard and Tosh, David 2009. Liver zonation occurs through a β-catenin–dependent, c-Myc–independent mechanism. Gastroenterology 136 (7) , pp. 2316-2324. 10.1053/j.gastro.2009.02.063

Burke, Zoe D., Reed, Karen Ruth, Yeh, Sheng-Wen, Meniel, Valerie S., Sansom, Owen J., Clarke, Alan R. and Tosh, David 2018. Spatiotemporal regulation of liver development by the Wnt/β- catenin pathway. Scientific Reports 8 , 2735. 10.1038/s41598-018-20888-y

Buslei, R., Kreutzer, J., Hofmann, B., Schmidt, V., Siebzehnrubl, Florian, Hahnen, E., Eyupoglu, I. Y., Fahlbusch, R. and Blumcke, I. 2006. Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas. Acta Neuropathologica 111 (3) , pp. 264-271. 10.1007/s00401-005-0009-9

Buslei, R., Nolde, M., Hofmann, B., Meissner, S., Eyupoglu, I. Y., Siebzehnrubl, Florian, Hahnen, E., Kreutzer, J. and Fahlbusch, R. 2005. Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. Acta Neuropathologica 109 (6) , pp. 589-597.

Buslei, Rolf, Hoelsken, Annett, Hofmann, Bernd, Kreutzer, Juergen, Siebzehnrubl, Florian, Hans, Volkmar, Oppel, Falk, Buchfelder, Michael, Fahlbusch, Rudolf and Bluemcke, Ingmar 2007. Nuclear beta-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas. Acta Neuropathologica 113 (5) , pp. 585-590.


Chapman, Rachel S., Duff, Eleanor K., Lourenco, Paula C., Tonner, Elizabeth, Flint, David J., Clarke, Alan Richard and Watson, Christine J. 2000. A novel role for IRF-1 as a suppressor of apoptosis. Oncogene 19 (54) , pp. 6386-6391. 10.1038/sj.onc.1204016

Chapman, Rachel S., Lourenco, Paula, Tonner, Elizabeth, Flint, David, Selbert, Stefan, Takeda, Kyoshi, Akira, Shizuo, Clarke, Alan Richard and Watson, Christine J. 2000. The role of Stat3 in apoptosis and mammary gland involution. In: Mol, Jan A. and Clegg, Roger A. eds. Biology of the Mammary Gland, Advances in Experimental Medicine and Biology, Kluwer, pp. 129-138. (10.1007/0-306-46832-8_16)

Cheng, T., Shen, H., Rodrigues, Neil, Stier, S. and Scadden, D. T. 2001. Transforming growth factor β1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21Cip1/Waf1or p27Kip1. Blood 98 (13) , pp. 3643-3649. 10.1182/blood.V98.13.3643

Cheng, Tao, Rodrigues, Neil, Shen, Hongmei, Yang, Yong-Guang, Dombkowski, David, Sykes, Megan and Scadden, David T. 2000. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287 (5459) , pp. 1804-1808. 10.1126/science.287.5459.1804

Clarke, Alan Richard 2000. Manipulating the germline: Its impact on the study of carcinogenesis. Carcinogenesis 21 (3) , pp. 435-441. 10.1093/carcin/21.3.435

Clarke, Alan Richard and Meniel, Valerie 2007. The intestinal stem cell niche studied through conditional transgenesis. Presented at: The Cancer Stem Cell Workshop, Berlin, Germany, November 15- 17 2006. Published in: Wiestler, O. D., Haendler, B. and Mumberg, D. eds. Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy. Ernst Schering Foundation Symposium Proceedings Berlin: Springer, pp. 99-108. 10.1007/2789_2007_046

Clarkson, Richard W. E. 2002. lkB kinase alpha: a link in the chain of the mammary cycle. Breast Cancer Research 4 , 173. 10.1186/bcr446

Clarkson, Richard W. E., Wayland, M. T., Lee, J., Freeman, T. and Watson, C. J. 2004. Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression. Breast Cancer Research 6 (2) , R92-R109.

Cole, Alicia, Ridgway, Rachel, Derkits, Sahra, Parry, Lee, Barker, Nick, Clevers, Hans, Clarke, Alan Richard and Sansom, Owen 2010. p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Molecular Medicine 2 (11) , pp. 472-486. 10.1002/emmm.201000101

Cole, Alicia M., Myant, Kevin, Reed, Karen Ruth, Ridgway, Rachel A., Athineos, Dimitris, Van den Brink, Gijs, Muncan, Vanesa, Clevers, Hans, Clarke, Alan Richard, Sicinski, Peter and Sansom, Owen J. 2010. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Research 70 (20) , pp. 8149-8158. 10.1158/0008-5472.CAN-10-0315

Colmont, Chantal Sophie, Ben Ketah, Antisar, Errington, Rachel Jane, Reed, Simon Huw, Udey, Mark C. and Patel, Girish Khandubai 2013. Human basal cell carcinoma tumor-initiating cells are resistant to etoposide [Letter]. Journal of Investigative Dermatology 134 (3) , pp. 867-870. 10.1038/jid.2013.377

Colmont, Chantal Sophie, Ben Ketah, Antisar, Reed, Simon Huw, Hawk, Nga V., Telford, William G., Ohyama, Manabu, Udeye, Mark C., Yee, Carole L., Vogel, Jonathan C. and Patel, Girish Khandubhai 2013. CD200-expressing human basal cell carcinoma cells initiate tumor growth. Proceedings of the National Academy of Sciences of the United States of America 110 (4) , pp. 1434-1439. 10.1073/pnas.1211655110

Colmont, Chantal Sophie, Harding, Keith Gordon, Piguet, Vincent and Patel, Girish Khandubhai 2012. Human skin cancer stem cells: a tale of mice and men. Experimental Dermatology 21 (8) , pp. 576-580. 10.1111/j.1600-0625.2012.01533.x

Coras, Roland, Hoelsken, Annett, Seufert, Sebastian, Hauke, Jan, Eyuepoglu, Ilker Y., Reichel, Martin, Traenkle, Christian, Siebzehnrubl, Florian, Buslei, Rolf, Bluemcke, Ingmar and Hahnen, Eric 2007. The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion. Molecular Cancer Therapeutics 6 (6) , pp. 1745-1754. 10.1158/1535-7163.MCT-06-0763

Coras, Roland, Siebzehnrubl, Florian, Pauli, Elisabeth, Huttner, Hagen B., Njunting, Marleisje, Kobow, Katja, Villmann, Carmen, Hahnen, Eric, Neuhuber, Winfried, Weigel, Daniel, Buchfelder, Michael, Stefan, Hermann, Beck, Heinz, Steindler, Dennis A. and Bluemcke, Ingmar 2010. Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. Brain 133 (11) , pp. 3359-3372. 10.1093/brain/awq215

Cowley, Michael, Garfield, Alastair S., Madon-Simon, Marta, Charalambous, Marika, Clarkson, Richard W. E., Smalley, Matthew John, Kendrick, Howard, Isles, Anthony Roger, Parry, Aled J., Carney, Sara, Oakey, Rebecca J., Heisler, Lora K., Moorwood, Kim, Wolf, Jason B. and Ward, Andrew 2014. Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PLoS Biology 12 (2) , e1001799. 10.1371/journal.pbio.1001799

Craiu, A., Saito, Y., Limon, A., Eppich, H. M., Olson, D. P., Rodrigues, Neil, Adams, G. B., Dombkowski, D., Richardson, P., Schlossman, R., Choi, P. S., Grogins, J., O'Connor, P. G., Cohen, K., Attar, E. C., Freshman, J., Rich, R., Mangano, J. A., Gribben, J. G., Anderson, K. C. and Scadden, D. T. 2005. Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function. Blood 105 (5) , pp. 2235-2238. 10.1182/blood-2003-12-4399

Cullingworth, Jan, Hooper, Martin L., Harrison, David J., Mason, John O., Sirard, Christian, Patek, Charles E. and Clarke, Alan Richard 2002. Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes. Oncogene 21 (30) , pp. 4696-4701. 10.1038/sj.onc.1205673


Daly, Carl S. 2013. The roles of the APC proteins in homeostasis and tumourigenesis. PhD Thesis, Cardiff University.
Item availability restricted.

Davies, Emma Jane, Marsh Durban, Victoria and Clarke, Alan Richard 2011. Origin and maintenance of the intestinal cancer stem cell. Molecular Carcinogenesis 50 (4) , pp. 254-263. 10.1002/mc.20631

Davies, Emma Jane, Marsh Durban, Victoria, Meniel, Valerie, Williams, Geraint Trfor and Clarke, Alan Richard 2014. PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. The Journal of Pathology 233 (1) , pp. 27-38. 10.1002/path.4312

De Navascues Melero, Joaquin and Modolell, J. 2007. tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification. Development 134 (9) , pp. 1779-1788. 10.1242/dev.02844

De Navascues Melero, Joaquin and Modolell, Juan 2010. The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. Mechanisms of Development 127 (9-12) , pp. 393-406. 10.1016/j.mod.2010.05.001

Deleyrolle, Loic P., Harding, Angus, Cato, Kathleen, Siebzehnrubl, Florian, Rahman, Maryam, Azari, Hassan, Olson, Sarah, Gabrielli, Brian, Osborne, Geoffrey, Vescovi, Angelo and Reynolds, Brent A. 2011. Evidence for label-retaining tumour-initiating cells in human glioblastoma. Brain 134 , pp. 1331-1343. 10.1093/brain/awr081

Dikovskaya, Dina, Schiffmann, David, Newton, Ian P., Oakley, Abigail, Kroboth, Karin, Sansom, Owen J., Jamieson, Thomas J., Meniel, Valerie, Clarke, Alan Richard and Nathke, Inke S. 2007. Correction 176, p. 183. Journal of cell biology 176 (3) , p. 369. 10.1083/jcb.20061009920070116c

Dikovskaya, Dina, Schiffmann, David, Newton, Ian P., Oakley, Abigail, Kroboth, Karin, Sansom, Owen J., Jamieson, Thomas J., Meniel, Valerie, Clarke, Alan Richard and Nathke, Inke S. 2007. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. Journal of cell biology 176 (2) , pp. 183-195. 10.1083/jcb.200610099

Dimitriou, Pantelitsa, Li, Jin, Tornillo, Giusy, McCloy, Thomas and Barrow, David 2021. Droplet microfluidics for tumor drug-related studies and programmable artificial cells. Global Challenges 5 (7) , 2000123. 10.1002/gch2.202000123

Dixon, P. F., Avery, S., Chambers, E., Feist, S., Mandhar, H., Parry, Lee, Stone, D. M., Stremmen, H. K., Thurlow, J. K., Lui, C. Tsin-yee and Way, K. 2003. Four years of monitoring for viral haemorrhagic septicaemia virus in marine waters around the United Kingdom. Disease of Aquatic Organisms 54 (3) , pp. 175-186. 10.3354/dao054175

Dixon, P.F., Feist, S., Kehoe, E., Parry, Lee, Stone, D.M. and Way, K. 1997. Isolation of viral haemorrhagic septicaemia virus from Atlantic herring Clupea harengus from the Atlantic herring Clupea harengus from the English channel. Diseases of Aquatic Organisms 30 (2) , pp. 81-89.

Dupre-Crochet, S., Figueroa, A., Hogan, Catherine, Ferber, E. C., Bialucha, C. U., Adams, J., Richardson, E. C. N. and Fujita, Y. 2007. Casein Kinase 1 Is a novel negative regulator of E-cadherin-based cell-cell contacts. Molecular and Cellular Biology 27 (10) , pp. 3804-3816. 10.1128/MCB.01590-06


Eccles, Suzanne A., Aboagye, Eric O., Ali, Simak, Anderson, Annie S., Armes, Jo, Berditchevski, Fedor, Blaydes, Jeremy P., Brennan, Keith, Brown, Nicola J., Bryant, Helen E., Bundred, Nigel J., Burchell, Joy M., Campbell, Anna M., Carroll, Jason S., Clarke, Robert B., Coles, Charlotte E., Cook, Gary J. R., Cox, Angela, Curtin, Nicola J., Dekker, Lodewijk V., dos Santos Silva, Isabel, Duffy, Stephen W., Easton, Douglas F., Eccles, Diana M., Edwards, Dylan R., Edwards, Joanne, Evans, D. Gareth, Fenlon, Deborah F., Flanagan, James M., Foster, Claire, Gallagher, William M., Garcia-Closas, Montserrat, Gee, Julia Margaret Wendy, Gescher, Andy J., Goh, Vicky, Groves, Ashley M., Harvey, Amanda J., Harvie, Michelle, Hennessy, Bryan T., Hiscox, Stephen Edward, Holen, Ingunn, Howell, Sacha J., Howell, Anthony, Hubbard, Gill, Hulbert-Williams, Nick, Hunter, Myra S., Jasani, Bharat, Jones, Louise J., Key, Timothy J., Kirwan, Cliona C., Kong, Anthony, Kunkler, Ian H., Langdon, Simon P., Leach, Martin O., Mann, David J., Marshall, John F., Martin, Lesley, Martin, Stewart G., Macdougall, Jennifer E., Miles, David W., Miller, William R., Morris, Joanna R., Moss, Sue M., Mullan, Paul, Natrajan, Rachel, O'Connor, James P. B., O'Connor, Rosemary, Palmieri, Carlo, Pharoah, Paul D. P., Rakha, Emad A., Reed, Elizabeth, Robinson, Simon P., Sahai, Erik, Saxton, John M., Schmid, Peter, Smalley, Matthew John, Speirs, Valerie, Stein, Robert, Stingl, John, Streuli, Charles H., Tutt, Andrew N. J., Velikova, Galina, Walker, Rosemary A., Watson, Christine J., Williams, Kaye J., Young, Leonie S. and Thompson, Alastair M. 2013. Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research 15 (5) , R92. 10.1186/bcr3493

Edmunds, Grace L., Smalley, Matthew J., Beck, Sam, Errington, Rachel J., Gould, Sara, Winter, Helen, Brodbelt, David and O'Neill, Dan 2021. Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study. Canine Medicine and Genetics 8 , 2. 10.1186/s40575-021-00100-7

Estrada, Marta F., Rebelo, Sofia P., Davies, Emma J., Pinto, Marta T., Pereira, Hugo, Santo, Vítor E., Smalley, Matthew John, Barry, Simon T., Gualda, Emilio J., Alves, Paula M., Anderson, Elizabeth and Brito, Catarina 2016. Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. Biomaterials 78 , pp. 50-61. 10.1016/j.biomaterials.2015.11.030

Eyupoglu, I. Y., Hahnen, E., Buslei, R., Siebzehnrubl, Florian, Savaskan, N. E., Luders, M., Trankle, C., Wick, W., Weller, M., Fahlbusch, R. and Blumcke, I. 2005. Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo. Journal of Neurochemistry 93 (4) , pp. 992-999. 10.1111/j.1471-4159.2005.03098.x

Eyupoglu, I. Y., Hahnen, E., Heckel, A., Siebzehnrubl, Florian, Buslei, R., Fahlbusch, R. and Blumcke, I. 2005. Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note. Journal of Neurosurgery 102 (4) , pp. 738-744. 10.3171/jns.2005.102.4.0738

Eyupoglu, I. Y., Hahnen, E., Tränkle, C., Savaskan, N. E., Siebzehnrubl, Florian, Buslei, R., Lemke, D., Wick, W., Fahlbusch, R. and Blümcke, I. 2006. Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275. Molecular Cancer Therapeutics 5 (5) , p. 1248. 10.1158/1535-7163.MCT-05-0533


Fang, Hsiao Yu, Martinez-Arias, Alfonso and De Navascues Melero, Joaquin 2016. Autocrine and paracrine Wingless signalling in the Drosophila midgut by both continuous gradient and asynchronous bursts of wingless expression. F1000Research 5 , 317. 10.12688/f1000research.8170.1

Feng, Gui Jie, Cavalli, Antonella and Milligan, Graeme 2002. Engineering a V2 vasopressin receptor agonist- and regulator of G-protein-signaling-sensitive G protein. Analytical Biochemistry 300 (2) , pp. 212-220. 10.1006/abio.2001.5448

Feng, Gui Jie, Cotta, Welwyn, Wei, Xiao-Qing, Poetz, Oliver, Evans, Rebecca Jane, Jardé, Thierry, Reed, Karen Ruth, Meniel, Valerie, Williams, Geraint Trefor, Clarke, Alan Richard and Dale, Trevor Clive 2012. Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology 143 (6) , pp. 1650-1659. 10.1053/j.gastro.2012.08.047

Feng, Gui-Jie, Goodridge, Helen S., Harnett, Margaret M., Wei, Xiao Qing, Nikolaev, Andrei V., Higson, Adrian P. and Liew, Foo -Y. 1999. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. Journal of Immunolgy 163 (12) , pp. 6403-6412.

Feng, Gui-Jie, Kellett, Elaine, Scorer, Carol A., Wilde, Jonathan, White, Julia H. and Milligan, Graeme 2003. Selective interactions between helix VIII of the human μ-opioid receptors and the C terminus of periplakin disrupt G protein activation. Journal of Biological Chemistry 278 (35) , pp. 33400-33407. 10.1074/jbc.M305866200

Flanagan, Dustin, Austin, Chloe, Vincan, Elizabeth and Phesse, Toby 2018. Wnt Signalling in gastrointestinal epithelial stem cells. Genes 9 (4) , 178. 10.3390/genes9040178

Flanagan, Dustin J, Vincan, Elizabeth and Phesse, Toby J. 2019. Wnt signaling in cancer: not a binary ON:OFF switch. Cancer Research 10.1158/0008-5472.CAN-19-1362

Flanagan, Dustin J., Barker, Nick, Nowell, Cameron, Clevers, Hans, Ernst, Matthias, Phesse, Toby J. and Vincan, Elizabeth 2017. Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo. Disease Models and Mechanisms 10 (8) , pp. 971-980. 10.1242/dmm.029876

Flanagan, Dustin J., Schwab, Renate H. M., Tran, Bang M., Phesse, Toby J. and Vincan, Elizabeth 2016. Isolation and culture of adult intestinal, gastric, and lver organoids for cre-recombinase-mediated gene deletion. Methods in Molecular Biology, Humana Press, pp. 1-11. (10.1007/7651_2016_14)

Freeman, Jamie, Smith, David, Latinkic, Branko, Ewan, Ken, Samuel, Lee, Zollo, Massimo, Marino, Natascia, Tyas, Lorraine, Jones, Nick and Dale, Trevor C. 2015. A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators. Molecular Cancer 14 , 206. 10.1186/s12943-015-0475-1

French, Rhiannon and Tornillo, Giusy 2019. Heterogeneity of mammary stem cells. Advances in Experimental Medicine and Biology 1169 , pp. 119-140. 10.1007/978-3-030-24108-7_7

Fujita, Yasuyuki, Hogan, Catherine and Braga, Vania M. M. 2006. Regulation of cell–cell adhesion by Rap1. Methods in Enzymology 407 , pp. 359-372. 10.1016/S0076-6879(05)07030-8


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Parry, Lee, Young, Madeleine, El Marjou, Fatima and Clarke, Alan Richard 2013. Evidence for a crucial role of Paneth Cells in mediating the intestinal response to injury. Stem Cells 31 (4) , pp. 776-785. 10.1002/stem.1326

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Rangaraj, Aravindan, Ye, Lin, Patel, Girish Khandubhai, Harding, Keith Gordon and Jiang, Wen Guo 2010. The role of Bik1 (BCL-2 interaction killer) in wound healing [Abstract]. Wound Repair and Regeneration 18 (6) , A92. 10.1111/j.1524-475X.2010.00633.x

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Reed, Karen Ruth, Korobko, Igor, Ninkina, Natalia, Korobko, Elena V., Hopkins, Ben R., Platt, James L., Buchman, Vladimir and Clarke, Alan Richard 2015. Hunk/Mak-v is a negative regulator of intestinal cell proliferation. BMC Cancer 15 , 110. 10.1186/s12885-015-1087-2

Reed, Karen Ruth, Meniel, Valerie, Marsh Durban, Victoria, Cole, Alicia, Sansom, Owen J. and Clarke, Alan Richard 2008. A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer 8 , 162. 10.1186/1471-2407-8-162

Reed, Karen Ruth, Sansom, Owen J., Hayes, Anthony Joseph, Gescher, Andreas J., Peters, Jefferey M. and Clarke, Alan Richard 2006. PPARδ status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer 6 (113) 10.1186/1471-2407-6-113

Reed, Karen Ruth, Sansom, Owen J., Hayes, Anthony Joseph, Gescher, Andreas J., Winton, Douglas J., Peters, Jeffrey M. and Clarke, Alan Richard 2004. PPARδ status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene 23 (55) , pp. 8992-8996. 10.1038/sj.onc.1208143

Reed, Karen Ruth, Song, Fei, Young, Madeleine, Hassan, N., Antoine, A. J., Gemici, Nesibe-Princess B, Clarke, Alan Richard and Jenkins, J. R. 2016. Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype. Oncotarget 7 (32) , pp. 51665-51673. 10.18632/oncotarget.10076

Reed, Karen Ruth, Tunster, Simon James, Young, Madeleine, Carrico, Adam Stephen, John, Rosalind Margaret and Clarke, Alan Richard 2012. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61 (10) , pp. 1435-1438. 10.1136/gutjnl-2011-300842

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Regan, Joseph L., Sourisseau, Tony, Soady, Kelly, Kendrick, Howard, McCarthy, Afshan, Tang, Chan, Brennan, Keith, Linardopoulos, Spiros, White, Donald E. and Smalley, Matthew John 2013. Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner. Cell Reports 4 (1) , pp. 110-123. 10.1016/j.celrep.2013.05.044

Richards, Alastair J., Hagelstein, Susan M., Patel, Girish Khandubhai, Ivins, Nicola M., Sweetland, Helen Margaret and Harding, Keith Gordon 2011. Early use of negative pressure therapy in combination with silver dressings in a difficult breast abscess. International Wound Journal 8 (6) , pp. 608-611. 10.1111/j.1742-481X.2011.00838.x

Riris, Solon, Cawood, Suzanne, Gui, Liming, Serhal, Paul and Homer, Hayden A. 2013. Immunofluorescence staining of spindles, chromosomes, and kinetochores in human oocytes. In: Homer, Hayden A. ed. Mammalian Oocyte Regulation: Methods and Protocols, Methods in Molecular Biology, vol. 957. New York: Humana Press, pp. 179-187. (10.1007/978-1-62703-191-2_12)

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Ruzov, Alexey, Shorning, Boris, Mortusewicz, Oliver, Dunican, Donncha S., Leonhardt, Heinrich and Meehan, Richard R. 2009. MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. Development 136 (13) , pp. 2277-2286. 10.1242/dev.032227


Sanders, Andrew James, Jiang, David G., Jiang, Wen Guo, Harding, Keith Gordon and Patel, Girish Khandubhai 2011. Activated leukocyte cell adhesion molecule impacts on clinical wound healing and inhibits HaCaT migration. International Wound Journal 8 (5) , pp. 500-507. 10.1111/j.1742-481X.2011.00823.x

Sansom, Owen J. and Clarke, Alan Richard 2000. P53 null mice: damaging the hypothesis? Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 452 (2) , pp. 149-162. 10.1016/S0027-5107(00)00089-0

Sansom, Owen J., Griffiths, David Francis Rees, Reed, Karen Ruth, Winton, Douglas J. and Clarke, Alan Richard 2005. Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene 24 , pp. 8205-8210. 10.1038/sj.onc.1208956

Sansom, Owen J., Meniel, Valerie, Muncan, Vanesa, Phesse, Toby, Wilkins, Julie Ann, Reed, Karen Ruth, Vass, Keith, Athineos, Dimitris, Clevers, Hans and Clarke, Alan Richard 2007. Myc deletion rescues Apc deficiency in the small intestine. Nature 446 (7136) , pp. 676-679. 10.1038/nature05674

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Sansom, Owen J., Reed, Karen Ruth, van de Wetering, M., Muncan, V., Winton, D. J., Clevers, H. and Clarke, Alan Richard 2005. Cyclin D1 is not an immediate target of β-Catenin following Apc loss in the intestine. Journal of Biological Chemistry 280 (31) , pp. 28463-28467. 10.1074/jbc.M500191200

Sansom, Owen J., Stark, Lesley A., Dunlop, Malcolm G. and Clarke, Alan Richard 2001. Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in ApcMin/+ and ApcMin/+, Msh2-/- mice. Cancer Research 61 , pp. 7060-7064.

Sansom, Owen J., Toft, Neil J., Winton, Douglas J. and Clarke, Alan Richard 2001. Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner. Oncogene 20 (27) , pp. 3580-3584. 10.1038/sj.onc.1204449

Sarkar, L., Cobourne, M., Naylor, S., Smalley, Matthew John, Dale, Trevor Clive and Sharpe, P. T. 2000. Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proceedings of the National Academy of Sciences of the United States of America 97 (9) , pp. 4520-4524. 10.1073/pnas.97.9.4520

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Shaw, Paul and Clarke, Alan Richard 2007. Murine models of intestinal cancer: Recent advances. DNA Repair 6 (10) , pp. 1403-1412. 10.1016/j.dnarep.2007.02.022

Shorning, Boris and Clarke, Alan Richard 2011. LKB1 loss of function studied in vivo. FEBS Letters 585 (7) , pp. 958-966. 10.1016/j.febslet.2011.01.019

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